- Osteoarthritis Overview Slideshow Pictures
- Osteoarthritis Quiz: Test Your Medical IQ
- Exercises for OA of the Knee Slideshow
- What is hylan G-F 20 (Synvisc, Synvisc One), and how does it work (mechanism of action)?
- What are the uses for Synvisc?
- What are the side effects of Synvisc?
- Which drugs or supplements interact with Synvisc?
- What's the dosage for Synvisc and Synvisc One, and how is the injection given?
- Is this drug safe to take if I'm pregnant or breastfeeding?
- What else should I know about this drug?
What is hylan G-F 20 (Synvisc, Synvisc One), and how does it work (mechanism of action)?
What is hylan G-F 20 (Synvisc, Synvisc One)?
Hylan G-F 20 (Synvisc, Synvisc One) is an injectable fluid that is used to treat osteoarthritis (OA) of the knee. Osteoarthritis is a type of arthritis in which the joints of the body degenerate and become painful and stiff. Osteoarthritis is the most common form of arthritis. Almost 10 million Americans suffer from the disease. Most people with OA are those 45 years old, and women. More women have OA than men.
How does Synvisc work?
Joints contain a fluid, called synovial fluid, which acts as a lubricant and shock absorber. Patients with osteoarthritis have synovial fluid that is thinner than normal, and, therefore, it is less effective as a lubricant and shock-absorber. Synvisc is an elastic fluid that is made from a substance called hyaluronan, that is found in normal joint fluid. Hyaluronan is the key substance in joint fluid that provides the shock-absorbing quality to the fluid, and it is essential for the proper functioning of joints. When Synvisc is injected into the knee of a patient with osteoarthritis, the drug helps to restore the shock-absorbing effect of the fluid within the knee. This can reduce pain, resulting in a more active lifestyle.
What brand names are available for hylan G-F 20?
Synvisc and Synvisc-One are the brand names available for this generic drug.
Do I need a prescription for Synvisc?
Yes, you need a prescription for this hylan G-F 20.
What are the uses for Synvisc?
Synvisc is used for treating pain caused by osteoarthritis of the knee.
What are the side effects of Synvisc?
About 1 in 14 persons experience pain or swelling in the injected knee, and one third of those who do, need to have fluid removed from the knee.
Common side effects include:
Other side effects include:
Which drugs or supplements interact with Synvisc?
There are no known drug interactions with Sinvisc.
What's the dosage for Synvisc and Synvisc One, and how is the injection given?
- Synvisc is injected into the knee by a doctor or other health care professional. A course of treatment consists of three injections with each injection seven days apart when using Synvisc.
- Alternatively Synvisc-One, which contains all 3 doses (48 mg/ 6 ml) can be injected once as a single injection.
Most people experience the greatest amount of relief from pain 8 to 12 weeks after beginning treatment. Some patients will require more than one course of treatment.
Is this drug safe to take if I'm pregnant or breastfeeding?
What else should I know about this drug?
What preparations of Synvisc are available?
Injection: 16 mg/2 ml, 48 mg/6 ml
How should I keep Synvisc stored?
Synvisc should be stored at room temperature, below 86 F (30 C). Any unused solution should be thrown out. It should not be frozen.
Latest Health News
- Lots of Nightmares in Middle Age Might Be Warning Sign of Dementia
- AHA News: Waiting For Takeoff, Her Heart Stopped. Flight Attendants Came to the Rescue.
- Big Studies Test Effectiveness of Common Diabetes Meds
- Can Deep Brain Stimulation Cure Severe OCD?
- A Good Night's Sleep Recharges Immune System
- More Health News »
Hylan G-F 20 (Synvisc, Synvisc One) is a drug prescribed for treating pain caused by osteoarthritis of the knee. Synovial fluid is a fluid in the joints that act as a lubricant and shock absorber. Patients with osteoarthritis (OA) have thinner synovial fluid than normal. Synvisc is an elastic fluid that acts as a lubricant and shock absorber, and thus helps restore the shock absorbing effect of the fluid within the knee.
Multimedia: Slideshows, Images & Quizzes
Osteoarthritis (OA): Treatment, Symptoms, Diagnosis
Osteoarthritis (OA) is a degenerative joint disease most often affecting major joints such as knees, hands, back, or hips....
Exercises for Knee Osteoarthritis and Joint Pain
Learn about osteoarthritis and exercises that relieve knee osteoarthritis pain, stiffness and strengthen the knee joint and...
Pain Management: 15 Easy Ways to Reduce Chronic Pain
Chronic pain can be a symptom of many conditions, including arthritis, headaches, and others. Comprehensive chronic pain...
Pain Quiz: Test Your IQ of Pain
Is pain all in the brain? Take the Pain Quiz to learn everything you've ever wanted to know about the unpleasant sensation we...
Picture of Osteoarthritis
Osteoarthritis is a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more...
Osteoarthritis: 15 Tips to Improve Daily Living With OA
Have arthritis in the knee? Osteoarthritis joint pain can make it hard to carry out activities of daily living. Cartilage...
Tips for Healthy Joints: Exercise, Nutrition, & More
Dealing with joint pain and arthritis? Learn why weight matters--and why NOT to stretch before exercise. See these solutions for...
Fun With Kids? Don't Let Arthritis Stop You
You can still have lots of fun with children despite arthritis. Our experts uncover ways to spend time with your kids or...
Active Living with Osteoarthritis
Check out this slideshow on Active Living From Day to Night with Osteoarthritis. Even with arthritis you can keep your active...
Related Disease Conditions
Acute injuries, medical conditions, and chronic use conditions are causes of knee pain. Symptoms and signs that accompany knee pain include redness, swelling, difficulty walking, and locking of the knee. To diagnose knee pain, a physician will perform a physical exam and also may order X-rays, arthrocentesis, blood tests, or a CT scan or MRI. Treatment of knee pain depends upon the cause of the pain.
A torn meniscus (knee cartilage) may be caused by suddenly stopping, sharply twisting, or deep squatting or kneeling when lifting heavy weight. Symptoms of a meniscal tear include pain with running or walking long distances, popping when climbing stairs, a giving way sensation, locking, or swelling. Treatment depends upon the severity, location, and underlying disease of the knee joint.
Osteoarthritis is a type of arthritis caused by inflammation, breakdown, and eventual loss of cartilage in the joints. Also known as degenerative arthritis, osteoarthritis can be caused by aging, heredity, and injury from trauma or disease.
Arthritis (Joint Inflammation)
Arthritis is inflammation of one or more joints. When joints are inflamed they can develop stiffness, warmth, swelling, redness and pain. There are over 100 types of arthritis, including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, lupus, gout, and pseudogout.
Pain management and treatment can be simple or complex, according to its cause. There are two basic types of pain, nociceptive pain and neuropathic pain. Some causes of neuropathic pain include: complex regional pain syndrome, interstitial cystitis, and irritable bowel syndrome. There are a variety of methods to treat chronic pain, which are dependant on the type of pain experienced.
Chronic pain is pain (an unpleasant sense of discomfort) that persists or progresses over a long period of time. In contrast to acute pain that arises suddenly in response to a specific injury and is usually treatable, chronic pain persists over time and is often resistant to medical treatments.
Treatment & Diagnosis
- Pain FAQs
- Drugs: Buying Prescription Drugs Online Safely
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: The Most Common Medication Errors
- Medication Disposal
- Dangers of Mixing Medications
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
Prevention & Wellness
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.