- What is hyaluronate injection, and how does it work (mechanism of action)?
- What are the uses for hyaluronate injection?
- What are the side effects of hyaluronate injection?
- What is the dosage for hyaluronate injection?
- Which drugs or supplements interact with hyaluronate injection?
- Is hyaluronate injection safe to take if I'm pregnant or breastfeeding?
- What else should I know about hyaluronate injection?
What is hyaluronate injection, and how does it work (mechanism of action)?
Hyaluronic acid is a natural chemical that is found in almost all species of animal and in various parts of the human body. It works as a biological lubricant, reducing friction between adjacent tissues. It is present in high amounts in joints and synovial fluid (the fluid that fills the knee joint).
Sodium hyaluronate is used for the treatment of pain due to osteoarthritis of the knee in patients who do not get adequate relief from simple pain medicines or from exercise and physical therapy. It is administered by injection directly into the knee joint (intra-articular injection).
The exact mechanism by which sodium hyaluronate products work is not known. The synovial fluid in the knees helps lubricate and cushion our joints during movement. Sodium hyaluronate is the major component in the synovial fluid. People with osteoarthritis do not have enough hyaluronic acid in their synovial fluid. It is thought that sodium hyaluronate injection helps restore synovial fluid, thereby reducing some of the pain and discomfort associated with osteoarthritis.
The first sodium hyaluronate injection was approved in the US in 1997.
What brand names are available for hyaluronate injection?
Hyalgan, Supartz, Euflexxa, Orthovisc
Is hyaluronate injection available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for hyaluronate injection?
What are the uses for hyaluronate injection?
Sodium hyaluronate (hyaluronan) intra-articular injection is used to treat knee pain from osteoarthritis in patients who do not receive pain relief from simple pain medications like acetaminophen (Tylenol and others).
What are the side effects of hyaluronate injection?
Common side effects include:
- Pain at the injection site
- Swelling of the knee
- Upset stomach
Other reported side effects include:
- Increased blood pressure
- Feeling sick
What is the dosage for hyaluronate injection?
Sodium hyaluronate is administered into the knee joint (intra-articular injection) once a week for a total of 3-5 injections. 20 mg (Euflexxa, Hyalgan) or 25 mg (Supartz) should be injected into the affected knee once weekly.
Which drugs or supplements interact with hyaluronate injection?
No clinically significant drug-drug interactions between sodium hyaluronate injection and other medications have been reported.
Is hyaluronate injection safe to take if I'm pregnant or breastfeeding?
It is not known whether sodium hyaluronate is safe to use during pregnancy because it has not been evaluated in pregnant women.
NURSING MOTHERS: It is not known if sodium hyaluronate can enter human milk. The safety and effectiveness of sodium hyaluronate has not been established in nursing mothers.
What else should I know about hyaluronate injection?
What preparations of hyaluronate-injection are available?
Solution for injection into the knee joint (intra-articular injection): 10 mg/ml or 15 mg/ml
How should I keep hyaluronate-injection stored?
Sodium hyaluronate should be stored in the original packaging below 25 C (77 F). It should be protected from light.
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Sodium hyaluronate (hyaluronan) intra-articular injection (Hyalgan, Supartz, Euflexxa, Orthovisc) is a prescription medication used to treat knee pain from osteoarthritis in patients who do not receive pain relief from simple pain medications like acetaminophen (Tylenol and others). Review side effects, drug interactions, dosage, storage, and pregnancy and breastfeeding information prior to taking this medication.
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Related Disease Conditions
Acute injuries, medical conditions, and chronic use conditions are causes of knee pain. Symptoms and signs that accompany knee pain include redness, swelling, difficulty walking, and locking of the knee. To diagnose knee pain, a physician will perform a physical exam and also may order X-rays, arthrocentesis, blood tests, or a CT scan or MRI. Treatment of knee pain depends upon the cause of the pain.
A torn meniscus (knee cartilage) may be caused by suddenly stopping, sharply twisting, or deep squatting or kneeling when lifting heavy weight. Symptoms of a meniscal tear include pain with running or walking long distances, popping when climbing stairs, a giving way sensation, locking, or swelling. Treatment depends upon the severity, location, and underlying disease of the knee joint.
Osteoarthritis is a type of arthritis caused by inflammation, breakdown, and eventual loss of cartilage in the joints. Also known as degenerative arthritis, osteoarthritis can be caused by aging, heredity, and injury from trauma or disease.
Arthritis (Joint Inflammation)
Arthritis is inflammation of one or more joints. When joints are inflamed they can develop stiffness, warmth, swelling, redness and pain. There are over 100 types of arthritis, including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, lupus, gout, and pseudogout.
Pain management and treatment can be simple or complex, according to its cause. There are two basic types of pain, nociceptive pain and neuropathic pain. Some causes of neuropathic pain include: complex regional pain syndrome, interstitial cystitis, and irritable bowel syndrome. There are a variety of methods to treat chronic pain, which are dependant on the type of pain experienced.
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.