- Type 2 Diabetes: Learn the Warning Signs
- Diabetes Friendly Dining
- Type 2 Diabetes: Test Your Medical IQ
- What is glyburide/metformin tablets, and how does it work (mechanism of action)?
- What are the uses for glyburide/metformin tablets?
- What are the side effects of glyburide/metformin tablets?
- What is the dosage for glyburide/metformin tablets?
- Which drugs or supplements interact with glyburide/metformin tablets?
- Is glyburide/metformin tablets safe to take if I'm pregnant or breastfeeding?
- What else should I know about glyburide/metformin tablets?
What is glyburide/metformin tablets, and how does it work (mechanism of action)?
- Glucovance (glyburide/metformin) is a combination antidiabetic medication containing glyburide and metformin. Glucovance is used to improve blood glucose (sugar) control in adults with type 2 diabetes mellitus.
- Glyburide is a second generation oral sulfonylurea. It helps to lower blood glucose by stimulating the release of insulin, the hormone responsible for regulating blood glucose.
- Metformin is an oral biguanide antidiabetic agent. It decreases the production of glucose in the liver, decreases the absorption of glucose by the intestines, and increases the uptake and use of blood glucose by cells throughout the body.
- In clinical studies, glyburide/metformin therapy was observed to be superior in improving fasting plasma glucose, post-meal blood glucose, and HbA1c levels versus treatment with glyburide or metformin alone.
- Glucovance was approved by the FDA in July, 2000.
What brand names are available for glyburide/metformin tablets?
Is glyburide/metformin tablets available as a generic drug?
Do I need a prescription for glyburide/metformin tablets?
What are the uses for glyburide/metformin tablets?
What are the side effects of glyburide/metformin tablets?
The most common side effects include
Other commonly reported side effects with Glucovance therapy include
Other side effects include
- hypoglycemia (low blood glucose),
- blood disorders,
- decrease blood sodium levels,
- sensitivity to the sunlight,
- liver disease,
- hives, and
- hypersensitivity type reactions.
Metformin can cause a rare but serious condition known as lactic acidosis, a build-up of acid in the blood. Lactic acidosis can cause death and requires immediate treatment. Symptoms of lactic acidosis include
- muscle pain,
- pain in the stomach,
- difficulty breathing,
- dizziness, and
- slow or irregular heartbeat.
Patients suspected of having signs or symptoms of lactic acidosis must seek emergency medical help.
What is the dosage for glyburide/metformin tablets?
For patients inadequately controlled on diet and exercise
- Generally, the recommended starting dose of Glucovance is 1.25/250 mg administered once daily with a meal.
- A starting dose of 1.25/ 250 mg twice daily may be considered for patients with HbA1c >9% or fasting plasma glucose (FPG) >200 mg/dL.
- If necessary, dosage may be increased in increments of 1.25/250 mg at two week intervals.
- The maximum daily dose of Glucovance is 20/2000 mg.
- For patients inadequately controlled on a sulfonylurea and/or metformin
- Generally, the recommended starting dose of Glucovance is 2.5 mg/500 mg or 5 mg/500 mg orally twice a day with meals.
- Metformin-containing drugs may be safely used in patients with mild to moderate renal impairment. Renal function should be assessed before starting treatment and at least yearly.
- Metformin should not be used by patients with an estimated glomerular filtration rate (eGFR) below 30 mL/minute/1.73 m2 and starting metformin in patients with an eGFR between 30-45 mL/minute/1.73 m2 is not recommended.
- Metformin should be stopped at the time of or before administering iodinated contrast in patients with an eGFR between 30 and 60 mL/minute/1.73 m2; in patients with a history of liver disease, alcoholism, or heart failure; or in patients who will be administered intra-arterial iodinated contrast.
- Kidney function should be evaluated 48 hours after receiving contrast and metformin may be restarted if kidney function is stable.
- The safety and efficacy of Glucovance has not been established in pediatric patients. Therefore, use of Glucovance in this patient population is not recommended.
Latest Diabetes News
Daily Health News
Which drugs or supplements interact with glyburide/metformin tablets?
- Drugs that cause blood glucose levels to increase may diminish the effectiveness of Glucovance therapy. When these drugs are stopped, patients should be closely observed for signs of low blood glucose. These drugs include
- Cimetidine (Tagamet), by decreasing the elimination of metformin from the body, can increase the amount of metformin in the blood by 40%. This may increase the frequency of side effects from metformin.
