Hesperidin

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What other names is Hesperidin known by?

Bioflavonoid, Bioflavonoid Complex, Bioflavonoid Concentrate, Bioflavonoid Extract, Bioflavonoïde, Bioflavonoïde d'Agrume, Bioflavonoïdes d'Agrumes, Citrus Bioflavones, Citrus Bioflavonoid, Citrus Bioflavonoids, Citrus Bioflavonoid Extract, Citrus Flavones, Citrus Flavonoids, Complexe de Bioflavonoïdes, Concentré de Bioflavonoïdes, Extrait de Bioflavonoïdes, Extrait de Bioflavonoïdes d'Agrumes, Flavonoid, Flavonoïde, Hesperidin Methyl Chalcone, Hesperidina, Hespéridine, Trimethylhesperidin-chalcon.

What is Hesperidin?

Hesperidin is a plant chemical that is classified as a "bioflavonoid." It is found primarily in citrus fruits. People use it as medicine.

Hesperidin alone, or in combination with other citrus bioflavonoids (diosmin, for example), is most often used for blood vessel conditions such as hemorrhoids, varicose veins, and poor circulation (venous stasis). It is also used to treat lymphedema, a condition involving fluid retention that can be a complication of breast cancer surgery.

Possibly Effective for...

  • Poor circulation in the legs (chronic venous insufficiency, CVI). Taking a particular product (Cyclo 3 Fort) containing hesperidin methyl chalcone, butcher's broom, and vitamin C by mouth seems to relieve the symptoms of poor circulation in the legs. Also, taking a specific product (Daflon 500, Les Laboratoires Servier) containing hesperidin and diosmin by mouth for 2-6 months seems to improve CVI symptoms, although taking the drug Venoruton might be more effective for treating this condition.
  • Hemorrhoids. Some research suggests that taking a specific product (Daflon 500, Les Laboratoires Servier) containing hesperidin and diosmin by mouth for up to 3 months improves symptoms of anal hemorrhoids. It may also prevent hemorrhoids from coming back after they have healed.
  • Leg ulcers from poor circulation (venous stasis ulcers). Taking a specific product (Daflon 500, Les Laboratoires Servier) containing hesperidin and diosmin by mouth for 2 months seems to improve the healing of small venous stasis ulcers when used along with compression dressings.

Insufficient Evidence to Rate Effectiveness for...

  • Diabetes. Early research suggests that taking one tablet of a specific product (Daflon 500, Les Laboratoires Servier) containing hesperidin and diosmin by mouth for 45 days decreases blood sugar levels and improves blood sugar control in women with type 2 diabetes.
  • Swelling of the arms (lymphedema). Early research suggests that taking a specific product (Cyclo 3 Fort) containing butcher's broom root extract, hesperidin methyl chalcone, and vitamin C by mouth for 90 days reduces swelling in the upper arm and forearm, and improves mobility and heaviness, in women with swelling of the arm after breast cancer treatment. However, other research shows that taking a specific product (Daflon 500, Les Laboratoires Servier) containing hesperidin and diosmin by mouth does not reduce arm swelling in women following breast cancer surgery.
  • Rheumatoid arthritis (RA). Early research suggests that drinking a beverage containing alpha-glucosyl hesperidin for 12 weeks improves symptoms of RA.
  • Varicose veins.
  • Other conditions.
More evidence is needed to rate the effectiveness of hesperidin for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

How does Hesperidin work?

Hesperidin may help blood vessels function better. It may also reduce inflammation.

Are there safety concerns?

Hesperidin is POSSIBLY SAFE for most people when taken by mouth for up to 6 months. The safety of using it for a longer period of time is unknown. Side effects include stomach pain and upset, diarrhea, and headache.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Hesperidin is POSSIBLY SAFE for pregnant or breast-feeding women when taken by mouth with diosmin.

Bleeding disorder: Hesperidin might slow blood clotting and increase the risk of bleeding. In theory, hesperidin might make bleeding disorders worse.

Low blood pressure: Hesperidin might lower blood pressure. In theory, taking hesperidin might make blood pressure become too low in people who already have low blood pressure.

Surgery: Hesperidin might prolong bleeding. There is concern that hesperidin might increase the risk of bleeding during and after surgical procedures. Stop taking hesperidin at least 2 weeks before a scheduled surgery.

Are there any interactions with medications?



Celiprolol
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Hesperidin may reduce how much celiprolol the body absorbs. This might decrease how well celiprolol works. Do not take hesperidin with celiprolol.



Diltiazem
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Hesperidin may reduce how much diltiazem the body absorbs. This might decrease how well diltiazem works. Do not take diltiazem with hesperidin.



Medications for high blood pressure (Antihypertensive drugs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Hesperidin might decrease blood pressure. Taking hesperidin along with medications used to lower high blood pressure might cause your blood pressure to go too low.

Some medications for high blood pressure include nifedipine (Adalat, Procardia), verapamil (Calan, Isoptin, Verelan), diltiazem (Cardizem), isradipine (DynaCirc), felodipine (Plendil), amlodipine (Norvasc), and others.



Medications moved by pumps in cells (P-Glycoprotein Substrates)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some medications are moved by pumps in cells. Hesperidin might make these pumps less active and increase the amount of some medications that get absorbed by the body. This might increase the amount of some medications in the body, which could lead to more side effects. But there is not enough information to know if this is a big concern.

Some medications that are moved by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.



Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Hesperidin might slow blood clotting. Taking hesperidin along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.



Sedative medications (Benzodiazepines)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Hesperidin might cause sleepiness and drowsiness. Drugs that cause sleepiness and drowsiness are called sedatives. Taking hesperidin along with sedative medications might cause too much sleepiness.

Some of these sedative medications include alprazolam (Xanax), clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), midazolam (Versed), temazepam (Restoril), triazolam (Halcion), and others.



Sedative medications (CNS depressants)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Hesperidin might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking hesperidin along with sedative medications might cause too much sleepiness. Taking hesperidin along with sedative medications used in surgery might cause prolonged sedation.

Some sedative medications include pentobarbital (Nembutal), phenobarbital (Luminal), secobarbital (Seconal), thiopental (Pentothal), fentanyl (Duragesic, Sublimaze), morphine, propofol (Diprivan), and others.



Verapamil
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Hesperidin may increase how much verapamil the body absorbs. This might increase the effects and side effects of verapamil. Do not take verapamil with hesperidin.

Dosing considerations for Hesperidin.

The following doses have been studied in scientific research:

BY MOUTH:
  • For the treatment of hemorrhoids inside the anus: 150 mg of hesperidin plus 1350 mg of diosmin twice daily for 4 days, followed by 100 mg of hesperidin and 900 mg of diosmin twice daily for 3 days.
  • For preventing the return of hemorrhoids inside the anus: 50 mg of hesperidin plus 450 mg of diosmin twice daily for 3 months.
  • For the treatment of leg ulcers caused by poor blood circulation (venous stasis ulcers): a combination of 100 mg of hesperidin and 900 mg of diosmin daily for up to 2 months.
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Reviewed on 3/29/2011 12:35:40 PM

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