- HCV Infection
- What Is HCV?
- Doctor Specialist
- Side Effects
- Liver Transplant
- Home Remedies
- Life Expectancy
Hepatitis C infection (HCV) definition and facts
- Hepatitis C (hep C, HCV) is one of several viruses that cause viral hepatitis (inflammation of the liver).
- About 2.4 million people are estimated to be currently living with hepatitis C in the U.S.
- Up to 85% of individuals who are initially (acutely) infected with hepatitis C will fail to eliminate the virus and will become chronically infected.
- Hepatitis C is spread through exposure to infected blood. Intravenous drug abuse with the use of contaminated, shared needles is the most common mode of transmission.
- The risk of acquiring hepatitis C through sexual contact or breastfeeding is very low.
- Generally, people with chronic infection with hepatitis C have no symptoms until they have extensive scarring of the liver (cirrhosis). Some individuals, however, may have fatigue and other non-specific symptoms before this occurs.
- In the U.S., infection with hepatitis C is the most common cause of chronic hepatitis and the most common reason for liver transplantation.
- Much progress has been made in the treatment of hepatitis C. The rate of cure has increased (above 90%-95%) with the development of direct-acting, all-oral antiviral medications.
- Treatment results in reduced inflammation and scarring of the liver in most patients who are cured of hepatitis C and also occasionally (but to a much lesser extent) in those who relapse or are not cured.
What is hepatitis C infection? How many people are infected?
Hepatitis C virus infection is an infection of the liver caused by the hepatitis C virus (also referred to as HCV or hep C). It is difficult for the human immune system to eliminate hepatitis C from the body, and infection with hepatitis C usually becomes chronic. Over decades, chronic infection with hepatitis C damages the liver and can cause liver failure. In the U.S., the CDC has estimated that approximately 41,200 new cases of hepatitis C occurred in 2016. When the virus first enters the body there usually are no symptoms, so this number is an estimate. About 75%-85% of newly infected people become chronically infected. In the U.S., more than 2 million people are estimated to be chronically infected with hepatitis C. Infection is most commonly detected among people who are 40 to 60 years of age, reflecting the high rates of infection in the 1970s and 1980s. There are 8,000 to 10,000 deaths each year in the U.S. related to hepatitis C infection. HCV infection is the leading cause of liver transplantation in the U.S. and is a risk factor for liver cancer. In 2016, 18,153 death certificates listed HCV as a contributing cause of death; this is believed to be an underestimate.
About 10%-20% of those who develop chronic HCV will develop cirrhosis within 20-30 years. Progression to cirrhosis may be accelerated by age over 50, male gender, alcohol consumption, nonalcoholic fatty liver disease (NASH), co-infection with hepatitis B or HIV, and immune suppressing drugs. HCV infection is the leading cause of liver transplantation due to liver failure in the U.S.
What is the hepatitis C virus?
Hepatitis means inflammation of the liver. Hepatitis C is one of several viruses that can cause viral hepatitis. It is unrelated to the other common hepatitis viruses (for example, hepatitis A or hepatitis B). Hepatitis C is a member of the Flaviviridae family of viruses. Other members of this family of viruses include those that cause yellow fever and dengue fever.
There are at least six different genotypes (strains) of the virus which have different genetic profiles (genotypes 1 to 6). In the U. S., genotype 1 is the most common strain of hepatitis C. Even within a single genotype there may be some variations (genotype 1a and 1b, for example). Genotyping is used to guide treatment because some viral genotypes respond better to some therapies than to others.
Like human immunodeficiency virus (HIV), hepatitis C multiplies very fast and attains very high levels in the body. The genes that make the surface proteins of the virus also mutate (change) quickly, and thousands of genetic variations of the virus ("quasi-species") are produced daily. It is impossible for the body to keep up with making anti-HCV antibodies against all of the quasi-species circulating at one time. It has not been possible yet to develop an effective vaccine because the vaccine must protect against all genotypes.
Hepatitis C infection in the liver triggers the immune system, which leads to inflammation. About 20%-30% of those acutely infected will experience typical hepatitis symptoms such as abdominal pain, jaundice, dark urine or clay-colored stools. However, chronic hepatitis C usually causes no symptoms until very late in the disease, and hepatitis C has been referred to by sufferers as the "sleeping dragon." Over several years or decades, chronic inflammation may cause death of liver cells and scarring ("fibrosis"). Extensive scarring in the liver is called cirrhosis. This progressively impairs vital functions of the liver. Cirrhotic livers are more prone to liver cancer. Drinking alcohol speeds up liver damage with hepatitis C. Concurrent HIV infection, as well as acute hepatitis A or B infection, will also accelerate progression to cirrhosis.
