August Flower, Grindelia, Grindelia camporum, Grindelia Herb, Grindelia robusta, Grindelia squarrosa, Grindeliae Herba, Grindélie, Grindélie Robuste, Grindélie Squarreuse, Gum Weed, Gumweed Herb, Herbe à Gomme, Rosin Weed, Tar Weed.
Insufficient Evidence to Rate Effectiveness for...
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
Gumweed is POSSIBLY SAFE for most people when taken by mouth. But it can cause some side effects such as stomach upset and diarrhea.
Allergy to ragweed, daisies, and related plants: Gumweed may cause an allergic reaction in people who are sensitive to the Asteraceae/Compositae plant family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many others. If you have allergies, be sure to check with your healthcare provider before taking gumweed.
The appropriate dose of gumweed depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for gumweed. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Afifi, U. and Aburjai, T. Antiplatelet activity of Varthemia iphionoides. Fitoterapia 2004;75:629-633.
Anonymous. Rhus toxicodendron. Lancet 1908;172:887.
Anonymous. The National Formulary 10
Anonymous. The Pharmacopoeia of the United States of America. 1905.
Anonymous. The therapeutic effects of Gindelia robusta. Lancet 1890;135:565.
Bohlman, F., Ahmed, M., Borthakur, N., Wallmeyer, M., Jakupovic, J., King, R. M., and Robinson, H. Diterpenes related to grindelic acid and further constituents from Grindelia species. Phytochem 1982;21:167-172.
Calderone, V., Chericoni, S., Martinelli, C., Testai, L., Nardi, A., Morelli, I., Breschi, M. C., and Martinotti, E. Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels. Naunyn Schmiedebergs Arch Pharmacol 2004;370:290-298.
Canavan, D. and Yarnell, E. Successful treatment of poison oak dermatitis treated with Grindelia spp. (Gumweed). J Altern Complement Med 2005;11(4):709-710. View abstract.
Hare, H. A. The National Standard Dispensatory. 1905.
Heim, K. E., Tagliaferro, A. R., and Bobilya, D. J. Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. J Nutr Biochem 2002;13(10):572-584. View abstract.
Hoffmann, J. J., Jolad, S. D., Timmermann, B. N., Bates, R. B., and Camou, F. A. Two grindelane diterpenoids from Grindelia camporum. Phytochem 1988;27:493-496.
Juzwiak, S., Wojcicki, J., Mokrzycki, K., Marchlewicz, M., Bialecka, M., Wenda-Rozewicka, L., Gawronska-Szklarz, B., and Drozdzik, M. Effect of quercetin on experimental hyperlipidemia and atherosclerosis in rabbits. Pharmacol Rep 2005;57(5):604-609. View abstract.
Knight, A. P. and Walter, R. G. Plants affecting the musculoskeletal system. 2004.
Kreutzer, S., Schimmer, O., and Waibel, R. [Triterpenoid sapogenins in the genus Grindelia]. Planta Med 1990;56(4):392-394. View abstract.
Moxan, A. L. and Rhian, M. Selenium poisoning. Physiol Rev 1943;203:305-337.
Parker, D. R. and Page, A. L. Plant uptake of selenium. 2005.
Spallholz, J. E. and Hoffman, D. J. Selenium toxicity: cause and effects in aquatic birds. Aquat.Toxicol 2002;57(1-2):27-37. View abstract.
Timmermann, B. N., Hoffmann, J. J., Jolad, S. D., and Schram, K. H. Grindelane diterpenoids from Grindelia squarrosa and G camporum. Phytochem 1985;24:1031-1034.
Timmermann, B. N., Hoffmann, J. J., Jolad, S. D., Bates, R. B., and Siahann, T. J. Diterpenoids and flavonoids from Grindelia discoidea. Phytochem 1986;25:723-727.
Timmermann, B. N., Luzbetak, B. J., Hoffmann, J. J., Jolad, S. D., Schram, K. H., Bates, R. B., and Klenck, R. E. Grindelane diterpenoids from Grindelia camporum and Chrysothamnus paniculatus. Phytochem 1983;22:523-525.
Timmermann, B. N., McLaughlin, S. P., and Hoffmann, J. J. Quantitative variation of grindelane diterpene acids in 20 species of North American Grindelia. Biochem Systemat Ecol 1987;15:401-410.
Trease, G. E. and Evans, W. C. Pharmacognosy, 11
Zhou, L., Fuentes, E. R., Hoffmann, J. J., and Timmermann, B. N. Diterpenoids from Grindelia tarapacana. Phytochem 1995;40:1201-1207.
Beck BM, Strike SS. Ethnobotany of the California Indians: Aboriginal uses of California's indigenous plants. Champaign, IL: Koeltz Scientific Books; 1994.