- Understanding Stroke Slideshow Pictures
- Take the Stroke Quiz
- Atrial Fibrillation Slideshow: Causes, Tests and Treatment
- Ibuprofen (Advil, Motrin) and Plavix (clopidogrel) quick overview
- What is ibuprofen? What is Plavix?
- What are the uses for ibuprofen vs. Plavix?
- What are the side effects of ibuprofen vs. Plavix?
- What are the drug interactions of ibuprofen vs. Plavix?
- Are ibuprofen or Plavix safe to take if I am pregnant or breastfeeding?
Ibuprofen (Advil, Motrin) and Plavix (clopidogrel) quick overview
- Ibuprofen (Advil, Motrin) is a nonsteroidal anti-inflammatory drug (NSAID) used for the management of mild to moderate pain, fever, and inflammation. Ibuprofen also is used to treat pain caused by osteoarthritis, rheumatoid arthritis, juvenile idiopathic arthritis, and menstrual cramps.
- Plavix (clopidogrel bisulfate) is an antiplatelet drug prescribed to prevent heart attacks, strokes, and death in people who have had previous heart attacks, strokes, unstable angina, or peripheral arterial disease (PAD, peripheral vascular disease).
- Ibuprofen and Plavix taken together increases the risk of bleeding.
- Ibuprofen does have some similar anti-platelet activity as Plavix; however, ibuprofen is usually is not used as an anti-platelet medication.
- Side effects of ibuprofen and Plavix that are similar include:
- Side effects of ibuprofen that are different from Plavix include:
- Side effects of Plavix that are different from ibuprofen include:
- Ibuprofen is available over-the-counter (OTC), while Plavix is a prescription medication.
- Brand names for ibuprofen include Advil and Motrin. The generic name for Plavix is clopidogrel bisulfate).
What is ibuprofen? What is Plavix?
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Other NSAIDs include aspirin, naproxen (Aleve), indomethacin (Indocin), and nabumetone (Relafen). NSAIDs are used to manage mild to moderate pain, fever, and inflammation. Pain, fever, and inflammation are promoted by the release in the body of chemicals called prostaglandins. Ibuprofen blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower levels of prostaglandins and reduced levels of inflammation, pain and fever.
Plavix (clopidogrel bisulfate) is an anti-platelet drug used to prevent blood clots. Plavix is used to reduce the risk of heart attacks and strokes, particularly in people with a recent history of stroke or heart attack, angina, and peripheral vascular disease. Plavix works by irreversibly binding to the P2Y12 receptor on platelets, preventing adenosine diphosphate (ADP) from activating platelets. It belongs to a class of drugs called P2Y12 inhibitors. Other P2Y12 inhibitors include ticagrelor (Brilinta) and prasugrel (Effient). Clopidogrel is similar to ticlopidine (Ticlid) in chemical structure and in the way it works.
What are the uses for ibuprofen vs. Plavix?
Ibuprofen is used for the treatment of mild to moderate pain, inflammation and fever caused by many and diverse diseases. It is used for treating dysmenorrhea (menstrual cramps), osteoarthritis, rheumatoid arthritis, and juvenile idiopathic arthritis.
Plavix is used for preventing strokes, heart attacks, and death in individuals who have had a previous stroke, unstable angina, heart attack or have peripheral arterial disease (PAD). The combination of Plavix and aspirin is better than aspirin or Plavix alone in preventing another heart attack but the risk of bleeding is higher.
What are the side effects of ibuprofen vs. Plavix?
Ibuprofen side effects
The most common side effects from ibuprofen are:
- ringing in the ears,
- abdominal pain,
- constipation, and
NSAIDs reduce the ability of blood to clot and therefore increase bleeding after an injury.
Ibuprofen may cause ulceration of the stomach or intestine, and the ulcers may bleed. Sometimes, ulceration can occur without abdominal pain; and due to bleeding, the only signs or symptoms of an ulcer may be black, tarry stools, weakness, and dizziness upon standing (orthostatic hypotension).
Sometimes, ulceration can occur without abdominal pain, due to the bleeding, and the only signs or symptoms of an ulcer are:
NSAIDs reduce the flow of blood to the kidneys and impair function of the kidneys. The impairment is most likely to occur in patients who already have impaired function of the kidney or congestive heart failure, and use of NSAIDs in these patients should be cautious.