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What are the symptoms of hepatitis C infection?
About 70%-80% of people have no symptoms when they first get HCV infection. The remaining 20%-30% may have
Early symptoms of hepatitis C may include dark urine, yellow eyes, or clay-colored stools though this is unusual. Over time, people with chronic HCV infection may develop signs of liver inflammation that suggests that the infection may be present. Infected individuals may become easily fatigued or complain of nonspecific symptoms. The later symptoms and signs of cirrhosis are often absent until inflammation is fairly advanced. As cirrhosis progresses, symptoms and signs increase and may include:
- Elevated liver enzymes in the blood
- Loss of appetite
- Weight loss
- Breast enlargement in men (gynecomastia)
- Redness of the palms of the hands
- Difficulty with the clotting of blood
- Spider-like blood vessels on the skin
- Abdominal pain
- Clay-colored stools
- Bleeding from the esophagus
- Fluid in the abdomen
- Yellow skin and eyes (jaundice)
What is the contagious period for hepatitis C?
Because hepatitis C is transmitted by exposure to blood, there is no specific period of contagiousness. People who develop chronic hepatitis C carry the virus in their blood and, therefore, are contagious to others for their entire life, unless they are cured of their hepatitis C.
How long does it take for symptoms to appear (incubation period) after contracting hepatitis C?
This is hard to say for certain what the incubation period for hepatitis C is, because most people who are infected with hepatitis C do not have symptoms early in the course of the infection. Those who develop symptoms early after getting infected (2 to 12 weeks on average, but may be longer) experience mild gastrointestinal symptoms that may not prompt a visit to the doctor.
How is hepatitis C spread?
- Like HIV and hepatitis B, hepatitis C (hepatitis C virus, or HCV) is spread by exposure to infected blood (blood-borne pathogen).
- The most common way of getting hepatitis C is from contaminated blood on needles shared by IV drug users. In a multi-state survey in 2017, about 53% of people who inject drugs were estimated to be HCV-infected.
- Accidental needlesticks in health care workers also have transmitted the virus. The average risk of getting hepatitis C infection from a stick with a contaminated needle is 1.8%.
- Before 1992, most people acquired the hepatitis C virus from blood transfusions or blood products. Since 1992, all blood products have been screened for hepatitis C, and cases of hepatitis C due to blood transfusion now are extremely rare.
- Hepatitis C infection also can be passed from mother to unborn child. Approximately 4%-7% of children born to mothers infected with hepatitis C become infected.
- Hepatitis C is not transmitted by breast milk. However, nipples may crack and bleed during the first few weeks until the nipples are adapted to nursing, and the infant may be exposed to infected blood. If this occurs, breastfeeding should stop, and milk production can be maintained by pumping the milk and discarding it until healed.
- A very small number of hepatitis C cases are transmitted through sexual intercourse. The risk of hepatitis C transmission from an infected individual to a non-infected spouse or sexual partner without the use of condoms over a lifetime has been estimated to be between 1% and 4%.
- Hepatitis C is not transmitted by casual contact, kissing, coughing, sneezing, or sharing eating utensils. There is no transmission by bug bites. However, because of the potential for blood exposure, members of the household are advised not to share shaving razors, nail clippers, or toothbrushes.
- Poor infection control practices during tattooing and body piercing potentially can lead to spread of infection. This may occur in prison or nonprofessional situations, but it has not been reported in licensed, commercial tattooing facilities where it has been studied.
- There have been some outbreaks of hepatitis C when instruments exposed to blood have been re-used without adequate cleaning and sterilization between patients.
- Hepatitis C can be transmitted from an organ donor to an organ recipient. Donors of organs are tested for hepatitis C.
- If the donor who provides the organ is infected with hepatitis C, it is offered to a recipient who also is infected with hepatitis C.
- For kidney transplant recipients, however, this does not seem to affect long-term outcome after transplantation.
- For liver transplant recipients who have hepatitis C and receive an organ from a person who is not infected with hepatitis C, the transplanted organ is expected to become infected within a few weeks. Fortunately, newer medications are allowing successful treatment of hepatitis C after transplants, and this area of medicine continues to evolve.
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Can hepatitis C infection affect other organs besides the liver?
Most of the signs and symptoms of hepatitis C infection relate to the liver. Less often, hepatitis C infection can affect organs other than the liver.
Hepatitis C infection can cause the body to produce abnormal antibodies called cryoglobulins. Cryoglobulins cause inflammation of arteries (vasculitis). This may damage skin, joints, and kidneys. Patients with cryoglobulinemia (cryoglobulins in the blood) may have
- joint pain,
- a raised purple rash on the legs, and
- generalized pain or swelling of their bodies.
