Medical Definition of Gilbert syndrome

Gilbert syndrome: A common but harmless genetic condition in which UDP-glucuronosyltransferase, a liver enzyme that is essential to the disposal of bilirubin, is abnormal. Mutations in the same gene cause the Crigler-Najjar syndrome, which is a more severe and dangerous form of hyperbilirubinemia (high bilirubin in the blood). Also known as hyperbilirubinemia type 1.

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Last Editorial Review: 1/24/2017