- Contrast media used for radiological procedures may reduce kidney function which reduces elimination of metformin, leading to increased concentrations of metformin in the blood. Metformin should be stopped 48 hours before and after use of contrast media.
- Alcohol consumption increases the effect of metformin on lactate production, increasing the risk of lactic acidosis.
- Certain drugs may increase the blood glucose lowering actions of glyburide. It is possible that hypoglycemia (low blood glucose) and symptoms from hypoglycemia may result. Such drugs include
- Coadministration of glyburide with bosentan (Tracleer) may cause an abnormal increase in liver enzymes. Therefore, concomitant use of these agents is not recommended.
- Colesevelam (Welchol) may reduce blood levels of glyburide. Patients are advised to take glyburide 1 hour before or 4 hours after colesevelam administration to minimize the risk of their interaction.
Is glyburide/metformin tablets safe to take if I'm pregnant or breastfeeding?
- Glucovance has not been adequately evaluated in pregnant women. Due to the lack of conclusive safety data, Glucovance should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. Glucovance is classified as FDA pregnancy risk category B.
- It is not known if Glucovance is excreted in breast milk. Due to the lack of safety data and the potential risk for hypoglycemia (low blood glucose) in nursing infants, use of Glucovance in nursing mothers is not recommended.
What else should I know about glyburide/metformin tablets?
What preparations of glyburide/metformin tablets are available?
Oral tablets: 1.25/250, 2.5/500, and 5/500 mg
How should I keep glyburide/metformin tablets stored?
- Tablets should be stored at room temperature, between 15 C and 30 C (59 F to 86 F).
- Tablets should be dispensed and stored in an air- tight, light resistance container.
Glucovance (glyburide/metformin) is a combination drug prescribed to treat type 2 diabetes in addition to diet and exercise. Side effects include diarrhea, nausea, upset stomach, headache, nausea, stomach pain. Drug interactions, dosage, storage, and pregnancy and breastfeeding safety information should be reviewed prior to taking this medication.
Multimedia: Slideshows, Images & Quizzes
Type 2 Diabetes: Signs, Symptoms, Treatments
Learn about type 2 diabetes warning signs, symptoms, diagnosis, and treatment options. Find out why thirst, headaches, and...
Diabetes: What Raises and Lowers Your Blood Sugar Level?
Want to lower your blood sugar? Learn to better control your glucose levels by preventing blood sugar spikes and swings to avoid...
Diabetes Diet: Healthy Meal Plans for Diabetes-Friendly Eating
Discover the best and worst meals for diabetes-savvy dining. See how to avoid carbs and control your blood sugar with healthier...
Heart Healthy Diet: 25 Foods You Should Eat
What foods are heart healthy? Learn what foods help protect your cardiovascular system from heart attack, coronary heart disease,...
The Best Diet Tips: How to Lose Weight the Healthy Way
Learn to lose weight in a realistic way that works. Find healthy weight loss by eating right, sleeping more, understanding...
How Diabetes Can Affect Your Feet
Learn more about diabetes related foot problems. For people with diabetes, too much glucose in the blood can cause serious foot...
Diabetes Nerve Pain: Improving Diabetic Peripheral Neuropathy
Learn how to cope with the symptoms of diabetic peripheral neuropathy through pain management exercises. Find relief for diabetic...
Foods to Boost Your Energy and Mood
Learn which foods may boost your energy level and have a positive impact on your mood. Foods such as salmon, Brazil nuts, and...
Fat-Burning Foods in Pictures: Blueberries, Green Tea, and More
Learn about fat-fighting foods such as grapefruit, hot peppers, vinegar, and more. Discover the benefits along with surprising...
Diet for Stress Management: Carbs, Nuts, and Other Stress-Relief Foods
While there are many ways to cope with stress, one strategy is to eat stress-fighting foods. Find out which foods to eat as part...
Diabetes Diet: 11 Low-Sugar Drink Ideas
Searching for low-sugar drink ideas? This pictures slideshow has eleven beverages ideal for people with diabetes and those...
How to Lose Weight Without Dieting: 24 Fast Facts
Weight loss without dieting? No diet, no problem. Learn the best way to lose weight with these weight loss tips designed to help...
