- What is Gardasil Vaccine (HPV), and how does it work (mechanism of action)?
- What are the uses for Gardasil Vaccine (HPV)?
- What are the side effects of Gardasil Vaccine (HPV)?
- What is the dosage for Gardasil Vaccine (HPV)?
- Which drugs or supplements interact with Gardasil Vaccine (HPV)?
- Is Gardasil Vaccine (HPV) safe to take if I'm pregnant or breastfeeding?
- What else should I know about Gardasil Vaccine (HPV)?
What is Gardasil Vaccine (HPV), and how does it work (mechanism of action)?
Gardasil is a human papillomavirus (HPV) vaccine. Gardasil is a sterile preparation for intramuscular injection and contains purified inactive proteins from HPV types 6, 11, 16, and 18. The proteins in Gardasil are structural, virus-like proteins (VLP) that resemble the HPV virus. The proteins can activate the immune system but cannot give rise to replicating virus. Viral proteins used in Gardasil are manufactured in yeast cells (S. cerevisiae) using recombinant technology. Once released from yeast cells, the VLPs are purified, combined with a catalyst (amorphous aluminum hydroxyphosphate sulfate) and a purification buffer. Human papillomavirus causes cervical cancer, cervical adenocarcinoma, vaginal cancer, genital warts, and anal cancer. Gardasil works by stimulating the immune system to attack HPV types 6, 11, 16, and 18. Once Gardasil is administered, the body's immune system recognizes the viral proteins in Gardasil as foreign, and develops antibodies against them, thus providing immunity from future infections. In the event of HPV exposure following vaccination, the body will already be primed to fight the infection. HPV types 6, 11, 16, and 18 are commonly associated with HPV infections. HPV 16 and 18 cause 70% of cervical cancer and HPV 6, 11, 16 and 18 cause approximately 90% of genital warts. The FDA approved Gardasil in June 2007.
What brand names are available for Gardasil Vaccine (HPV)?
Is Gardasil Vaccine (HPV) available as a generic drug?
GENERIC AVAILABLE: No
Do I need a prescription for Gardasil Vaccine (HPV)?
What are the uses for Gardasil Vaccine (HPV)?
In girls and women
Gardasil is a vaccine used in girls and women 9 through 26 years of age for the prevention of the following diseases caused by Human Papillomavirus (HPV):
And the following precancerous or dysplastic lesions:
- Cervical intraepithelial neoplasia (CIN)
- Cervical adenocarcinoma in situ (AIS)
- Vulvar intraepithelial neoplasia (VIN)
- Vaginal intraepithelial neoplasia (VaIN)
- Anal intraepithelial neoplasia (AIN)
In boys and men
Gardasil is used in boys and men 9 through 26 years of age for the prevention of the following diseases caused by HPV:
And the following precancerous or dysplastic lesions:
- Anal intraepithelial neoplasia (AIN)
What are the side effects of Gardasil Vaccine (HPV)?
The most common side effects of Gardasil are:
- mild or moderate pain,
- itching, and
- redness at the injection site.
Other important side effects include:
People allergic to any component in Gardasil should not use Gardasil.
What is the dosage for Gardasil Vaccine (HPV)?
Gardasil 0.5 ml is injected intramuscularly as three separate doses. The first dose is administered at the patient's convenience, the second dose two months after the first dose, and the third dose six months after the first dose.
Which drugs or supplements interact with Gardasil Vaccine (HPV)?
Gardasil may be administered concomitantly (at different sites) with hepatitis B vaccine, Menactra (Meningococcal Polysaccharide Diphtheria Toxoid Conjugate Vaccine), and Adacel (Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed). The use of immunosuppressive drugs reduces the efficacy of Gardasil. Hormonal contraceptives do not interact with Gardasil.
Is Gardasil Vaccine (HPV) safe to take if I'm pregnant or breastfeeding?
Gardasil has not been adequately evaluated in pregnant women. It should only be used in pregnant women if it is clearly needed.
