- Irritable Bowel Syndrome (IBS) Slideshow Pictures
- Digestive Disease Myths
- Irritable Bowel Syndrome (IBS) Quiz
- What is hyoscyamine sublingual, and how does it work (mechanism of action)?
- What are the uses for hyoscyamine sublingual?
- What are the side effects of hyoscyamine sublingual?
- What is the dosage for hyoscyamine sublingual?
- Which drugs or supplements interact with hyoscyamine sublingual?
- Is hyoscyamine sublingual safe to take if I'm pregnant or breastfeeding?
- What else should I know about hyoscyamine sublingual?
What is hyoscyamine sublingual, and how does it work (mechanism of action)?
- Hyoscyamine is an anticholinergic drug used for treating irritable bowel syndrome, peptic ulcer disease, hypermotility of the lower urinary tract, and gastrointestinal disorders.
- Anticholinergics work by blocking the action of acetylcholine in the brain and at nerves throughout the body. Acetylcholine is a neurotransmitter. Neurotransmitters are chemicals made and released by nerves that travel to nearby nerves or, in the case of acetylcholine, nearby muscles and glands where they attach to receptors on the surface of the nerve, muscle or glandular cells.
- The attachment of the neurotransmitter can stimulate or inhibit the activity of the receptor-containing cells. Anticholinergic drugs like hyoscyamine affect the function of many organs by preventing acetylcholine from binding to its receptors.
- Hyoscyamine decreases the activity of muscles in the intestine and lower urinary tract. It reduces the production of sweat, saliva, digestive juices, urine, and tears. It also reduces the production of bronchial secretions.
What brand names are available for hyoscyamine sublingual?
Is hyoscyamine sublingual available as a generic drug?
Do I need a prescription for hyoscyamine sublingual?
What are the side effects of hyoscyamine sublingual?
Side effects include:
Other side effects include:
- Decreased sweating (anhidrosis)
- Blurred vision
- Dilation of the pupil of the eye (mydriasis)
- Loss of taste
- Stomach pain
- Allergic reactions
Possible serious side effects include:
What is the dosage for hyoscyamine sublingual?
- The recommended oral dose of immediate release tablet or drops for treating irritable bowel syndrome, gastrointestinal disorders, or peptic ulcer disease is 0.125 mg to 0.25 mg every 4 hours.
- The maximum dose is 1.5 mg daily.
- The dose of immediate release formulations for treating hypermotility disorder is 0.15 to 0.3 mg orally every 6 hours.
Which drugs or supplements interact with hyoscyamine sublingual?
- The risk of adverse effects increases when hyoscyamine is combined with other drugs that block the action of acetylcholine. Such drugs include antimuscarinics, amantadine, haloperidol, phenothiazines, monoamine oxidase (MAO) inhibitors, tricyclic antidepressants, or some antihistamines.
- Antacids may interfere with the absorption of extended release hyoscyamine.
Latest Digestion News
Is hyoscyamine sublingual safe to take if I'm pregnant or breastfeeding?
What else should I know about hyoscyamine sublingual?
What preparations of hyoscyamine sublingual are available?
- Capsules or tablet Extended Release: 0.375 mg.
- Elixir: 0.125 mg/5 ml.
- Injections: 0.5 mg/ml.
- Oral Drops: 0.125 mg/ml.
- Tablet: 0.125 mg
How should I keep hyoscyamine sublingual stored?
- Hyoscyamine should be stored at room temperature between 20 C and 25 C (68 F and 77 F).
Hyoscyamine sublingual (Levbid, Levsin, Nulev, Anaspaz) is a prescription drug used to treat IBS (irritable bowel disease), stomach ulcers, hypermotility of the lower urinary tract, and GI disorders. Side effects may include dry eyes, constipation, confusion urinary retention, excitement. Drug interactions, dosage, and pregnancy and breastfeeding safety information should be reviewed prior to taking any medication.
Multimedia: Slideshows, Images & Quizzes
Irritable Bowel Syndrome (IBS) Quiz: Test Your Medical IQ
What are symptoms of irritable bowel syndrome (IBS)? Take this quiz and get quick facts on causes and treatment options for this...
Picture of Peptic Ulcer
A hole in the lining of the stomach, duodenum, or esophagus. See a picture of Peptic Ulcer and learn more about the health topic.
IBS - Irritable Bowel Syndrome: Symptoms, Diet, Treatment
What is irritable bowel syndrome (IBS)? Learn about symptoms, causes, and foods that trigger IBS. Get lifestyle tips for managing...
