- What is Gardasil Vaccine (HPV), and how does it work (mechanism of action)?
- What brand names are available for Gardasil Vaccine (HPV)?
- Is Gardasil Vaccine (HPV) available as a generic drug?
- Do I need a prescription for Gardasil Vaccine (HPV)?
- What are the side effects of Gardasil Vaccine (HPV)?
- What is the dosage for Gardasil Vaccine (HPV)?
- Which drugs or supplements interact with Gardasil Vaccine (HPV)?
- Is Gardasil Vaccine (HPV) safe to take if I'm pregnant or breastfeeding?
- What else should I know about Gardasil Vaccine (HPV)?
What is Gardasil Vaccine (HPV), and how does it work (mechanism of action)?
Gardasil is a human papillomavirus (HPV) vaccine. Gardasil is a sterile preparation for intramuscular injection and contains purified inactive proteins from HPV types 6, 11, 16, and 18. The proteins in Gardasil are structural, virus-like proteins (VLP) that resemble the HPV virus. The proteins can activate the immune system but cannot give rise to replicating virus. Viral proteins used in Gardasil are manufactured in yeast cells (S. cerevisiae) using recombinant technology. Once released from yeast cells, the VLPs are purified, combined with a catalyst (amorphous aluminum hydroxyphosphate sulfate) and a purification buffer. Human papillomavirus causes cervical cancer, cervical adenocarcinoma, vaginal cancer, genital warts, and anal cancer. Gardasil works by stimulating the immune system to attack HPV types 6, 11, 16, and 18. Once Gardasil is administered, the body's immune system recognizes the viral proteins in Gardasil as foreign, and develops antibodies against them, thus providing immunity from future infections. In the event of HPV exposure following vaccination, the body will already be primed to fight the infection. HPV types 6, 11, 16, and 18 are commonly associated with HPV infections. HPV 16 and 18 cause 70% of cervical cancer and HPV 6, 11, 16 and 18 cause approximately 90% of genital warts. The FDA approved Gardasil in June 2007.
What are the side effects of Gardasil Vaccine (HPV)?
The most common side effects of Gardasil are:
- mild or moderate pain,
- itching, and
- redness at the injection site.
Other important side effects include:
People allergic to any component in Gardasil should not use Gardasil.
What is the dosage for Gardasil Vaccine (HPV)?
Gardasil 0.5 ml is injected intramuscularly as three separate doses. The first dose is administered at the patient's convenience, the second dose two months after the first dose, and the third dose six months after the first dose.
Which drugs or supplements interact with Gardasil Vaccine (HPV)?
Gardasil may be administered concomitantly (at different sites) with hepatitis B vaccine, Menactra (Meningococcal Polysaccharide Diphtheria Toxoid Conjugate Vaccine), and Adacel (Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed). The use of immunosuppressive drugs reduces the efficacy of Gardasil. Hormonal contraceptives do not interact with Gardasil.
Is Gardasil Vaccine (HPV) safe to take if I'm pregnant or breastfeeding?
Gardasil has not been adequately evaluated in pregnant women. It should only be used in pregnant women if it is clearly needed.
It is not known whether Gardasil or the antibodies induced by Gardasil are excreted in breast milk.
What else should I know about Gardasil Vaccine (HPV)?
What preparations of Gardasil Vaccine (HPV) are available?
Injection: 0.5 ml single-dose vial and pre-filled syringe
How should I keep Gardasil Vaccine (HPV) stored?
Gardasil should be stored refrigerated at 2 C to 8 C (36 F to 46 F) and should be protected from light and not frozen.
Gardasil HPV Vaccine (Recombinant Human Papillomavirus Quadrivalent Vaccine) is a vaccine synthesized using recombinant technology. Gardasil is a single dose injection. Gardasil is for the prevention of HPV types 6, 11, 16, and 18 infections in girls and women aged 9 to 26 years. Gardasil also approved for preventing genital warts caused by HPV types 6 and 11 in males aged 9 to 26 years. Gardasil protects against cervical cancer, abnormal or precancerous cervical, vaginal, or vulvar lesions, and genital warts. Side effects of Gardasil include fever, vomiting, nausea, fainting, dizziness, pain, swelling, itching, or redness at the site of injection.
Multimedia: Slideshows, Images & Quizzes
Picture of Genital Warts (HPV)
A wart in the moist skin of the genitals or around the anus. See a picture of Genital Warts (HPV) and learn more about the health...
Viral Infection Types, Treatment, and Prevention
Watch this slideshow on Viral Infections and learn about types, treatment, and prevention of illnesses caused by viruses....
Cervical Cancer Symptoms, Stages, and Treatment
Cervical cancer is commonly caused by human papillomavirus (HPV) infections. Learn about vaccines to prevent cervical cancer. Get...
Health Screening Tests Every Woman Needs
What is a health screening? Why is it important to know your blood pressure? How long will your health screening take? Learn...
Related Disease Conditions
STDs in Men
Sexually transmitted diseases (STDs) are infections transmitted during sexual contact. They may be caused by viruses, bacteria,...
Genital Warts (HPV) Infection in Women
Genital warts is a sexually transmitted infection (STI, STD) caused by the human papillomavirus (HPV). It is the most common STD...
Cancer is a disease caused by an abnormal growth of cells, also called malignancy. It is a group of 100 different diseases, and...
Cervical Cancer (Cancer of the Cervix)
Cervical cancer is cancer of the entrance to the womb (uterus). Regular pelvic exams and Pap testing can detect precancerous...
