Hereditary Spherocytosis: Symptoms & Signs

Medically Reviewed on 9/24/2020

Hereditary spherocytosis is a genetic disorder that results in red blood cells with an abnormal shape (a sphere).

Signs and symptoms of hereditary spherocytosis can include symptoms related to anemia (a low red blood cell count) such as

Other associated signs and symptoms can include

Cause of hereditary spherocytosis

Inherited genetic mutations typically cause the condition. The abnormal red blood cells are fragile and possess a short life span as compared to normal red blood cells.

Other hereditary spherocytosis symptoms and signs

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Jameson, J. Larry, et al. Harrison's Principles of Internal Medicine, 20th Ed. New York: McGraw-Hill Education, 2018.