- What is hepatitis b vaccine-injection, and how does it work (mechanism of action)?
- What are the uses for hepatitis b vaccine-injection?
- What are the side effects of hepatitis b vaccine-injection?
- What is the dosage for hepatitis b vaccine-injection?
- Which drugs or supplements interact with hepatitis b vaccine-injection?
- Is hepatitis b vaccine-injection safe to take if I'm pregnant or breastfeeding?
- What else should I know about hepatitis b vaccine-injection?
What is hepatitis b vaccine-injection, and how does it work (mechanism of action)?
Hepatitis B is easily spread through contact with blood or other fluids of an infected person. People may also become infected from touching or coming into contact with a contaminated object. The hepatitis B virus can live on surfaces for up to 7 days. Some ways that people may become infected include:
- Transmission during birth from an infected mother to her newborn
- Contact with blood or other body fluids though breaks in the skin such as bites, cuts, or sores
- Contact with objects that have blood or body fluids on them such as razors or toothbrushes that may themselves come into contact with other person's blood
- Having unprotected sex with an infected person
- Sharing needles used to inject illicit drugs
- Getting stuck with a previously used needle that is contaminated
Hepatitis B can cause an acute (short term) illness, with symptoms that include:
- Loss of appetite
- Jaundice (yellowing of the skin or eyes)
- Pain in muscles, joints, and stomach
- Additionally, some patients may develop a long term (chronic) infection which can lead to:
- Liver damage
- Liver cancer
Getting vaccinated against the hepatitis B virus is the best way to prevent these problems. Hepatitis B vaccines are made from noninfectious parts of HBV using recombinant DNA technology. The vaccines are sterile preparations for intramuscular injection and contain purified inactive proteins from the surface of HBV. The proteins can activate the immune system but cannot give rise to a replicating virus. Viral proteins used in HBV vaccines are manufactured in yeast cells (S. cerevisiae) using recombinant technology. Hepatitis B vaccines work by stimulating the immune system to attack the viral proteins. When a hepatitis B vaccine is administered, the body's immune system recognizes the viral proteins in the vaccine as foreign, and develops antibodies against them, thus providing immunity from future infections. In the event of HBV exposure following vaccination, the body will already be primed to fight the infection.
The FDA approved the first HBV vaccine in 1983.
What brand names are available for hepatitis b vaccine-injection?
Recombivax HB, Engerix-B
Is hepatitis b vaccine-injection available as a generic drug?
Do I need a prescription for hepatitis b vaccine-injection?
What are the uses for hepatitis b vaccine-injection?
Hepatitis B vaccine is used to prevent hepatitis B, a serious infection that affects the liver.
Most children are given their first shot at birth, followed by a 2nd shot at 1-2 months of age, and a 3rd shot at 6-18 months of age. Also, anyone who is 18 years of age or younger and hasn't received the vaccine should be vaccinated.
Additionally, all unvaccinated adults at risk for hepatitis B infection should be vaccinated. This includes:
- Partners or people infected with hepatitis B
- Men who have sex with men
- People who inject street drugs
- People with more than one sex partner
- People with chronic liver or kidney disease
- People under the age of 60 who have type 1 or 2 diabetes
- People with jobs that expose them to human blood or other body fluids
- People who live with a family member infected with hepatitis B
- Kidney dialysis patients
- People who travel to countries where hepatitis B is common
- People with HIV infection
- People who live or work in institution for the developmentally disabled
- Anyone else who wishes to be protected from the hepatitis B infection
What are the side effects of hepatitis b vaccine-injection?
Common side effects of HBV vaccines include:
Other reported side effects include:
Latest Digestion News
Daily Health News
What is the dosage for hepatitis b vaccine-injection?
- Dosing for children and adolescents is 3 doses of 0.5 mL given on 0, 1, and 6 month schedule.
- The dose for adults is 3 doses of 1 ml given on 0, 1, and 6 month schedule.
Which drugs or supplements interact with hepatitis b vaccine-injection?
Patients with a weak immune system may not fully benefit from the hepatitis B vaccine.
- Some medications may decrease the effectiveness of the hepatitis B vaccine. Examples include fingolimod (Gilenya), belimumab (Benlysta), anakinra (Kineret), adalimumab (Humira), infliximab (Remicade), antineoplastic agents (anti-cancer medications), and other immunosuppressives.
- Cancer patient's receiving treatment with anti-cancer medications and those taking immunosuppressant medications should ask their doctor or pharmacist if the hepatitis B vaccine is right for them.
Is hepatitis b vaccine-injection safe to take if I'm pregnant or breastfeeding?
- There are no adequate or well-controlled trials of hepatitis B vaccine use in pregnant women. Therefore, hepatitis B vaccine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
- It is not known if the hepatitis B vaccine is excreted into human milk after administration to the mother. The manufacturer recommends caution when given to nursing mothers.
What else should I know about hepatitis b vaccine-injection?
What preparations of hepatitis b vaccine-injection are available?
- Suspension for injection in single does vials and syringes: Recombivax 0.5 ml (5 mcg), 1 ml (10 mcg); Engerix-B 0.5 ml (10 mcg), 1 ml (20 mcg).
How should I keep hepatitis b vaccine-injection stored?
Hepatitis B vaccine should be stored in the refrigerator, between 2 C to 8 C (36 F to 46 F).
Subscribe to MedicineNet's General Health Newsletter
Engerix-B and Recombivax HB are vaccinations against the hepatitis B virus.
Multimedia: Slideshows, Images & Quizzes
Hepatitis C, Hep B, Hep A: Symptoms, Causes, Treatment
Hepatitis C, B, and A are viruses that cause liver inflammation. Hepatitis B vaccines and hepatitis A vaccines are available....