Related Disease Conditions
Colic in Babies
Colic is crying or fussing that begins suddenly, lasting for a total of three hours a day and happening more than three days a week for about three weeks. Symptoms include the baby's face turning red, the belly is distended, the feet may be cold, the hands clenched, and the legs may alternate between being flexed or extended. Treatment may involve ruling out other causes of the fussing and the doctor prescribing anti-gas bubbly medicine.
Diverticulitis (Diverticulosis, Diverticular Disease)
Most people with diverticulosis have few if any symptoms at all. When people do experience signs and symptoms of diverticulosis (diverticular disease) they may include abdominal pain, abdominal cramps, diarrhea, constipation, and bloating. Diverticulitis is a condition in which diverticuli in the colon rupture. The rupture results in infection in the tissues that surround the colon. Treatment methods for diverticulitis includes prescription medications, and in some cases, diverticulitis surgery.
Irritable Bowel Syndrome (IBS)
Irritable bowel syndrome (IBS) is a GI (gastrointestinal) disorder with signs and symptoms that include abdominal pain, bloating, increased gas (flatulence), abdominal cramping, diarrhea, constipation, and food intolerance.Two new tests are now available that may help diagnose irritable bowel syndrome with diarrhea and constipation (IBS-M) irritable bowel syndrome with diarrhea (IBS-D), and irritable bowel syndrome with constipation (IBS-C). Treatment for IBS includes diet changes, medications, and other lifestyle changes to manage symptoms.
Acute and Chronic Pancreatitis
Pancreatitis is a rare disease in which the pancreas becomes inflamed. There are two types of pancreatitis: acute and chronic. Symptoms of pancreatitis include abdominal pain, fever, nausea, vomiting, and a rapid pulse. Treatment of pancreatitis often requires hospitalization.
Parkinson's disease is a slowly progressive neurological disease characterized by a fixed inexpressive face, a tremor at rest, slowing of voluntary movements, a gait with short accelerating steps, peculiar posture and muscle weakness, caused by degeneration of an area of the brain called the basal ganglia, and by low production of the neurotransmitter dopamine. Most patients are over 50, but at least 10 percent are under 40.
Peptic Ulcer (Stomach Ulcer)
Peptic or stomach ulcers are ulcers are an ulcer in the lining of the stomach, duodenum, or esophagus. Ulcer formation is related to H. pylori bacteria in the stomach, use of anti-inflammatory medications, and cigarette smoking. Symptoms of peptic or stomach ulcers include abdominal burning or hunger pain, indigestion, and abdominal discomfort after meals. Treatment for stomach ulcers depends upon the cause.
Ulcerative colitis is a chronic inflammation of the colon. Symptoms include abdominal pain, diarrhea, and rectal bleeding. Ulcerative colitis is closely related to Crohn's disease, and together they are referred to as inflammatory bowel disease. Treatment depends upon the type of ulcerative colitis diagnosed.
Diarrhea is a change is the frequency and looseness of bowel movements. Symptoms associated with diarrhea are cramping, abdominal pain, and the sensation of rectal urgency. Causes of diarrhea include viral, bacterial, or parasite infection, gastroenteritis, food poisoning, and drugs. Absorbents and anti-motility medications are used to treat diarrhea.
There are many types of urinary incontinence (UI), which is the accidental leakage of urine. These types include stress incontinence, urge incontinence, and overflow incontinence. Urinary incontinence in men may be caused by prostate or nerve problems. Treatment depends upon the type and severity of the UI and the patient's lifestyle.
Urinary Incontinence in Children
Urinary incontinence in children (enuresis) is twice as common in boys as in girls and may occur during the daytime or nighttime. Nighttime urinary incontinence is also called bedwetting and sleepwetting. The cause of nighttime incontinence in children is unknown. Daytime incontinence in children may be caused by an overactive bladder. Though many children overcome urinary incontinence naturally, it may be necessary to treat incontinence with medications, bladder training and moisture alarms, which wake the child when he or she begins to urinate.
Nerve Disease and Bladder Control
A nerve problem might affect your bladder control if the nerves that are supposed to carry messages between the brain and the bladder do not work properly. Such problems include urine retention, poor control of sphincter muscles, and overactive bladder. Treatment depends upon the cause of the nerve damage and resulting type of bladder control problem.
IBS-D (Irritable Bowel Syndrome with Diarrhea)
IBS-D or irritable bowel syndrome with diarrhea refers to IBS with diarrhea. Symptoms of IBS-D include intestinal gas (flatulence), loose stools, frequent stools, abdominal pain, diarrhea, and nausea. New non-FDA approved IBS tests may help diagnose IBS and IBS-D. Treatment of IBS-D is geared to toward managing symptoms with diet, medication, and lifestyle changes.
Treatment & Diagnosis
Medications & Supplements
Prevention & Wellness
Subscribe to MedicineNet's General Health Newsletter
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
FDA Prescribing Information