Reviewed on 6/11/2021
Other Name(s):

Hortensia, Hortensia en Arbre, Hortensia de Virginie, Hortension Arborescent, Hydrangea arborscens, Mountain Hydrangea, Seven Barks, Smooth Hydrangea, Viburnum alnifolium, Viburnum americanum, Wild Hydrangea.


Hydrangea is a plant. The root and rhizome (underground stem) are used to make medicine.

Hydrangea is used for urinary tract problems such as infections of the bladder, urethra and prostate; enlarged prostate; and kidney stones. It is also used for hay fever.

How does it work?

The chemicals in hydrangea may cause increased urine output, which could help some urinary tract problems.


Next to red peppers, you can get the most vitamin C from ________________. See Answer

Uses & Effectiveness

Insufficient Evidence to Rate Effectiveness for...

More evidence is needed to rate the effectiveness of hydrangea for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

Side Effects

Hydrangea is POSSIBLY SAFE for most people when taken by mouth for only a few days. Side effects include nausea, vomiting, diarrhea, dizziness, and chest tightness.

It's LIKELY UNSAFE to use more than 2 grams of dried hydrangea rhizome/root at a time. It is also LIKELY UNSAFE to use hydrangea for long period of time.


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Special Precautions & Warnings

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking hydrangea if you are pregnant or breast-feeding. Stay on the safe side and avoid use.


LithiumInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.

Hydrangea might have an effect like a water pill or "diuretic." Taking hydrangea might decrease how well the body gets rid of lithium. This could increase how much lithium is in the body and result in serious side effects. Talk with your healthcare provider before using this product if you are taking lithium. Your lithium dose might need to be changed.


The appropriate dose of hydrangea depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for hydrangea. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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Bruynzeel, D. P. and Hausen, B. M. Allergic contact dermatitis to hydrangea. Contact Dermatitis 1987;16(3):181. View abstract.

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Ishih, A., Miyase, T., and Terada, M. Comparison of antimalarial activity of the alkaloidal fraction of Hydrangea macrophylla var. Otaksa leaves with the hot-water extract in ICR mice infected with Plasmodium yoelii 17 XL. Phytother.Res. 2003;17(6):633-639. View abstract.

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Matsuda, H., Wang, Q., Matsuhira, K., Nakamura, S., Yuan, D., and Yoshikawa, M. Inhibitory effects of thunberginols A and B isolated from Hydrangeae Dulcis Folium on mRNA expression of cytokines and on activation of activator protein-1 in RBL-2H3 cells. Phytomedicine. 2008;15(3):177-184. View abstract.

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Rademaker, M. Occupational contact dermatitis to hydrangea. Australas.J.Dermatol. 2003;44(3):220-221. View abstract.

Tsuji, Y., Denda, S., Soma, T., Raftery, L., Momoi, T., and Hibino, T. A potential suppressor of TGF-beta delays catagen progression in hair follicles. J.Investig.Dermatol.Symp.Proc. 2003;8(1):65-68. View abstract.

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Yoshida, K., Ito, D., Shinkai, Y., and Kondo, T. Change of color and components in sepals of chameleon hydrangea during maturation and senescence. Phytochemistry 4-16-2008; View abstract.

Zhang, H., Matsuda, H., Kumahara, A., Ito, Y., Nakamura, S., and Yoshikawa, M. New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium). Bioorg.Med.Chem.Lett. 9-1-2007;17(17):4972-4976. View abstract.

Hamid S, Rojter S, Vierling J. Protracted cholestatic hepatitis after the use of Prostata. Ann Intern Med 1997;127:169-70. View abstract.