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- What is glyburide, and how does it work (mechanism of action)?
- What brand names are available for glyburide?
- Is glyburide available as a generic drug?
- Do I need a prescription for glyburide?
- What are the side effects of glyburide?
- What is the dosage for glyburide?
- Which drugs or supplements interact with glyburide?
- Is glyburide safe to take if I'm pregnant or breastfeeding?
- What else should I know about glyburide?
What is glyburide, and how does it work (mechanism of action)?
Glyburide is an oral, glucose-lowering drug in a class of diabetic drugs called sulfonylureas that is used for treating diabetes. Other sulfonylureas include glipizide (Glucotrol), glimepiride (Amaryl), tolbutamide (Orinase), tolazamide, and chlorpropamide (Diabinese). Insulin is a hormone that is made in the pancreas. When released into the blood, insulin reduces the formation of glucose by the liver and causes cells in the body to remove the glucose (“sugar”) from the blood. Patients with type 2 diabetes have high glucose levels in their blood because the cells in their bodies are resistant to the effect of insulin, and the pancreas cannot produce enough insulin to overcome the insulin resistance of the body's cells. As a result, their liver produces and releases too much glucose. In addition, Glyburide reduces glucose in the blood by stimulating the pancreas to produce more insulin. Glyburide is not a cure for diabetes. The FDA approved glyburide in May 1984.
What are the side effects of glyburide?
Common side effects include nausea, heartburn, rashes, low blood sugar, blurred vision and weight gain. Rare but serious side effects include hepatitis, jaundice, and low blood sodium levels (hyponatremia).
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What is the dosage for glyburide?
- The recommended starting dose is 2.5 to 5 mg daily of regular tablets or 1.5-3 mg daily of micronized tablets.
- The maintenance dose is 1.25 to 20 mg of regular tablets and 0.75 to 12 mg of micronized tablets given daily or in divided doses every 12 hours.
- The maximum dose is 20 mg of regular tablets and 12 mg of micronized tablets daily.
Glyburide usually is administered with the first main meal of the day.
Which drugs or supplements interact with glyburide?
Bosentan (Tracleer) may increase the breakdown of glyburide in the liver. Bosentan and glyburide should not be used together because blood levels of both drugs decrease, potentially reducing their effect, and there is an increase in liver toxicity.
Is glyburide safe to take if I'm pregnant or breastfeeding?
It is not known whether glyburide is excreted in breast milk. Since many sulfonylureas are excreted in breast milk and potentially may harm the infant, alternative diabetic therapies should be considered or breast feeding should be discontinued.
What else should I know about glyburide?
What preparations of glyburide are available?
Tablets: 1.25, 2.5, and 5 mg. Tablets (micronized): 1.5, 3, 5, and 6 mg.
How should I keep glyburide stored?
Glyburide should be stored at room temperature, 15 C - 30 C (59 F- 86 F).
Reference: FDA Prescribing Information
Glyburide (Micronase, Diabeta, Glynase Prestab) is a drug prescribed for the treatment of type 2 diabetes. It is recommended that glyburide be combined with diet and exercise for controlling blood glucose levels. Side effects, drug interactions, dosage, and safety during pregnancy should be reviewed prior to taking this medication.
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Diabetes MellitusDiabetes is a chronic condition characterized by high levels of sugar (glucose) in the blood. The two types of diabetes are referred to as type 1 (insulin dependent) and type 2 (non-insulin dependent). Symptoms of diabetes include increased urine output, thirst, hunger, and fatigue. Treatment of diabetes depends on the type.
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- and a diabetic diet.
- weight reduction,
- a diabetic diet,
- and exercise.
A diabetic diet, or diabetes diet helps keep blood glucose levels in the target range for patients. Exercise and medication may also help stabilize blood glucose levels. Keeping track of when you take your diabetic medicine, keeping track of food choices, eating the proper amount of fruits, vegetables, carbohydrates, and fats will also help maintain proper blood glucose levels. Foods that raise blood sugar levels are "high glycemic index foods;" examples include:
- Short-grain white rice
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- Many fruits
- Non-starchy vegetables
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glipizideGlipizide, (Glipizide XL, Glucotrol, Glucotrol XL) is a drug prescribed for the treatment of type 2 diabetes. Glipizide should be combined with diet and exercise for the best results. Drug interactions, warnings and precautions, patient efficacy should be reviewed prior to taking this medication.
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Type 1 vs Type 2 Diabetes Similarities Differences
Diabetes mellitus is a metabolic condition in which a person's blood sugar (glucose) levels are too high. Over 29.1 million children and adults in the US have diabetes. Of that, 8.1 million people have diabetes and don't even know it. Type 1 diabetes (insulin-dependent, juvenile) is caused by a problem with insulin production by the pancreas. Type 2 diabetes (non-insulin dependent) is caused by:
Eating a lot of foods and drinking beverages with simple carbohydrates (pizza, white breads, pastas, cereals, pastries, etc.) and simple sugars (donuts, candy, etc.)
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- Lack of activity
While the signs and symptoms of both types of diabetes are the same, which include:
- Increased urination
- Increased hunger
- Increased thirst
- Unexplained weight loss.
However, the treatments are different. Type 1 diabetes is insulin dependent, which means a person with this type of diabetes requires treatment with insulin. People with type 2 diabetes require medication, lifestyle changes like eating a healthy diet, and getting regular exercise.
Type 2 Diabetes
Type 2 diabetes is a condition in which a person's pancreas does not produce enough insulin to meet the needs of the body. Causes of type 2 diabetes are a sedentary lifestyle, eating excess sugar and carbohydrates, lack of exercise, being overweight, and genetics. Symptoms of type 2 diabetes are often subtle, but may include:
- Urine odor
- Unintentional weight gain or loss
- Frequent urination
- Dark skin under the chin, armpits, or groin
Type 2 diabetes is diagnosed by a blood test. Treatment for type 2 diabetes are a healthy type 2 diabetes diet, exercise, stress reduction, and medication. Type 2 diabetes is a preventable disease. Incorporating healthy lifestyle changes (for example, eating a healthy diet, exercising more, and reducing stress) can prevent type 2 diabetes.