It is not known whether Gardasil or the antibodies induced by Gardasil are excreted in breast milk.
What else should I know about Gardasil Vaccine (HPV)?
What preparations of Gardasil Vaccine (HPV) are available?
Injection: 0.5 ml single-dose vial and pre-filled syringe
How should I keep Gardasil Vaccine (HPV) stored?
Gardasil should be stored refrigerated at 2 C to 8 C (36 F to 46 F) and should be protected from light and not frozen.
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Gardasil HPV Vaccine (Recombinant Human Papillomavirus Quadrivalent Vaccine) is a vaccine synthesized using recombinant technology. Gardasil is a single dose injection. Gardasil is for the prevention of HPV types 6, 11, 16, and 18 infections in girls and women aged 9 to 26 years. Gardasil also approved for preventing genital warts caused by HPV types 6 and 11 in males aged 9 to 26 years. Gardasil protects against cervical cancer, abnormal or precancerous cervical, vaginal, or vulvar lesions, and genital warts. Side effects of Gardasil include fever, vomiting, nausea, fainting, dizziness, pain, swelling, itching, or redness at the site of injection.
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Related Disease Conditions
STDs in Men
Sexually transmitted diseases (STDs) are infections transmitted during sexual contact. They may be caused by viruses, bacteria, or parasites. STDs in men cause no symptoms or symptoms like genital burning, itching, sores, rashes, or discharge. Common infections that are sexually transmitted in men include gonorrhea, chlamydia, syphilis, hepatitis C and B, genital warts, human papillomavirus (HPV), and genital herpes. Some STDs in men are treatable while others are not. STDs are diagnosed with tests that identify proteins or genetic material of the organisms causing the infection. The prognosis of an STD depends on whether the infection is treatable or not. Use of latex condoms can help reduce the risk of contracting an STD but it does not eliminate the risk entirely.
Genital Warts (HPV) Infection in Women
Genital warts is a sexually transmitted infection (STI, STD) caused by the human papillomavirus (HPV). It is the most common STD in the US. The warts can appear anywhere on the skin where sexual contact has occurred. The warts look like raised, flesh-colored lumps or bumps that have a cauliflower-like appearance. Signs and symptoms of genital warts in women include vaginal, vulva, or groin pain, itching, and burning where the wart(s) is. Treatment can remove warts or lesions, but it does not prevent spread of the virus, and the warts usually grow back. Removing genital warts does not prevent the infection from spreading elsewhere on the body. There is no cure for genital warts, and there is no vaccine to prevent them; however, there is a vaccine to prevent infection from four common types of HPV. Gardasil vaccine available for female adolescents and teens to prevent HPV infection and cervical cancer.
Cancer is a disease caused by an abnormal growth of cells, also called malignancy. It is a group of 100 different diseases, and is not contagious. Cancer can be treated through chemotherapy, a treatment of drugs that destroy cancer cells.
Sexually Transmitted Diseases in Women (STD)
Sexually transmitted diseases (STDs) are among the most common infectious diseases in the United States. STDs can be spread through any type of sexual activity involving the sex organs, the anus or mouth, or through contact with blood during sexual activity. Examples of STDs include, chancroid, chlamydia, gonorrhea, granuloma inguinale, lymphogranuloma venereum, syphilis, genital herpes, genital warts, hepatitis B, trichomoniasis, pubic lice (crabs), and scabies.Treatment is generally with antibiotics; however, some STDs that go untreated can lead to death.
Cervical Cancer (Cancer of the Cervix)
Cervical cancer is cancer of the entrance to the womb (uterus). Regular pelvic exams and Pap testing can detect precancerous changes in the cervix. Precancerous changes in the cervix may be treated with cryosurgery, cauterization, or laser surgery. The most common symptom of cancer of the cervix is abnormal bleeding.