In addition, infected individuals with cryoglobulinemia may develop Raynaud's phenomenon in which the fingers and toes turn color (white, then purple, then red), and become painful at cold temperatures.
Who is at high risk and should be tested for hepatitis C infection?
The U.S. Preventive Health Services task force recommends that all adults born between 1945 and 1965 be tested once routinely for hepatitis C, regardless of whether risk factors for hepatitis C are present. One-time testing also is recommended for:
- People who currently inject drugs or snort drugs, or ever did so, even once many years previously
- People with persistently elevated alanine aminotransferase (ALT) level, a liver enzyme found in blood
- People who have HIV infection
- Children born to HCV- or HIV-infected mothers
- People who were ever on long-term hemodialysis
- People who got a tattoo in an unregulated setting, such as prison or by an unlicensed person
- People who received clotting factor produced before 1987
- People who received transfusions or organ transplants before July 1992, or who were notified that they received blood from a donor who later tested positive for hepatitis C infection
- Health care, emergency medical, and public safety workers after a needlestick, eye or mouth exposure to hepatitis C-infected blood
People who may have been exposed to hepatitis C in the previous 6 months should be tested for viral RNA load rather than anti-HCV antibody, because antibody may not be present for up to 12 weeks or longer after infection, although HCV RNA may be detectable in blood as soon as 2-3 weeks after infection.
In general, yearly screening may be appropriate for people with ongoing risk factors such as repeated sexually transmitted diseases (STDs) or many sex partners, ongoing IV drug use, or long-term sex partners of people with hepatitis C. Whether or not to test these people is determined on a case-by-case decision.
Is screening for hepatitis C recommended during pregnancy?
There is a 4%-7% risk of transmitting HCV from mother to infant with each pregnancy. Currently, there is no CDC recommendation for routine hepatitis C screening during pregnancy, and there is no currently recommended medicine to prevent transmission from mother to infant (prophylaxis). However, CDC is monitoring research findings and may make recommendations in the future as evidence arises.
While data is still limited, a recent study of over 1,000 cases in the United Kingdom found that 11% of infants had been infected at birth, and that these infants were likely to develop cirrhosis in their early 30s. The case for screening for HCV during pregnancy includes the potential to safely treat mothers during pregnancy with direct-acting antiviral agents (DAAs) to treat the mother before cirrhosis develops, prevent infant transmission, and prevent transmission to others. Children born to HCV-infected mothers may also be offered treatment at an early age to prevent cirrhosis, as well as transmission to others. Coordination of care between multiple specialists will be important to accomplish these goals.
Children of HCV-infected mothers may be screened for hepatitis C as early as 1-2 months of age using hepatitis C viral load or PCR testing (See Blood tests for hepatitis C). Antibodies to hepatitis C passed from the mother to child will be present for up to 18 months, so children should be tested for HCV antibody no earlier than this.
What type of doctor treats hepatitis C?
Hepatitis C is treated by either a gastroenterologist, a hepatologist (a gastroenterologist with additional training in liver disease), or an infectious disease specialist. The treatment team may include more than one specialist, depending on the extent of liver damage.Surgeons who specialize in surgery of the liver, including liver transplantation, are part of the medical team and should see patients with advanced disease (liver failure or cirrhosis) early, before the patient needs a liver transplant. They may be able to identify issues that need to be addressed before surgery can be considered. Other persons who can be helpful in managing patients include dietitians to consult on nutritional issues and pharmacists to assist with management of drugs.
How is hepatitis C diagnosed?
Blood tests for hepatitis C
There are several blood tests for the diagnosis of hepatitis C infection. Blood can be tested for antibody to hepatitis C (anti-HCV antibody). It takes about 8-12 weeks on average, and up to 6 months, for antibodies to develop after the initial infection with hepatitis C, so screening for antibodies may miss a few newly infected individuals. Having antibodies is not an absolute indication of active, multiplying hepatitis C virus, but if the antibody test is positive (antibody is present), the statistical probability of active infection is greater than 99%.
Several tests are available to measure the amount of hepatitis C virus in a person's blood (the viral load). The hepatitis C virus's RNA can be identified by a type of test called polymerase chain reaction (PCR) that detects circulating virus in the blood as early as 2-3 weeks after infection, so it can be used to detect suspected acute infection with hepatitis C early infection. It also is used to determine whether active hepatitis is present in someone who has antibodies to hepatitis C, and to follow the viral load during treatment.
