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- What brand names are available for glimepiride?
- Is glimepiride available as a generic drug?
- Do I need a prescription for glimepiride?
- What are the uses for glimepiride?
- What are the side effects of glimepiride?
- What is the dosage for glimepiride?
- Which drugs or supplements interact with glimepiride?
- Is glimepiride safe to take if I'm pregnant or breastfeeding?
- What else should I know about glimepiride?
What are the uses for glimepiride?
What are the side effects of glimepiride?
Common side effects of glimepiride include:
Possible serious side effects of glimepiride include:
- Low blood platelets
- Low sodium
- Sensitivity to sunlight
- Liver dysfunction
- Serious allergic reactions
Low blood sugar (hypoglycemia) can occur during glimepiride therapy. Symptoms of low blood sugar include:
- Heart palpitations
- Numbness around the mouth
- Tingling in the fingers
- Muscle weakness
- Blurred vision
- Excessive yawning
- Loss of consciousness
Glimepiride is a derivative of a sulfonamide drug. People allergic to other sulfonamide-related drugs may develop an allergic reaction to glimepiride. Anyone who has an allergic reaction to sulfa drugs should not take glimepiride.
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What is the dosage for glimepiride?
Like other medicines used to treat diabetes, the dose of glimepiride is individualized using periodic measurements of blood sugar to determine the best dose. The usual starting dose is 1 or 2 mg given orally once daily with breakfast or the first major meal of the day. The dose may be increased by 1-2 mg in 1-2 weeks interval up to 8mg maximum based on blood sugar response and given once daily.
Which drugs or supplements interact with glimepiride?
- Some medications when given with glimepiride may reduce its ability to lower blood sugar. These drugs include diuretics, for example, hydrochlorothiazide (Microzide, and many combinations with other drugs), loop diuretics (for example, furosemide [Lasix]), corticosteroids such as prednisone and methylprednisolone (Medrol), phenytoin (Dilantin), colesevelam (Welchol), danazol and somatropin (Genotropin). Rifampin increases the breakdown of glimepiride by liver enzymes. This might reduce the effect of glimepiride and result in higher levels of sugar in the blood.
- Beta blockers such as propranolol (Inderal) and atenolol (Tenormin) can cause low or high blood sugar. Additionally, they can directly reverse the sugar-lowering effect of sulfonylureas and render them less effective. Beta blockers also can blunt some of the body's protective responses to low blood sugar, thus making it difficult for patients to recognize reactions due to low blood sugar (hypoglycemia).
- Certain drugs when given with glimepiride may increase the risk of low blood sugar (hypoglycemia). These include nonsteroidal anti-inflammatory drugs or NSAIDs (for example ibuprofen), sulfa drugs, warfarin (Coumadin), miconazole (Oravig), fluconazole (Diflucan), chloramphenicol, cimetidine (Tagamet HB), ranitidine (Zantac), clarithromycin (Biaxin), MAO Inhibitors (for example, isocarboxazid [Marplan] and phenelzine [Nardil]), mifepristone (Mifeprex), probenecid, quinolone antibiotics and selective serotonin reuptake inhibitors or SSRIs (for example paroxetine [Paxil], fluoxetine [Prozac] and sertraline [Zoloft]) and voriconazole (Vfend). Blood sugar should be closely monitored when interacting drugs are given with glimepiride.
- Combination glimepiride with insulin and use in patients with congestive heart failure may increase risk of other heart related side effects.
Is glimepiride safe to take if I'm pregnant or breastfeeding?
- In animal studies, glimepiride and other sulfonylureas were associated with a higher risk of fetal death. However, there have been no good studies in women. Abnormal blood sugar concentrations (high or low) during pregnancy increase the risk of abnormalities in the fetus. Therefore, physicians must carefully weigh the benefits and risks of sulfonylurea treatment during pregnancy. Insulin is the drug of choice for treating diabetes in pregnant women.
- It is not known if glimepiride is excreted in breast milk like other sulfonylureas. Because of the risk of low blood sugar in the infant, it is recommended that glimepiride be discontinued in nursing mothers. If therapy other than diet and exercise is needed, insulin is preferred.
What else should I know about glimepiride?
What preparations of glimepiride are available?
Tablets: 1, 2, and 4 mg
How should I keep glimepiride stored?
Tablets should be stored at room temperature, between 15 C and 30 C (59 F and 86 F).
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antidiabetics-oralType 2 diabetes oral medications are prescribed to treat type 2 diabetes in conjuction with lifestyle changes like diet and exercise. There are nine classes of drugs approved for the treatment of type 2 diabetes. Examples of type 2 oral diabetes medications include acarbose (Precose), chlorpropamide (Diabinese), glipizide (Glucotrol, Glucotrol XL), and metformin (Glucophage). Side effects, drug interactions, warnings and precautions, dosage, and breastfeeding and pregnancy safety information should be reviewed prior to taking any medication.
Diabetes and Eye ProblemsDiabetes and eye problems are generally caused by high blood sugar levels over an extended period of time. Types of eye problems in a person with diabetes include glaucoma, cataracts, and retinopathy. Examples of symptoms include blurred vision, headaches, eye aches, pain, halos around lights, loss of vision, watering eyes. Treatment for eye problems in people with diabetes depend on the type of eye problem. Prevention of eye problems include reducing blood pressure, cholesterol levels, quitting smoking, and maintaining proper blood glucose levels.
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Diabetes Foot ProblemsLearn more about diabetes related foot problems. For people with diabetes, too much glucose in the blood can cause serious foot complications such as nerve damage, infection, and ulcers. Find tips for proper foot care to help prevent serious complications.
Diabetes MellitusDiabetes is a chronic condition characterized by high levels of sugar (glucose) in the blood. The two types of diabetes are referred to as type 1 (insulin dependent) and type 2 (non-insulin dependent). Symptoms of diabetes include increased urine output, thirst, hunger, and fatigue. Treatment of diabetes depends on the type.
Diabetes TreatmentThe major goal in treating diabetes is controlling elevated blood sugar without causing abnormally low levels of blood sugar. Type 1 diabetes is treated with:
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- weight reduction,
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A diabetic diet, or diabetes diet helps keep blood glucose levels in the target range for patients. Exercise and medication may also help stabilize blood glucose levels. Keeping track of when you take your diabetic medicine, keeping track of food choices, eating the proper amount of fruits, vegetables, carbohydrates, and fats will also help maintain proper blood glucose levels. Foods that raise blood sugar levels are "high glycemic index foods;" examples include:
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Diabetic Home Care and MonitoringManaging your diabetes is a full time commitment. The goal of diabetic therapy is to control blood glucose levels and prevent the complications of diabetes. Information about exercise, diet, and medication will help you manage your diabetes better. Blood glucose reagent strips, blood glucose meters, urine glucose tests, tests for urinary ketones, continuous glucose sensors, and Hemoglobin A1C testing information will enable you to mange your diabetes at home successfully.
Diabetic neuropathy a condition in which nerve damage has occurred as a complication of diabetes. The pain from the nerve damage can be severe with tingling or numbness in the part of the body affected. Diabetic neuropathy can occur anywhere in the body. Diabetic neuropathy can cause symptoms like intense pain, numbness, burning, or tingling in the part of the body affected by the condition.
There are four types of neuropathy include peripheral, autonomic, proximal and focal. Natural therapies and medications may help relieve the pain and other symptoms of diabetic neuropathy.
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