Eupatoire Pourpre, Eupatoriadelphus purpureus, Eupatorium purpureum, Herbe de Joe Pye, Joe Pye, Joe-Pye Weed, Kidney Root, Purple Boneset, Queen of the Meadow, Raíz de Eupatorio, Roter Wasserhanf, Trumpet Weed.
Gravel root is an herb. The bulb, root, and parts that grow above the ground are used to make medicine.
People also use gravel root for arthritis-like pain (rheumatism) and gout, as well as for fever from malaria, dengue virus, or typhus. Gravel root is also used to reduce stomach acid, increase urine flow, cause vomiting, and cause sweating; and as a stimulant and tonic.
How does it work?
Gravel root might work for certain conditions by reducing swelling (inflammation).
Insufficient Evidence to Rate Effectiveness for...
- Urinary and kidney stones.
- Urinary tract infections.
- Arthritis-like pain.
- Other conditions.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).
There's a lot of concern about using gravel root as medicine, because it contains chemicals called hepatotoxic pyrrolizidine alkaloids (PAs), which may block blood flow in the veins and cause liver damage. Hepatotoxic PAs might also cause cancer and birth defects. Gravel root preparations that are not certified and labeled “hepatotoxic PA-free” are considered LIKELY UNSAFE.
It's also LIKELY UNSAFE to apply gravel root to broken skin. The dangerous chemicals in gravel root can be absorbed quickly through broken skin and can lead to dangerous body-wide toxicity. Steer clear of skin products that aren't certified and labeled “hepatotoxic PA-free.”
There is not enough information to know if it's safe to apply gravel root to unbroken skin. It's best to avoid use.
It is also LIKELY UNSAFE to use gravel root preparations that might contain hepatotoxic PAs if you are breast-feeding. These chemicals can pass into breast-milk and might harm the nursing infant.
It's not known whether products that are certified hepatotoxic PA-free are safe to use during pregnancy or breast-feeding. Stay in the safe side and avoid using any gravel root preparation if you are pregnant or breast-feeding.
Allergy to ragweed and related plants: Gravel root may cause an allergic reaction in people who are allergic to the Asteraceae/Compositae plant family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many others. If you have allergies, be sure to check with your healthcare provider before taking gravel root.
LithiumInteraction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Gravel root might have an effect like a water pill or "diuretic." Taking gravel root might decrease how well the body gets rid of lithium. This could increase how much lithium is in the body and result in serious side effects. Talk with your healthcare provider before using this product if you are taking lithium. Your lithium dose might need to be changed.
Medications that increase break down of other medications by the liver (Cytochrome P450 3A4 [CYP3A4] inducers)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider.
Gravel root is broken down by the liver. Some chemicals that form when the liver breaks down gravel root can be harmful. Medications that cause the liver to break down gravel root might enhance the toxic effects of chemicals contained in gravel root.
The appropriate dose of gravel root depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for gravel root. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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Habtemariam, S. Antiinflammatory activity of the antirheumatic herbal drug, gravel root (Eupatorium purpureum): further biological activities and constituents. Phytother.Res. 2001;15(8):687-690. View abstract.
Tundis, R., Loizzo, M. R., Statti, G. A., Passalacqua, N. G., Peruzzi, L., and Menichini, F. Pyrrolizidine alkaloid profiles of the Senecio cineraria group (Asteraceae). Z.Naturforsch.C. 2007;62(7-8):467-472. View abstract.
Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. View abstract.
Food and Drug Administration. FDA Advises Dietary Supplement Manufacturers to Remove Comfrey Products From the Market. July 6, 2001. Available at: http://www.cfsan.fda.gov/~dms/dspltr06.html.
Habtemariam S. Cistifolin, an integrin-dependent cell adhesion blocker from the anti- rheumatic herbal drug, gravel root (rhizome of Eupatorium purpureum). Planta Med 1998;64:683-5. View abstract.
Klepser TB, Klepser ME. Unsafe and potentially safe herbal therapies. Am J Health Syst Pharm 1999;56:125-38. View abstract.
Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. View abstract.
WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.