People who are allergic to other NSAIDs, including aspirin, should not use ibuprofen. Individuals with asthma are more likely to experience allergic reactions to ibuprofen and other NSAIDs.
Other serious side effects associated with NSAIDs are:
- fluid retention (edema),
- blood clots,
- heart attacks,
- hypertension (high blood pressure), and
- heart failure.
NSAIDs (except low- dose aspirin) may increase the risk of potentially fatal heart attacks, stroke, and related conditions in people with or without heart disease or risk factors for heart disease. The increased risk of heart attack or stroke may occur as early as the first week of use and the risk may increase with longer use and is higher in patients who have underlying risk factors for heart and blood vessel disease. Therefore, NSAIDs should not be used for the treatment of pain resulting from coronary artery bypass graft (CABG) surgery.
Plavix side effects
People tolerate clopidogrel in the same way as aspirin.
The more common side effects of clopidogrel are:
Severe side effects and adverse reactions to Plavix include:
- severe bleeding,
- allergic reactions,
- pancreatitis, and
- liver failure.
Ticlopidine (Ticlid) is an antiplatelet medication quite similar to clopidogrel. It has been associated with a severe reduction in white blood cell count in between 0.8% and 1% of persons. The risk of this dangerous side effect with clopidogrel is about 0.04%, much less than with ticlopidine but twice that of aspirin.
Clopidogrel rarely causes a condition called thrombotic thrombocytopenic purpura (TTP) in one out of every 250,000 people. TTP is a serious condition in which blood clots form throughout the body. Blood platelets, which participate in clotting, are consumed, and the result can be bleeding because enough platelets are no longer left to allow blood to clot normally. For comparison, the related drug, ticlodipine (Ticlid), causes TTP 17-50 times more frequently than clopidogrel.
What are the drug interactions of ibuprofen vs. Plavix?
Ibuprofen drug interactions
Ibuprofen is associated with several suspected or probable interactions that can affect the action of other drugs.
- Ibuprofen may increase the blood levels of lithium (Eskalith, Lithobid) by reducing the excretion of lithium by the kidneys. Increased levels of lithium may lead to lithium toxicity.
- Ibuprofen may reduce the blood pressure-lowering effects of drugs that are given to reduce blood pressure. This may occur because prostaglandins play a role in the regulation of blood pressure.
- When ibuprofen is used in combination with methotrexate (Rheumatrex, Trexall) or aminoglycosides (for example, gentamicin) the blood levels of the methotrexate or aminoglycoside may increase, presumably because their elimination from the body is reduced. This may lead to more methotrexate or aminoglycoside-related side effects.
- Ibuprofen increases the negative effect of cyclosporine on kidney function.
- Individuals taking oral blood thinners or anticoagulants, for example, warfarin (Coumadin), should avoid ibuprofen because ibuprofen also thins the blood, and excessive blood thinning may lead to bleeding.
- If aspirin is taken with ibuprofen there may be an increased risk for developing an ulcer.
- Persons who have more than three alcoholic beverages per day may be at increased risk of developing stomach ulcers when taking ibuprofen or other NSAIDs.
- Combining SSRIs or selective serotonin reuptake inhibitors (for example, fluoxetine [Prozac], citalopram [Celexa], paroxetine [Paxil, Paxil CR, Pexeva) with NSAIDs may increase the likelihood of upper gastrointestinal bleeding.
Plavix drug interactions
- The combination of clopidogrel with nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin, Advil, Nuprin), naproxen (Naprosyn, Aleve), diclofenac (Voltaren), etodolac (Lodine), nabumetone (Relafen), fenoprofen (Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis; Oruvail), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), tolmetin (Tolectin), and mefenamic acid (Ponstel) may increase the risk of stomach and intestinal bleeding.
- Combining clopidogrel with warfarin (Coumadin) or other drugs that cause bleeding increases the risk of bleeding.
