Brand Name: Genvoya
Generic Name: elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide
Drug Class: nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs)
What is Genvoya, and how is it used?
Genvoya is a prescription medicine that is used without other antiviral medicines to treat Human Immunodeficiency Virus-1 (HIV-1) in adults and children who weigh at least 55 pounds (25 kg):
- who have not received anti-HIV-1 medicines in the past, or
- to replace their current anti-HIV-1 medicines for people whose healthcare provider determines that they meet certain requirements.
HIV-1 is the virus that causes AIDS (Acquired Immune Deficiency Syndrome).
Genvoya contains the prescription medicines elvitegravir, cobicistat, emtricitabine and tenofovir alafenamide.
What are the side effects of Genvoya?
POST TREATMENT ACUTE EXACERBATION OF HEPATITIS B
Severe acute exacerbations of hepatitis B have been reported in patients who are coinfected with HIV-1 and HBV and have discontinued products containing emtricitabine and/or tenofovir disoproxil fumarate (TDF), and may occur with discontinuation of Genvoya. Hepatic function should be monitored closely with both clinical and laboratory follow-up for at least several months in patients who are coinfected with HIV-1 and HBV and discontinue Genvoya. If appropriate, anti-hepatitis B therapy may be warranted.
Genvoya can cause serious side effects, including:
- Worsening of Hepatitis B infection. If you have hepatitis B virus (HBV) infection and take Genvoya, your HBV may get worse (flare-up) if you stop taking Genvoya. A “flare-up” is when your HBV infection suddenly returns in a worse way than before.
- Do not run out of Genvoya. Refill your prescription or talk to your healthcare provider before your Genvoya is all gone.
- Do not stop taking Genvoya without first talking to your healthcare provider. If you stop taking Genvoya, your healthcare provider will need to check your health often and do blood tests regularly for several months to check your HBV infection. Tell your healthcare provider about any new or unusual symptoms you may have after you stop taking Genvoya.
Other side effects of Genvoya
Genvoya may cause serious side effects, including:
- Changes in your immune system (Immune Reconstitution Syndrome) can happen when you start taking HIV-1 medicines. Your immune system may get stronger and begin to fight infections that have been hidden in your body for a long time. Tell your healthcare provider right away if you start having any new symptoms after starting your HIV-1 medicine.
- New or worse kidney problems, including kidney failure. Your healthcare provider should do blood and urine tests to check your kidneys when starting and during treatment with Genvoya. Your healthcare provider may tell you to stop taking Genvoya if you develop new or worse kidney problems.
- Too much lactic acid in your blood (lactic acidosis). Too much lactic acid is a serious but rare medical emergency that can lead to death. Tell your healthcare provider right away if you get these symptoms: weakness or being more tired than usual, unusual muscle pain, being short of breath or fast breathing, stomach pain with nausea and vomiting, cold or blue hands and feet, feel dizzy or lightheaded, or a fast or abnormal heartbeat.
- Severe liver problems. In rare cases, severe liver problems can happen that can lead to death. Tell your healthcare provider right away if you get these symptoms: skin or the white part of your eyes turns yellow, dark “tea-colored” urine, light-colored stools, loss of appetite for several days or longer, nausea, or stomach-area pain.
The most common side effect of Genvoya is nausea.
These are not all the possible side effects of Genvoya.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800- FDA-1088.
What is the dosage for Genvoya?
- Take Genvoya exactly as your healthcare provider tells you to take it. Genvoya is taken by itself (not with other HIV-1 medicines) to treat HIV-1 infection.
- Take Genvoya 1 time each day with food.
- If you are on dialysis, take your daily dose of Genvoya following dialysis.
- Do not change your dose or stop taking Genvoya without first talking with your healthcare provider. Stay under a healthcare provider's care during treatment with Genvoya.
- If you need to take a medicine for indigestion (antacid) that contains aluminum hydroxide, magnesium hydroxide, or calcium carbonateduring treatment with Genvoya, take it at least 2 hours before or after you take Genvoya.
