- What is granisetron transdermal system (patch), and how does it work (mechanism of action)?
- What brand names are available for granisetron transdermal system (patch)?
- Is granisetron transdermal system (patch) available as a generic drug?
- Do I need a prescription for granisetron transdermal system (patch)?
- What are the side effects of granisetron transdermal system (patch)?
- What is the dosage for granisetron transdermal system (patch)?
- Which drugs or supplements interact with granisetron transdermal system (patch)?
- Is granisetron transdermal system (patch) safe to take if I'm pregnant or breastfeeding?
- What else should I know about granisetron transdermal system (patch)?
What is granisetron transdermal system (patch), and how does it work (mechanism of action)?
Sancuso is granisetron delivered via a transdermal patch system for the prevention of nausea and vomiting resulting from chemotherapy for cancer. Other formulations of granisetron (for example, Kytril) are administered by mouth or injection. Certain chemotherapeutic agents used for treating cancer stimulate the release of a neurotransmitter called serotonin from nerves in the brain. Neurotransmitters are chemicals that nerves use to communicate with one another. Released serotonin binds to other nerves in an area of the brain called the chemoreceptor trigger zone, causing nausea and vomiting. Granisetron, the active ingredient in Sancuso, prevents serotonin from binding to nerves in the chemoreceptor trigger zone thereby preventing nausea and vomiting. The FDA approved Sancuso in September 2008.
What are the side effects of granisetron transdermal system (patch)?
Allergic reactions may occur rarely.
Application site reactions (redness, bumps, rashes, blisters) may occur. The patch must be removed if serious skin reactions or generalized skin reactions occur. Light exposure (sunlight, sun lamps, tanning beds) may reduce the effect of granisetron, and granisetron may cause light sensitivity. To avoid light exposure, the application site should be covered with clothing during therapy and for 10 days after the patch is removed. Granisetron may mask the symptoms of certain gastrointestinal conditions, for example, gastroparesis or ileus (paralysis of the muscles of the stomach and small intestine, respectively) by reducing the nausea and vomiting that are their primary symptoms.
What is the dosage for granisetron transdermal system (patch)?
A single patch is applied to clean, dry, intact healthy skin on the upper outer arm 24-48 hours before chemotherapy is begun and not removed until at least 24 hours after completion of chemotherapy. The patch may be worn for up to seven days. It should not be applied on skin that is red, irritated, or damaged because of concerns about increasing inflammation and increased absorption of drug. Each patch is packed in a pouch and should be applied immediately after the pouch has been opened. The patch should not be cut into pieces.
Which drugs or supplements interact with granisetron transdermal system (patch)?
Drug interaction studies have not been conducted with granisetron. Granisetron is broken down in the body by cytochrome P-450 liver enzymes. Drugs that increase (for example, phenobarbital) or decrease (for example, ketoconazole [Nizoral, Extina, Xolegel, Kuric]) the activity of cytochrome P-450 liver enzymes may affect the levels of granisetron in the body.
Is granisetron transdermal system (patch) safe to take if I'm pregnant or breastfeeding?
What else should I know about granisetron transdermal system (patch)?
What preparations of granisetron transdermal system (patch) are available?
Transdermal patch delivering 3.1 mg/24 h
How should I keep granisetron transdermal system (patch) stored?
Sancuso should be store in the original package at 15 C and 30 C (59 F and 86 F).
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Related Disease Conditions
Cancer is a disease caused by an abnormal growth of cells, also called malignancy. It is a group of 100 different diseases, and is not contagious. Cancer can be treated through chemotherapy, a treatment of drugs that destroy cancer cells.
Colon cancer (bowel cancer) is a malignancy that arises from the inner lining of the colon. Most, if not all, of these cancers develop from colonic polyps. Removal of these precancerous polyps can prevent colon cancer.
Pancreatic cancer is a malignant tumor of the pancreas. Pancreatic cancer has been called a "silent" disease because early pancreatic cancer usually does not cause early symptoms. Typically, pancreatic cancer has metastasized (spread to adjacent organs, such as the liver) by the time most people receive a dignosis of pancreatic cancer. Symptoms and signs usually appear later in the course of the disease and include jaundice, back pain, nausea, weight loss, itching, and loss of appetite. Treatment depends upon the type of pancreatic cancer but may include surgery, chemotherapy, and/or radiation therapy.
