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- What is hydrocodone and ibuprofen, and how does it work (mechanism of action)?
- What brand names are available for hydrocodone and ibuprofen?
- Is hydrocodone and ibuprofen available as a generic drug?
- Do I need a prescription for hydrocodone and ibuprofen?
- What are the side effects of hydrocodone and ibuprofen?
- What is the dosage for hydrocodone and ibuprofen?
- Which drugs or supplements interact with hydrocodone and ibuprofen?
- Is hydrocodone and ibuprofen safe to take if I'm pregnant or breastfeeding?
- What else should I know about hydrocodone and ibuprofen?
What is hydrocodone and ibuprofen, and how does it work (mechanism of action)?
Vicoprofen is a combination of an opioid analgesic (hydrocodone bitartrate, a pain reliever related to narcotics) and a nonsteroidal anti-inflammatory drug (ibuprofen). Both medications are effective for pain management. It is estimated that one tablet of Vicoprofen is as effective as two tablets of Tylenol #3 (acetaminophen 300 mg plus codeine 30 mg). Vicoprofen was approved by the FDA in 1997.
What are the side effects of hydrocodone and ibuprofen?
The most frequent side effects experienced with hydrocodone include:
- dyspepsia (indigestion),
- anxiety, nervousness, and somnolence (drowsiness).
Other important side effects include constipation and spasm of the ureter, which can lead to difficulty inurinating.
The most common side effects of ibuprofen involve the gastrointestinal system. It can cause ulcerations, abdominal pain, cramping, nausea, gastritis, and even serious gastrointestinal bleeding. Sometimes, stomach ulceration and bleeding can occur without abdominal pain, and black tarry stools, weakness, and dizziness upon standing may be the only signs of internal bleeding. Rash, kidney impairment, ringing in the ears (tinnitus), and lightheadedness can also occur.
Hydrocodone can depress breathing, and is used with caution in the elderly, debilitated patients and those with a history of ulcer or serious lung disease. Hydrocodone can impair thinking and the physical abilities required for driving or operating machinery. Hydrocodone may be habit forming. Mental and physical dependence can occur but are unlikely when used for short-term pain relief.
Quick GuideChronic Pain Syndrome: Treatment and Management for CPS
What is the dosage for hydrocodone and ibuprofen?
The usual dose of Vicoprofen is one tablet every 4 to 6 hours as needed for pain. The manufacturer recommends a maximum of 5 tablets per day and a short-term duration of treatment (less than 10 days).
Which drugs or supplements interact with hydrocodone and ibuprofen?
Hydrocodone, like other narcotic pain-relievers, interacts with medications and drugs that slow the brain's processes, such as alcohol, barbiturates, skeletal muscle relaxants including carisoprodol (Soma), cyclobenzaprine (Flexeril), and benzodiazepines (for example, lorazepam [Ativan], and clonazepam [Klonopin]).
Opioids such as hydrocodone can slow bowel motility. When combined with medications that possess anticholinergic activity, this effect on the bowel may be accentuated, leading to marked constipation. Such drugs include dicyclomine (Bentyl), some antihistamines (for example, carbinoxamine [Rondec], clemastine [Tavist], diphenhydramine [Benadryl], promethazine [Phenergan]); some phenothiazines (for example, thioridazine [Mellaril], triflupromazine [Stelazine]); some tricyclic antidepressants (for example, amitriptyline [Elavil, Endep] amoxapine [Asendin], clomipramine [Anafranil], protriptyline [Vivactil]); clozapine (Clozaril), cyclobenzaprine (Flexeril), and disopyramide (Norpace). The use of antidiarrheals (for example, diphenoxylate [Lomotil], loperamide [Imodium]) in persons taking opioid analgesics such as hydrocodone can lead to severe constipation and possibly greater sedation.
Ibuprofen, which has blood thinning (anticoagulant) properties, is used with caution in patients taking other blood thinning anticoagulants such as warfarin (Coumadin), because of an increased risk of bleeding. Concurrent use of ibuprofen and clopidogrel (Plavix) can also lead to increased risk of bleeding. Patients taking lithium (Eskalith, Lithobid) can develop toxic blood lithium levels if ibuprofen is taken at the same time. Ibuprofen may increase methotrexate (Rheumatrex, Trexall) toxicity when used together.
Is hydrocodone and ibuprofen safe to take if I'm pregnant or breastfeeding?
Hydrocodone and ibuprofen crosses the placenta. However, there is not enough information known about the effects of hydrocodone and ibuprofen on the fetus. Physicians may choose to use hydrocodone and ibuprofen if the benefits outweigh potential risks.