Blood tests are also performed to identify the genotypes of HCV. Genotypes respond differently to different treatment, so this information is important in selection of the most appropriate treatment regimen.
Estimation of liver fibrosis using blood tests also is quite reliable in diagnosing clinically significant scarring; these include FIB-4, FibroSure, Fibrotest, and aspartate aminotransferase-to-platelet ratio index (APRI).
Liver biopsy and non-invasive tests for hepatitis C
The next step is to determine the level of liver scarring that has occurred. Liver biopsy allows examination of a small sample of liver tissue under a microscope, however, liver biopsy is an invasive test, and has significant risks of bleeding. It also might miss abnormal areas in early disease.
Non-invasive tests have largely replaced liver biopsy except in special situations. Liver stiffness indicates that advanced liver scarring or cirrhosis may be present. Transient elastography may be used to measure this stiffness by ultrasound or magnetic resonance imaging (MRI).
Pre-treatment evaluation for hepatitis C also should include:
- Testing for HIV
- Testing for antibodies to hepatitis B and hepatitis A and vaccination if antibodies are not present
- If past or current hepatitis B infection is detected, it may need to be treated at the same time. There are reports of hepatitis B that reactivated or progressed to serious liver failure or death in some patients who were treated only for hepatitis C. This has been reported to occur during or even after HCV treatment.
- Recommending abstinence from alcohol use
- Counseling about measures to prevent the spread of hepatitis C and HIV
- If cirrhosis is present, vaccination against pneumococcal infection, regardless of age
What medications cure hepatitis C infection?
Interferons, for example, Roferon-A and Infergen, and pegylated interferons such as Peg-IntronT, Pegasys, were mainstays of treatment for years. Interferons produced sustained viral response (SVR, or cure) of up to 15%. Later, peglatedll forms produced SVR of 50%-80%. These drugs were injected, had many adverse effects, required frequent monitoring, and were often combined with oral ribavirin, which caused anemia. Treatment durations ranged up to 48 weeks.
Direct-acting anti-viral agents (DAAs) are antiviral drugs that act directly on hepatitis C multiplication.
- They are taken by mouth, are well tolerated, and cure over 90% of patients.
- Treatment time is much shorter, often 12 weeks, depending on drug and genotype.
- Similar to treatments for HIV, treatment of HCV is most effective if the drugs are given in combination.
- The earliest options were sofosbuvir (Sovaldi) and simeprevir (Olysio). These were approved by the FDA in 2013.
- Ledipasvir and sofosbuvir (Harvoni) followed as a once-a-day combination pill, in 2014.
- With this combination of DAAs, about 94%-99% of people achieve an SVR (cure) in 12 weeks with few side effects.
- Ombitasvir, paritaprevir and ritonavir co-packaged with dasabuvir tablets (Viekira Pak), is a combination approved in 2014. SVR with this combination is 91%-100%. The combination of elbasvir and grazoprevir (Zepatier) was approved in 2016. SVR with this combination depends on the HCV genotype and whether individual patient factors require the addition of ribavirin. Genotype 1 has a 94%-97% SVR, and SVR is 97%-100% in genotype 4.
- In August 2017, FDA approved an 8-week regimen of glecaprevir and pibrentasvir (Mavryet) for all HCV genotypes. Unlike some of the earlier regimens, this combination is effective whether or not the patient has cirrhosis. It also can be given to people on kidney dialysis, whose kidney function limits treatment options. Moreover, this regimen is effective in people with genotype 1 who have failed treatment with some of the other regimens.
What are the treatment guidelines for hepatitis C?
Hepatitis C treatment is best discussed with a doctor or specialist familiar with current and developing options as this field is changing, and even major guidelines may become outdated quickly.
The latest treatment guidelines by the American Association for the Study of Liver Disease (AASLD) and Infectious Disease Society of America (IDSA) recommends use of DAAs as first-line treatment for hepatitis C infection. The choice of DAA varies by specific virus genotype, and the presence or absence of cirrhosis. In the U.S., specific insurance providers also might influence the choice due to the high cost of DAAs. Although the individual, public health, and cost benefits of treating all patients with hepatitis C is clear, the most difficult barrier to treating all people with HCV is the very high cost of the drug regimens. Patients are encouraged to discuss options with their health care professional.
Treatment is recommended in all patients with chronic hepatitis C unless they have a short life expectancy that is not related to liver disease. Severe life-threatening liver disease may require liver transplantation. Newer therapies with DAAs have allowed more and more patients to be treated.
What are the goals of therapy for hepatitis C infection?