- Clopidogrel is converted to its active form by enzymes in the liver. Drugs that reduce the activity of these enzymes, for example, omeprazole (Prilosec, Zegerid) or esomeprazole (Nexium) may reduce the activity of clopidogrel and should not be used with clopidogrel. Other drugs that also may react with clopidogrel in a similar fashion include fluoxetine (Prozac, Sarafem), cimetidine (Tagamet), fluconazole (Diflucan), ketoconazole (Nizoral, Extina, Xolegel, Kuric), voriconazole (Vfend), ethaverine (Ethatab, Ethavex), felbamate (Felbatol), and fluvoxamine (Luvox).
Are ibuprofen or Plavix safe to take if I am pregnant or breastfeeding?
Ibuprofen and pregnancy safety
- There are no adequate studies of ibuprofen in pregnant women. Therefore, ibuprofen is not recommended during pregnancy. Ibuprofen should be avoided in late pregnancy due to the risk of premature closure of the ductus arteriosus in the fetal heart.
- Ibuprofen is excreted in breast milk but the American Academy of Pediatrics states that ibuprofen is compatible with breastfeeding.
Plavix and pregnancy safety
- There are no adequate studies of clopidogrel in pregnant women.
- Studies in rats have shown that clopidogrel appears in breast milk; however, it is not known whether it also appears in human breast milk. Because of a potential for side effects in the nursing infant, the physician must weigh the potential benefits and possible risks before prescribing clopidogrel to nursing mothers.
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Ibuprofen is an anti-inflammatory medication (NSAID) used for the treatment of mild to moderate pain and fever. Plavix (clopidogrel) is a blood thinner (anti-platelet) drug used for the prevention of strokes, heart attacks, and peripheral artery disease. Ibuprofen also thins the blood. If ibuprofen and Plavix are taken together it creates an interaction that thins the blood even more, which may cause gastrointestinal bleeding from ulcers in the digestive tract.
Common side effects of ibuprofen and Plavix include headaches, dizziness, rash, abdominal pain, and diarrhea. Side effects of ibuprofen that do not occur with Plavix include ringing in the ears, heartburn, drowsiness, nausea, and constipation. Serious side effects of Plavix that do not occur with ibuprofen include pancreatitis, severe bleeding, allergic reactions, and liver failure. Plavix also interacts with many other drugs so check with your doctor or pharmacist before taking over the counter medication or other prescription before taking Plavix.
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How the Heart Works: Sides, Chambers, and Function
The heart is a very important organ in the body. It is responsible for continuously pumping oxygen and nutrient-rich blood throughout your body to sustain life. It is a fist-sized muscle that beats (expands and contracts) 100,000 times per day, pumping a total of five or six quarts of blood each minute, or about 2,000 gallons per day.
A stroke is an interruption of the blood supply to part of the brain caused by either a blood clot (ischemic) or bleeding (hemorrhagic). Symptoms of a stroke may include: weakness, numbness, double vision or vision loss, confusion, vertigo, difficulty speaking or understanding speech. A physical exam, imaging tests, neurological exam, and blood tests may be used to diagnose a stroke. Treatment may include administration of clot-busting drugs, supportive care, and in some instances, neurosurgery. The risk of stroke can be reduced by controlling high blood pressure, high cholesterol, diabetes, and stopping smoking.
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Heart Attack Symptoms and Early Warning Signs
Recognizing heart attack symptoms and signs can help save your life or that of someone you love. Some heart attack symptoms, including left arm pain and chest pain, are well known but other, more nonspecific symptoms may be associated with a heart attack. Nausea, vomiting, malaise, indigestion, sweating, shortness of breath, and fatigue may signal a heart attack. Heart attack symptoms and signs in women may differ from those in men.
Arthritis (Joint Inflammation)
Arthritis is inflammation of one or more joints. When joints are inflamed they can develop stiffness, warmth, swelling, redness and pain. There are over 100 types of arthritis, including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, lupus, gout, and pseudogout.
Stroke vs. Mini-Stroke (TIA) Differences
A stroke or "brain attack" occurs when a blood clot or artery ruptures within the brain. The rupture or clot causes brain cell damage or death. A mini-stroke (TIA, transient ischemic attack) is caused by brain cells that dysfunctional over a short period. Stroke and mini-stroke warning signs of stroke and mini stroke are the same, and include, speech problems, weakness, numbness, and facial droop. Side effects of stroke may be permanent and you may never regain full function of the parts of the body affected. Mini-stroke side effects usually resolve within minutes to a couple of days. A transient ischemic attack (mini-stroke) is a precursor for stroke because 40% of individuals who have a mini-stroke will have a stroke within a year. Treatment of stroke depends upon the type and parts of the body affected.