Nausea and Vomiting
Nausea is an uneasiness of the stomach that often precedes vomiting. Nausea and vomiting are not diseases, but they are symptoms of many conditions. There are numerous cases of nausea and vomiting. Some causes may not require medical treatment, for example, motion sickness, and other causes may require medical treatment by a doctor, for example, heart attack, lung infections, bronchitis, and pneumonia. Some causes of nausea and vomiting may be life-threatening, for example, heart attack, abdominal obstruction, and cancers. Treatment of nausea and vomiting depends upon the cause.
Cancers that form from brain tissue are called primary brain tumors. Brain tumors may be malignant (brain cancer) or benign. Certain risk factors, such as working in an oil refinery, as a chemist, or embalmer, increase the likelihood of developing brain cancer. Symptoms include headaches, weakness, seizures, difficulty walking, blurry vision, nausea,vomiting, and changes in speech, memory, or personality. Treatment may involve surgery, radiation therapy, or chemotherapy.
Lung cancer kills more men and women than any other form of cancer. Eight out of 10 lung cancers are due to tobacco smoke. Lung cancers are classified as either small-cell or non-small-cell lung cancers.
Bone cancer is a rare type of cancer that occurs in cells that make up the bones. Primary bone cancer that arises in bone cells is different than metastatic bone cancer, which is cancer that arises in another part of the body and then spreads to the bones. Hereditary and environmental factors likely contribute to the risk of bone cancer. Signs and symptoms of bone cancer may include pain, the presence of a mass or lump, and bone fractures. There are different types of bone cancer (osteosarcoma, chondrosarcoma, Ewing's sarcoma, pleomorphic sarcoma, fibrosarcoma). Treatment for bone cancer may include surgical removal of the tumor, chemotherapy, radiation, and/or a stem cell transplant. The prognosis for bone cancer depends on the type of cancer and the extent of spread.
Though uterine cancer's cause is unknown, there are many factors that will put a woman at risk, including being over age 50, having endometrial hyperplasia, using hormone replacement therapy, obesity, using tamoxifen, being Caucasian, and/or having colorectal cancer. Symptoms and signs of cancer of the uterus (endometrial cancer) include abnormal vaginal bleeding, painful urination, painful intercourse, and pelvic pain. Treatment depends on staging and may include radiation therapy or hormone therapy.
Nausea and vomiting after eating are symptoms that may be caused by many conditions. Antiemetics are drugs that help get rid of nausea and vomiting. Though some antiemetics for motion sickness and mild nausea remedies are available over the counter (OTC), most require a medical evaluation and prescription. Read experts describing what causes nausea and how to stop nausea and vomiting.
Skin cancers occur when skin cells undergo malignant transformations and grow into tumors. The most common types of skin cancer, basal cell carcinoma and squamous cell carcinoma, are highly curable when they are diagnosed and treated early. Sun exposure, tanning beds, depressed immune system, radiation exposure, and certain viral infections are risk factors for skin cancer. Skin cancers are treated with surgery or radiation. The prognosis of nonmelanoma skin cancers is generally very good.
There are many types of ovarian cancer, epithelial carcinoma is the most common. Women with a family history of ovarian cancer have an increased risk of developing the disease. Some ovarian cancer symptoms include abdominal pain, nausea, diarrhea, constipation, and abnormal vaginal bleeding, however, they usually do not present until the disease has progressed. Early diagnosis is important for successful treatment.
Though the cause of stomach cancer is unknown, risk factors for stomach cancer include diet, H. pylori infection, smoking age, gastritis, stomach surgery, family history, and pernicious anemia. Symptoms include stomach discomfort, feeling full after a small meal, nausea and vomiting, and weight loss. Treatment depends upon staging and may involve surgery, radiation therapy, or chemotherapy.
Esophageal cancer is a disease in which malignant cells form in the esophagus. Risk factors of cancer of the esophagus include smoking, heavy alcohol use, Barrett's esophagus, being male and being over age 60. Severe weight loss, vomiting, hoarseness, coughing up blood, painful swallowing, and pain in the throat or back are symptoms. Treatment depends upon the size, location and staging of the cancer and the health of the patient.
Treatment for bladder cancer depends on the stage of the disease, the grade of the tumor, and the type of bladder cancer. Options for treatment include surgery, radiation therapy, chemotherapy, and biological therapy.