The ultimate goals of antiviral therapy are to
- prevent transmission of hepatitis C,
- normalize liver tests,
- reduce inflammation and scarring,
- prevent progression to cirrhosis and liver cancer, and
- improve survival and quality of life.
A side goal is preventing co-infections with other hepatitis viruses, such as A and B, which can cause more liver disease than HCV alone. These can be prevented by vaccines and treatment.
What is the treatment for people with acute hepatitis C infection?
When people first get hepatitis C, the infection is said to be acute. Most people with acute hepatitis C do not have symptoms so they are not recognized as being infected. However, some have low-grade fever, fatigue or other symptoms that lead to an early diagnosis. Others who become infected and have a known exposure to an infected source, such as a needlestick injury, are monitored closely.
Treatment decisions should be made on a case-by-case basis. Response to treatment is higher in acute hepatitis infection than chronic infection. However, many experts prefer to hold off treatment for 8-12 weeks to see whether the patient naturally eliminates the virus without treatment. Approaches to treatment are evolving. Patients with acute hepatitis C infection should discuss treatment options with a health care professional who is experienced in treating the disease. There is no established treatment regimen at this time.
How effective is hepatitis C treatment? Is hepatitis C curable?
If the hepatitis C RNA remains undetectable at the end of the treatment and follow-up period, this is called a sustained virologic response (SVR) and is considered a cure. Over 90% of people treated with DAAs are cured. These people have significantly reduced liver inflammation, and liver scarring may even be reversed.
About 5% of people who are treated for HCV infection are not cured by some of the older regimens. These people may still have options for cure with the newer regimens.
Who should not receive treatment with antiviral therapy?
Few people with hepatitis C are at risk for problems if they are treated, however there are some factors that affect treatment regimens, such as concurrent HIV medications and kidney dysfunction. Some drugs are not safe for people with cirrhosis. Individuals who are unable to comply with the treatment schedule for psychological reasons or ongoing drug or alcohol abuse may not be good candidates for treatment because the drugs are very costly and require adherence to the pill regimen and regular follow-up visits. There are some important drug interactions with some of the medications that should be considered by the health care professional.
People with past hepatitis B or who have chronic active hepatitis B should not be treated for HCV without treating for HBV as well. As highly effective treatment for HCV has emerged, reports of serious hepatitis B have come to light. Similar to HCV, hepatitis B usually does not clear from the liver after acute infection, even though it is far less likely to cause chronic active hepatitis than hepatitis C infection. It remains dormant in most people, but it can reactivate with changes in the immune system. It is not clear why eliminating the HCV can allow the HBV infection to flare up. Hepatitis B screening is an important part of the hepatitis C evaluation. Those who have laboratory evidence of active or past infection with HBV should be monitored while receiving HCV treatment.
What are the side effects of treatments for hepatitis C infection?
Side effects of interferon or pegylated interferon
- The most common side effects of interferon or pegylated interferon include fever, flu-like symptoms, and depression. Patients must be monitored closely for depression. Risk of suicide is a reason to avoid interferons.
- Interferons also reduce white blood cell and/or red blood cell counts (leucopenia and anemia, respectively). This may cause increased susceptibility to infection. Interferons also increase the risk of certain cancers. Death rarely occurs as a result of therapy, but may occur from progression of liver failure in patients with advanced cirrhosis.
Side effects of ribavirin
- Ribavirin most commonly causes anemia due to destruction of red blood cells (hemolysis). This can be severe enough that people with heart disease may suffer a heart attack from insufficient blood flow, so people with heart disease should not receive this drug. Anemia improves with a reduction in the dose of ribavirin. Injected growth factor (erythropoietin) that stimulates the production of red blood cells often is used to improve the anemia associated with ribavirin. Ribavirin also accumulates in the testicles and ovaries and causes birth defects in animals. Although no birth defects have been reported in humans, both men and women should use contraceptive measures to avoid pregnancy during and for at least six months after ribavirin treatment.
Side effects of DAAs
Compared to interferons and ribavirin drugs, the side effects of DAAs are far fewer and more tolerable. These side effects usually do not require discontinuation of therapy and are self-limiting after completion of therapy.
- The most common and significant side effects of boceprevir (Victrelis), sofosbuvir (Sovaldi), and ledipasvir/sofosbuvir (Harvoni) include
- The most common side effects of simeprevir (Olysio) include
- Simeprevir has significant drug interactions with other medications. Certain medications can affect levels of simeprevir in the body and make simeprevir less effective or more toxic.
