- Estrogen-Receptive Breast Cancer
- Hormone Therapy
- Side Effects
- Ovarian Suppression
Since estrogen stimulates the growth of some breast cancers, hormone therapy can help slow the growth of breast cancers that are estrogen receptor-positive.
What is estrogen-receptive breast cancer?
- HER2-positive breast cancer
- HER2-negative breast cancer or hormone-receptive breast cancer (estrogen-receptive or progesterone receptive cancer)
The HER2 protein is a receptor found on the surface of breast cells that is involved in the normal growth of breast cells. When there is a defect in the HER2 gene that controls the production of HER2, it makes more than the required copies of HER2. Excess of HER2 results in breast cell overgrowth, which can lead to HER2-positive cancer.
When a person has been diagnosed with breast cancer, doctors check if they have HER2-positive breast cancer or hormone-receptive breast cancer. Diagnosis is made based on tests that check for the presence of HER2 protein in the breast tissue.
Positive test results indicate HER2-positive cancer, while negative test results indicate hormone-receptive breast cancer, which may be either estrogen-positive or progesterone-positive cancer. Out of all breast cancer cases, 80% are estrogen-positive.
Detecting the type of breast cancer is essential to determining treatment: treatments targeted at HER2 protein, estrogen, or progesterone.
What are different types of hormone therapy?
Of the five types of hormone therapy, the two most common are:
- Drugs that block estrogen receptors
- Treatments that lower estrogen levels
Three other types of hormone treatments that are rarely used now include:
Which drugs help lower estrogen levels in breast cancer?
Aromatase inhibitors (AIs) lower estrogen levels by stopping estrogen production. They work by blocking the aromatase enzyme. The aromatase enzyme helps produce estrogen in the fat tissue of postmenopausal women or women whose estrogen production has stopped due to treatments. Apart from use in postmenopausal women, these drugs can be used in premenopausal women in combination with another treatment, ovarian suppression.
Taken in the form of daily oral pills, the AIs used in the treatment of breast cancer include:
What are the possible side effects of aromatase inhibitors?
Possible side effects include:
What is ovarian suppression in breast cancer?
Because the ovaries produce the majority of estrogen in premenopausal women, removing them or blocking them is one way to lower estrogen levels in breast cancer:
- Oophorectomy: Oophorectomy involves surgical removal of the ovaries.
- Luteinizing hormone-releasing hormone (LHRH) analogs: These block the signals that stimulate estrogen production in the ovaries. Common LHRH drugs include goserelin and leuprolide.
- Chemotherapy medications: Some chemotherapy medications damage the ovaries temporarily or permanently so that the ovaries stop producing estrogen.
Chalasani P. Breast Cancer Treatment & Management. Medscape. https://emedicine.medscape.com/article/1947145-treatment#d13
American Cancer Society. Hormone Therapy for Breast Cancer. https://www.cancer.org/cancer/breast-cancer/treatment/hormone-therapy-for-breast-cancer.html
Top How Do You Reduce Estrogen After Breast Cancer Related Articles
Breast cancer is an invasive tumor that develops in the mammary gland. Breast cancer is detected via mammograms, breast self-examination (BSE), biopsy, and specialized testing on breast cancer tissue. Treatment of breast cancer may involve surgery, radiation, hormone therapy, chemotherapy, and targeted therapy. Breast cancer risk may be lowered by managing controllable risk factors.
What you should know about breast cancer
- Breast cancer is the most common cancer among American women.
- One in every eight women in the United States develops breast cancer.
- There are many types of breast cancer that differ in their capability of spreading (metastasize) to other body tissues.
- The causes of breast cancer are unknown, although medical professionals have identified a number of risk factors.
- There are 11 common types of breast cancer and 4 uncommon types of breast cancer.
- Breast cancer early signs and symptoms include
- a lump in the breast or armpit,
- bloody nipple discharge,
- inverted nipple,
- orange-peel texture or dimpling of the breast's skin (peau d'orange),
- breast pain or sore nipple,
- swollen lymph nodes in the neck or armpit, and
- a change in the size or shape of the breast or nipple.
