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- What is glyburide, and how does it work (mechanism of action)?
- What brand names are available for glyburide?
- Is glyburide available as a generic drug?
- Do I need a prescription for glyburide?
- What are the side effects of glyburide?
- What is the dosage for glyburide?
- Which drugs or supplements interact with glyburide?
- Is glyburide safe to take if I'm pregnant or breastfeeding?
- What else should I know about glyburide?
What is glyburide, and how does it work (mechanism of action)?
Glyburide is an oral, glucose-lowering drug in a class of diabetic drugs called sulfonylureas that is used for treating diabetes. Other sulfonylureas include glipizide (Glucotrol), glimepiride (Amaryl), tolbutamide (Orinase), tolazamide, and chlorpropamide (Diabinese). Insulin is a hormone that is made in the pancreas. When released into the blood, insulin reduces the formation of glucose by the liver and causes cells in the body to remove the glucose (“sugar”) from the blood. Patients with type 2 diabetes have high glucose levels in their blood because the cells in their bodies are resistant to the effect of insulin, and the pancreas cannot produce enough insulin to overcome the insulin resistance of the body's cells. As a result, their liver produces and releases too much glucose. In addition, Glyburide reduces glucose in the blood by stimulating the pancreas to produce more insulin. Glyburide is not a cure for diabetes. The FDA approved glyburide in May 1984.
What are the side effects of glyburide?
Common side effects include nausea, heartburn, rashes, low blood sugar, blurred vision and weight gain. Rare but serious side effects include hepatitis, jaundice, and low blood sodium levels (hyponatremia).
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What is the dosage for glyburide?
- The recommended starting dose is 2.5 to 5 mg daily of regular tablets or 1.5-3 mg daily of micronized tablets.
- The maintenance dose is 1.25 to 20 mg of regular tablets and 0.75 to 12 mg of micronized tablets given daily or in divided doses every 12 hours.
- The maximum dose is 20 mg of regular tablets and 12 mg of micronized tablets daily.
Glyburide usually is administered with the first main meal of the day.
Which drugs or supplements interact with glyburide?
Bosentan (Tracleer) may increase the breakdown of glyburide in the liver. Bosentan and glyburide should not be used together because blood levels of both drugs decrease, potentially reducing their effect, and there is an increase in liver toxicity.
Is glyburide safe to take if I'm pregnant or breastfeeding?
It is not known whether glyburide is excreted in breast milk. Since many sulfonylureas are excreted in breast milk and potentially may harm the infant, alternative diabetic therapies should be considered or breast feeding should be discontinued.
What else should I know about glyburide?
What preparations of glyburide are available?
Tablets: 1.25, 2.5, and 5 mg. Tablets (micronized): 1.5, 3, 5, and 6 mg.
How should I keep glyburide stored?
Glyburide should be stored at room temperature, 15 C - 30 C (59 F- 86 F).
Glyburide (Micronase, Diabeta, Glynase Prestab) is a drug prescribed for the treatment of type 2 diabetes. It is recommended that glyburide be combined with diet and exercise for controlling blood glucose levels. Side effects, drug interactions, dosage, and safety during pregnancy should be reviewed prior to taking this medication.
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canagliflozinCanagliflozin (Invokana) is a medication prescribed for the treatment of type 2 diabetes in combination with diet and exercise. Side effects, drug interactions, dosage, and pregnancy safety information should be reviewed prior to taking this medication.
chlorpropamideChlorpropamide (Diabinese) is an oral medication used to strictly control blood sugar (gluclose) levels in people with diabetes. Side effects, drug interactions, warnings and precautions, and pregnancy safety information should be reviewed prior to taking any medication.
Diabetes MellitusDiabetes is a chronic condition characterized by high levels of sugar (glucose) in the blood. The two types of diabetes are referred to as type 1 (insulin dependent) and type 2 (non-insulin dependent). Symptoms of diabetes include increased urine output, thirst, hunger, and fatigue. Treatment of diabetes depends on the type.