- The combination of ombitasvir, paritaprevir, and ritonavir tablets with dasabuvir tablets (Viekira Pak) is very well tolerated, and the most commonly reported side effects are
- trouble sleeping, and
- The combination of elbasvir and grazoprevir (Zepatier) is well-tolerated. Most common side effects include
- The combination of glecaprevir and pibrentasvir (Mavryet) is well tolerated. Most common side effects include
- Use of milk thistle should be discussed with the treating doctor, because it interacts with several DAAs.
Patients with hepatitis B co-infection should be monitored for symptoms of reactivation of hepatitis, which are the same as the symptoms of acute hepatitis. The treating doctor may perform blood screening for this as well.
Is liver transplantation an option for a person with hepatitis C?
Hepatitis C is the leading reason for 40% to 45% of liver transplants in the U.S. Hepatitis C usually recurs after transplantation and infects the new liver. Approximately 25% of these patients with recurrent hepatitis will develop cirrhosis within five years of transplantation. Despite this, the five-year survival rate for patients with hepatitis C is similar to that of patients who are transplanted for other types of liver disease.
Most transplant centers delay therapy until recurrent hepatitis C in the transplanted liver is confirmed. Oral, highly effective, direct-acting antivirals have shown encouraging results in patients who have undergone liver transplantation for hepatitis C infection and have recurrent hepatitis C. The choice of therapy needs to be individualized and is rapidly evolving.
How is monitoring done after treatment for hepatitis C?
Once patients successfully complete treatment, the viral load after treatment determines if there is an SVR or cure. If cure is achieved (undetectable viral load after treatment), no further additional testing is recommended unless the patient has cirrhosis. Those who are not cured will need continued monitoring for progression of liver disease and its complications.
While cure eliminates worsening of fibrosis by hepatitis C, complications may still affect those with cirrhosis. These individuals still need regular screening for liver cancer as well as monitoring for esophageal varices that may bleed.
Because hepatitis B co-infection may reactivate or worsen even after treatment for HCV, monitoring for hepatitis symptoms may be needed after the end of therapy.
What home remedies are available for hepatitis C?
At this time there are no effective home or over-the-counter treatments for hepatitis C.
What are the complications of undiagnosed hepatitis C?
- Hepatitis C is known to be associated with two skin conditions, lichen planus and porphyria cutanea tarda.
- Diabetes, heart disease, and arterial blockage are more common among patients with chronic hepatitis C infection than in the general population. It may be that liver damage and chronic inflammation caused by hepatitis C may affect the levels of blood fats (lipids) and blood sugar.
- Low platelet counts may occur as a result of the destruction of platelets by antibodies.
- Hepatitis C also is associated with B-cell lymphoma, a cancer of the blood.
End-stage liver disease
Over several years or decades, chronic inflammation may cause death of liver cells and cirrhosis (scaring, fibrosis). When the liver becomes cirrhotic, it becomes stiff, and it cannot perform its normal functions of clearing waste products from the blood. As fibrosis worsens, symptoms of liver failure begin to appear. This is called "decompensated cirrhosis" or "end-stage liver disease." Symptoms of end-stage liver disease include:
- Small spider veins begin to appear on the skin as the stiff, scarred liver obstructs the forward flow of blood.
- Body fluids back up and accumulate in the abdomen (ascites).
- The spleen enlarges because of back-pressure.
- Yellowing of eyes and skin (jaundice) occurs because the liver is not clearing bilirubin (a yellow pigment from breakdown of red blood cells) from the blood.
- A serious complication is severe bleeding from varicose veins that develop in the swallowing tube or esophagus (esophageal varices).
Cirrhosis-associated immune dysfunction syndrome
The liver and spleen have an important function of clearing bacteria from the blood stream. Cirrhosis affects many areas of immune function, including attraction of white blood cells to bacteria, reduced killing of bacteria, reduced production of proteins involved in immune defenses, and decreased life span of white blood cells involved in immune defenses. This may be referred to as having cirrhosis-associated immune dysfunction syndrome or CAIDS.
- Fluid in the abdomen often becomes infected (spontaneous bacterial peritonitis), and preventive antibiotics may be given for this type of infection.
- Bacteria also may enter the bloodstream easily (bacterial translocation), referred to as sepsis, especially when esophageal varices bleed.
- Individuals may succumb to many types of bacterial infections more easily than normal, but some are specific to liver disease. People with chronic hepatitis C and fibrosis should avoid being exposed to these bacteria.
- Vibrio species of bacteria are a serious risk from eating raw oysters or exposure to sea water. Vibrio vulnificus may cause sepsis, cellulitis, and necrotizing fasciitis, a “flesh-eating” infection.
- Listeria species may cause sepsis and meningitis, and are a risk from unpasteurized dairy products and salty processed meats.