Early Warning Signs and Symptoms of Stroke (FAST)
Stroke is a serious medical condition. If you think you or someone you know is having a stroke call 911 immediately. There are two main types of strokes, hemorrhagic and ischemic (the most common type). A hemorrhagic stroke occurs due to a blood vessel rupture in the brain. An ischemic stroke occurs when a blood clot becomes lodged in a blood vessel in the brain, which causes a loss of blood supply to the brain, possibly causing brain tissue death. FAST is an acronym that helps people identify stroke signs and symptoms so they can act fast and call 911. Face drooping, Arm weakness, and Speech difficulty are indicators that a person may be having a stroke and it is Time to seek emergency medical treatment. Additional signs and symptoms of stroke may include weakness, difficulty walking, blurred vision, dizziness, headache, confusion, difficulty speaking, and loss of sensation. Stroke is a major cause of death and disability in the U.S. Early identification and treatment of stroke helps reduce the risk of morbidity and mortality.
Peripheral Vascular Disease
Peripheral vascular disease (PVD) refers to diseases of the blood vessels (arteries and veins) located outside the heart and brain. While there are many causes of peripheral vascular disease, doctors commonly use the term peripheral vascular disease to refer to peripheral artery disease (peripheral arterial disease, PAD), a condition that develops when the arteries that supply blood to the internal organs, arms, and legs become completely or partially blocked as a result of atherosclerosis. Peripheral artery disease symptoms include intermittent leg pain while walking, leg pain at rest, numbness in the legs or feet, and poor wound healing in the legs or feet. Treatment for peripheral artery disease include lifestyle measures, medication, angioplasty, and surgery.
Heart Attack (Myocardial Infarction)
A heart attack happens when a blood clot completely obstructs a coronary artery supplying blood to the heart muscle. A heart attack can cause chest pain, heart failure, and electrical instability of the heart.
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Transient Ischemic Attack (TIA, Mini-Stroke)
When a portion of the brain loses blood supply, through a blood clot or embolus, a transient ischemic attack (TIA, mini-stroke) may occur. If the symptoms do not resolve, a stroke most likely has occurred. Symptoms of TIA include: confusion, weakness, lethargy, and loss of function to one side of the body. Risk factors for TIA include vascular disease, smoking, high blood pressure, high cholesterol, and diabetes. Treatment depends upon the severity of the TIA, and whether it resolves.
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Migraine and Stroke
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Heart Attack vs. Heartburn
Heartburn is a symptom of another disease or medical problem and can be described as a feeling of burning in the chest accompanied by symptoms of nausea, vomiting, or a sour taste or food stuck in the back of the throat. Heart attack occurs when an artery in the heart is completely blocked by a blood clot, which causes that portion of heart muscle to die. Heart attack also has symptoms of chest pain, nausea, and vomiting, however, other warning signs and symptoms of a heart attack are unusual weakness or fatigue, and persistent and/or increased severity of symptoms over a few minutes. Heart attack is a life threatening emergency. If you think you or someone you are with is having a heart attack, call 911 immediately for urgent medical treatment. It may save your life.
Heart Attack vs. Stroke Symptoms, Differences, and Similarities
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Heart Attack Treatment
A heart attack involves damage or death of part of the heart muscle due to a blood clot. The aim of heart attack treatment is to prevent or stop this damage to the heart muscle. Heart attack treatments included medications, procedures, and surgeries to protect the heart muscle against injury.
Heart Attacks in Women
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Pain Management: Musculoskeletal Pain
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Heart Attack Prevention
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Treatment & Diagnosis
Medications & Supplements
- Nonsteroidal Antiinflammatory Drugs (NSAIDs)
- Anticoagulants (Anticoagulant Drug Class)
- ibuprofen (Advil, Motrin, Nuprin)
- Aspirin vs. Plavix (clopidogrel)
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- Ibuprofen vs. Meloxicam (Mobic) for Pain
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- clopidogrel bisulfate (Plavix)
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- Types of Osteoarthritis Medications
- Duexis (ibuprofen and famotidine)
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