Travel Tips for Better Diabetes Control
Traveling with diabetes can be intimidating, but it shouldn't stop you! Learn tips for packing your diabetic supplies, how to...
Popular Dieting Myths and Facts
Can't tell fact from fiction about weight loss and healthy eating? Discover the truth behind some of the most common diet and...
Pictures of 10 Muscle-Building Exercises for Diabetes
Watch this slideshow on Diabetes and Exercise. If you have diabetes, see how strengthening your muscles with these 10 weight...
Sugar Addiction Facts: Cravings, Hidden Sugar, and More in Pictures
Learn about sugar addiction to see why we often crave sweets and binge on carbs. Learn how sugar affects the brain and get tips...
Food Swaps for Meals and Snacks for Heart Health in Pictures
Explore 10 food swaps for heart-wise dining. Learn what food to buy and how to cook in order to make a big difference for your...
Diabetes Management Tips and Preventing Complications
Learn 10 simple ways to better manage your diabetes. See tips for controlling blood sugar, diet and exercise and other helpful...
Diet Mistake Pictures: Crash Diets, High-Calorie Drinks, and More
Discover 10 common diet mistakes that may be preventing you from losing weight. Learn to avoid these diet blunders and watch the...
Diabetes: 15 Famous Celebrities With Diabetes
See pictures of celebrities that have been diagnosed with type 1 or type 2 diabetes including Mary Tyler Moore, Salma Hayek, and...
Diet and Nutrition Quiz: Plans & Facts
Even if you think you're getting enough fruits and vegetables per day, how can you be sure? Take the Diet & Nutrition Quiz to...
Diet-Wrecking Foods: Smoothies, Lattes, Popcorn, and More in Pictures
It may seem healthy, but is it really? Many food frauds masquerade as diet food. See 23 foods that seem healthy but can be...
Fat and Fats Quiz: Fatty Food & Body Fat Percentage
Take this online Fat & Fats Quiz to learn if you really are what you eat!
Sugar Quiz: Facts on Diet & Sugar
Sugar lurks in surprising places. Take the Sugar Quiz to learn of the many ways sugar sneaks into your diet and see what you know...
Food Portion Distortion Quiz: Correct Serving Size
Are your portions deceiving you? Take the Food Portion Distortion Quiz to find out how and why gigantic portions trick you into...
Protein Quiz: Foods High in Protein
Protein is a staple in our diets, but what happens if we get too much? Take this quiz to find out the truth about protein and...
Type 2 Diabetes: Test Your Medical IQ
What causes type 2 diabetes? Can it be prevented? Take this online quiz and challenge your knowledge of this common condition....
Superfoods Quiz: List of Top Superfoods
Take our Superfoods Quiz! Get to know how unprocessed, raw, organic foods and healthy drinks are rich in nutrients and dietary...
Salt Quiz: Test Your Diet IQ
Do you love salt? Take the online Salt Quiz to get the facts about dietary salts and sodium in fruits, vegetables, processed...
Diabetes Quiz: Test Your Medical IQ
Take the Diabetes Quiz and learn the causes, signs, symptoms, and types of this growing epidemic. What does diabetes have to do...
Healthy Indulgences for Under $15 With Pictures
Isn't it time you took care of yourself? Good food, relaxation, laughter -- we offer 15 great ideas for affordable, healthy...
Best and Worst-Appetizers: Spinach Dip, Potato Skins, and More
A tasty appetizer can be a great start to any meal--but some appetizers are diet disasters. Potato skins and cheese fries pack on...
12 Reasons to Love the Mediterranean Diet
The Mediterranean diet is a delicious way to eat healthy. We show you how to get the most from this diet with foods like olive...
10 Tips for a Healthier Fast Food Diet
Losing weight is tough on the road. Fast food can't compare to the health of a well-planned, balanced diet. But if you must eat...
Snacks With 100 Calories or Less
Reducing calories is an effective weight loss strategy. Here are 25 100-calorie snacks that offer quick, satisfying solutions to...
Food Cravings Slideshow: Chocolate, Carbs, Salt, Sugar
Learn which food cravings can wreck your diet. Whether your craving something creamy or crunchy, sweet or salty, food cravings...
Healthy Living: 20 Common Health Myths Exposed
Can vitamin C cure colds? Read as we dispel the half-truths and common myths of health, from X-rays to eggs, from the...