- Yersinia species may be picked up from raw or undercooked pork, especially intestines (chitterlings).
Can hepatitis C be prevented?
Transmission of hepatitis C can be prevented in several ways.
Prevention programs aim at needle sharing among drug addicts. Needle exchange programs and education have reduced transmission of hepatitis C infection. However, IV drug users are a difficult to reach population, and rates of hepatitis C remain high among them.
Among health care workers, safe needle-usage techniques have been developed to reduce accidental needlesticks. Newer needle systems prevent manual recapping of needles after use of syringes, which is a frequent cause of accidental needlesticks
There is no clear way to prevent hepatitis C transmission from mother to fetus at this time.
People with multiple sexual partners should use barrier precautions such as condoms to limit the risk of hepatitis C and other sexually transmitted diseases, including HIV.
If one partner is infected, monogamous couples may want to consider the low risk of transmission of hepatitis C infection when deciding whether to use condoms during sex. Some couples may decide to use them and some may not.
Screening of the blood supply has almost eliminated the risk of transmission of hepatitis C infection through transfusion.
People with hepatitis C infection should not share razors or toothbrushes with others because of the possibility that these items may be contaminated with blood.
People who want to get a body piercing(s) or tattoo(s) are encouraged to do so only at licensed piercing and tattoo shops (facilities), and verify that the body piercing or tattoo shop uses infection-control practices.
It is critical that physicians and clinics follow manufacturers and regulatory agency directions for sterilizing/cleaning instruments and that disposable instruments be discarded properly. There is no need to use special isolation procedures when dealing with hepatitis C infected patients.
What is the prognosis of hepatitis C?
In general, among patients with untreated hepatitis C:
- 75% to 85% become chronically infected,
- 60% to 70% develop liver disease,
- 5% to 20% develop cirrhosis, and
- 1% to 5% will die from complications of cirrhosis or liver cancer.
Drinking alcohol and acquiring other hepatitis viruses are risk factors for worse liver disease. People with chronic hepatitis C should avoid drinking alcohol and should be screened for antibodies to hepatitis A and B. If they do not have antibodies, they should be vaccinated against these other hepatitis viruses.
People with hepatitis C should be educated about preventing HIV infection. Infection with both HIV and hepatitis C speeds up and worsens liver damage caused by hepatitis C. Hepatitis C also can affect the HIV infection and how it is treated. About 25% of people with HIV infection are co-infected (also infected) with hepatitis C, and up to 90% of IV drug users with HIV are co-infected with hepatitis C. Screening for hepatitis viruses is important in all people infected with HIV, just as screening for HIV is important in people who have hepatitis C.
Liver cancer (hepatocellular carcinoma, or hepatoma) is associated with cirrhosis from chronic hepatitis C. Some experts recommend screening patients with hepatitis C infection and cirrhosis for liver cancer periodically.
What is the current research and what is in the future for hepatitis C?
As our knowledge of hepatitis C increases, more and more patients are being diagnosed with chronic infection. Current research is very active and includes diagnosis, natural history, treatment, and vaccine development. Thus the field is constantly changing, with new guidelines added frequently.
Health Solutions From Our Sponsors
"HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C." American Association for the Study of Liver Diseases. Updated: May 24, 2018.
CDC. "Hepatitis C FAQs for Health Professional." Centers for Disease Control and Prevention. Updated: July 2, 2019.
CDC. "Epidemiology and Prevention of HIV and and Viral Hepatitis Co-infections." Updated: Jan 23, 2019.
Hong, Julie et al. "Reducing mother-to-child transmission of HCV: Is it attainable with a multidisciplinary approach?" Journal of Hepatology 71.1: 229–230.
Modin, Line et al. "Epidemiology and natural history of hepatitis C virus infection among children and young people." Journal of Hepatology 70.3: 371–378.
World Health Organization. "Hepatitis C." Updated: July 9, 2019.
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Alpha-Fetoprotein Blood TestAlpha-fetoprotein (AFP) blood test is the most widely used biochemical blood tests. High levels of AFP in the blood are seen in three situations; HCC (hepatocellular carcinoma), cancer of the testes or ovaries, and liver cancer.
Antinuclear Antibody TestAntinuclear antibodies (ANAs), unusual antibodies that can bind to certain structures within the nucleus of the cells, are found in patients whose immune system may be predisposed to cause inflammation against their own body tissues. ANAs are indicative of the potential presence of an autoimmune illness.
