Histoplasmosis: Symptoms & Signs

Medically Reviewed on 9/24/2021

Histoplasmosis is a fungal infection. Most people who are exposed to this fungus do not develop the disease, and it is most severe in people with decreased function of the immune system.

Signs and symptoms of histoplasmosis appear from 3 to 17 days after exposure. Symptoms and signs can include

Without treatment, the disease can spread to involve the eyes or central nervous system, leading to seizures and confusion.

Cause of Histoplasmosis

Infection with the fungus Histoplasma capsulatum causes histoplasmosis. People acquire the infection by inhaling airborne spores of the fungus. The fungus is commonly found in the U.S., in the Ohio and Mississippi River valleys, in soil contaminated by bird or bat droppings.

Other histoplasmosis symptoms and signs

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References
Jameson, J. Larry, et al. Harrison's Principles of Internal Medicine, 20th Ed. New York: McGraw-Hill Education, 2018.