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- What is hydrocodone and ibuprofen, and how does it work (mechanism of action)?
- What brand names are available for hydrocodone and ibuprofen?
- Is hydrocodone and ibuprofen available as a generic drug?
- Do I need a prescription for hydrocodone and ibuprofen?
- What are the side effects of hydrocodone and ibuprofen?
- What is the dosage for hydrocodone and ibuprofen?
- Which drugs or supplements interact with hydrocodone and ibuprofen?
- Is hydrocodone and ibuprofen safe to take if I'm pregnant or breastfeeding?
- What else should I know about hydrocodone and ibuprofen?
What is hydrocodone and ibuprofen, and how does it work (mechanism of action)?
Vicoprofen is a combination of an opioid analgesic (hydrocodone bitartrate, a pain reliever related to narcotics) and a nonsteroidal anti-inflammatory drug (ibuprofen). Both medications are effective for pain management. It is estimated that one tablet of Vicoprofen is as effective as two tablets of Tylenol #3 (acetaminophen 300 mg plus codeine 30 mg). Vicoprofen was approved by the FDA in 1997.
What are the side effects of hydrocodone and ibuprofen?
The most frequent side effects experienced with hydrocodone include:
- dyspepsia (indigestion),
- anxiety, nervousness, and somnolence (drowsiness).
Other important side effects include constipation and spasm of the ureter, which can lead to difficulty inurinating.
The most common side effects of ibuprofen involve the gastrointestinal system. It can cause ulcerations, abdominal pain, cramping, nausea, gastritis, and even serious gastrointestinal bleeding. Sometimes, stomach ulceration and bleeding can occur without abdominal pain, and black tarry stools, weakness, and dizziness upon standing may be the only signs of internal bleeding. Rash, kidney impairment, ringing in the ears (tinnitus), and lightheadedness can also occur.
Hydrocodone can depress breathing, and is used with caution in the elderly, debilitated patients and those with a history of ulcer or serious lung disease. Hydrocodone can impair thinking and the physical abilities required for driving or operating machinery. Hydrocodone may be habit forming. Mental and physical dependence can occur but are unlikely when used for short-term pain relief.
Quick GuideChronic Pain Syndrome: Treatment and Management for CPS
What is the dosage for hydrocodone and ibuprofen?
The usual dose of Vicoprofen is one tablet every 4 to 6 hours as needed for pain. The manufacturer recommends a maximum of 5 tablets per day and a short-term duration of treatment (less than 10 days).
Which drugs or supplements interact with hydrocodone and ibuprofen?
Hydrocodone, like other narcotic pain-relievers, interacts with medications and drugs that slow the brain's processes, such as alcohol, barbiturates, skeletal muscle relaxants including carisoprodol (Soma), cyclobenzaprine (Flexeril), and benzodiazepines (for example, lorazepam [Ativan], and clonazepam [Klonopin]).
Opioids such as hydrocodone can slow bowel motility. When combined with medications that possess anticholinergic activity, this effect on the bowel may be accentuated, leading to marked constipation. Such drugs include dicyclomine (Bentyl), some antihistamines (for example, carbinoxamine [Rondec], clemastine [Tavist], diphenhydramine [Benadryl], promethazine [Phenergan]); some phenothiazines (for example, thioridazine [Mellaril], triflupromazine [Stelazine]); some tricyclic antidepressants (for example, amitriptyline [Elavil, Endep] amoxapine [Asendin], clomipramine [Anafranil], protriptyline [Vivactil]); clozapine (Clozaril), cyclobenzaprine (Flexeril), and disopyramide (Norpace). The use of antidiarrheals (for example, diphenoxylate [Lomotil], loperamide [Imodium]) in persons taking opioid analgesics such as hydrocodone can lead to severe constipation and possibly greater sedation.
Ibuprofen, which has blood thinning (anticoagulant) properties, is used with caution in patients taking other blood thinning anticoagulants such as warfarin (Coumadin), because of an increased risk of bleeding. Concurrent use of ibuprofen and clopidogrel (Plavix) can also lead to increased risk of bleeding. Patients taking lithium (Eskalith, Lithobid) can develop toxic blood lithium levels if ibuprofen is taken at the same time. Ibuprofen may increase methotrexate (Rheumatrex, Trexall) toxicity when used together.