HPV (Human Papillomavirus) Infection
HPVs or human papillomaviruses are a group of viral infections of the skin and mucous membranes. Certain high-risk types of HPV infection cause certain cancers (cervical, penile, anal, vaginal, and oral). There are no signs or symptoms of HPV infection. HPV infection is an extremely common STD, and is highly contagious. A person is at a higher risk of getting HPV infection if they have a number of different sex partners; have a weakened immune system (for example, HIV/AIDS); or has breaks in the skin (cuts or abrasions) that come into contact with an infected person or contaminated surface. HPV vaccinations are available to prevent HPV infection. Treatment for HPV infection are antiviral medications. There is no cure for HPV infection.
Anal cancer, cancer located at the end of the large intestine, has symptoms that include anal or rectal bleeding, anal pain or pressure, anal discharge or itching, a change in bowel movements, and/or a lump in the anal region. Treatment for anal cancer may involve radiation, chemotherapy, or surgery and depends upon the stage of the cancer, its location, whether cancer is eradicated after the first treatment, and whether the patient has HIV.
Cervical dysplasia is a condition in which the cells of the inner lining of the cervix have precancerous changes. There are two types of cervical dysplasia; 1) squamous intraepithelial lesion, and 2) cervical intraepithelial neoplasia. Cervical dysplasia is caused by infection of the cervix with HPV (human papillomavirus). There are various diagnostic measures for cervical dysplasia. Treatment generally depends upon the progression of the dysplasia: mild, moderate, or severe.
Vaginal cancer is fairly uncommon. There are two types of vaginal cancer: squamous cell carcinoma and adenocarcinoma. Risk factors include being 60 or older, exposure to DES while in the womb, HPV infection, and having a history of abnormal cervical cells. Painful intercourse, pelvic pain, vaginal lumps, and abnormal vaginal bleeding or discharge are all symptoms of vaginal cancer. Treatment depends upon the stage of the vaginal cancer and may involve surgery, radiation therapy, chemotherapy, and the use of radiosensitizers.
Children's health is focused on the well-being of children from conception through adolescence. There are many aspects of children's health, including growth and development, illnesses, injuries, behavior, mental illness, family health, and community health.
Women's health is an important topic area to guide a woman through the stages of her life, as well as knowing the conditions and diseases that may occur. Educating yourself so that the transitions into different phases of life is key to a healthy, happy, and productive life.
Genital Warts in Men (HPV)
The HPV virus (genital warts) in men can cause health problems. Genital warts are confined primarily to the moist skin of the genitals or around the anus. Genital warts are caused by the human papillomaviruses (HPVs), which are transmitted through sexual contact.
Disease Prevention for Teens
Teenagers recognize that they are developmentally between child and adult. Teen health prevention includes maintaining a healthy diet, exercising regularly, preventing injuries and screening annually for potential health conditions that could adversely affect teenage health.
Sexually Transmitted Diseases and Pregnancy (STDs)
When you are pregnant, many sexually transmitted diseases (STDs) can be especially harmful to you and your baby. These STDs include herpes, HIV/AIDS, genital warts (HPV), hepatitis B, chlamydia, syphilis, gonorrhea, and trichomoniasis. Symptoms include bumps, sores, warts, swelling, itching, or redness in the genital region. Treatment of STDs while pregnant depends on how far along you are in the pregnancy and the progression of the infection.
Certain behavioral, lifestyle, and environmental factors contribute to cancer. Cancer prevention involves modifying these factors to decrease cancer risk. Tobacco use, alcohol consumption, physical inactivity, inadequate fruit and vegetable intake, and obesity increase the risk of certain cancers. Vaccines, genetic testing, and cancer screening also play a role in cancer prevention.
Disease Prevention in Women
Disease prevention in women includes screening tests that are a basic part of prevention medicine. All screening tests are commonly available through your general doctor. Some specialized tests may be available elsewhere.
Treatment & Diagnosis
Medications & Supplements
Prevention & Wellness
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