- What is Gardasil Vaccine (HPV), and how does it work (mechanism of action)?
- What brand names are available for Gardasil Vaccine (HPV)?
- Is Gardasil Vaccine (HPV) available as a generic drug?
- Do I need a prescription for Gardasil Vaccine (HPV)?
- What are the side effects of Gardasil Vaccine (HPV)?
- What is the dosage for Gardasil Vaccine (HPV)?
- Which drugs or supplements interact with Gardasil Vaccine (HPV)?
- Is Gardasil Vaccine (HPV) safe to take if I'm pregnant or breastfeeding?
- What else should I know about Gardasil Vaccine (HPV)?
What is Gardasil Vaccine (HPV), and how does it work (mechanism of action)?
Gardasil is a human papillomavirus (HPV) vaccine. Gardasil is a sterile preparation for intramuscular injection and contains purified inactive proteins from HPV types 6, 11, 16, and 18. The proteins in Gardasil are structural, virus-like proteins (VLP) that resemble the HPV virus. The proteins can activate the immune system but cannot give rise to replicating virus. Viral proteins used in Gardasil are manufactured in yeast cells (S. cerevisiae) using recombinant technology. Once released from yeast cells, the VLPs are purified, combined with a catalyst (amorphous aluminum hydroxyphosphate sulfate) and a purification buffer. Human papillomavirus causes cervical cancer, cervical adenocarcinoma, vaginal cancer, genital warts, and anal cancer. Gardasil works by stimulating the immune system to attack HPV types 6, 11, 16, and 18. Once Gardasil is administered, the body's immune system recognizes the viral proteins in Gardasil as foreign, and develops antibodies against them, thus providing immunity from future infections. In the event of HPV exposure following vaccination, the body will already be primed to fight the infection. HPV types 6, 11, 16, and 18 are commonly associated with HPV infections. HPV 16 and 18 cause 70% of cervical cancer and HPV 6, 11, 16 and 18 cause approximately 90% of genital warts. The FDA approved Gardasil in June 2007.
What are the side effects of Gardasil Vaccine (HPV)?
The most common side effects of Gardasil are:
- mild or moderate pain,
- itching, and
- redness at the injection site.
Other important side effects include:
People allergic to any component in Gardasil should not use Gardasil.
Quick GuideSTD Diagnosis, Images, Symptoms, Treatment
What is the dosage for Gardasil Vaccine (HPV)?
Gardasil 0.5 ml is injected intramuscularly as three separate doses. The first dose is administered at the patient's convenience, the second dose two months after the first dose, and the third dose six months after the first dose.
Which drugs or supplements interact with Gardasil Vaccine (HPV)?
Gardasil may be administered concomitantly (at different sites) with hepatitis B vaccine, Menactra (Meningococcal Polysaccharide Diphtheria Toxoid Conjugate Vaccine), and Adacel (Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed). The use of immunosuppressive drugs reduces the efficacy of Gardasil. Hormonal contraceptives do not interact with Gardasil.
Is Gardasil Vaccine (HPV) safe to take if I'm pregnant or breastfeeding?
Gardasil has not been adequately evaluated in pregnant women. It should only be used in pregnant women if it is clearly needed.
It is not known whether Gardasil or the antibodies induced by Gardasil are excreted in breast milk.
What else should I know about Gardasil Vaccine (HPV)?
What preparations of Gardasil Vaccine (HPV) are available?
Injection: 0.5 ml single-dose vial and pre-filled syringe
How should I keep Gardasil Vaccine (HPV) stored?
Gardasil should be stored refrigerated at 2 C to 8 C (36 F to 46 F) and should be protected from light and not frozen.
Gardasil HPV Vaccine (Recombinant Human Papillomavirus Quadrivalent Vaccine) is a vaccine synthesized using recombinant technology. Gardasil is a single dose injection. Gardasil is for the prevention of HPV types 6, 11, 16, and 18 infections in girls and women aged 9 to 26 years. Gardasil also approved for preventing genital warts caused by HPV types 6 and 11 in males aged 9 to 26 years. Gardasil protects against cervical cancer, abnormal or precancerous cervical, vaginal, or vulvar lesions, and genital warts. Side effects of Gardasil include fever, vomiting, nausea, fainting, dizziness, pain, swelling, itching, or redness at the site of injection.
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CancerCancer is a disease caused by an abnormal growth of cells, also called malignancy. It is a group of 100 different diseases, and is not contagious. Cancer can be treated through chemotherapy, a treatment of drugs that destroy cancer cells.
Cervical CancerCervical cancer is cancer of the entrance to the womb (uterus). Regular pelvic exams and Pap testing can detect precancerous changes in the cervix. Precancerous changes in the cervix may be treated with cryosurgery, cauterization, or laser surgery. The most common symptom of cancer of the cervix is abnormal bleeding.