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Diabetes TreatmentThe major goal in treating diabetes is controlling elevated blood sugar without causing abnormally low levels of blood sugar. Type 1 diabetes is treated with:
- and a diabetic diet.
- weight reduction,
- a diabetic diet,
- and exercise.
A diabetic diet, or diabetes diet helps keep blood glucose levels in the target range for patients. Exercise and medication may also help stabilize blood glucose levels. Keeping track of when you take your diabetic medicine, keeping track of food choices, eating the proper amount of fruits, vegetables, carbohydrates, and fats will also help maintain proper blood glucose levels. Foods that raise blood sugar levels are "high glycemic index foods;" examples include:
- Short-grain white rice
Foods that help maintain good blood sugar levels are foods that are low on the glycemic index, for example:
- Rolled or steel-cut oats
- Many fruits
- Non-starchy vegetables
Diabetic Home Care and MonitoringManaging your diabetes is a full time commitment. The goal of diabetic therapy is to control blood glucose levels and prevent the complications of diabetes. Information about exercise, diet, and medication will help you manage your diabetes better. Blood glucose reagent strips, blood glucose meters, urine glucose tests, tests for urinary ketones, continuous glucose sensors, and Hemoglobin A1C testing information will enable you to mange your diabetes at home successfully.
Drug InteractionsDrug interactions occur frequently. Get facts about the types of drug interactions, what substances or other things that may interact with drugs such as OTC drug and prescription drugs, vitamins, food(s) (grapefruit), and laboratory tests. Find out how to protect yourself from potential drug interactions.
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Amaryl (glimepiride) is a drug prescribed to treat individuals with type 2 diabetes that cannot be controlled by a strict diabetes diet. Side effects include:
Drug interactions, warnings and precautions, and pregnancy and breastfeeding safety information should be reviewed prior to taking any medication.
glipizideGlipizide, (Glipizide XL, Glucotrol, Glucotrol XL) is a drug prescribed for the treatment of type 2 diabetes. Glipizide should be combined with diet and exercise for the best results. Drug interactions, warnings and precautions, patient efficacy should be reviewed prior to taking this medication.
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Low blood sugar, or hypoglycemia, is a syndrome in which a person's blood sugar is dangerously low. People with type 1 and type 2 diabetes are at risk for this condition. There are other diseases that can cause a person's blood sugar levels to go too low, for example, pancreatitis, Cushing's syndrome, and pancreatic cancer. Symptoms and signs that your blood sugar levels are too low include:
- Intense hunger
If your blood sugars become too have the following nearby as a quick treatment.
- Table sugar
- Glucose tablets
Type 1 vs Type 2 Diabetes Similarities Differences
Diabetes mellitus is a metabolic condition in which a person's blood sugar (glucose) levels are too high. Over 29.1 million children and adults in the US have diabetes. Of that, 8.1 million people have diabetes and don't even know it. Type 1 diabetes (insulin-dependent, juvenile) is caused by a problem with insulin production by the pancreas. Type 2 diabetes (non-insulin dependent) is caused by:
Eating a lot of foods and drinking beverages with simple carbohydrates (pizza, white breads, pastas, cereals, pastries, etc.) and simple sugars (donuts, candy, etc.)
- Consuming too many products with artificial sweeteners (We found out that they are bad for us!)
- Lack of activity
While the signs and symptoms of both types of diabetes are the same, which include:
- Increased urination
- Increased hunger
- Increased thirst
- Unexplained weight loss.
However, the treatments are different. Type 1 diabetes is insulin dependent, which means a person with this type of diabetes requires treatment with insulin. People with type 2 diabetes require medication, lifestyle changes like eating a healthy diet, and getting regular exercise.
Type 2 Diabetes
Type 2 diabetes is a condition in which a person's pancreas does not produce enough insulin to meet the needs of the body. Causes of type 2 diabetes are a sedentary lifestyle, eating excess sugar and carbohydrates, lack of exercise, being overweight, and genetics. Symptoms of type 2 diabetes are often subtle, but may include fatigue, urine odor, unintentional