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What is Giapreza and how does it work?
- Giapreza (angiotensin II) is a vasoconstrictor to increase blood pressure in adults with septic or other distributive shock.
- Angiotensin II is a naturally occurring peptide hormone of the renin-angiotensin-aldosterone system (RAAS) that causes vasoconstriction and an increase in blood pressure.
- Giapreza is a sterile, aqueous solution of synthetic human angiotensin II for intravenous administration by infusion.
What are the side effects of Giapreza?
Common side effects of Giapreza include:
What is the dosage for Giapreza?
- The recommended starting dosage of Giapreza is 20 nanograms (ng)/kg/min via continuous intravenous infusion.
- Administration through a central venous line is recommended.
- Monitor blood pressure response and titrate Giapreza every 5 minutes by increments of up to 15 ng/kg/min as needed to achieve or maintain target blood pressure.
- Do not exceed 80 ng/kg/min during the first 3 hours of treatment.
- Maintenance doses should not exceed 40 ng/kg/min.
- Doses as low as 1.25 ng/kg/min may be used.
- Once the underlying shock has sufficiently improved, down-titrate every 5 to 15 minutes by increments of up to 15 ng/kg/min based on blood pressure.
What drugs interact with Giapreza?
Is Giapreza safe to take when pregnant or breastfeeding?
- The published data on angiotensin II use in pregnant women are not sufficient to determine a drug-associated risk of adverse developmental outcomes.
- It is not known whether Giapreza is present in human milk.
- No data are available on the effects of angiotensin II on the breastfed child or the effects on milk production.
Giapreza (angiotensin II) is a vasoconstrictor to increase blood pressure in adults with septic or other distributive shock. Angiotensin II is a naturally occurring peptide hormone of the renin-angiotensin-aldosterone system (RAAS) that causes vasoconstriction and an increase in blood pressure.
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Related Disease Conditions
Medical shock is a life-threatening medical condition. There are several types of medical shock, including: septic shock, anaphylactic shock, cardiogenic shock, hypovolemic shock, and neurogenic shock. Causes of shock include: heart attack, heart failure, heavy bleeding (internal and external), infection, anaphylaxis, spinal cord injury, severe burns, chronic vomiting or diarrhea. Low blood pressure is the key sign of sock. Treatment is dependant upon the type of shock.
Sepsis (blood poisoning) is a potentially deadly infection with signs and symptoms that include elevated heart rate, low or high temperature, rapid breathing and/or a white blood cell count that is too high or too low and has more than 10% band cells. Most cases of sepsis are caused by bacterial infections, and some cases are caused by fungal infections. Treatment requires hospitalization, IV antibiotics, and therapy to treat any organ dysfunction.
Toxic Shock Syndrome (TSS)
Toxic shock syndrome (TSS) is an infection caused by Streptococcus or Staphylococcus. Toxic shock syndrome symptoms include low blood pressure, fever, and a rash with peeling skin. Treatment involves IV fluids to treat the shock, IV antibiotics, cleaning infected wounds, and hospitalization in the intensive care for other assorted treatments.
Is Sepsis Contagious?
Sepsis is a potentially life-threatening infection that may be caused by: bacteria, fungi, viruses, or parasites. Sepsis spreads within the body from the infection site. Treatment of sepsis typically involves the administration of intravenous medications.
Septic shock is a system-wide infection that causes low blood pressure and organ failure. Symptoms and signs include vomiting, nausea, anxiety, confusion, fever, shakes, chills, rapid heart rate, and increased breathing rate. Treatment may incorporate intravenous fluids and antibiotics and possible intubation.
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