Hepatitis: How Do You Get Hepatitis A, B, and C?
Hepatitis C virus and hepatitis B can make an infected person very sick and they are risk factors for liver cancer, liver...
Picture of Hepatitis B
Inflammation of the liver due to the hepatitis B virus (HBV), once thought to be passed only through blood products. See a...
Related Disease Conditions
Liver disease can be cause by a variety of things including infection (hepatitis), diseases, for example, gallstones, high cholesterol or triglycerides, blood flow obstruction to the liver, and toxins (medications and chemicals). Symptoms of liver disease depends upon the cause and may include nausea, vomiting, upper right abdominal pain, and jaundice. Treatment depends upon the cause of the liver disease.
Liver (Anatomy and Function)
The liver is the largest gland and organ in the body. There are a variety of liver diseases caused by liver inflammation, scarring of the liver, infection of the liver, gallstones, cancer, toxins, genetic diseases, and blood flow problems. Symptoms of liver disease generally do not occur until the liver disease is advanced. Some symptoms of liver disease include jaundice, nausea and vomiting, easy bruising, bleeding excessively, fatigue, weakness, weight loss, shortness of breath, leg swelling, impotence, and confusion. Treatment of diseases of the liver depends on the cause.
Hepatitis (Viral Hepatitis A, B, C, D, E, G)
Hepatitis is most often viral, due to infection with one of the hepatitis viruses (A, B, C, D, E, F (not confirmed), and G) or another virus (such as those that cause infectious mononucleosis, cytomegalovirus disease). The main nonviral causes of hepatitis are alcohol and drugs. Many patients infected with hepatitis A, B, and C have few or no symptoms of illness. For those who do develop symptoms of viral hepatitis, the most common are flu-like symptoms including: loss of appetite, nausea, vomiting, fever, weakness, tiredness, and aching in the abdomen. Treatment of viral hepatitis is dependent on the type of hepatitis.
Bile Duct Cancer (Cholangiocarcinoma)
Bile duct cancer (cholangiocarcinoma) is a rare type of cancer that arises from cells that line the drainage system from the liver and gallbladder to the intestine. Symptoms of bile duct cancer include jaundice, itching, weight loss, and abdominal pain. Physical examination, specialized blood tests, and imaging tests may be used to diagnose bile duct cancer. Treatment for bile duct cancer may include chemotherapy, radiation therapy, and photodynamic therapy. Bile duct cancer typically has a poor prognosis. Preventing liver damage may decrease the risk of developing bile duct cancer.
Leukemia is a type of cancer of the blood cells in which the growth and development of the blood cells are abnormal. Strictly speaking, leukemia should refer only to cancer of the white blood cells (the leukocytes) but in practice it can apply to malignancy of any cellular element in the blood or bone marrow, as in red cell leukemia (erythroleukemia).
Burns (First Aid)
Burn types are based on their severity: first-degree burns, second-degree burns, and third-degree burns. First-degree burns are similar to a painful sunburn. The damage is more severe with second-degree burns, leading to blistering and more intense pain. The skin turns white and loses sensation with third-degree burns. Burn treatment depends upon the burn location, total burn area, and intensity of the burn.
Hepatitis B (HBV, Hep B)
The hepatitis B virus (HBV, hep B) is a unique, coated DNA virus belonging to the Hepadnaviridae family of viruses. The course of the virus is determined primarily by the age at which the infection is acquired and the interaction between the virus and the body's immune system. Successful treatment is associated with a reduction in liver injury and fibrosis (scarring), a decreased likelihood of developing cirrhosis and its complications, including liver cancer, and a prolonged survival.
Hepatitis A and B Vaccinations
Hepatitis A and hepatitis B are the two most commnon viruses that infect the liver. Hepatitis A and Hepatitis B can be prevented and treated with immunizations (vaccinations) such as Havrix, Vaqta, Twinrix, Comvax, Pediarix, and hepatitis b immune globulin (HBIG).
Is Hepatitis Contagious?
Hepatitis means "inflammation of the liver," and there are several different types of such as A, B, C, D, and E. Some types of hepatitis are contagious and some types are not. Hepatitis symptoms vary upon the type of disease; however, the following symptoms may develop in someone with hepatitis: fatigue, nausea and vomiting, abdominal pain and discomfort, jaundice (yellowing of the skin and whites of the eyes), and loss of appetite. Treatment for hepatitis depends upon the cause. Some types of hepatitis have a vaccine to prevent spread of disease such as hepatitis A and B.
Is Hepatitis B Contagious?
Hepatitis B is a type of liver infection. Hepatitis B is spread through person-to-person contact or through personal items like razors, toothbrushes, etc. Symptoms of hepatitis B include fever, yellowish skin (jaundice), dark urine, fatigue, nausea, and vomiting. There is no drug to cure hepatitis B; however, there is a hepatitis B vaccine available.
First Aid and CPR
First aid is providing medical assistance to someone a sick or injured person. The type of first aid depends on their condition. Preparedness is key to first aid, like having basic medical emergency kits in your home, car, boat, or RV. Many minor injuries may require first aid, including cuts, puncture wounds, sprains, strains, and nosebleeds. Examples of more critical first aid emergencies include heart attacks, strokes, seizures, and heatstroke.
Liver Cancer (Hepatocellular Cancer) Prevention
Avoiding certain risk factors (such as hepatitis B and C, cirrhosis, and aflatoxin) can lower one's risk of developing liver cancer. Getting the hepatitis B vaccine is a protective factor against liver cancer.
Treatment & Diagnosis
Medications & Supplements
Prevention & Wellness
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
FDA Prescribing Information