The Worst Foods in Your Fridge
What are the worst foods to eat in your fridge? From mayonnaise to ice cream and butter to processed lunch meats, learn about the...
Portion Control Tips: Lose Weight and Stick to Your Diet
Portion control can help with weight loss and help you stick to a healthy diet. But how much is too much? This photo guide will...
Easy, Tasty Grilled Foods for Dinner Tonight in Pictures
Explore easy and tasty grilled foods. When your rushed to get dinner on the table, fire up the grill and use these delicious,...
13 Easy Ways to Eat More Greens
Learn 13 easy ways to add more greens to your diet. Discover how to add kale, spinach, broccoli rabe and more into your diet.
Slideshow: 25 Ways to Get Ready for Swimsuit Season
Discover 25 ways to get ready for swimsuit season. See exercises, diet tips, and other healthy beauty fixes that will motivate...
Tips to Eat Healthy When You Dine Out in Pictures
Recognize the dangers of eating out and stay on your healthy diet at restaurants. Learn about healthy eating at restaurants,...
Fast-Food Sandwiches: Good and Bad Choices For Your Diet
Want to know what the good and bad fast-food sandwiches choices are? Our experts explore the nutrition facts of major restaurant...
Low-Carb Snacks in Pictures
Interested in low-carb snacking? Here are some ideas about smart snacks that are filling and low in carbohydrates.
Related Disease Conditions
Type 2 Diabetes Diet Plan
A type 2 diabetes diet or a type 2 diabetic diet is important for blood sugar (glucose) control in people with diabetes to prevent complications of diabetes. There are a variety of type 2 diabetes diet eating plans such as the Mediterranean diet, Paleo diet, ADA Diabetes Diet, and vegetarian diets.Learn about low and high glycemic index foods, what foods to eat, and what foods to avoid if you have type 2 diabetes.
Diabetes (Type 1 and Type 2)
Diabetes is a chronic condition characterized by high levels of sugar (glucose) in the blood. The two types of diabetes are referred to as type 1 (insulin dependent) and type 2 (non-insulin dependent). Symptoms of diabetes include increased urine output, thirst, hunger, and fatigue. Treatment of diabetes depends on the type.
Low Blood Sugar (Hypoglycemia)
Low blood sugar, or hypoglycemia, is a syndrome in which a person's blood sugar is dangerously low. People with type 1 and type 2 diabetes are at risk for this condition. There are other diseases that can cause a person's blood sugar levels to go too low, for example, pancreatitis, Cushing's syndrome, and pancreatic cancer. Symptoms and signs that your blood sugar levels are too low include palpitations, trembling, intense hunger, sweating, nervousness, and weakness. If your blood sugars become too low, use these nearby as a quick treatment table sugar, soda, juice, and glucose tablets.
A stroke is an interruption of the blood supply to part of the brain caused by either a blood clot (ischemic) or bleeding (hemorrhagic). Symptoms of a stroke may include: weakness, numbness, double vision or vision loss, confusion, vertigo, difficulty speaking or understanding speech. A physical exam, imaging tests, neurological exam, and blood tests may be used to diagnose a stroke. Treatment may include administration of clot-busting drugs, supportive care, and in some instances, neurosurgery. The risk of stroke can be reduced by controlling high blood pressure, high cholesterol, diabetes, and stopping smoking.
Type 2 Diabetes
Type 2 diabetes is a chronic condition that may be reversible with diet and lifestyle changes. Symptoms include excessive thirst, frequent urination, weight loss, fatigue, and an unusual odor to your urine. Most people don't know they have type 2 diabetes until they have a routine blood test. Treatment options include medications, a type 2 diabetes diet, and other lifestyle changes.
Diabetes Treatment: Medication, Diet, and Insulin
The major goal in treating diabetes is controlling elevated blood sugar without causing abnormally low levels of blood sugar. Type 1 diabetes is treated with: insulin, exercise, and a diabetic diet. Type 2 diabetes is first treated with: weight reduction, a diabetic diet, and exercise. When these measures fail to control the elevated blood sugar, oral medications are used. If oral medications are still insufficient, insulin medications are considered.