Sexually Transmitted Diseases in Women (STD)
Sexually transmitted diseases (STDs) are among the most common infectious diseases in the United States. STDs can be spread...
Cervical dysplasia is a condition in which the cells of the inner lining of the cervix have precancerous changes. There are two...
HPV (Human Papillomavirus Infection)
HPVs or human papillomaviruses are a group of viral infections of the skin and mucous membranes. Certain high-risk types of HPV...
Anal cancer, cancer located at the end of the large intestine, has symptoms that include anal or rectal bleeding, anal pain or...
Children's health is focused on the well-being of children from conception through adolescence. There are many aspects of...
Women's health is an important topic area to guide a woman through the stages of her life, as well as knowing the conditions and...
Vaginal cancer is fairly uncommon. There are two types of vaginal cancer: squamous cell carcinoma and adenocarcinoma. Risk...
Genital Warts in Men (HPV)
The HPV virus (genital warts) in men can cause health problems. Genital warts are confined primarily to the moist skin of the...
Teenagers recognize that they are developmentally between child and adult. Teen health prevention includes maintaining a healthy...
Certain behavioral, lifestyle, and environmental factors contribute to cancer. Cancer prevention involves modifying these factors...
Sexually Transmitted Diseases and Pregnancy (STDs)
When you are pregnant, many sexually transmitted diseases (STDs) can be especially harmful to you and your baby. These STDs...
Disease Prevention in Women
Disease prevention in women includes screening tests that are a basic part of prevention medicine. All screening tests are...
Treatment & Diagnosis
Medications & Supplements
Prevention & Wellness
- Teen Who Defied Mom to Get Vaccinated Testifies Before Congress
- Still Too Few Teens Getting the HPV Vaccine
- Vaccines: Not Just for Kids
- HPV Vaccination Rates Continue to Lag in U.S.
- How Necessary Is HPV Cervical Cancer Screening for Women After Age 55?
- The Real Reasons Parents Refuse HPV Vaccination
- Preteens' HPV Shot Won't Encourage Early Sex, Study Says
- HPV Vaccine Approved for People Through Age 45
- FDA Expands Gardasil to Cover Adults to Age 45
- HPV Vaccination Rates Rising Among U.S. Teens
- Promoting HPV Vaccine Doesn't Prompt Risky Sex by Teens: Study
- Catch-Up HPV Shots Work for Teen Girls
- Why More Teens Aren't Getting Protection Against Common STD
- Many Doctors Don't Push HPV Shots Equally. See Who's Left Out
- HPV Vaccine Safe for Adult Women: Study
- 1 in 9 American Men Infected With Oral HPV
- Cancer Experts Endorse CDC's HPV Vaccine Guidelines
- Study Hints at HPV Vaccine's Cancer Prevention Promise
- HPV Vaccine Rates Highest in Poor and Hispanic Communities: Study
- Too Few Preteen Girls Get HPV Vaccine, CDC Says
- Too Few Boys Get HPV Vaccine, CDC Study Finds
- HPV Vaccination Tied to Drop in Precancerous Cervical Lesions in U.S.
- College Kids Don't Understand the HPV Threat
- E-Reminders May Boost HPV Vaccination Rates
- HPV Vaccine Produces Early Benefits for Teen Girls: Study
- Study Supports HPV Vaccination Guidelines
- HPV Vaccination Does Not Appear to Boost Risky Teen Sex, Study Shows
- Many U.S. Girls Aren't Getting HPV Vaccine, Study Finds
- Study: HPV Vaccine Doesn't Increase Risk for Multiple Sclerosis
- HPV Vaccination Rates Lowest in States With Highest Cervical Cancer Rates: Study
- Too Few Teens Receive HPV Shot, CDC Says
- Cervical Cancer Vaccine Doesn't Boost Clot Risk: Study
- Study Adds to Evidence That HPV Vaccine Helps Guard Against Cervical Cancer
- Partial HPV Vaccine Series May Help Prevent Genital Warts in Girls
- President's Panel Calls for More Girls, Boys to Get HPV Vaccine
- HPV Vaccination Rates Might Rise If More Docs Recommended It
- Many Young Americans Know Little About Cervical Cancer Vaccine
- Single Dose of HPV Vaccine May Be Enough to Guard Against Cervical Cancer
- HPV Vaccine Might Shield Women Against Throat Cancer: Study
- U.K. Experts Urge HPV Vaccine for Young Gay Men
- Girls May Need Fewer Gardasil Shots, Study Suggests
- HPV Vaccination Sends Genital Wart Cases Plummeting: Study
- Parents' Worries About HPV Vaccine on the Rise: Study
- For One Woman, HPV Vaccine Was a 'No-Brainer'
- Too Few Girls Get HPV Vaccine Against Cancer: CDC
- Preteens More Likely to Report HPV Vaccine Side Effects
- HPV Test Beats Pap Test for Cervical Cancer Screening
- Study: HPV Vaccine Doesn't Encourage Risky Sexual Activity
- Males 11-21 Should Get Gardasil HPV Vaccine
- Half of Men Have Genital HPV
- HPV Shot Prevents Genital Warts in Boys and Men
- Gardasil Approved for Anal Cancer Prevention
- Gardasil HPV Vaccine Stopping Genital Warts
- HPV Vaccine: Cost-effective Way to Prevent Anal Cancer
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.