- High Blood Pressure Slideshow Pictures
- Take the Salt Quiz!
- Lowering Blood Pressure Exercise Tips Pictures
- What brand names are available for hydrochlorothiazide?
- Is hydrochlorothiazide available as a generic drug?
- Do I need a prescription for hydrochlorothiazide?
- Why is hydrochlorothiazide prescribed to patients?
- What are the side effects of hydrochlorothiazide?
- What is the dosage for hydrochlorothiazide?
- Which drugs or supplements interact with hydrochlorothiazide?
- Is hydrochlorothiazide safe to use during pregnancy or while breastfeeding?
- What else should I know about hydrochlorothiazide?
What brand names are available for hydrochlorothiazide?name="brand_names">
What brand names are available for hydrochlorothiazide?
- Hydrodiuril, Ezide, Hydro-Par, and Microzid are brand names that are no longer available in the US.
Quick GuideHow to Lower Blood Pressure: Exercise Tips
Why is hydrochlorothiazide prescribed to patients?
- Hydrochlorothiazide is used to treat excessive fluid accumulation and swelling (edema) of the body caused by heart failure, cirrhosis, chronic kidney failure, corticosteroid medications, and nephrotic syndrome.
- It also is used alone or in conjunction with other blood pressure lowering medications to treat high blood pressure.
- Although hydrochlorothiazide is approved for treating edema in cirrhosis of the liver, it is rarely used because of the availability of other diuretics that are more effective.
- Hydrochlorothiazide can be used to treat calcium-containing kidney stones because it decreases the amount of calcium excreted by the kidneys in the urine and thus decreases the amount of calcium in urine to form stones.
What are the side effects of hydrochlorothiazide?name="side_effects">
What are the side effects of hydrochlorothiazide?
Side effects of hydrochlorothiazide include
- low blood pressure,
- light sensitivity (rash caused by sunlight),
- nausea, and
- abdominal pain.
More serious side effects include
- electrolyte disturbances,
- jaundice, and
- anaphylaxis (a life-threatening allergic reaction).
Patients allergic to sulfa may also be allergic to hydrochlorothiazide because of the similarity in the chemical structure of the medications.
Hydrochlorothiazide can aggravate kidney dysfunction and is used with caution in patients with kidney disease. Hydrochlorothiazide can lower blood potassium, sodium, and magnesium levels. Low potassium and magnesium levels can lead to abnormalities in heart rhythm, especially in patients already taking digoxin (Lanoxin). During hydrochlorothiazide treatment, supplementation with potassium is common to prevent low potassium levels.
Blood uric acid levels can increase during hydrochlorothiazide treatment, and this elevation may cause an episode of acute gout in some individuals. Thiazide diuretics may increase blood sugar (glucose) levels and precipitate diabetes.
What is the dosage for hydrochlorothiazide?name="dosage">
What is the dosage for hydrochlorothiazide?
- Hydrochlorothiazide may be taken with or without food.
- The usual adult dose for hypertension is 12.5 to 50 mg once daily.
- The usual adult dose for treating edema is 25-100 mg once daily or in divided doses.
Quick GuideHow to Lower Blood Pressure: Exercise Tips
Which drugs or supplements interact with hydrochlorothiazide?name="interact">
Which drugs or supplements interact with hydrochlorothiazide?
- Hydrochlorothiazide reduces the elimination of lithium (Lithobid, Eskalith) by the kidneys and can lead to lithium toxicity.
- Nonsteroidal anti-inflammatory drugs (NSAIDs), for example, ibuprofen (Motrin), may reduce the blood pressure lowering effects of hydrochlorothiazide. Blood sugar levels can be elevated by hydrochlorothiazide, necessitating adjustment in the doses of medications that are used for treating diabetes.
- Combining hydrochlorothiazide with corticosteroids may increase the risk for low levels of blood potassium and other electrolytes. Low blood potassium (hypokalemia) can increase the toxicity of digoxin (Lanoxin).
- Cholestyramine (Questran, Questran Light) and colestipol (Colestid) bind to hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by 43% to 85%.
Is hydrochlorothiazide safe to use during pregnancy or while breastfeeding?name="pregnancy">
Is hydrochlorothiazide safe to use during pregnancy or while breastfeeding?
- There are no adequate studies of hydrochlorothiazide in pregnant women. Thiazides may increase the risk of fetal or neonatal jaundice, low platelet levels, and possibly other adverse reactions that have occurred in adults.
