hylan G-F 20 (Synvisc, Synvisc One)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

View Osteoarthritis Overview Slideshow Pictures

What is hylan G-F 20 (Synvisc, Synvisc One), and how does it work (mechanism of action)?

What is hylan G-F 20 (Synvisc, Synvisc One)?

Hylan G-F 20 (Synvisc, Synvisc One) is an injectable fluid that is used to treat osteoarthritis (OA) of the knee. Osteoarthritis is a type of arthritis in which the joints of the body degenerate and become painful and stiff. Osteoarthritis is the most common form of arthritis. Almost 10 million Americans suffer from the disease. Most people with OA are those 45 years old, and women. More women have OA than men.

How does Synvisc work?

Joints contain a fluid, called synovial fluid, which acts as a lubricant and shock absorber. Patients with osteoarthritis have synovial fluid that is thinner than normal, and, therefore, it is less effective as a lubricant and shock-absorber. Synvisc is an elastic fluid that is made from a substance called hyaluronan, that is found in normal joint fluid. Hyaluronan is the key substance in joint fluid that provides the shock-absorbing quality to the fluid, and it is essential for the proper functioning of joints. When Synvisc is injected into the knee of a patient with osteoarthritis, the drug helps to restore the shock-absorbing effect of the fluid within the knee. This can reduce pain, resulting in a more active lifestyle.

What are the uses for Synvisc?

Synvisc is used for treating pain caused by osteoarthritis of the knee.

What are the side effects of Synvisc?

About 1 in 14 persons experience pain or swelling in the injected knee, and one third of those who do, need to have fluid removed from the knee.

Common side effects include:

Other side effects include:

  • Injection site pain
  • Injection site stiffness
  • Injection site redness
  • Skin rash
  • Itching
  • Facial flushing
  • Facial swelling

Which drugs or supplements interact with Synvisc?

There are no known drug interactions with Sinvisc.

Quick GuideOsteoarthritis (OA): Treatment, Symptoms, Diagnosis

Osteoarthritis (OA): Treatment, Symptoms, Diagnosis

What's the dosage for Synvisc and Synvisc One, and how is the injection given?

  • Synvisc is injected into the knee by a doctor or other health care professional. A course of treatment consists of three injections with each injection seven days apart when using Synvisc.
  • Alternatively Synvisc-One, which contains all 3 doses (48 mg/ 6 ml) can be injected once as a single injection.

Most people experience the greatest amount of relief from pain 8 to 12 weeks after beginning treatment. Some patients will require more than one course of treatment.

What brand names are available for hylan G-F 20?

Synvisc and Synvisc-One are the brand names available for this generic drug.

Do I need a prescription for Synvisc?

Yes, you need a prescription for this hylan G-F 20.

Is this drug safe to take if I'm pregnant or breastfeeding?

  • No adequate studies have been done in pregnant women with this drug.
  • The risks of Synvisc during breastfeeding are not known. It is not known if Synvisc is excreted into breast milk.

What else should I know about this drug?

What preparations of Synvisc are available?

Injection: 16 mg/2 ml, 48 mg/6 ml

How should I keep Synvisc stored?

Synvisc should be stored at room temperature, below 86 F (30 C). Any unused solution should be thrown out. It should not be frozen.

Reference: FDA Prescribing Information

Subscribe to MedicineNet's Arthritis Newsletter

By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time.

FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

See more info: hylan G-F 20 on RxList
Reviewed on 5/22/2017
Reference: FDA Prescribing Information

Health Solutions From Our Sponsors