- Type 2 Diabetes: Learn the Warning Signs
- Diabetes Friendly Dining
- Type 2 Diabetes: Test Your Medical IQ
- What is glyburide, and how does it work (mechanism of action)?
- What brand names are available for glyburide?
- Is glyburide available as a generic drug?
- Do I need a prescription for glyburide?
- What are the side effects of glyburide?
- What is the dosage for glyburide?
- Which drugs or supplements interact with glyburide?
- Is glyburide safe to take if I'm pregnant or breastfeeding?
- What else should I know about glyburide?
What is glyburide, and how does it work (mechanism of action)?
Glyburide is an oral, glucose-lowering drug in a class of diabetic drugs called sulfonylureas that is used for treating diabetes. Other sulfonylureas include glipizide (Glucotrol), glimepiride (Amaryl), tolbutamide (Orinase), tolazamide, and chlorpropamide (Diabinese). Insulin is a hormone that is made in the pancreas. When released into the blood, insulin reduces the formation of glucose by the liver and causes cells in the body to remove the glucose (“sugar”) from the blood. Patients with type 2 diabetes have high glucose levels in their blood because the cells in their bodies are resistant to the effect of insulin, and the pancreas cannot produce enough insulin to overcome the insulin resistance of the body's cells. As a result, their liver produces and releases too much glucose. In addition, Glyburide reduces glucose in the blood by stimulating the pancreas to produce more insulin. Glyburide is not a cure for diabetes. The FDA approved glyburide in May 1984.
What is the dosage for glyburide?
- The recommended starting dose is 2.5 to 5 mg daily of regular tablets or 1.5-3 mg daily of micronized tablets.
- The maintenance dose is 1.25 to 20 mg of regular tablets and 0.75 to 12 mg of micronized tablets given daily or in divided doses every 12 hours.
- The maximum dose is 20 mg of regular tablets and 12 mg of micronized tablets daily.
Glyburide usually is administered with the first main meal of the day.
Which drugs or supplements interact with glyburide?
Bosentan (Tracleer) may increase the breakdown of glyburide in the liver. Bosentan and glyburide should not be used together because blood levels of both drugs decrease, potentially reducing their effect, and there is an increase in liver toxicity.
Is glyburide safe to take if I'm pregnant or breastfeeding?
It is not known whether glyburide is excreted in breast milk. Since many sulfonylureas are excreted in breast milk and potentially may harm the infant, alternative diabetic therapies should be considered or breast feeding should be discontinued.
Glyburide (Micronase, Diabeta, Glynase Prestab) is a drug prescribed for the treatment of type 2 diabetes. It is recommended that glyburide be combined with diet and exercise for controlling blood glucose levels. Side effects, drug interactions, dosage, and safety during pregnancy should be reviewed prior to taking this medication.
Multimedia: Slideshows, Images & Quizzes
Related Disease Conditions
Diabetes (Type 1 and Type 2)
Diabetes is a chronic condition characterized by high levels of sugar (glucose) in the blood. The two types of diabetes are...
Low Blood Sugar (Hypoglycemia)
Low blood sugar, or hypoglycemia, is a syndrome in which a person's blood sugar is dangerously low. People with type 1 and type 2...
Tips for Managing Type 1 and 2 Diabetes at Home
Managing your diabetes is a full time commitment. The goal of diabetic therapy is to control blood glucose levels and prevent the...
Type 2 Diabetes
Type 2 diabetes is a condition in which a person's pancreas does not produce enough insulin to meet the needs of the body....
A diabetic diet, or diabetes diet helps keep blood glucose levels in the target range for patients. Exercise and medication may...
Diabetes Treatment (Type 1 and Type 2 Medications and Diet)
The major goal in treating diabetes is controlling elevated blood sugar without causing abnormally low levels of blood sugar....
Type 1 vs Type 2 Diabetes (Similarities and Differences)
Diabetes mellitus is a metabolic condition in which a person's blood sugar (glucose) levels are too high. Over 29.1 million...
Treatment & Diagnosis
- Diabetes FAQs
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Medication Disposal
- Dangers of Mixing Medications
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
Prevention & Wellness
- Metformin Still Best as First Type 2 Diabetes Treatment
- Gestational Diabetes Drug Might Raise Babies' Complication Risk
- Common Diabetes Drugs May Carry Risk, Study Suggests
- Popular Diabetes Meds Put to the Test
- Metformin Outperforms Common Class of Diabetes Drugs in Study
- Metformin: Safer for Heart Than Older Diabetes Drugs?
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.