- Osteoarthritis Overview Slideshow Pictures
- Osteoarthritis Tips for Living Better Daily Slideshow
- Exercises for OA of the Knee Slideshow
- What is hylan G-F 20 (Synvisc, Synvisc One), and how does it work (mechanism of action)?
- What are the uses for Synvisc?
- What are the side effects of Synvisc?
- Which drugs or supplements interact with Synvisc?
- What's the dosage for Synvisc and Synvisc One, and how is the injection given?
- What brand names are available for hylan G-F 20?
- Do I need a prescription for Synvisc?
- Is this drug safe to take if I'm pregnant or breastfeeding?
- What else should I know about this drug?
What is hylan G-F 20 (Synvisc, Synvisc One), and how does it work (mechanism of action)?
What is hylan G-F 20 (Synvisc, Synvisc One)?
Hylan G-F 20 (Synvisc, Synvisc One) is an injectable fluid that is used to treat osteoarthritis (OA) of the knee. Osteoarthritis is a type of arthritis in which the joints of the body degenerate and become painful and stiff. Osteoarthritis is the most common form of arthritis. Almost 10 million Americans suffer from the disease. Most people with OA are those 45 years old, and women. More women have OA than men.
How does Synvisc work?
Joints contain a fluid, called synovial fluid, which acts as a lubricant and shock absorber. Patients with osteoarthritis have synovial fluid that is thinner than normal, and, therefore, it is less effective as a lubricant and shock-absorber. Synvisc is an elastic fluid that is made from a substance called hyaluronan, that is found in normal joint fluid. Hyaluronan is the key substance in joint fluid that provides the shock-absorbing quality to the fluid, and it is essential for the proper functioning of joints. When Synvisc is injected into the knee of a patient with osteoarthritis, the drug helps to restore the shock-absorbing effect of the fluid within the knee. This can reduce pain, resulting in a more active lifestyle.
What are the uses for Synvisc?
Synvisc is used for treating pain caused by osteoarthritis of the knee.
What are the side effects of Synvisc?
About 1 in 14 persons experience pain or swelling in the injected knee, and one third of those who do, need to have fluid removed from the knee.
Common side effects include:
Other side effects include:
Which drugs or supplements interact with Synvisc?
There are no known drug interactions with Sinvisc.
What's the dosage for Synvisc and Synvisc One, and how is the injection given?
- Synvisc is injected into the knee by a doctor or other health care professional. A course of treatment consists of three injections with each injection seven days apart when using Synvisc.
- Alternatively Synvisc-One, which contains all 3 doses (48 mg/ 6 ml) can be injected once as a single injection.
Most people experience the greatest amount of relief from pain 8 to 12 weeks after beginning treatment. Some patients will require more than one course of treatment.
What brand names are available for hylan G-F 20?
Synvisc and Synvisc-One are the brand names available for this generic drug.
Is this drug safe to take if I'm pregnant or breastfeeding?
What else should I know about this drug?
What preparations of Synvisc are available?
Injection: 16 mg/2 ml, 48 mg/6 ml
How should I keep Synvisc stored?
Synvisc should be stored at room temperature, below 86 F (30 C). Any unused solution should be thrown out. It should not be frozen.
Hylan G-F 20 (Synvisc, Synvisc One) is a drug prescribed for treating pain caused by osteoarthritis of the knee. Synovial fluid is a fluid in the joints that act as a lubricant and shock absorber. Patients with osteoarthritis (OA) have thinner synovial fluid than normal. Synvisc is an elastic fluid that acts as a lubricant and shock absorber, and thus helps restore the shock absorbing effect of the fluid within the knee. This drug is administered as an injection of 16 mg/2 ml and 48 mg/6ml by a doctor or other healthcare professional. There are no known drug interactions with Synvisc. There aren't any adequate drug studies for Synvisc during pregnancy or while breastfeeding. Synvisc is secreted into breast milk.
Common side effects include:
- Joint swelling
- Joint stiffness
- Injection site reactions
- Muscle pain
- Itching or skin irritation around the knee
More serious side effects are:
Talk with your doctor, pharmacist, or other healthcare professional with questions about Synvisc or Synvisc One.
If you notice other effects not listed above, contact your doctor or pharmacist. In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Read the entire hylan G-F 20 (Synvisc, Synvisc One) drug consumer monograph >>
Multimedia: Slideshows, Images & Quizzes
Pain Quiz: Test Your IQ of Pain
Is pain all in the brain? Take the Pain Quiz to learn everything you've ever wanted to know about the unpleasant sensation we...
Picture of Osteoarthritis
Osteoarthritis is a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more...
Exercises for Knee Osteoarthritis and Joint Pain
Learn about osteoarthritis and exercises that relieve knee osteoarthritis pain, stiffness and strengthen the knee joint and...
Osteoarthritis (OA): Treatment, Symptoms, Diagnosis
Osteoarthritis (OA) is a degenerative joint disease affecting both cartilage and bone. Joints most often affected by...
Osteoarthritis: 15 Tips to Improve Daily Living With OA
Osteoarthritis joint pain can make it hard to carry out activities of daily living. Cartilage destruction can cause symptoms like...
Fun With Kids and More Ways to Live With OA in Pictures
You can still have lots of fun with children despite arthritis. Our experts uncover ways to spend time with your kids or...
Exercises for Osteoarthritis -- Yoga, Swimming, & More
Check out this slideshow on Active Living From Day to Night with Osteoarthritis. Even with arthritis you can keep your active...
Tips for Healthy Joints: Exercise, Nutrition, & More in Pictures
Dealing with joint pain and arthritis? Learn why weight matters--and why NOT to stretch before exercise. See these solutions for...
Pain Management: 15 Easy Ways to Reduce Chronic Pain
Chronic pain can be a symptom of many conditions, including arthritis, headaches, and others. Comprehensive pain management...
Related Disease Conditions
Acute injuries, medical conditions, and chronic use conditions are causes of knee pain. Symptoms and signs that accompany knee...
Osteoarthritis is a type of arthritis caused by inflammation, breakdown, and eventual loss of cartilage in the joints. Also...
Arthritis is inflammation of one or more joints. When joints are inflamed they can develop stiffness, warmth, swelling, redness...
Chronic pain is pain (an unpleasant sense of discomfort) that persists or progresses over a long period of time. In contrast to...
Pain management and treatment can be simple or complex, according to its cause. There are two basic types of pain, nociceptive...
A torn meniscus (knee cartilage) may be caused by suddenly stopping, sharply twisting, or deep squatting or kneeling when lifting...
Treatment & Diagnosis
- Pain FAQs
- Medication Disposal
- Dangers of Mixing Medications
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
Prevention & Wellness
Quick GuideOsteoarthritis (OA): Treatment, Symptoms, Diagnosis
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.