GENERIC NAME: TRIAMTERENE/HYDROCHLOROTHIAZIDE - ORAL (HYE-droe-KLOR-oh-THYE-a-zide/try-AM-ter-een)
BRAND NAME(S): Dyazide, Maxzide
WARNING: This medication can raise your body's potassium levels. This effect is more likely to occur in patients with kidney disease, diabetes, or serious illness or in the elderly. Potassium levels must be closely monitored on a regular basis while taking this medication. If not treated, high potassium levels can sometimes be fatal. Seek immediate medical attention if you develop any of these rare but serious symptoms: muscle weakness, very slow heartbeat.
USES: This medication is a combination of two "water pills" (diuretics). It increases the amount of urine you make, which causes your body to get rid of excess water. Hydrochlorothiazide/triamterene is used in patients who have developed or are at risk for developing serious potassium loss with hydrochlorothiazide treatment alone.This drug is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.This medication also reduces swelling/fluid retention (edema) seen with conditions such as congestive heart failure, liver disease, or kidney disease. This can help to improve symptoms such as trouble breathing.
HOW TO USE: Take this medication by mouth with or without food, usually once a day, or as directed by your doctor. The dosage is based on your medical condition and response to therapy.If you take this drug too close to bedtime, you may need to wake up to urinate. Therefore, it is best to take this medication at least 4 hours before your bedtime. Consult your doctor or pharmacist if you have questions about your dosing schedule.Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time of the day as directed. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick. Do not stop taking this medication without consulting your doctor.Cholestyramine and colestipol can decrease the absorption of hydrochlorothiazide. If you are taking either of these drugs, separate hydrochlorothiazide/triamterene from cholestyramine by at least 4 hours and from colestipol by at least 2 hours.If your condition persists or worsens, contact your doctor or pharmacist.
SIDE EFFECTS: See also Warning section.Dizziness, lightheadedness, headache, blurred vision, loss of appetite, stomach upset, diarrhea, or constipation may occur as your body adjusts to the medication. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.This medication may lead to excessive loss of body water and minerals. Tell your doctor immediately if you have any of these unlikely but serious symptoms of dehydration or mineral loss: muscle cramps or weakness, confusion, severe dizziness, unusual dry mouth or thirst, nausea or vomiting, fast/irregular heartbeat, unusual decrease in the amount of urine, fainting, seizures.Tell your doctor immediately if any of these unlikely but serious side effects occur: numbness/tingling of the arms/legs, decreased sexual ability, kidney stones.Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: persistent sore throat or fever, easy bleeding or bruising, stomach/abdominal pain, persistent nausea/vomiting, yellowing of eyes/skin.A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before taking hydrochlorothiazide/triamterene, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe kidney disease (e.g., inability to make urine or anuria), high blood potassium levels (hyperkalemia), severe liver disease.Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease (e.g., kidney stones), liver disease, untreated mineral imbalance (e.g., sodium, chloride), gout, lupus, metabolic imbalance (e.g., acidosis), folic acid deficiency.If you have diabetes, hydrochlorothiazide may affect your blood sugar levels. Check your blood sugar levels regularly as directed and share the results with your doctor. Tell your doctor immediately if you have symptoms of high blood sugar such as increased thirst/urination. Your doctor may need to adjust your anti-diabetic medication or diet.This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths or sunlamps. Use a sunscreen and wear protective clothing when outdoors.Before having surgery, tell your doctor or dentist that you are taking this medication.This drug may make you dizzy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages.To minimize dizziness and lightheadedness, get up slowly when rising from a seated or lying position.Caution is advised when using this drug in the elderly because they may be more sensitive to its effects, especially dizziness.This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.Hydrochlorothiazide passes into breast milk. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.See also the How to Use section.This drug should not be used with the following medications because very serious interactions may occur: dofetilide, eplerenone, other potassium-sparing diuretics (e.g., spironolactone, amiloride), tacrolimus.If you are currently using any of these medications, tell your doctor or pharmacist before starting hydrochlorothiazide/triamterene.Do not take potassium supplements or salt substitutes containing potassium without talking to your doctor or pharmacist first. This medicine can raise your potassium levels, which rarely can cause very serious side effects.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: cisapride, ACE inhibitors (e.g., captopril, lisinopril), angiotensin receptor blockers (e.g., losartan, valsartan), cholestyramine, colestipol, diazoxide, digoxin, lithium, nonsteroidal anti-inflammatory drugs (e.g., ibuprofen, indomethacin).Check the labels on all your medicines (e.g., cough-and-cold products, diet aids) because they may contain ingredients that could increase your blood pressure. Ask your pharmacist about the safe use of those products.This product can affect the results of certain lab tests. Make sure laboratory personnel and your doctors know you use this drug.This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. Symptoms of overdose may include fainting, severe weakness, a severe decrease in amount of urine, or slow or shallow breathing.
