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- What is hydrocodone and ibuprofen, and how does it work (mechanism of action)?
- What brand names are available for hydrocodone and ibuprofen?
- Is hydrocodone and ibuprofen available as a generic drug?
- Do I need a prescription for hydrocodone and ibuprofen?
- What are the side effects of hydrocodone and ibuprofen?
- What is the dosage for hydrocodone and ibuprofen?
- Which drugs or supplements interact with hydrocodone and ibuprofen?
- Is hydrocodone and ibuprofen safe to take if I'm pregnant or breastfeeding?
- What else should I know about hydrocodone and ibuprofen?
What is hydrocodone and ibuprofen, and how does it work (mechanism of action)?
Vicoprofen is a combination of an opioid analgesic (hydrocodone bitartrate, a pain reliever related to narcotics) and a nonsteroidal anti-inflammatory drug (ibuprofen). Both medications are effective for pain management. It is estimated that one tablet of Vicoprofen is as effective as two tablets of Tylenol #3 (acetaminophen 300 mg plus codeine 30 mg). Vicoprofen was approved by the FDA in 1997.
What are the side effects of hydrocodone and ibuprofen?
The most frequent side effects experienced with hydrocodone include:
- dyspepsia (indigestion),
- anxiety, nervousness, and somnolence (drowsiness).
Other important side effects include constipation and spasm of the ureter, which can lead to difficulty inurinating.
The most common side effects of ibuprofen involve the gastrointestinal system. It can cause ulcerations, abdominal pain, cramping, nausea, gastritis, and even serious gastrointestinal bleeding. Sometimes, stomach ulceration and bleeding can occur without abdominal pain, and black tarry stools, weakness, and dizziness upon standing may be the only signs of internal bleeding. Rash, kidney impairment, ringing in the ears (tinnitus), and lightheadedness can also occur.
Hydrocodone can depress breathing, and is used with caution in the elderly, debilitated patients and those with a history of ulcer or serious lung disease. Hydrocodone can impair thinking and the physical abilities required for driving or operating machinery. Hydrocodone may be habit forming. Mental and physical dependence can occur but are unlikely when used for short-term pain relief.
Quick GuideChronic Pain Syndrome: Treatment and Management for CPS
What is the dosage for hydrocodone and ibuprofen?
The usual dose of Vicoprofen is one tablet every 4 to 6 hours as needed for pain. The manufacturer recommends a maximum of 5 tablets per day and a short-term duration of treatment (less than 10 days).
Which drugs or supplements interact with hydrocodone and ibuprofen?
Hydrocodone, like other narcotic pain-relievers, interacts with medications and drugs that slow the brain's processes, such as alcohol, barbiturates, skeletal muscle relaxants including carisoprodol (Soma), cyclobenzaprine (Flexeril), and benzodiazepines (for example, lorazepam [Ativan], and clonazepam [Klonopin]).
Opioids such as hydrocodone can slow bowel motility. When combined with medications that possess anticholinergic activity, this effect on the bowel may be accentuated, leading to marked constipation. Such drugs include dicyclomine (Bentyl), some antihistamines (for example, carbinoxamine [Rondec], clemastine [Tavist], diphenhydramine [Benadryl], promethazine [Phenergan]); some phenothiazines (for example, thioridazine [Mellaril], triflupromazine [Stelazine]); some tricyclic antidepressants (for example, amitriptyline [Elavil, Endep] amoxapine [Asendin], clomipramine [Anafranil], protriptyline [Vivactil]); clozapine (Clozaril), cyclobenzaprine (Flexeril), and disopyramide (Norpace). The use of antidiarrheals (for example, diphenoxylate [Lomotil], loperamide [Imodium]) in persons taking opioid analgesics such as hydrocodone can lead to severe constipation and possibly greater sedation.
Ibuprofen, which has blood thinning (anticoagulant) properties, is used with caution in patients taking other blood thinning anticoagulants such as warfarin (Coumadin), because of an increased risk of bleeding. Concurrent use of ibuprofen and clopidogrel (Plavix) can also lead to increased risk of bleeding. Patients taking lithium (Eskalith, Lithobid) can develop toxic blood lithium levels if ibuprofen is taken at the same time. Ibuprofen may increase methotrexate (Rheumatrex, Trexall) toxicity when used together.
Is hydrocodone and ibuprofen safe to take if I'm pregnant or breastfeeding?
Hydrocodone and ibuprofen crosses the placenta. However, there is not enough information known about the effects of hydrocodone and ibuprofen on the fetus. Physicians may choose to use hydrocodone and ibuprofen if the benefits outweigh potential risks.
It is not known if hydrocodone is secreted in breast milk.
What else should I know about hydrocodone and ibuprofen?
What preparations of hydrocodone and ibuprofen are available?