- Hydrochlorothiazide is excreted in breast milk. Intense diuresis using hydrochlorothiazide may reduce the production of breast milk. Otherwise hydrochlorothiazide is considered safe to use during nursing if required by the mother.
What else should I know about hydrochlorothiazide?name="what_else">
What else should I know about hydrochlorothiazide?
What preparations of hydrochlorothiazide are available?
- Tablets: 12.5, 25, 50 and 100 mg
- Capsules: 12.5 mg
How should I keep hydrochlorothiazide stored?
Hydrochlorothiazide should be stored at room temperature, 15 C to 30 C (59 F to 86 F), in a tight, light-resistant container.
How does hydrochlorothiazide work?
- Hydrochlorothiazide is a diuretic (water pill) used for treating high blood pressure (hypertension) and accumulation of fluid (edema). It works by blocking salt and fluid reabsorption from the urine in the kidneys, causing increased urine output (diuresis). Its mechanism of action in lowering high blood pressure is not well understood.
- Hydrochlorothiazide is used in combination with many other drugs
When was hydrochlorothiazide approved by the FDA?
- The FDA approved hydrochlorothiazide in February 1959.
Reference: FDA Prescribing Information
Quick GuideHow to Lower Blood Pressure: Exercise Tips
Hydrochlorothiazide (Microzide, Hydrodiuril, Ezide, and Hydro-Par have been discontinued) is a diuretic drug prescribed to treat
- high blood pressure,
- edema caused by heart failure,
- chronic kidney failure,
- nephrotic syndrome, and
- corticosteroid medications.
Multimedia: Slideshows, Images & Quizzes
Heart Disease: Causes of a Heart Attack
Learn about heart disease and heart attack symptoms and signs of a heart attack in men and women. Read about heart disease...
Kidney Stones: Symptoms, Causes, and Treatment
What causes kidney stones? Learn to recognize the symptoms and signs of kidney stone pain. Explore kidney stone treatment and how...
High Blood Pressure Symptoms, Causes, Treatments
What causes high blood pressure (hypertension)? Know the warning signs and symptoms of high blood pressure. Read about high blood...
Am I Having a Heart Attack? Symptoms of Heart Disease
Heart attacks symptoms vary greatly for men and women, from anxiety and fatigue to nausea and sweating. Learn the warning signs...
High Blood Pressure (Hypertension) Quiz: Symptoms, Signs & Causes
Take this quiz and test your IQ of high blood pressure (hypertension), the cardiovascular disease that causes most strokes and...
Heart Disease Quiz: Test Your Medical IQ
Take our Heart Disease Quiz to get answers and facts about high cholesterol, atherosclerosis prevention, and the causes,...
Liver Disease Quiz: Fatty Liver Disease, Cirrhosis & Symptoms
What is liver disease? Take the Liver Disease Quiz and test your knowledge about this organ and its function....
Picture of Hypertension
High blood pressure, defined as a repeatedly elevated blood pressure exceeding 140 over 90 mmHg -- a systolic pressure above 140...
Picture of Blood Pressure
The blood pressure is the pressure of the blood within the arteries. See a picture of Blood Pressure and learn more about the...
Picture of Kidney Stone Crystal
Kidney stones are made of salts and minerals in the urine that stick together, creating small "pebbles" formed within the kidney...
Picture of Kidney Stone Diagnosis
The diagnosis of kidney stones is suspected by the typical pattern of symptoms when other possible causes of the abdominal or...
Picture of Kidney Stone
A stone in the kidney (or lower down in the urinary tract). See a picture of Kidney Stone and learn more about the health topic....
Picture of Heart Detail
The heart is composed of specialized cardiac muscle, and it is four-chambered, with a right atrium and ventricle, and an...
Picture of Liver
Front View of the Liver. The liver is a large, meaty organ that sits on the right side of the belly. See a picture of the Liver...
Picture of Kidneys
The kidneys are a pair of organs located in the back of the abdomen. See a picture of the Kidneys and learn more about the health...
Picture of Heart
The muscle that pumps blood received from veins into arteries throughout the body. See a picture of the Heart and learn more...
Heart-Healthy Diet: 25 Foods to Protect Your Cardiovascular System
See 25 foods loaded with heart-healthy nutrients that help protect your cardiovascular system. Plus, find easy meal/recipes and...