Cervical Cancer SlidesCervical cancer is commonly caused by human papillomavirus (HPV) infections. Learn about vaccines to prevent cervical cancer. Get information about cervical cancer symptoms, stages, life expectancy, and available treatment options.
Childhood Vaccination ScheduleChildhood immunizations can protect children from potentially deadly diseases. Vaccinations included on the childhood immunization schedule include Hib, polio, DTaP, MMR, HPV, flu, chickenpox, meningitis, rotavirus, pneumonia, hepatitis A, and hepatitis B.
Female Screening TestsWhat is a health screening? Why is it important to know your blood pressure? How long will your health screening take? Learn about wellness screenings for women for breast cancer, HIV, diabetes, osteoporosis, skin cancer, and more.
Gardasil HPV VaccineGardasil is the first vaccine available on the market to prevent cervical cancer, genital warts, and precancerous genital lesions due to HPV. The CDC recommends the HPV vaccine for girls 11 and 12 years of age. Girls as young as nine may begin the vaccine. The vaccine is also recommended for females between the ages of 13 through 26 who have not been previously vaccinated.
Genital Warts PicturesA wart in the moist skin of the genitals or around the anus. See a picture of Genital Warts (HPV) and learn more about the health topic.
Genital Warts In WomenGenital warts is a sexually transmitted infection (STI, STD) caused by the human papillomavirus (HPV). It is the most common STD in the US. The warts can appear anywhere on the skin where sexual contact has occurred.
The warts look like raised, flesh-colored lumps or bumps that have a cauliflower-like appearance. Signs and symptoms of genital warts in women include vaginal, vulva, or groin pain, itching, and burning where the wart(s) is.
Treatment can remove warts or lesions, but it does not prevent spread of the virus, and the warts usually grow back. Removing genital warts does not prevent the infection from spreading elsewhere on the body.
There is no cure for genital warts, and there is no vaccine to prevent them; however, there is a vaccine to prevent infection from four common types of HPV. Gardasil vaccine available for female adolescents and teens to prevent HPV infection and cervical cancer.
HPV Infection Human Papillomavirus
HPVs or human papillomaviruses are a group of viral infections of the skin and mucous membranes. Certain high-risk types of HPV infection cause certain cancers (cervical, penile, anal, vaginal, and oral). There are no signs or symptoms of HPV infection.
HPV infection is an extremely common STD, and is highly contagious. A person is at a higher risk of getting HPV infection if they
- have a number of different sex partners;
- have a weakened immune system (for example, HIV/AIDS); or
- has breaks in the skin (cuts or abrasions) that come into contact with an infected person or contaminated surface.
HPV vaccinations are available to prevent HPV infection. Treatment for HPV infection are antiviral medications. There is no cure for HPV infection.
ImmunizationsImmunizations can prevent many diseases nowadays. It's important to follow the vaccination guidelines recommended on the CDC's vaccination schedule for adults and adolescents in order to stay informed about new vaccines and to learn how often and when the vaccines should be administered.
Pap SmearA Pap smear (Pap test) is a medical procedure to screen for abnormal cells of the cervix. A woman should have her first Pap smear (in general) three years after vaginal intercourse, or no later than 21 years of age. The risks for women at increased risk for having an abnormal Pap smear include: HPV (genital warts), smoking, a weakened immune system, medications (diethylstilbestrol), and others. Some of the conditions that may result in an abnormal Pap smear include: absence of endocervical cells, unreliable Pap smear due to inflammation, atypical squamous cells (ASCUS), low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL), cervical intraepithelial neoplasia (CIN), and carcinoma in situ.
Sexually Transmitted Diseases (STDs In Women)
Sexually transmitted diseases, or STDs, are infections that are transmitted during any type of sexual exposure, including intercourse (vaginal or anal), oral sex, and the sharing of sexual devices, such as vibrators. Women can contract all of the STDs, but may have no symptoms, or have different symptoms than men do. Common STDs in women are:
- Zika virus
- Genital herpes
- Hepatitis B
- Hepatitis C
- Pubic lice
- Genital warts
Treatment for STDs depends upon the type.
STDs in Men Overview
Sexually transmitted diseases (STDs) are infections transmitted during sexual contact. They may be caused by viruses, bacteria, or parasites. STDs in men cause no symptoms or symptoms like
genital burning, itching, sores, rashes, or discharge.
Common infections that are sexually transmitted in men include gonorrhea, chlamydia, syphilis, hepatitis C and B, genital warts, human papillomavirus (HPV), and genital herpes.
Some STDs in men are treatable while others are not. STDs are diagnosed with tests that identify proteins or genetic material of the organisms causing the infection. The prognosis of an STD depends on whether the infection is treatable or not. Use of latex condoms can help reduce the risk of contracting an STD but it does not eliminate the risk entirely.
Viral InfectionsWatch this slideshow on Viral Infections and learn about types, treatment, and prevention of illnesses caused by viruses.