- What is heparin-injection, and how does it work (mechanism of action)?
- What brand names are available for heparin-injection?
- Is heparin-injection available as a generic drug?
- Do I need a prescription for heparin-injection?
- What are the side effects of heparin-injection?
- What is the dosage for heparin-injection?
- Which drugs or supplements interact with heparin-injection?
- Is heparin-injection safe to take if I'm pregnant or breastfeeding?
- What else should I know about heparin-injection?
What is heparin-injection, and how does it work (mechanism of action)?
Heparin is a widely used injectable anticoagulant (stops the formation of blood clots). The blood coagulation system is composed of various steps and heparin acts at multiple sites in this process. Heparin prevents blood clots by blocking the action of two of the 12 clot-promoting proteins in blood (factors X and II) whose action is necessary for blood to clot. The FDA approved heparin in 1939.
What brand names are available for heparin-injection?
Hemochron, Hep-Lock, Hep-Lock U/P, Heparin in 5% Dextrose, Heparin Lock Flush, HepFlush-10
What are the side effects of heparin-injection?
The most common side effects are hemorrhage (bleeding), thrombocytopenia (decrease platelet count), heparin induced thrombocytopenia (HIT), heparin induced thrombocytopenia and thrombosis (HITT), injection site discomfort/irritation, allergy or hypersensitivity type reactions, and increase in liver enzymes.
What is the dosage for heparin-injection?
Doses vary considerably based on use and desired level of anticoagulation. Consult published guidelines for various uses (myocardial infarction, DVT, pulmonary embolism, for example) and the manufacturer's recommendations as dosage varies; some patients may require dosage adjustments if they have certain conditions (for example, renal or liver problems).
Which drugs or supplements interact with heparin-injection?
Medications that increase the risk of bleeding will add to the effects of heparin and further increase the risk of bleeding that is associated with heparin. Such medications include aspirin, clopidogrel (Plavix), warfarin (Coumadin), other anticoagulants, and nonsteroidal anti-inflammatory drugs such as ibuprofen (Motrin; Advil), naproxen (Naprosyn), diclofenac (Voltaren), and others.
Is heparin-injection safe to take if I'm pregnant or breastfeeding?
Heparin has not been adequately evaluated in pregnant women. Heparin should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Preservative-free heparin is recommended when heparin is needed during pregnancy.
It is not known whether heparin is excreted into breast milk. However, due to its large molecular weight, it is thought that heparin is not likely to be excreted into breast milk. Preservative-free heparin is recommended when heparin is needed during breastfeeding.
What else should I know about heparin-injection?
What preparations of heparin-injection are available?
Injectable Solution: 1000, 2500, 5000, 10000, 20000 units/ml.
Heparin Lock Flush: 10, 100 units/ml.
Premixed Solution: 20000 units/500 ml, 25000 units/250 ml, 25000 units/500 ml.
How should I keep heparin-injection stored?
Heparin sodium injections should be stored at 20 C to 25 C (68 F to 77 F).
REFERENCE: FDA Prescribing Information
Heparin sodium (Hemochron, Hep-Lock, Hep-Lock U/P, Heparin in 5% Dextrose, Heparin Lock Flush, HepFlush-10) is a drug used to stop the formation of blood clots. Side effects, drug interactions, dosage, storage, and safety information should be reviewed prior to taking this prescription drug.
Multimedia: Slideshows, Images & Quizzes
Related Disease Conditions
Deep Vein Thrombosis (DVT, Blood Clot in the Legs)
Deep vein thrombosis (DVT) is a blood clot in the deep veins, and can be caused by broken bones, trauma to a limb, immobility,...
Atrial flutter is a problem with the atria of the heart. In atrial flutter the atria of the heart rapidly and repeatedly beat...
Heart Attack Treatment
A heart attack involves damage or death of part of the heart muscle due to a blood clot. The aim of heart attack treatment is to...
Treatment & Diagnosis
Medications & Supplements
Daily Health News
Subscribe to MedicineNet's General Health Newsletter
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Top heparin-injection Related ArticlesComplete List
Anticoagulants drug class of blood thinners
Anticoagulants are drugs that inhibits blood clots from forming in the veins and arteries of the body. There are a variety of uses for these drugs, which include the treatment or prevention of:
- Deep vein thrombosis (DVT)
- Blood clot in the lung (pulmonary embolism)
- Blood clots during AFib
- Heart attack
Common side effects of anticoagulants include:
- Flatulence (intestinal gas)
- Local injection site reactions
- Bruises caused by trauma (ecchymosis)
Drug and supplement interactions and pregnancy and breastfeeding safety should be reviewed prior to using anticoagulant drugs.
Atrial flutter is a problem with the atria of the heart. In atrial flutter the atria of the heart rapidly and repeatedly beat due to an anomaly in the electrical system of the heart. It is a type of arrhythmia and can be dangerous because complications can develop easily. Signs and symptoms of atrial flutter include:
- Near fainting
- Mild shortness of breath
While the exact cause of this condition is not clearly understood, it's most likely related to your health, what medical conditions you certainly have, poor diet, lack of exercise, and drinking too much alcohol.
This condition is diagnosed by physical examination, medical history, and a sawtooth ECG wave pattern.
Deep Vein Thrombosis
Deep vein thrombosis (DVT) is a blood clot in the deep veins, and can be caused by broken bones, trauma to a limb, immobility, medications, smoking, cancer, genetic predisposition, and cancer. Symptoms of a deep vein thrombosis in a leg are
- warmth, and
Treatment for DVT include medications and surgery.
DVT SlideshowDeep vein thrombosis (DVT) is a dangerous and sometimes fatal blood clot that occurs deep within the lower leg or thigh. Understand the symptoms, treatment and prevention of deep vein thrombosis (DVT).
Heart Attack TreatmentA heart attack involves damage or death of part of the heart muscle due to a blood clot. The aim of heart attack treatment is to prevent or stop this damage to the heart muscle. Heart attack treatments included medications, procedures, and surgeries to protect the heart muscle against injury.