Food Swaps for Meals and Snacks for Heart Health in Pictures
Explore 10 food swaps for heart-wise dining. Learn what food to buy and how to cook in order to make a big difference for your...
Related Disease Conditions
Kidney failure can occur from an acute event or a chronic condition or disease. Prerenal kidney failure is caused by blood loss,...
Congestive Heart Failure (CHF) Symptoms, Stages, and Prognosis
Congestive heart failure (CHF) refers to a condition in which the heart loses the ability to function properly. Heart disease,...
Cirrhosis of the liver refers to a disease in which normal liver cells are replaced by scar tissue caused by alcohol and viral...
Liver disease can be cause by a variety of things including infection (hepatitis), diseases such as: gallstones, high...
Kidney stones are solid masses of crystalline material that form in the kidneys. Symptoms of kidney stones can include pain,...
Edema is the swelling of tissues as a result of excess water accumulation. Peripheral edema occurs in the feet and legs. There...
High Blood Pressure (Hypertension)
High blood pressure is defined as a pressure of 140/90 mmHg or higher in the arteries. Genetic factors, high salt intake, and...
Liver (Anatomy and Function)
The liver is the largest gland and organ in the body. There are a variety of liver diseases caused by liver inflammation,...
Heart failure (congestive) is caused by many conditions including coronary artery disease, heart attack, cardiomyopathy, and...
High Blood Pressure Treatment
High blood pressure (hypertension) means high pressure (tension) in the arteries. Treatment for high blood pressure include...
Febrile seizures, or convulsions caused by fever, can be frightening in small children or infants. However, in general, febrile...
Treatment & Diagnosis
- High Blood Pressure FAQs
- Heart Disease FAQs
- Liver Disease FAQs
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Generic Drugs, Are They as Good as Brand-Names?
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Medication Disposal - What to Do with Old or Unusable Medication
- Dangers of Mixing Medications
Medications & Supplements
- High Blood Pressure Drugs (Hypertension)
- furosemide (Lasix)
- Drugs: What You Should Know About Your Drugs
- Drug Interactions
- Congestive Heart Failure Medications
- chlorthalidone, Thalitone (Hygroton discontinued brand in USA)
- losartan and hydrochlorothiazide, Hyzaar
- lisinopril and hydrochlorothiazide, Zestoretic, Prinzide
- valsartan/hydrochlorothiazide (Diovan HCT)
- benazepril and hydrochlorothiazide, Lotensin HCT
- enalapril and hydrochlorothiazide, Vaseretic
- captopril and hydrochlorothiazide, Capozide
Prevention & Wellness
Daily Health News
Heart Health Resources
Subscribe to MedicineNet's Heart Health Newsletter
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Top hydrochlorothiazide Related ArticlesComplete List
CirrhosisCirrhosis of the liver refers to a disease in which normal liver cells are replaced by scar tissue caused by alcohol and viral hepatitis B and C. This disease leads to abnormalities in the liver's ability to handle toxins and blood flow, causing:
- internal bleeding,
- kidney failure,
- mental confusion,
- body fluid accumulation, and
- frequent infections.
Congestive Heart Failure (CHF) OverviewCongestive heart failure (CHF) refers to a condition in which the heart loses the ability to function properly. Heart disease, high blood pressure, diabetes, myocarditis, and cardiomyopathies are just a few potential causes of congestive heart failure. Signs and symptoms of congestive heart failure may include fatigue, breathlessness, palpitations, angina, and edema. Physical examination, patient history, blood tests, and imaging tests are used to diagnose congestive heart failure. Treatment of heart failure consists of lifestyle modification and taking medications to decrease fluid in the body and ease the strain on the heart. The prognosis of a patient with congestive heart failure depends on the stage of the heart failure and the overall condition of the individual.
Edema is the swelling of tissues as a result of excess water accumulation. Peripheral edema occurs in the feet and legs. There are two types of edema, non-pitting edema and pitting edema. Causes of pitting edema is caused by systemic diseases (most commonly involving the heart, liver, and kidneys), and medications. Local conditions that cause edema are thrombophlebitis and varicose veins. Edema or swelling of the legs, feet, ankles, and face are common during pregnancy. Idiopathic edema is edema in which the cause is not known. Pitting edema is scored on pitting edema measurement scales. Edema is generally treated with medication.