NOTES: Do not share this medication with others. Lifestyle changes such as stress reduction programs, exercise, and dietary changes may increase the effectiveness of this medicine. Talk to your doctor or pharmacist about lifestyle changes that might benefit you.Laboratory and/or medical tests (e.g., blood mineral levels such as potassium, kidney and liver function tests, cholesterol level) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.Have your blood pressure checked regularly while taking this medication. Discuss with your doctor how to monitor your own blood pressure.
MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
STORAGE: Store at controlled room temperature away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.MEDICAL ALERT: Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).
Latest MedicineNet News
Daily Health News
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Top triamterene and hydrochlorothiazide Related Articles
Cirrhosis (Liver)Cirrhosis of the liver refers to a disease in which normal liver cells are replaced by scar tissue caused by alcohol and viral hepatitis B and C. This disease leads to abnormalities in the liver's ability to handle toxins and blood flow, causing internal bleeding, kidney failure, mental confusion, coma, body fluid accumulation, and frequent infections.
Symptoms include yellowing of the skin (jaundice), itching, and fatigue.
The prognosis is good for some people with cirrhosis of the liver, and the survival can be up to 12 years; however the life expectancy is about 6 months to 2 years for people with severe cirrhosis with major complications.
Congestive Heart Failure (CHF)Congestive heart failure (CHF) refers to a condition in which the heart loses the ability to function properly. Heart disease, high blood pressure, diabetes, myocarditis, and cardiomyopathies are just a few potential causes of congestive heart failure. Signs and symptoms of congestive heart failure may include fatigue, breathlessness, palpitations, angina, and edema. Physical examination, patient history, blood tests, and imaging tests are used to diagnose congestive heart failure. Treatment of heart failure consists of lifestyle modification and taking medications to decrease fluid in the body and ease the strain on the heart. The prognosis of a patient with congestive heart failure depends on the stage of the heart failure and the overall condition of the individual.
Drug interactions occur frequently. Get facts about the types of drug interactions, what substances or other things that may interact with drugs such as OTC drug and prescription drugs, vitamins, food(s) (grapefruit), and laboratory tests. Find out how to protect yourself from potential drug interactions.
Drugs: Questions to Ask Your Doctor or Pharmacist about Your DrugsImportant information about your drugs should be reviewed prior to taking any prescription drug. Side effects, drug interactions, warnings and precauctions, dosage, what the drug is used for, what to do if you miss a dose, how the drug is to be stored, and generic vs. brand names.
Edema (Pitting)Edema is the swelling of tissues as a result of excess water accumulation. Peripheral edema occurs in the feet and legs. There are two types of edema, non-pitting edema and pitting edema. Causes of pitting edema is caused by systemic diseases (most commonly involving the heart, liver, and kidneys), and medications. Local conditions that cause edema are thrombophlebitis and varicose veins. Edema or swelling of the legs, feet, ankles, and face are common during pregnancy. Idiopathic edema is edema in which the cause is not known. Pitting edema is scored on pitting edema measurement scales. Edema is generally treated with medication.
ElectrolytesElectrolytes are substances that become ions in solution and acquire the capacity to conduct electricity. The balance of the electrolytes in our bodies is essential for normal function of our cells and our organs. Common electrolytes include sodium, potassium, chloride, and bicarbonate. The functions and normal range values for these electrolytes are important, and if an electrolyte is at an extreme low or high, it can be fatal.