Bilirubin TestBilirubin is a waste product of the normal breakdown of red blood cells in the liver. Normal bilirubin levels vary from lab to lab, and range from around 0.2 to 1.2 mg/dL. High levels of bilirubin can be diagnosed with a bilirubin blood test. Causes of elevated levels of bilirubin in the blood can be caused by infections, viral hepatitis, anemia, genetic diseases, and liver problems. Symptoms of elevated bilirubin levels depend on the cause; however, jaundice is a common sign. Treatment for elevated bilirubin levels depend on the cause.
Blood TransfusionDuring a blood transfusion, blood or blood products are transferred from one person to another. There are two types of transfusions, autologous (your own blood), and donor blood (someone else's blood). There are four blood types: A; B; C; and O.
In addition, each person's blood is either Rh-positive or Rh-negative. It is important to know what to expect before, during, and after a blood transfusion, and the risks, side effecs, or complications of blood transfusions.
CT Scan (Computerized Tomography)A CT scan is an X-ray procedure that combines many X-ray images with the aid of a computer to generate cross-sectional and three-dimensional images of internal organs and structures of the body. A CT scan is a low-risk procedure. Contrast material may be injected into a vein or the spinal fluid to enhance the scan.
Cirrhosis (Liver)Cirrhosis of the liver refers to a disease in which normal liver cells are replaced by scar tissue caused by alcohol and viral hepatitis B and C. This disease leads to abnormalities in the liver's ability to handle toxins and blood flow, causing internal bleeding, kidney failure, mental confusion, coma, body fluid accumulation, and frequent infections.
Symptoms include yellowing of the skin (jaundice), itching, and fatigue.
The prognosis is good for some people with cirrhosis of the liver, and the survival can be up to 12 years; however the life expectancy is about 6 months to 2 years for people with severe cirrhosis with major complications.
Drug Abuse and AddictionDrug abuse and addiction is a chronic disease that causes drug-seeking behavior and drug use despite negative consequences to the user and those around him. Though the initial decision to use drugs is voluntary, changes in the brain caused by repeated drug abuse can affect a person's self-control and ability to make the right decisions and increase the urge to take drugs. Drug abuse and addiction are preventable.
Hepatitis C QuizHow many Americans have hepatitis C? Take this quiz to learn the facts about this chronic disease.
Hepatitis C, Hep B, Hep A: Symptoms, Causes, TreatmentHepatitis C, B, and A are viruses that cause liver inflammation. Hepatitis B vaccines and hepatitis A vaccines are available. Hepatitis symptoms may not appear for weeks to months after infection. Hepatitis A transmission occurs most often via contaminated food. Hepatitis B and hepatitis C transmission require contact with infected bodily fluids or blood.
Liver Damage CausesAlcohol and acetaminophen are well-known liver dangers, but what else can be harmful? WebMD says some of them may surprise you.
What Is Viral Hepatitis? How You Catch Hepatitis A, B, and CHepatitis C virus and hepatitis B can make an infected person very sick and they are risk factors for liver cancer, liver disease, liver failure, and liver damage. Prior to 1992, blood transfusion was a risk for contracting hepatitis C infection. Hepatitis B and C are blood-borne infections, while hepatitis A is easier to catch, but less serious.
Liver Blood TestsAn initial step in detecting liver damage is a simple blood test to determine the presence of certain liver enzymes in the blood. Under normal circumstances, these enzymes reside within the cells of the liver. But when the liver is injured, these enzymes are spilled into the blood stream, and can lead to diseases like fatty liver, type 2 diabetes, obesity, and hepatitis. Several medications also can increase liver enzyme test results.
Liver DiseaseLiver disease can be cause by a variety of things including infection (hepatitis), diseases, for example, gallstones, high cholesterol or triglycerides, blood flow obstruction to the liver, and toxins (medications and chemicals). Symptoms of liver disease depends upon the cause and may include nausea, vomiting, upper right abdominal pain, and jaundice. Treatment depends upon the cause of the liver disease.
Liver Disease QuizWhat is liver disease? Take the Liver Disease Quiz and test your knowledge about this organ and its function.
Liver PictureFront View of the Liver. The liver is a large, meaty organ that sits on the right side of the belly. See a picture of the Liver and learn more about the health topic.
STD QuizThere are more sexually transmitted diseases than just the ones you've heard of. Find out what you've been missing with the STD Quiz.
STDs in MenSymptoms of sexually transmitted diseases (STDs) in men include painful urination, bumps or sores on the penis, and penile discharge and itching. Learn about the most common STDs in men.
What's a Virus?Is a virus alive? Learn the definition of a virus. Viral infections like COVID-19 can occur in your eyes, mouth, skin, or anywhere else. Should you use antibiotics to treat the flu? Is this STD a bacterium or a virus? Get the answers to the most common questions about viral infections.