- Breast cancer can also be symptom free, which makes following national screening recommendations an important practice.
- Breast cancer is diagnosed during a physical exam, by a self-exam of the breasts, mammography, ultrasound testing, and biopsy.
- Treatment of breast cancer depends on the type of cancer and its stage (0-IV) and may involve surgery, radiation, or chemotherapy.
Young Women & Breast CancerIs breast cancer genetic? Should I get tested for the BRCA gene? What every young women should know about breast cancer. Discover the signs and symptoms of breast cancer and other crucial breast cancer facts.
Breast Cancer: Diet Tips for Breast CancerNo single food or diet plan prevents breast cancer, but what you eat plays a role in how likely you are to get the disease or whether or not it comes back once you’ve had it.
Breast Cancer Follow-Up Self-ExamA breast cancer follow-up self-exam is a test that may help a woman detect a recurrence of the disease. A woman should perform a monthly self-exam of both breasts as well as attend scheduled follow-up appointments to detect any breast cancer recurrence early. Lymph node involvement, tumor size, hormone receptor status, histologic grade, nuclear grade, and oncogene expression help determine the likelihood of a recurrence.
Breast Cancer Growth RateThe available evidence suggests that breast cancer may begin to grow around 10 years before it is detected. However, the time for development differs from tumor to tumor.
Where Breast Cancer SpreadsWhen breast cancer spreads, or metastasizes, it often goes to these five places: the lymph nodes, bones, liver, lungs, and brain. See how breast cancer metastasis affects the body, possible symptoms, and treatment.
Breast Cancer QuizThis Breast Cancer Quiz features signs, symptoms, facts, causes, common forms, terms, risk factors, statistics, and more. Increase your awareness of breast cancer now!
Breast Cancer TreatmentBreast cancer treatments depend upon the type of breast cancer that is present as well as the stage (extent of spread) of the tumor. Treatment for early breast cancer typically involves surgery to remove the tumor. After surgery, medical professionals may administer radiation therapy, chemotherapy, or targeted therapy.
Everyday Habits to Lower Breast Cancer RiskConcerned about your breast cancer risk? Here are everyday health habits you can adopt to improve your odds.
Genetic Testing for Breast CancerIntensive genetic counseling is required before undergoing genetic tests for breast cancer. During this educational counseling session, the health care provider can fully explain the benefits and risks of genetic testing and answer any questions you may have. You will also be required to sign a consent form prior to participating in any genetic tests. The form is an agreement between you and your doctor, showing that you have discussed the test and how its results might affect your family.
Hormone TherapyEstrogen therapy, estrogen/progestin therapy, and hormone therapy are terms that refer to the administration of estrogen or estrogen/progestin for the purpose of suppressing hot flashes. Side effects of hormone therapy include headaches, nausea, breast pain, blood clots, breast cancer, heart disease, abnormal vaginal bleeding, stroke, and uterine cancer.
Is HER2-Positive Good or Bad?Breast cancer is the most common cancer affecting women in the United States. Based on what type of proteins of breast cells are responsible for breast cancer, breast cancer is divided into two types include HER2-positive and HER2-negative.
Radiation Therapy for Breast CancerRadiation therapy for breast cancer is a form of treatment that utilizes high-energy rays to kill cancer cells. Check out the center below for more medical references on breast cancer, including multimedia (slideshows, images, and quizzes), related disease conditions, treatment and diagnosis, medications, and prevention or wellness.
Role of Estrogen Receptors in Breast CancerEstrogen receptors (ERs) are receptors that are activated by the hormone estrogen (one of the female sex hormones). They are found most commonly in the inner lining of the uterus (endometrium), breast cells, ovarian cells, and a part of the brain (the hypothalamus).
What Foods To Avoid If You Have Estrogen Positive Breast CancerBreast cancer is the most common cancer affecting women in the United States. Based on the type of proteins in the breast cells responsible for breast cancer, breast cancer is divided into two types