Prostate cancer is the most common cancer after skin cancer in men in the US and the second leading cause of cancer death. Prostate-specific antigen (PSA) testing has made the detection of prostate cancer easier in its early stages. Ninety-two out of 100 men get diagnosed when the cancer is limited to the prostate.
Most men are diagnosed with prostate cancer in their senior years and only 1 out of 36 men die from it. Death from prostate cancer most often happens when cancer has spread (metastasized) to other organs in the body. This is known as the advanced stage of prostate cancer.
The chances of survival decrease as cancer spreads beyond the prostate. If cancer has metastasized to other parts of the body, only three out of 10 men will survive for five years after the diagnosis.
Advanced stage prostate cancer or metastasized prostate cancer
Cancerous cells may spread to organs other than the site of origin. In the case of prostate cancer, this tendency is decreased, but it can happen. Advanced stage prostate cancer is defined based on the Gleason score, which is based on the TNM staging of cancer. T stands for tumor size, N stands for lymph node involvement and M stands for metastasis.
Prostate cancer can kill in the end through metastases that can develop in
Metastasis to the bone can cause too much bone calcium to be released into the blood. The condition is known as hypercalcemia. Hypercalcemia can disrupt the functioning of organs, such as the kidney and heart. In severe cases, high calcium levels can lead to death.
Metastasis to the lungs can cause the affected lung to collapse or cause a lung infection that becomes difficult to treat. This can severely decrease the affected person’s ability to draw oxygen into the body.
Paraneoplastic syndrome associated with prostate cancer may cause symptoms such as neuropathy, difficulty walking, loss of muscle tone, loss of fine motor coordination, memory loss, seizures, sensory loss in the limbs and vertigo or dizziness. Paraneoplastic syndromes are a group of rare disorders that are triggered by an abnormal immune system response to cancerous cells. These cells mostly attack the nerve and the muscle cells throughout the body.
Advanced stage cancer leads to malnutrition, which can cause muscle wasting, weight loss and fatigue. It may even repress the healthy immune system to an extent that the person develops fungal infections and sepsis.
How is advanced prostate cancer treated?
Androgen deprivation therapy (ADT) is usually the choice of treatment of metastatic prostate cancer. Also known as hormone therapy, it is also used for treating patients who are unfit or unwilling to undergo surgery or/and radiation therapy.
Examples of hormone therapies for advanced prostate cancer include
Other treatment options for prostate cancer are
- Radiation therapy involves the use of high-energy waves to destroy cancer cells. It is the most preferred cancer therapy for older men or those with other coexisting conditions.
- This is a treatment involving anticancer medications that kill rapidly multiplying cells. Examples of chemotherapy medications in advanced prostate cancer include
- Also known as biologic therapy, immunotherapy involves using the immune system to fight cancers. Examples include
- Colony-stimulating factors
- Monoclonal antibodies
Patients with advanced prostate cancer may decide to stop the medications because of the severe side effects that come with the treatment. They may opt for hospice or palliative care, which is available in many hospitals. Palliative care is a special kind of treatment reserved for people with a terminal illness. It aims to alleviate the symptoms as well as provide them comfort and better quality of life.
Alternative practices, such as yoga and meditation, also help people affected with cancer feel relaxed and enable them to take control of their situation.
Participating in a prostate cancer support group can also help the affected person to deal with their cancer effectively. They can ask their doctor or search online for such support groups.
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Early-Stage Prostate Cancer Treatment
If prostate cancer is detected early and appears to be slow-growing, invasive procedures, chemotherapy, radiation and other approaches can sometimes do more harm than good. Many prostate cancer treatments come with side effects, like incontinence or impotence, so it’s in the patient’s interest to put off invasive treatments as long as is medically safe. Active surveillance is where doctors "watch and wait" for changes that could prompt medical intervention.
How Quickly Does Prostate Cancer Spread?Prostate cancer is a cancer that develops in the prostate gland in men and it is one of the most common types of cancer. In some cases, it can take up to eight years to spread from the prostate to other parts of the body (metastasis), typically the bones. In other cases, it may be more aggressive.
Prostate cancer is the most common cancer in men after skin cancer.
- Risk factors include age, family history, ethnicity, and diet.
- Prostate cancer is diagnosed by a digital rectal exam, prostate-specific antigen (PSA) test, and prostate biopsy.
- Symptoms may include
- frequent need to urinate,
- incontinence, pain,
- blood in the urine,
- fatigue, and more.
- Prognosis and treatment depend on cancer staging.
- Watchful waiting,
- cryotherapy, and
- other management strategies are available.
- Research and clinical trials strive to find new and better treatments for prostate cancer.
Prostate Cancer QuizIs prostate cancer the most common cancer in men? Take this prostate cancer quiz to find out and learn the causes, symptoms, and treatments of this disease.
Prostate Cancer Facts
Prostate cancer is a leading cause of cancer and cancer death in males; in some men, identifying it early may prevent or delay metastasis and death from prostate cancer.
- The prostate is a walnut-shaped gland that is a part of the male reproductive system that wraps around the male urethra at it exits the bladder.
- Prostate cancer is common in men over 50 years of age, with the risk of developing prostate cancer increases with aging.
Signs of Prostate Cancer: Symptoms, PSA Test, TreatmentsWhat is prostate cancer? Prostate cancer is the most common cancer in men. Learn the signs and symptoms of prostate cancer, along with causes and treatments. Know the stages, survival rates and how to lower your risk of prostate cancer.
Prostate Cancer Early Signs and Symptoms
Difficulty with urination – frequency, weak stream, trouble getting started, etc. – is usually the first sign of prostate cancer. But these and other early symptoms of prostatic cancer can also come from benign prostate conditions, so diagnostic testing is important, including PSA tests and digital rectal exam.
Prostate Cancer ScreeningProstate cancer screening may be able to detect cancer before a person has developed any symptoms. Prostate cancer is the most common nonskin cancer among American men. Tests commonly used to screen for prostate cancer include a digital rectal exam and a prostate-specific antigen test (PSA test).
Prostate Cancer Staging and Survival Rates
The prognosis for prostate cancer, as with any cancer, depends on how advanced the cancer has become, according to established stage designations. The patient's PSA score at diagnosis, as well as their Gleason score (the grading system used to determine the aggressiveness of prostate cancer) determines the prognosis and final stage designation. Prostate cancer has a high survival rate in general, but your chances depend on the stage of the cancer.
What Are the 5 Warning Signs of Prostate Cancer?Prostate cancer rarely produces symptoms in the early stage; however, few signs can help in detecting prostate cancer.
What Foods Kill Prostate Cancer?Prostate cancer refers to the uncontrolled growth of cells in the prostate gland. There is no particular food or recipe that can directly kill prostate cancer cells. Some foods that may be helpful in prostate cancer recovery and relapse prevention include foods containing lycopene, beans, green tea, cruciferous vegetables and fruit like cranberries, strawberries, blueberries and pomegranates.
What Happens If You Don't Treat Prostate Cancer?If prostate cancer is left untreated, it may grow and possibly spread out of the prostate gland to the local tissues or distant sites such as liver and lungs.