Signs and symptoms of penile cancer include a lump on the penis and redness, irritation, or a sore on the penis. Risk of penis cancer is higher in uncircumcised men, due to a higher risk of HPV infection. Other risk factors include being over 60, having phimosis, having poor hygiene, using tobacco products, and having many sex partners. Prognosis and treatment depend upon the tumor's location and size, the stage of the cancer, and whether the cancer was recently diagnosed or if it recurred.
There are several types of kidney cancer, including renal cell cancer (renal adenocarcinoma or hypernephroma), transitional cell carcinoma, and Wilms tumor. Symptoms of kidney cancer include blood in the urine, an abdominal lump or mass, chronic pain in the side, and tiredness. Treatment of kidney cancer -- which may include surgery, arterial embolization, radiation therapy, biological therapy or chemotherapy -- depends upon the stage of the disease and the patient's overall health.
Testicular cancer symptoms include a painless lump or swelling in a testicle, testicle or scrotum pain, a dull ache in the abdomen, back, or groin, and a feeling of heaviness in the scrotum. Treatment for cancer of the testicles depends on the type of cancer (seminoma or nonseminoma), the stage of the cancer, and the patient's age and health.
Breast cancer is an invasive tumor that develops in the mammary gland. Breast cancer is detected via mammograms, breast self-examination (BSE), biopsy, and specialized testing on breast cancer tissue. Treatment of breast cancer may involve surgery, radiation, hormone therapy, chemotherapy, and targeted therapy. Breast cancer risk may be lowered by managing controllable risk factors.
Anal cancer, cancer located at the end of the large intestine, has symptoms that include anal or rectal bleeding, anal pain or pressure, anal discharge or itching, a change in bowel movements, and/or a lump in the anal region. Treatment for anal cancer may involve radiation, chemotherapy, or surgery and depends upon the stage of the cancer, its location, whether cancer is eradicated after the first treatment, and whether the patient has HIV.Anal cancer is usually curable when found localized. Early detection remains the key to long-term survival as it is in many forms of cancer.
Vaginal cancer is fairly uncommon. There are two types of vaginal cancer: squamous cell carcinoma and adenocarcinoma. Risk factors include being 60 or older, exposure to DES while in the womb, HPV infection, and having a history of abnormal cervical cells. Painful intercourse, pelvic pain, vaginal lumps, and abnormal vaginal bleeding or discharge are all symptoms of vaginal cancer. Treatment depends upon the stage of the vaginal cancer and may involve surgery, radiation therapy, chemotherapy, and the use of radiosensitizers.
Head and Neck Cancer
Head and neck cancer is cancer of the oral cavity, salivary glands, paranasal sinuses and nasal cavity, pharynx, larynx, or lymph nodes in the upper part of the neck. These cancers account for 3% to 5% of cancers in the U.S. Tobacco and alcohol use are important risk factors. Treatment may involve surgery, radiation therapy, and/or chemotherapy.
Salivary Gland Cancer
Salivary gland cancer is cancer that affects the parotid glands, sublingual glands, or the submandibular glands. Risk factors include older age, radiation therapy treatment to head or neck, and being exposed to certain substances at work. Signs include fluid draining from the ear, pain, numbness, weakness, trouble swallowing, and a lump. Treatment depends upon the stage of the cancer and usually involves surgery, radiation therapy, chemotherapy, or radiosensitizers.
Gallbladder cancer is a rare form of cancer with symptoms that include jaundice, abdominal pain, fever, nausea and vomiting, abdominal lumps, and bloating. Risk factors include being female and Native American. Treatment of gallbladder cancer depends upon the stage of the cancer, the type of gallbladder cancer, and whether the cancer can be removed by surgery.
Nasopharyngeal cancer is a form of cancer in which malignant cells form in the nasopharynx tissues. Risk factors include being of Chinese or Asian ancestry and exposure to the Epstein-Barr virus. Symptoms and signs of nasopharyngeal cancer include a sore throat, a lump in the neck or nose, trouble hearing, nosebleeds, headaches, and trouble hearing, breathing, or speaking. Treatment depends upon the stage of the cancer, the tumor size, the type of cancer, and the patient's health and age.
Cancer pain results from the tumor pressing on nerves or invading bones or organs. Cancer treatments like chemotherapy, radiation, or surgery can also cause pain. Over-the-counter pain relievers, prescription medications, radiation, biofeedback, and relaxation techniques are just some treatments for cancer pain.
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