Last Editorial Review: 6/11/2021
Other Name(s):

Caoutchouc Mexicain, Mexican Rubber, Parthenium argentatum.


Guayule is a shrub. The latex is used as a rubber alternative.

How does it work?

There isn't enough information to know how guayule might work as a medicine.


Next to red peppers, you can get the most vitamin C from ________________. See Answer

Uses & Effectiveness

Insufficient Evidence to Rate Effectiveness for...

  • Hypoallergenic rubber alternative.
  • Other conditions.
More evidence is needed to rate the effectiveness of guayule for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

Side Effects

It isn't known if guayule is safe or what the possible side effects might be.


Vitamin D Deficiency: How Much Vitamin D Is Enough? See Slideshow

Special Precautions & Warnings

Pregnancy and breast-feeding: Not enough is known about the use of guayule during pregnancy and breast-feeding. Stay on the safe side and avoid use.


The appropriate dose of guayule depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for guayule. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

FDA Logo

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


Cornish K, Lytle CD. Viral impermeability of hypoallergenic, low protein, guayule latex films. J Biomed Mater Res 1999;47(3):434-7. View abstract.

Foster MA, Coffelt TA. Guayule agronomics: establishment, irrigated production, and weed control. Industrial Crops Prod 2005;22:27-40.

Nakayama FS. Guayule future development. Industrial Crops Prod 2005;22:3-13.

Pan Z, Durst F, Werck-Reichhart D, et al. The major protein of guayule rubber particles is a cytochrome P450. Characterization based on cDNA cloning and spectroscopic analysis of the solubilized enzyme and its reaction products. J Biol Chem 1995;270(15):8487-94. View abstract.

Parra-Delgado H, Garcia-Pillado F, Sordo M, et al. Evaluation of the cytotoxicity, cytostaticity and genotoxicity of argentatins A and B from Parthenium argentatum (Gray). Life Sci 2005;77(22):2855-65. View abstract.

Siler DJ, Cornish K, Hamilton RG. Absence of cross-reactivity of IgE antibodies from subjects allergic to Hevea brasiliensis latex with a new source of natural rubber latex from guayule (Parthenium argentatum). J Allergy Clin Immunol 1996;98(5 Pt 1):895-902. View abstract.