- What is hydrocodone homatropine?
- What is hydrocodone homatropine used for?
- What are the side effects of hydrocodone homatropine?
- What is the dosage for hydrocodone homatropine?
- Which drugs or supplements interact with hydrocodone homatropine?
- Is hydrocodone homatropine safe to use during pregnancy or while breastfeeding?
- What else should I know about hydrocodone homatropine?
What is hydrocodone homatropine?
Hydrocodone is an opioid narcotic pain-reliever cough suppressant that is similar to codeine, oxycodone, morphine, methadone, fentanyl, and other opioids.
Is hydrocodone homatropine available as a generic drug?
Yes
What is hydrocodone homatropine used for?
Hydrocodone homatropine is prescribed for the treatment of cough in adults and in children 6 years of age and older.
What are the side effects of hydrocodone homatropine?
The most common side effects of hydrocodone are:
- lightheadedness,
- dizziness,
- sedation,
- nausea,
- vomiting.
Other important side effects include
- drowsiness,
- constipation,
- spasm of the ureter, and
- difficulty in urinating.
Hydrocodone can impair thinking and the physical abilities required for driving or operating machinery. Hydrocodone can depress breathing, and should be used with caution in elderly, debilitated patients and in patients with serious lung disease. Hydrocodone is habit forming. Mental and physical dependence can occur when used long-term.
Homatropine can increase pressure inside the eye and this is dangerous for those with glaucoma.
What is the dosage for hydrocodone homatropine?
- The dose for adults and children older than 12 years is one tablet (5 mg/1.5 mg) orally every 4 to 6 hours. The maximum dose is 30 mg/9 mg (6 tablets) in 24 hours.
- Children 6 to 12 years of age receive a 1/2 tablet (2.5 mg/0.75 mg) every 4 to 6 hours not to exceed 3 tablets (15 mg/4.5 mg)

QUESTION
Which illness is known as a viral upper respiratory tract infection? See AnswerWhich drugs or supplements interact with hydrocodone homatropine?
Combining alcohol and other sedatives with hydrocodone can lead to increased sedation and even cause confusion. Hydrocodone should not be taken with any of the monoamine oxidase inhibitor (MAOI) class of antidepressants, for example, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl), and procarbazine (Matulane) or other drugs that inhibit monoamine oxidase, for example, linezolid (Zyvox). Such combinations may lead to confusion, high blood pressure, tremor, hyperactivity, coma, and death.
Hydrocodone should not be administered within 14 days of stopping an MAOI.
Is hydrocodone homatropine safe to use during pregnancy or while breastfeeding?
There are no adequate studies of hydrocodone in pregnant women. Hydrocodone is excreted in breast milk, and, therefore, should be used cautiously by nursing mothers.
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What else should I know about hydrocodone homatropine?
What preparations of hydrocodone homatropine are available?
How should I keep hydrocodone homatropine stored?
Hydrocodone homatropine should be stored at room temperature, between 15 C to 30 C (59 F to 86 F).
How does hydrocodone homatropine work?
- Hydrocodone, like other opioids, stimulates receptors on nerves in the brain to increase the threshold to pain (the amount of stimulation it takes to feel pain) and reduce the perception of pain (the perceived importance of the pain).
- It also works directly on the cough center in the brain to reduce cough.
- Homatropine blocks the action of acetylcholine, a chemical (neurotransmitter) that nerves use to communicate. It is added in low doses to discourage deliberate overdoses of hydrocodone.
When was hydrocodone homatropine approved by the FDA?
The FDA approved hydrocodone homatropine in July 1985.

SLIDESHOW
A Cold or The Flu? How to Tell the Difference See SlideshowSummary
Hydrocodone/homatropine (Tussigon; Hycodan [discontinued in US]) is a narcotic pain reliever prescribed for the relief of cough in adults. Side effects, drug interactions, and warnings and cautions should be reviewed prior to taking this medication.
Related Disease Conditions
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Upper Respiratory Infection (URI)
An upper respiratory infection is a contagious infection of the structures of the upper respiratory tract, which includes the sinuses, nasal passages, pharynx, and larynx. Common causes of an upper respiratory infection include bacteria and viruses such as rhinoviruses, group A streptococci, influenza, respiratory syncytial, whooping cough, diphtheria, and Epstein-Barr. Examples of symptoms of upper respiratory infection include sneezing, sore throat, cough, fever, and nasal congestion. Treatment of upper respiratory infections are based upon the cause. Generally, viral infections are treated symptomatically with over-the-counter (OTC) medication and home remedies.
-
Chronic Cough
Chronic cough is a cough that does not go away and is generally a symptom of another disorder such as asthma, allergic rhinitis, sinus infection, cigarette smoking, GERD, postnasal drip, bronchitis, pneumonia, medications, and less frequently tumors or other lung disease. Chronic cough treatment is based on the cause, but may be soothed natural and home remedies.
-
Common Cold
The common cold (viral upper respiratory tract infection) is a contagious illness that may be caused by various viruses. Symptoms include a stuffy nose, headache, cough, sore throat, and maybe a fever. Antibiotics have no effect upon the common cold, and there is no evidence that zinc and vitamin C are effective treatments.
-
Emphysema
Emphysema is a COPD (chronic obstructive pulmonary disease) that often occurs with other obstructive pulmonary problems and chronic bronchitis. Causes of emphysema include chronic cigarette smoking, exposure to secondhand smoke, air pollution, and in the underdeveloped parts of the world. Symptoms of emphysema include chronic cough, chest discomfort, breathlessness, and wheezing. Treatments include medication and lifestyle changes.
-
Lung Anatomy
The lungs are primarily responsible for the exchange of oxygen and carbon dioxide between the air we breathe and the blood. Eliminating carbon dioxide from the blood is important, because as it builds up in the blood, headaches, drowsiness, coma, and eventually death may occur. The air we breathe in (inhalation) is warmed, humidified, and cleaned by the nose and the lungs.
-
Flu (Influenza)
Influenza (flu) is a respiratory illness caused by a virus. Flu symptoms include fever, cough, sore throat, runny nose, headache, fatigue, and muscle aches. The flu may be prevented with an annual influenza vaccination.
-
Chronic Bronchitis
Chronic bronchitis is a cough that occurs daily with production of sputum that lasts for at least 3 months, 2 years in a row. Causes of chronic bronchitis include cigarette smoking, inhaled irritants, and underlying disease processes (such as asthma, or congestive heart failure). Symptoms include cough, shortness of breath, and wheezing. Treatments include bronchodilators and steroids. Complications of chronic bronchitis include COPD and emphysema.
-
Children's Cough Causes and Treatments
Children's cough causes include infection, acid reflux, asthma, allergies or sinus infection, whooping cough, and exposure to irritants. Treatment for a child's cough include cough medicine for children over the age of four.
-
What Is Bronchiectasis?
Bronchiectasis has three types: cylindrical bronchiectasis, saccular or varicose bronchiectasis, and cystic bronchiectasis. Causes of bronchiectasis include infection, environmental exposure, drug or alcohol abuse, and alpha-1 antitrypsin (congenital). Symptoms of bronchiectasis include shortness of breath, fatigue, chronic cough, bloody sputum, and wheezing. Treatment for bronchiectasis includes antibiotics and possibly surgery.
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