Hereditary Angioedema: Symptoms & Signs

Medically Reviewed on 6/25/2021

Hereditary angioedema (HAE) is a rare genetic disease that causes swelling of the skin and the tissues beneath the skin.

Signs and symptoms of hereditary angioedema include

Other associated symptoms and signs can include

  • mood changes,
  • swelling of the hands and feet, or
  • laryngeal edema that can actually result in asphyxiation.

Multiple reoccurrences of the signs and symptoms typically occur.

Cause of hereditary angioedema

It is caused by low production of a C1 inhibitor protein, or C1-INH (type I HAE), or production of a faulty C1 inhibitor protein (type II HAE). The condition is inherited in an autosomal dominant manner, meaning that one affected parent can pass the condition to the child.

Other hereditary angioedema symptoms and signs

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References
Jameson, J. Larry, et al. Harrison's Principles of Internal Medicine, 20th Ed. New York: McGraw-Hill Education, 2018.