Is hydrocodone and ibuprofen safe to take if I'm pregnant or breastfeeding?
Hydrocodone and ibuprofen crosses the placenta. However, there is not enough information known about the effects of hydrocodone and ibuprofen on the fetus. Physicians may choose to use hydrocodone and ibuprofen if the benefits outweigh potential risks.
It is not known if hydrocodone is secreted in breast milk.
What else should I know about hydrocodone and ibuprofen?
What preparations of hydrocodone and ibuprofen are available?
Tablets: hydrocodone bitartrate 7.5 mg and ibuprofen 200 mg.
How should I keep hydrocodone and ibuprofen stored?
Tablets should be stored at room temperature between 15 C - 30 C (59 F - 86 F).
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Top hydrocodone and ibuprofen Related Articles
Acetaminophen vs Ibuprofen Side Effects
Acetaminophen (Tylenol and many other brand names is an pain reliever (analgesic) and fever reducer (antipyretic ). Scientists do not know the exact mechanism of action of acetaminophen. Ibuprofen (Advil) is an NSAID (nonsteroidal inti-inflammatory drug) used for the treat inflammation, fever, and mild pain. Ibuprofen works in relieving mild pain, inflammation, and fever by blocking an enzyme that makes chemicals released in the body that promote inflammation (prostaglandins). Prostaglandins promote inflammation in the body.
Common side effects of both acetaminophen and ibuprofen include rash, nausea, and headache.
Side effects specific to acetaminophen include kidney damage, anemia, thrombocytopenia, serious skin reactions, and liver failure.
Side effects of specific to ibuprofen include tinnitus (ringing in the ears), dizziness, drowsiness, stomach pain, constipation, and heartburn.
Dosage depends upon whether the person using acetaminophen or ibuprofen.
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Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce mild to moderate pain, inflammation, and fever. Ibuprofen works by blocking an enzyme that makes prostaglandin (a hormone-like substance that participates in a variety of body functions), which results in lower levels of prostaglandins in the body. Lower levels of prostaglandins reduce pain, inflammation, and fever.
Ibuprofen is prescribed to treat diseases and conditions that cause mild to moderate pain, fever, and inflammation. For example, Pain from strains and sprains; pain from cuts, scrapes, and puncture wounds; muscle aches and pains; tooth pain; common cold; mild headache; some arthritis conditions; joint pain; and to reduce fever.
Common side effects of ibuprofen include, diarrhea, constipation, nausea, heartburn, belly pain, drowsiness, headaches, tinnitus (ringing in the ears), and mild rash.
More serious side effects and adverse effects include, increased bleeding after injury, stomach ulcers, impaired kidney function, severe allergic reaction (anaphylaxis), blood clots, heart attack, heart failure, and high blood pressure.
The maximum dose prescribed under a doctor's care is 3.2 g daily. Otherwise, the over-the-counter (OTC) maximum daily dose is 1.2 g daily. Dosage depends upon the age, weight, and any current medical conditions of the patient. Several drugs interact with ibuprofen so check with your doctor, pharmacist, or other health care professional with questions in regard to this drug. Doctors don't know if it is safe to take ibuprofen if your are pregnant, therefore it is not recommended if you are pregnant. According to the American Academy of Pediatrics, ibuprofen is safe to take while breastfeeding.
REFERENCE: FDA Prescribing Information.
Ibuprofen vs Meloxicam
Ibuprofen (Advil, Motrin, and many other brand names) and meloxicam (Mobic) belong to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs), and are used to manage mild to moderate pain, inflammation, and fever. NSAIDs block enzymes that make chemicals that contribute to inflammation (prostaglandins), which reduces prostaglandin levels and thus inflammation. Meloxicam is a prescription drug and is stronger than ibuprofen (which is available over-the-counter (OTC) at relieving pain and inflammation.
Common side effects of both ibuprofen and meloxicam include heartburn, constipation, drowsiness, dizziness, abdominal pain, tinnitus, rash, nausea, and diarrhea. Both NSAIDs have serious side effects that include edema, blood clots, heart attacks, high blood pressure, heart failure, and stomach ulcers.
Other side effects of meloxicam include intestinal gas, headache, joint pain, back pain, insomnia, itching, bladder infection, skin rash, and upper respiratory tract infection.
