hydrocortisone rectal foam (Cortifoam, Anusol-HC, Anucort-HC)

What is hydrocortisone-rectal foam, and how does it work (mechanism of action)?

Hydrocortisone is a natural corticosteroid produced by the adrenal glands that are located adjacent to the kidneys. Corticosteroids have potent anti-inflammatory properties and are used in a wide variety of inflammatory conditions such as arthritis, colitis, asthma, bronchitis, certain skin rashes, and allergic or inflammatory conditions of the nose and eyes. There are numerous preparations of corticosteroids including oral tablets, capsules, liquids, topical creams and gels, inhalers and eye drops, as well as injectable and intravenous solutions. Hydrocortisone that is used for rectal conditions is discussed in this article. The FDA approved hydrocortisone in December 1952.

What brand names are available for hydrocortisone-rectal foam?

Cortifoam, Anusol-HC, Anucort-HC, Proctocort, Colocort, Cortenema, Hemmorex-HC

Is hydrocortisone-rectal foam available as a generic drug?


Do I need a prescription for hydrocortisone-rectal foam?


What are the uses for hydrocortisone-rectal foam?

Hydrocortisone is used rectally for the treatment of ulcerative proctitis, inflamed hemorrhoids, and anal itching, burning, and inflammation caused by several conditions that affect the anal area.

What are the side effects of hydrocortisone-rectal foam?

Hydrocortisone's most common side effects when applied to the rectum include:

Other side effects include:


Everyone has hemorrhoids. See Answer

What is the dosage for hydrocortisone-rectal foam?

For proctitis the usual dosage is one suppository applied in the morning and night time. Severe cases may require application 3 times daily or 2 suppositories twice daily. One enema is applied at bedtime for 21 days or until symptoms resolve. The dosing for foam is one applicator once daily or every 12 hours for 2-3 weeks, then every other day if necessary.

Which drugs or supplements interact with hydrocortisone-rectal foam?

The risk of drug interactions is low when hydrocortisone is administered rectally.

What else should I know about hydrocortisone-rectal foam?

What preparations of hydrocortisone-rectal foam are available?

Enema: 100 mg/60 ml; Foam: 10% (15 g); Suppository: 25 and 30 mg

How should I keep hydrocortisone-rectal foam stored?

Hydrocortisone should be store at room temperature, 20 C to 25 C (68 F to 77 F), in a sealed container.


hydrocortisone rectal foam (Cortifoam, Anusol-HC, Anucort-HC, Proctocort, Colocort, Cortenema, Hemmorex-HC) is a medication used to treat ulcerative proctitis, hemorrhoids, anal itching, burning, and inflammation. Side effects, drug interactions, and pregnancy safety information should be reviewed prior to using this medication.

Treatment & Diagnosis

Medications & Supplements

Prevention & Wellness

Health Solutions From Our Sponsors

FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Medically reviewed by John P. Cunha, DO, FACOEP; Board Certified Emergency Medicine

REFERENCE: FDA Prescribing Information.