Febrile SeizuresFebrile seizures, or convulsions caused by fever, can be frightening in small children or infants. However, in general, febrile seizures are harmless. Febrile seizure is not epilepsy. It is estimated that one in every 25 children will have at least one febrile seizure. It is important to know what to do to help your child if he/she has a febrile seizure. Some of the features of a febrile seizure include losing consciousness, shaking, moving limbs on both sides of the body, and lasts 1-2 minutes. Less commonly, a febrile seizure may only affect one side of the body.
furosemide (Lasix)Furosemide (Lasix) is a diuretic medicine that doctors prescribe to treat excess accumulation of fluid or swelling of the body (edema) caused by cirrhosis, chronic kidney failure, heart failure, and kidney disease. Review the side effects, drug interactions, dosage, and pregnancy and breastfeeding information before using furosemide.
High Blood Pressure (Hypertension)
High blood pressure (hypertension) is a disease in which pressure within the arteries of the body is elevated. About 75 million people in the US have hypertension (1 in 3 adults), and only half of them are able to manage it. Many people do not know that they have high blood pressure because it often has no has no warning signs or symptoms.
Systolic and diastolic are the two readings in which blood pressure is measured. The American College of Cardiology released new guidelines for high blood pressure in 2017. The guidelines now state that blood normal blood pressure is 120/80 mmHg. If either one of those numbers is higher, you have high blood pressure.
The American Academy of Cardiology defines high blood pressure slightly differently. The AAC considers 130/80 mm Hg. or greater (either number) stage 1 hypertension. Stage 2 hypertension is considered 140/90 mm Hg. or greater.
If you have high blood pressure you are at risk of developing life threatening diseases like stroke and heart attack.
REFERENCE: CDC. High Blood Pressure. Updated: Nov 13, 2017.
High Blood Pressure Drugs (Hypertension)High blood pressure (hypertension) medications include drugs from a variety of different drug classes and types. ACE inhibitors, ARB (angiotensin receptor blockers), beta blockers, calcium channel blockers (CCBs), diuretics, alpha-blockers, alpha-beta blockers. Clonidine (Catapres) and minoxidil also are drugs prescribed for the treatment of high blood pressure. Side effects, warnings and precautions, safety information, and pregnancy and breastfeeding safety information should be reviewed prior to taking any medication.
High Blood Pressure Treatment (Natural Home Remedies, Diet, Medications)High blood pressure (hypertension) means high pressure (tension) in the arteries. Treatment for high blood pressure include lifestyle modifications (alcohol, smoking, coffee, salt, diet, exercise), drugs and medications such as ACE inhibitors, angiotensin receptor blockers, beta blockers, diuretics, calcium channel blockers (CCBs), alpha blockers, clonidine, minoxidil, and Exforge.
Hypertension PictureHigh blood pressure, defined as a repeatedly elevated blood pressure exceeding 140 over 90 mmHg -- a systolic pressure above 140 with a diastolic pressure above 90. See a picture of Hypertension and learn more about the health topic.
Parathyroidectomy SurgeryParathyroidectomy is the removal of one or more of the parathyroid glands to treat hyperparathyroidism. Risks of parathyroidectomy include:
- paralysis of the vocal cords,
- difficulty swallowing thin liquids,
- difficulty breathing,
- and drug reactions.
- damage to the recurrent laryngeal nerve,
- bleeding or hematoma,
- problems maintaining calcium levels in the blood,
- need for further and more aggressive surgery,
- need for a limited or total thyroidectomy,
- prolonged pain,
- impaired healing,
- and recurrence of the tumor.
Aldactone (spironolactone)Aldactone (spironolactone) is classified as a potassium-sparing diuretic. It is prescribed for the treatment of congestive heart failure, cirrhosis of the liver, and kidney disease. It can also be used in combination with other drugs to treat diuretic induced low potassium and high blood pressure. Review side effects, drug interactions, dosage, and pregnancy and breastfeeding safety information prior to taking any medication.