hydrocodone and ibuprofen

Medically Reviewed on 3/28/2023

Generic Name: hydrocodone and ibuprofen

Brand Names: Vicoprofen, Reprexain, Xylon

Drug Class: Analgesics, NSAID/Opioid Combos

What is hydrocodone and ibuprofen, and what is it used for?

Vicoprofen is a combination of an opioid analgesic (hydrocodone bitartrate, a pain reliever related to narcotics) and a nonsteroidal anti-inflammatory drug (ibuprofen). Both medications are effective for pain management. Hydrocodone and ibuprofen (Vicoprofen) is an opioid analgesic prescribed for the management of moderate to severe pain, used on a short-term basis. It is estimated that one tablet of Vicoprofen is as effective as two tablets of Tylenol #3 (acetaminophen 300 mg plus codeine 30 mg). Vicoprofen was approved by the FDA in 1997.

What are the side effects of hydrocodone and ibuprofen?

The most frequent side effects experienced with hydrocodone include:

Other important side effects include constipation and spasm of the ureter, which can lead to difficulty in urinating.

The most common side effects of ibuprofen involve the gastrointestinal system. It can cause ulcerations, abdominal pain, cramping, nausea, gastritis, and even serious gastrointestinal bleeding. Sometimes, stomach ulceration and bleeding can occur without abdominal pain, and black tarry stools, weakness, and dizziness upon standing may be the only signs of internal bleeding. Rash, kidney impairment, ringing in the ears (tinnitus), and lightheadedness can also occur.

Hydrocodone can depress breathing, and is used with caution in the elderly, debilitated patients and those with a history of ulcer or serious lung disease. Hydrocodone can impair thinking and the physical abilities required for driving or operating machinery. Hydrocodone may be habit forming. Mental and physical dependence can occur but are unlikely when used for short-term pain relief.

What is the dosage for hydrocodone and ibuprofen?

The usual dose of Vicoprofen is one tablet every 4 to 6 hours as needed for pain. The manufacturer recommends a maximum of 5 tablets per day and a short-term duration of treatment (less than 10 days).


Medically speaking, the term "myalgia" refers to what type of pain? See Answer

Which drugs interact with hydrocodone and ibuprofen?

Pregnancy and breastfeeding

Hydrocodone and ibuprofen crosses the placenta. However, there is not enough information known about the effects of hydrocodone and ibuprofen on the fetus. Physicians may choose to use hydrocodone and ibuprofen if the benefits outweigh potential risks.

It is not known if hydrocodone is secreted in breast milk.

What else should I know about hydrocodone and ibuprofen?

What preparations of hydrocodone and ibuprofen are available?
  • Tablets: hydrocodone bitartrate 7.5 mg and ibuprofen 200 mg.
How should I keep hydrocodone and ibuprofen stored?
  • Tablets should be stored at room temperature between 15 C - 30 C (59 F - 86 F).


Hydrocodone and ibuprofen is an opioid analgesic prescribed for the management of moderate to severe pain, used on a short-term basis. The most frequent side effects experienced with hydrocodone include lightheadedness, dizziness, sedation, nausea, dyspepsia (indigestion), vomiting, anxiety, nervousness, and somnolence (drowsiness).

Treatment & Diagnosis

Medications & Supplements

Prevention & Wellness

FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Medically Reviewed on 3/28/2023
FDA Prescribing Information