ElectrolytesElectrolytes are substances that become ions in solution and acquire the capacity to conduct electricity. The balance of the electrolytes in our bodies is essential for normal function of our cells and our organs. Common electrolytes include sodium, potassium, chloride, and bicarbonate. The functions and normal range values for these electrolytes are important, and if an electrolyte is at an extreme low or high, it can be fatal.
Heart Disease SlideshowLearn about heart disease and heart attack symptoms and signs of a heart attack in men and women. Read about heart disease diagnostic tests, treatments, and prevention strategies.
Heart Disease QuizTake our Heart Disease Quiz to get answers and facts about high cholesterol, atherosclerosis prevention, and the causes, symptoms, treatments, testing, and procedures for medically broken hearts.
Heart SymptomsHeart attacks symptoms vary greatly for men and women, from anxiety and fatigue to nausea and sweating. Learn the warning signs of a heart attack and know the symptoms that may require an immediate trip to the hospital.
Illustrations of the HeartThe muscle that pumps blood received from veins into arteries throughout the body. See a picture of the Heart and learn more about the health topic.
High Blood Pressure HypertensionHigh blood pressure is defined as a pressure of 140/90 mmHg or higher in the arteries. Genetic factors, high salt intake, and increased arterial stiffness cause high blood pressure. Dizziness, headache, nausea, and shortness of breath are just a few symptoms of high blood pressure. Untreated high blood pressure increases the risk of heart disease, kidney disease, atherosclerosis, eye damage, stroke, and increased risk of aneurysms. High blood pressure can be managed with weight loss, lifestyle changes, and medication.
High Blood PressureWhat causes high blood pressure (hypertension)? Know the warning signs and symptoms of high blood pressure. Read about high blood pressure medications, diet, and long term treatments.
Take the HBP QuizTake this quiz and test your IQ of high blood pressure (hypertension), the cardiovascular disease that causes most strokes and heart attacks. How are dizziness, snoring, and gout related to HBP? Find the answer and learn how medical treatments and lifestyle adjustments fight this common problem.
Kidney FailureKidney failure can occur from an acute event or a chronic condition or disease. Prerenal kidney failure is caused by blood loss, dehydration, or medication. Some of the renal causes of kidney failure are:
- multiple myeloma, and
- acute glomerulonephritis.
- bladder obstruction,
- prostate problems,
- tumors, or
- kidney stones.
Kidney Stone SlideshowWhat causes kidney stones? Learn to recognize the symptoms and signs of kidney stone pain. Explore kidney stone treatment and how to prevent kidney stones.
Kidney StonesKidney stones are solid masses of crystalline material that form in the kidneys. Symptoms of kidney stones can include pain, nausea, vomiting, and even fever and chills. Kidney stones are diagnosed via CT scans and specialized X-rays. Treatment of kidney stones involves drinking lots of fluids and taking over-the-counter pain medications to medical intervention including prescription medications, lithotripsy, and sometimes even surgery.
Liver (Anatomy and Function)The liver is the largest gland and organ in the body. There are a variety of liver diseases caused by liver inflammation, scarring of the liver, infection of the liver, gallstones, cancer, toxins, genetic diseases, and blood flow problems. Symptoms of liver disease generally do not occur until the liver disease is advanced. Some symptoms of liver disease include jaundice, nausea and vomiting, easy bruising, bleeding excessively, fatigue, weakness, weight loss, shortness of breath, leg swelling, impotence, and confusion. Treatment of diseases of the liver depend upon the cause.
Liver DiseaseLiver disease can be cause by a variety of things including infection (hepatitis), diseases such as:
- high cholesterol or triglycerides,
- blood flow obstruction to the liver, and
- toxins (medications and chemicals).
- upper right abdominal pain, and
Liver Disease QuizWhat is liver disease? Take the Liver Disease Quiz and test your knowledge about this organ and its function.
ParathyroidectomyParathyroidectomy is the removal of one or more of the parathyroid glands to treat hyperparathyroidism. Risks of parathyroidectomy include:
- paralysis of the vocal cords,
- difficulty swallowing thin liquids,
- difficulty breathing,
- and drug reactions.
- damage to the recurrent laryngeal nerve,
- bleeding or hematoma,
- problems maintaining calcium levels in the blood,
- need for further and more aggressive surgery,
- need for a limited or total thyroidectomy,
- prolonged pain,
- impaired healing,
- and recurrence of the tumor.