glycopyrrolate (Robinul, Robinul Forte, Cuvposa, Glycate)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jerry R. Balentine, DO, FACEP
    Jerry R. Balentine, DO, FACEP

    Jerry R. Balentine, DO, FACEP

    Dr. Balentine received his undergraduate degree from McDaniel College in Westminster, Maryland. He attended medical school at the Philadelphia College of Osteopathic Medicine graduating in1983. He completed his internship at St. Joseph's Hospital in Philadelphia and his Emergency Medicine residency at Lincoln Medical and Mental Health Center in the Bronx, where he served as chief resident.

woman with abdominal pain

What is glycopyrrolate-injection, and how does it work (mechanism of action)?

Glycopyrrolate is a synthetic anti-cholinergic medication. Glycopyrrolate works by blocking acetylcholine activity on smooth muscles and other tissues. Acetylcholine is neurotransmitter, a chemical that nerves use for communicating. Blocking of acetylcholine leads to decrease in volume and acidity of stomach secretions and decrease in pharyngeal, tracheal, and bronchial secretions. It also reverses symptoms of excessive bronchial secretions, bronchospasm, low heart rate, and intestinal hypermotility caused by medications that increase the action of acetylcholine. The FDA approved glycopyrrolate in August 1961.

What brand names are available for glycopyrrolate-injection?

Robinul, Robinul Forte, Cuvposa, Glycate

Is glycopyrrolate-injection available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for glycopyrrolate-injection?

Yes

What are the side effects of glycopyrrolate-injection?

Common side effects of glycopyrrolate are:

Quick GuideDigestive Disorders: Common Misconceptions

Digestive Disorders: Common Misconceptions

What is the dosage for glycopyrrolate-injection?

Adults

  • Preanesthetic medication: Inject 0.004 mg/kg intramuscularly or intravenously 30 to 60 minutes prior to surgery.
  • Intraoperative medication: Inject 0.1 mg as a single dose intravenously every 2 to 3 minutes as needed.
  • Reversal of neuromuscular blockade: Inject 0.2 mg for each 1 mg of neostigmine or 5 mg of pyridostigmine given.
  • Peptic ulcer: Inject 0.1 mg intramuscularly or intravenously at 4-hour intervals, up to 3 to 4 times daily. May increase to 0.2 mg if needed.

Children

  • Preanesthetic medication (children over 2 years of age): Inject 0.004 mg/kg intramuscularly, given 30 to 60 minutes prior to anesthesia, narcotic, or sedative.
  • Preanesthetic medication (Infants of 1 month to 2 years of age): Inject up to 0.009 mg/kg.
  • Intraoperative medication: Inject 0.004 mg/kg as single dose intravenously every 2 to 3 minutes as needed. Do not exceed 0.1 mg in a single dose.
  • Reversal of neuromuscular blockade: Inject 0.2 mg for each 1 mg of neostigmine or 5 mg of pyridostigmine given.

Glycopyrrolate Injection is not recommended for the treatment of peptic ulcer in pediatric patients.

Which drugs or supplements interact with glycopyrrolate-injection?

Glycopyrrolate should not be used with anti-cholinergic drugs such as phenothiazines, Parkinson's drugs, or tricyclic antidepressants because it can significantly increase anticholinergic side effects like mydriasis (pupil dilation), high blood pressure (hypertension), flushing, fever, and increased heart rate.

Glycopyrrolate should be used with caution with potassium chloride because concomitant use can decrease bowel movement and can cause irritation or lesions in the stomach and intestine.

Is glycopyrrolate-injection safe to take if I'm pregnant or breastfeeding?

There are no adequate studies done on glycopyrrolate to determine safe and effective use in pregnant women. It has been shown that small amounts of glycopyrrolate will pass the placental barrier.

It is not known whether glycopyrrolate enters breast milk; therefore, it is best to be cautious before using it in nursing mothers. Anticholinergics may cause suppression of lactation.

What else should I know about glycopyrrolate-injection?

What preparations of glycopyrrolate-injection are available?

Glycopyrrolate injection is available in 0.2 mg/ml strength in 1 ml and 2 ml single-use vials. It is also available in 5 ml and 20 ml multi-use vials. All vials contain benzyl alcohol 0.9% as preservative.

How should I keep glycopyrrolate-injection stored?

Store Glycopyrrolate injection at room temperature between 20 C and 25 C (68 F and 77 F).

REFERENCE: FDA Prescribing Information.

Quick GuideDigestive Disorders: Common Misconceptions

Digestive Disorders: Common Misconceptions

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Reviewed on 10/7/2015
References
REFERENCE: FDA Prescribing Information.

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