Hereditary Angioedema: Symptoms & Signs

Hereditary angioedema (HAE) is a rare genetic disease that causes swelling of the skin and the tissues beneath the skin.

Signs and symptoms of hereditary angioedema include

• swelling of the skin,
• extreme fatigue or tiredness,
• headache,
• muscle aches,
• tingling in the skin,
• abdominal or belly pain,
• nausea and vomiting,
• diarrhea,
• hoarseness, and
• shortness of breath.

Other associated symptoms and signs can include

• mood changes,
• swelling of the hands and feet, or
• laryngeal edema that can actually result in asphyxiation.

Multiple reoccurrences of the signs and symptoms typically occur.

Cause of hereditary angioedema

It is caused by low production of a C1 inhibitor protein, or C1-INH (type I HAE), or production of a faulty C1 inhibitor protein (type II HAE). The condition is inherited in an autosomal dominant manner, meaning that one affected parent can pass the condition to the child.

Other hereditary angioedema symptoms and signs

• Abdominal or Belly Pain
• Diarrhea
• Extreme Fatigue or Tiredness
• Headache
• Hoarseness
• Laryngeal Edema That Can Actually Result in Asphyxiation
• Mood Changes
• Muscle Aches
• Nausea and Vomiting
• Shortness of Breath
• Swelling of the Hands and Feet
• Swelling of the Skin
• Tingling in the Skin

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