Hydrazine Sulfate

What other names is Hydrazine Sulfate known by?

Sehydrin, Sulfate d'Hydrazine, Sulfato de Hidracina.

What is Hydrazine Sulfate?

Hydrazine sulfate is a chemical used in industry and as jet fuel. Some people use it as medicine.

Hydrazine sulfate is used for treating colon and rectal (colorectal) cancer, lung cancer, brain cancer (neuroblastoma), Hodgkin's disease (lymph cancer), and other cancers. It is also used for the general weight loss and wasting (cachexia) associated with cancer.

Possibly Ineffective for...

Likely Ineffective for...

  • Lung cancer. Adding hydrazine sulfate to chemotherapy doesn't significantly improve quality of life, tumor response, weight gain, or survival in most people with a type of lung cancer called non-small-cell lung cancer.

Insufficient Evidence to Rate Effectiveness for...

  • Brain tumor: Taking hydrazine sulfate along with chemotherapy may improve nerve-related symptoms in people with brain cancer. It may also help reduce the size of tumors in people with a specific type of brain cancer called glioblastoma.
  • General weight loss and wasting associated with cancer. Early research suggests that hydrazine sulfate might slow weight loss in some cancer patients.
  • Hodgkin's disease (lymph cancer). Some research suggests that hydrazine sulfate might slow the progress of advanced Hodgkin's disease.
  • Nerve cancer (neuroblastoma). There is some evidence that hydrazine sulfate might prevent the growth of neuroblastoma.
  • Other conditions.
More evidence is needed to rate the effectiveness of hydrazine sulfate for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

Quick GuideVitamin D Deficiency: How Much Vitamin D Is Enough?

Vitamin D Deficiency: How Much Vitamin D Is Enough?

How does Hydrazine Sulfate work?

Hydrazine sulfate may block chemical reactions in the body that might lead to malnutrition and muscle wasting associated with cancer.

Are there safety concerns?

Hydrazine sulfate is POSSIBLY UNSAFE. It has been linked to cases of liver damage, seizure, coma, and death.

Hydrazine sulfate can cause some side effects including nausea, vomiting, dizziness, drowsiness, nerve problems, violent behavior, restlessness, seizures, coma, confusion, mood stimulation, excitement, weakness, irregular breathing, abnormal blood sugar levels, rash, and kidney damage.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Hydrazine sulfate is POSSIBLY UNSAFE for anyone, including pregnant and breast-feeding women. It has been linked to cases of liver damage, seizure, coma, and death.

Diabetes: Hydrazine sulfate might lower blood sugar levels in people with diabetes. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you have diabetes and use hydrazine sulfate.

Liver disease:Hydrazine sulfate might damage the liver. It might be unsafe for people with liver disease.

Surgery: Since hydrazine sulfate might to affect blood glucose levels, there is a concern that it might interfere with blood glucose control during and after surgery. Stop using hydrazine sulfate at least 2 weeks before a scheduled surgery.

Are there any interactions with medications?



Isoniazid (INH, Nydrazid)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Isoniazid is a drug used for tuberculosis. The body breaks isoniazid down to hydrazine. Using both isoniazid and hydrazine might increase the risk of liver damage.



Medications for depression (MAOIs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Hydrazine sulfate contains a chemical that affects the body. This chemical might increase the side effects of some medications used for depression.

Some of these medications used for depression include phenelzine (Nardil), tranylcypromine (Parnate), and others.



Medications for diabetes (Antidiabetes drugs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Hydrazine sulfate might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking hydrazine sulfate along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.



Sedative medications (CNS depressants)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Hydrazine sulfate might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking hydrazine sulfate along with sedative medications might cause too much sleepiness.

Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.

Dosing considerations for Hydrazine Sulfate.

The appropriate dose of hydrazine sulfate depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for hydrazine sulfate. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Last Editorial Review: 3/29/2011

Health Solutions From Our Sponsors