Tablets: hydrocodone bitartrate 7.5 mg and ibuprofen 200 mg.
How should I keep hydrocodone and ibuprofen stored?
Tablets should be stored at room temperature between 15 C - 30 C (59 F - 86 F).
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce mild to moderate pain, inflammation, and fever. Ibuprofen works by blocking an enzyme that makes prostaglandin (a hormone-like substance that participates in a variety of body functions), which results in lower levels of prostaglandins in the body. Lower levels of prostaglandins reduce pain, inflammation, and fever.
Ibuprofen is prescribed to treat diseases and conditions that cause mild to moderate pain, fever, and inflammation. For example, Pain from strains and sprains; pain from cuts, scrapes, and puncture wounds; muscle aches and pains; tooth pain; common cold; mild headache; some arthritis conditions; joint pain; and to reduce fever.
Common side effects of ibuprofen include, diarrhea, constipation, nausea, heartburn, belly pain, drowsiness, headaches, tinnitus (ringing in the ears), and mild rash.
More serious side effects and adverse effects include, increased bleeding after injury, stomach ulcers, impaired kidney function, severe allergic reaction (anaphylaxis), blood clots, heart attack, heart failure, and high blood pressure.
The maximum dose prescribed under a doctor's care is 3.2 g daily. Otherwise, the over-the-counter (OTC) maximum daily dose is 1.2 g daily. Dosage depends upon the age, weight, and any current medical conditions of the patient. Several drugs interact with ibuprofen so check with your doctor, pharmacist, or other health care professional with questions in regard to this drug. Doctors don't know if it is safe to take ibuprofen if your are pregnant, therefore it is not recommended if you are pregnant. According to the American Academy of Pediatrics, ibuprofen is safe to take while breastfeeding.
REFERENCE: FDA Prescribing Information.
Ibuprofen vs Meloxicam
Ibuprofen (Advil, Motrin, and many other brand names) and meloxicam (Mobic) belong to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs), and are used to manage mild to moderate pain, inflammation, and fever. NSAIDs block enzymes that make chemicals that contribute to inflammation (prostaglandins), which reduces prostaglandin levels and thus inflammation. Meloxicam is a prescription drug and is stronger than ibuprofen (which is available over-the-counter (OTC) at relieving pain and inflammation.
Common side effects of both ibuprofen and meloxicam include heartburn, constipation, drowsiness, dizziness, abdominal pain, tinnitus, rash, nausea, and diarrhea. Both NSAIDs have serious side effects that include edema, blood clots, heart attacks, high blood pressure, heart failure, and stomach ulcers.
Other side effects of meloxicam include intestinal gas, headache, joint pain, back pain, insomnia, itching, bladder infection, skin rash, and upper respiratory tract infection.
The dosage for ibuprofen is 1 to 2 tablets every 4 to 6 hours. No more than 6 tablets should be taken in 24 hours unless advised by a doctor or other healthcare professional. Meloxicam is only taken once a day. Dosage depends upon the condition being treated.
Ibuprofen vs Naproxen
Ibuprofen (Advil, Motrin) and naproxen (Aleve) are drugs available without a prescription that relieve mild to moderate pain, inflammation, and fever. Ibuprofen and naproxen belong to the nonsteroidal anti-inflammatory drug class or NSAIDs. NSAIDs like ibuprofen and naproxen block chemicals in the body called prostaglandins that promote pain, inflammation, and fever. Blocking prostaglandins in the body reduce pain, inflammation, and fever.
Since both ibuprofen and naproxen are NSAIDs, they have similar side effects and adverse effects. Ibuprofen and naproxen may increase the risk of blood clots, heart attack, and stroke. Common side effects of both drugs include heartburn, constipation, nausea, diarrhea, abdominal pain, dizziness, headaches, drowsiness, and tinnitus (ringing in the ears). Other serious side effects include edema, high blood pressure, and heart failure.
Ibuprofen and naproxen are available in a variety of forms and strengths. Check with your doctor or pharmacist about questions you have in regard to NSAIDs.
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Side effects include:
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Drug interactions, dosing, and pregnancy and breastfeeding safety information are provided.
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Oxycodone vs Tramadol for Pain
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- Dry mouth
Serious side effects for oxycodone and tramadol differ. Oxycodone and tramadol are habit forming drugs and patients may become addicted. Withdrawal symptoms include:
Drug interactions, dosing, and pregnancy and breastfeeding safety information differs for these drugs and should be reviewed prior to administration.
Oxycodone vs. Hydrocodone
Oxycodone and hydrocodone are prescription opioid pain medications. Both drugs have similar uses and side effects, for example:
Both drugs also are available in combination with other drugs. Examples of brand names include:
- Zohydro ER
Drug interactions, dosage, uses, and pregnancy and breastfeeding safety information should be reviewed prior to taking any medication.
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