Granulomatosis With Polyangiitis (GPA): Symptoms & Signs

Medically Reviewed on 7/10/2020

Granulomatosis with polyangiitis (GPA) is an uncommon type of inflammation of small arteries and veins (vasculitis). GPA in its classic form involves inflammation of the arteries that supply blood to the tissues of the lungs, nasal passages, and kidneys, although other types of the condition can occur. In addition to the vasculitis, a specific type of inflammatory reaction occurs known as granuloma formation, when affected tissues are examined under the microscope.

Signs and symptoms of granulomatosis with polyangiitis include

Other possible associated symptoms and signs include

Cause of granulomatosis with polyangiitis (GPA)

Doctors do not understand the exact cause of GPA.

Other granulomatosis with polyangiitis (gpa) symptoms


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Jameson, J. Larry, et al. Harrison's Principles of Internal Medicine, 20th Ed. New York: McGraw-Hill Education, 2018.