It is not known if hydrocodone is secreted in breast milk.
What else should I know about hydrocodone and ibuprofen?
What preparations of hydrocodone and ibuprofen are available?
Tablets: hydrocodone bitartrate 7.5 mg and ibuprofen 200 mg.
How should I keep hydrocodone and ibuprofen stored?
Tablets should be stored at room temperature between 15 C - 30 C (59 F - 86 F).
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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Analgesics, AntipyreticsOver-the-counter pain medication and fever reducers include aspirin, acetaminophen and nonsteroidal antiinflammatory drugs (NSAIDs). Side effects, drug interactions, warnings and precautions, pregnancy and breastfeeding safety, and patient information should be reviewed prior to taking any medication.
Back Pain QuizThere are numerous causes of chronic lower back pain and only one ailment gets more complaints. What is it? Quiz your knowledge of symptoms, treatments, problems, and reasons for common back pain.
Drug AbuseDrug addiction is a chronic disease that causes drug-seeking behavior and drug use despite negative consequences to the user and those around him. Though the initial decision to use drugs is voluntary, changes in the brain caused by repeated drug abuse can affect a person's self-control and ability to make the right decisions and increase the urge to take drugs. Drug abuse and addiction are preventable.
Drug Abuse SlideshowWhat is drug abuse? Learn about prescription drug abuse and over-the-counter (OTC) drugs, including depressants, pain relievers, and stimulants.
Drug InteractionsDrug interactions occur frequently. Get facts about the types of drug interactions, what substances or other things that may interact with drugs such as OTC drug and prescription drugs, vitamins, food(s) (grapefruit), and laboratory tests. Find out how to protect yourself from potential drug interactions.
Drugs: What You Should Know About Your DrugsImportant information about your drugs should be reviewed prior to taking any prescription drug. Side effects, drug interactions, warnings and precauctions, dosage, what the drug is used for, what to do if you miss a dose, how the drug is to be stored, and generic vs. brand names.
hydrocodone/acetaminophenHydrocodone/acetaminophen (Vicodin, Vicodin ES, Vicodin HP, Anexsia, Lortab, Lorcet, Lorcet Plus, Norco, Zydone) is a narcotic pain reliever and cough suppressant. Hydrocodone/acetaminophen is prescribed for moderate to moderately severe pain. Side effects, drug interactions, warnings and precautions should be reviewed prior to taking any medication.
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce mild to moderate pain, inflammation, and fever. Ibuprofen works by blocking an enzyme that makes prostaglandin (a hormone-like substance that participates in a variety of body functions), which results in lower levels of prostaglandins in the body. Lower levels of prostaglandins reduce pain, inflammation, and fever.
Ibuprofen is prescribed to treat diseases and conditions that cause mild to moderate pain, fever, and inflammation. For example, Pain from strains and sprains; pain from cuts, scrapes, and puncture wounds; muscle aches and pains; tooth pain; common cold; mild headache; some arthritis conditions; joint pain; and to reduce fever.
Common side effects of ibuprofen include, diarrhea, constipation, nausea, heartburn, belly pain, drowsiness, headaches, tinnitus (ringing in the ears), and mild rash.
More serious side effects and adverse effects include, increased bleeding after injury, stomach ulcers, impaired kidney function, severe allergic reaction (anaphylaxis), blood clots, heart attack, heart failure, and high blood pressure.
The maximum dose prescribed under a doctor's care is 3.2 g daily. Otherwise, the over-the-counter (OTC) maximum daily dose is 1.2 g daily. Dosage depends upon the age, weight, and any current medical conditions of the patient. Several drugs interact with ibuprofen so check with your doctor, pharmacist, or other health care professional with questions in regard to this drug. Doctors don't know if it is safe to take ibuprofen if your are pregnant, therefore it is not recommended if you are pregnant. According to the American Academy of Pediatrics, ibuprofen is safe to take while breastfeeding.
REFERENCE: FDA Prescribing Information.
Knee Pain FactsAcute injuries, medical conditions, and chronic use conditions are causes of knee pain. Symptoms and signs that accompany knee pain include redness, swelling, difficulty walking, and locking of the knee. To diagnose knee pain, a physician will perform a physical exam and also may order X-rays, arthrocentesis, blood tests, or a CT scan or MRI. Treatment of knee pain depends upon the cause of the pain.
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Restless Leg SyndromeRestless leg syndrome (RLS) is a common cause for painful legs that typically eases with motion, and becomes worse and more noticeable at rest. This characteristic nighttime worsening can frequently lead to insomnia. Treatment of the symptoms of restless leg syndrome is generally with medication as well as treating any underlying condition causing restless leg syndrome.
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