IBS: What is Fedotazine? Is it used in IBS?


Topic: Irritable Bowel Syndrome (IBS), June 2000

Dr. Lee:
A 50 year old sufferer of IBS was told by her doctor about a new drug called fedotazine, a 5-H7 receptor antagonist. What is fedotazine? Do you know any clinical trials she can participate in?

Dr. Marks:
Fedotazine, like alosetron , works via neurotransmitters, but in the case of fedotazine, it works on a different neurotransmitter, one referred to as an opioid neurotransmitter. Moreover, fedotazine strengthens the effects of the neurotransmitter on nerves in contrast to alosetron, which blocks the effects. Fedotazine is being studied in irritable bowel, but it has not been approved for use by the FDA in the US. I am not aware of studies at the present time with irritable bowel and fedotazine. It would really depend on what part of the country the viewer is in as to whether participation would be practical or not.

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