The dosage for ibuprofen is 1 to 2 tablets every 4 to 6 hours. No more than 6 tablets should be taken in 24 hours unless advised by a doctor or other healthcare professional. Meloxicam is only taken once a day. Dosage depends upon the condition being treated.
Ibuprofen vs Naproxen
Ibuprofen (Advil, Motrin) and naproxen (Aleve) are drugs available without a prescription that relieve mild to moderate pain, inflammation, and fever. Ibuprofen and naproxen belong to the nonsteroidal anti-inflammatory drug class or NSAIDs. NSAIDs like ibuprofen and naproxen block chemicals in the body called prostaglandins that promote pain, inflammation, and fever. Blocking prostaglandins in the body reduce pain, inflammation, and fever.
Since both ibuprofen and naproxen are NSAIDs, they have similar side effects and adverse effects. Ibuprofen and naproxen may increase the risk of blood clots, heart attack, and stroke. Common side effects of both drugs include heartburn, constipation, nausea, diarrhea, abdominal pain, dizziness, headaches, drowsiness, and tinnitus (ringing in the ears). Other serious side effects include edema, high blood pressure, and heart failure.
Ibuprofen and naproxen are available in a variety of forms and strengths. Check with your doctor or pharmacist about questions you have in regard to NSAIDs.
Knee Pain FactsAcute injuries, medical conditions, and chronic use conditions are causes of knee pain. Symptoms and signs that accompany knee pain include redness, swelling, difficulty walking, and locking of the knee. To diagnose knee pain, a physician will perform a physical exam and also may order X-rays, arthrocentesis, blood tests, or a CT scan or MRI. Treatment of knee pain depends upon the cause of the pain.
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Narcotic analgesics (also called opioids) are medications prescribed to treat moderate to severe pain. Examples (list) include:
Side effects include:
- Dry mouth
Drug interactions, dosing, and pregnancy and breastfeeding safety information are provided.
Neck PainNeck pain (cervical pain) may be caused by any number of disorders and diseases. Tenderness is another symptom of neck pain. Though treatment for neck pain really depends upon the cause, treatment typically may involve heat/ice application, traction, physical therapy, cortisone injection, topical anesthetic creams, and muscle relaxants.
Oxycodone vs Tramadol for Pain
Oxycodone and tramadol are prescription medications used to manage acute and chronic moderate to severe pain. Oxycodone is an opiate (narcotic) derived drug whereas tramadol is a man-made synthetic drug. Tramadol is not a narcotic, and it is not a nonsteroidal anti-inflammatory drug (NSAIDs). Some of the side effects of oxycodone and tramadol are the same, for example:
- Dry mouth
Serious side effects for oxycodone and tramadol differ. Oxycodone and tramadol are habit forming drugs and patients may become addicted. Withdrawal symptoms include:
Drug interactions, dosing, and pregnancy and breastfeeding safety information differs for these drugs and should be reviewed prior to administration.
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- interstitial cystitis,
- and irritable bowel syndrome.
Take the Pain QuizIs pain all in the brain? Take the Pain Quiz to learn everything you've ever wanted to know about the unpleasant sensation we call pain.
PericarditisPericarditis is the inflammation of the pericardial sac that surrounds the heart. The causes of pericarditis include injury from heart attack, heart surgery, trauma; viral or fungal infection, HIV, tumors, mixed connective tissue disease, metabolic disease, medication reactions, or idiopathic. Treatment for pericarditis is generally medication, however, sometimes surgery is necessary.
Restless Leg SyndromeRestless leg syndrome (RLS) is a common cause for painful legs that typically eases with motion, and becomes worse and more noticeable at rest. This characteristic nighttime worsening can frequently lead to insomnia. Treatment of the symptoms of restless leg syndrome is generally with medication as well as treating any underlying condition causing restless leg syndrome.
Whiplash is a common injury to a person's neck following a car accident (in most cases). Symptoms include:
- neck pain,
- neck and shoulder stiffness,
- shoulder pain,
- jaw pain,
- arm pain,
- weakness of the arm(s),
- visual disturbances, and
Diagnosis is generally with a physical exam, X-rays, or possibly an MRI. Treatment generally includes physical therapy and time.