Type 1 vs. Type 2 Diabetes: Differences
Diabetes mellitus is a metabolic condition in which a person's blood sugar (glucose) levels are too high. Over 29.1 million children and adults in the US have diabetes. Of that, 8.1 million people have diabetes and don't even know it. Type 1 diabetes (insulin-dependent, juvenile) is caused by a problem with insulin production by the pancreas. Type 2 diabetes (non-insulin dependent) is caused by: Eating a lot of foods and drinking beverages with simple carbohydrates (pizza, white breads, pastas, cereals, pastries, etc.) and simple sugars (donuts, candy, etc.) Consuming too many products with artificial sweeteners (We found out that they are bad for us!) Lack of activity Exercise Stress Genetics While the signs and symptoms of both types of diabetes are the same, which include: Increased urination Increased hunger Increased thirst Unexplained weight loss. However, the treatments are different. Type 1 diabetes is insulin dependent, which means a person with this type of diabetes requires treatment with insulin. People with type 2 diabetes require medication, lifestyle changes like eating a healthy diet, and getting regular exercise.
Diabetes Foot Problems
Diabetes related foot problems can affect your health with two problems: diabetic neuropathy, where diabetes affects the nerves, and peripheral vascular disease, where diabetes affects the flow of blood. Common foot problems for people with diabetes include athlete's foot, fungal infection of nails, calluses, corns, blisters, bunions, dry skin, foot ulcers, hammertoes, ingrown toenails, and plantar warts.
Eye Problems and Diabetes
Diabetes and eye problems are generally caused by high blood sugar levels over an extended period of time. Types of eye problems in a person with diabetes include glaucoma, cataracts, and retinopathy. Examples of symptoms include blurred vision, headaches, eye aches, pain, halos around lights, loss of vision, watering eyes. Treatment for eye problems in people with diabetes depend on the type of eye problem. Prevention of eye problems include reducing blood pressure, cholesterol levels, quitting smoking, and maintaining proper blood glucose levels.
Sex, Urinary, and Bladder Problems of Diabetes
Having diabetes can mean early onset and increased severity of bladder symptoms (urinary incontinence and urinary tract infections) and changes in sexual function. Men may have erectile dysfunction; and women may have problems with sexual response and vaginal lubrication. Keep your diabetes under control, and you can lower your risk of sexual and urologic problems.
Types of Diabetes Type 2 Medications
Type 2 diabetes oral medications are prescribed to treat type 2 diabetes in conjuction with lifestyle changes like diet and exercise. There are nine classes of drugs approved for the treatment of type 2 diabetes. Examples of type 2 oral diabetes medications include acarbose (Precose), chlorpropamide (Diabinese), glipizide (Glucotrol, Glucotrol XL), and metformin (Glucophage). Side effects, drug interactions, warnings and precautions, dosage, and breastfeeding and pregnancy safety information should be reviewed prior to taking any medication.
Diabetes and Kidney Disease
In the United States diabetes is the most common cause of kidney failure. High blood pressure and high levels of blood glucose increase the risk that a person with diabetes will eventually progress to kidney failure. Kidney disease in people with diabetes develops over the course of many years. albumin and eGFR are two key markers for kidney disease in people with diabetes. Controlling high blood pressure, blood pressure medications, a moderate protein diet, and compliant management of blood glucose can slow the progression of kidney disease. For those patients who's kidneys eventually fail, dialysis or kidney transplantation is the only option.
Tips for Managing Type 1 and 2 Diabetes at Home
Managing your diabetes is a full time commitment. The goal of diabetic therapy is to control blood glucose levels and prevent the complications of diabetes. Information about exercise, diet, and medication will help you manage your diabetes better. Blood glucose reagent strips, blood glucose meters, urine glucose tests, tests for urinary ketones, continuous glucose sensors, and Hemoglobin A1C testing information will enable you to mange your diabetes at home successfully.
Diabetes: Caring for Your Diabetes at Special Times
Taking care of a disease such as diabetes is a life-long process. Learn how to care for yourself or loved one with diabetes in situations such as illness, work, school, travel, or a natural disaster.
Treatment & Diagnosis
Medications & Supplements
- metformin (Glucophage, Glucophage XR, Glumetza, Fortamet, Riomet)
- Metformin vs. Lantus
- metformin and sitagliptin (Janumet)
- canagliflozin (Invokana)
- glipizide and metformin
- Types of Diabetes Type I And II Medications
- Avandamet (rosiglitazone/metformin)
- Side Effects of Glucovance (glyburide/metformin)
Prevention & Wellness
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.