- Do not miss a dose of Genvoya.
- When your Genvoya supply starts to run low, get more from your healthcare provider or pharmacy. This is very important because the amount of virus in your blood may increase if the medicine is stopped for even a short time. The virus may develop resistance to Genvoya and become harder to treat.
- If you take too much Genvoya, call your healthcare provider or go to the nearest hospital emergency room right away.
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What else should I know about Genvoya?
It is not known if Genvoya is safe and effective in children who weigh less than 55 pounds (25 kg).
Do not take Genvoya if you also take a medicine that contains:
- alfuzosin hydrochloride
- ergot-containing medicines, including:
- dihydroergotamine mesylate
- ergotamine tartrate
- methylergonovine maleate
- midazolam, when taken by mouth
- sildenafil, when used for treating the lung problem, pulmonary arterial hypertension
- St. John's wort (Hypericum perforatum) or a product that contains St. John's wort.
What should I tell my healthcare provider before taking Genvoya?
Before taking Genvoya, tell your healthcare provider about all of your medical conditions, including if you:
- have liver problems, including hepatitis B infection
- have kidney problems
- are pregnant or plan to become pregnant.
- It is not known if Genvoya can harm your unborn baby.
- Genvoya should not be used during pregnancy because you may not have enough Genvoya in your body during pregnancy.
- Tell your healthcare provider if you become pregnant during treatment with Genvoya. Your healthcare provider may prescribe different medicines if you become pregnant while taking Genvoya.
- Pregnancy Registry: There is a pregnancy registry for women who take antiretroviral medicines during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. Talk with your healthcare provider about how you can take part in this registry.
- are breastfeeding or plan to breastfeed. Do not breastfeed if you take Genvoya.
- You should not breastfeed if you have HIV-1 because of the risk of passing HIV-1 to your baby.
- At least one of the medicines in Genvoya can pass to your baby in your breast milk. It is not known if the other medicines in Genvoya can pass into your breast milk.
Talk with your healthcare provider about the best way to feed your baby during treatment with Genvoya.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Some medicines may interact with Genvoya. Keep a list of your medicines and show it to your healthcare provider and pharmacist when you get a new medicine.
- You can ask your healthcare provider or pharmacist for a list of medicines that interact with Genvoya.
- Do not start a new medicine without telling your healthcare provider. Your healthcare provider can tell you if it is safe to take Genvoya with other medicines.
Genvoya is a prescription medicine that is used without other antiviral medicines to treat Human Immunodeficiency Virus-1 (HIV-1) in adults and children. The most common side effect of Genvoya is nausea. Genvoya may cause serious side effects, including changes in your immune system (Immune Reconstitution Syndrome), new or worse kidney problems, including kidney failure, too much lactic acid in your blood (lactic acidosis), and severe liver problems.
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Detectable viral load is defined as having more than 200 copies of the human immunodeficiency virus (HIV) per milliliter of blood.
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HIV (human immunodeficiency virus) infection left untreated causes AIDS (acquired immunodeficiency syndrome). The human immunodeficiency virus (HIV) is a type of virus called a retrovirus, which can infect humans when it comes in contact with tissues that line the vagina, anal area, mouth, or eyes, or through a break in the skin. HIV infection is generally a slowly progressive disease in which the virus is present throughout the body at all stages of the disease. Three stages of HIV infection have been described. The initial stage of infection (primary infection), which occurs within weeks of acquiring the virus, often is characterized by the flu- or mono-like illness that generally resolves within weeks. The stage of chronic asymptomatic infection (meaning a long duration of infection without symptoms) lasts an average of eight to 10 years without treatment. The stage of symptomatic infection, in which the body's immune (or defense) system has been suppressed and complications have developed, is called the acquired immunodeficiency syndrome (AIDS). The symptoms are caused by the complications of AIDS, which include one or more unusual infections or cancers, severe loss of weight, and intellectual deterioration (called dementia). When HIV grows (that is, by reproducing itself), it acquires the ability to change (mutate) its own structure. These mutations enable the virus to become resistant to previously effective drug therapy. The goals of drug therapy are to prevent damage to the immune system by the HIV virus and to halt or delay the progress of the infection to symptomatic disease. Therapy for HIV includes combinations of drugs that decrease the growth of the virus to such an extent that the treatment prevents or markedly delays the development of viral resistance to the drugs. The best combination of drugs for HIV are those that effectively suppress viral replication in the blood and also are well tolerated and simple to take so that people can take the medications consistently without missing doses.
What Foods Should HIV Patients Avoid?
People living with HIV face several health challenges because their bodies must work harder to fight infections. HIV patients should avoid foods high in sodium, sugar, and trans and saturated fats.
Can the HIV Virus Go Away?
There is no cure or vaccine for human immunodeficiency virus (HIV) infection; however, early treatment can help increase the life expectancy of infected people.
Can I Get HIV From Surfaces?
Studies proved that HIV cannot be transmitted through surfaces such as toilet seats, chairs, doorknobs, drinking glasses and bedsheets. The virus cannot survive outside a human host; hence, transmission through air, water (swimming pools), insect bite or casual contacts such as handshake, hug or touch is not possible.
Is It Possible for HIV to Go Away on Its Own?
When a person contracts the human immunodeficiency virus (HIV), they are infected for life; however, early treatment can help them live normal lives.
HIV vs. AIDS
Human immunodeficiency virus causes HIV infection. Acquired immunodeficiency syndrome (AIDS) is a condition that results after HIV has extensively damaged a person's immune system. Risk factors for HIV and AIDS include use of contaminated needles or syringes, unprotected sex, STDs, receiving a blood transfusion prior to 1985 in the United States, having many sex partners, and transmission from a mother to her child.
Can HIV be Cured Naturally?
HIV stands for human immunodeficiency virus. If someone has HIV it means that they have been diagnosed with the HIV infection. AIDS (acquired immune deficiency syndrome); however, is the most advanced or final stage of the HIV infection. It is important to get tested for HIV in the early stages of infection to minimize the damage to the immune system. Successful treatment aims to reduce HIV load to a level that is harmless to the body.
Can I Test HIV Positive If My Viral Load is Undetectable?
You can still test positive for the human immunodeficiency virus (HIV) even if your viral load is undetectable.
Can I Get HIV From Casual Contact Like Hugging or Touching?
Human immunodeficiency virus (HIV) cannot spread through casual contact such as hugging or touching. HIV does not spread through urine, saliva, tears, sweat, kissing (closed mouth or social kissing), shaking hands, sharing utensils, sharing food or drinks, sharing clothes, or from toilet seats. HIV is spread through bodily fluids from a person with HIV.
HIV Medications List and Drug Charts
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As of now, there is no permanent HIV cure, but antiretroviral treatment can effectively control HIV.
HIV/AIDS Infection Transmission and Prevention
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HIV/AIDS Facts: What Is HIV?
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HIV Life Expectancy and Long-term Outlook
With early diagnosis and proper treatment, people with HIV can live a healthy and long life. There is no generalized definitive period for which a person with HIV can live.
What Does HIV Do to a Person?
Human immunodeficiency virus (HIV) attacks and weakens the immune system, impairing the body's ability to fight diseases and infections.
When should you start HIV medication?
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What Is the Difference Between HIV and AIDS?
HIV is a virus that causes immunosuppression. The difference between HIV and AIDS is that HIV is the first stage of the viral illness while AIDS represents the progression of the illness.
How Many HIV Treatments Are There?
Treatment for human immunodeficiency virus (HIV) often involves a combination of anti-HIV drugs. There are 7 HIV drug classes based on how they fight HIV.
How Is HIV Currently Being Treated?
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