Galphimia Glauca

Last Editorial Review: 6/11/2021
Other Name(s):

Thryallis glauca.


Galphimia glauca is a small evergreen shrub found in the tropical areas of Mexico and Central America.

People take Galphimia glauca by mouth for hayfever caused by ragweed, generalized anxiety disorder (GAD), asthma, bloody diarrhea, fever, and seizures.

How does it work?

Galphimia glauca might block reactions in the body that cause allergy symptoms. It might also reduce anxiety and have sedative effects.


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Uses & Effectiveness

Insufficient Evidence to Rate Effectiveness for...

  • Hayfever caused by ragweed. Some early research shows that taking a homeopathic (diluted) formulation of Galphimia glauca up to four times daily might improve hay fever symptoms affecting the eyes after 2-5 weeks of treatment. However, it is not clear if it really benefits people with hay fever.
  • Generalized anxiety disorder (GAD). Early research shows that taking a capsule containing dried Galphimia glauca extract 310 mg twice daily for 4 weeks decreases anxiety as well as the drug lorazepam in people with GAD.
  • Asthma.
  • Bloody diarrhea.
  • Fever.
  • Seizures.
  • Other conditions.
More evidence is needed to rate Galphimia glauca for these uses.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

Side Effects

Galphimia glauca is LIKELY SAFE when taken by mouth in homeopathic (diluted) amounts, short-term. Homeopathic formulations have been used safely for up to 5 weeks. However, homeopathic products contain no measureable amount of active ingredient.

Galphimia glauca is POSSIBLY SAFE when taken by mouth and appropriately as medicine, short-term. Capsules containing 310 milligrams of Galphimia glauca have been used safely for up to 4 weeks.


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Special Precautions & Warnings

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking Galphimia glauca if you are pregnant or breast-feeding. Stay on the safe side and avoid use. However, if it is used as a homeopathic (diluted) preparation, it is unlikely that Galphimia glauca would have any side effect on pregnancy or breast-feeding. This is because most homeopathic preparations contain little or no active ingredient.


The appropriate dose of Galphimia glauca depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for Galphimia glauca (in children/in adults). Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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Aguilar-Santamaria, L., Ramirez, G., Herrera-Arellano, A., et al. Toxicological and cytotoxic evaluation of standardized extracts of Galphimia glauca. J Ethnopharmacol 2007;109(1):35-40. View abstract.

Campos, M. G., Toxqui, E., Tortoriello, J., et al. Galphimia glauca organic fraction antagonizes LTD(4)-induced contraction in guinea pig airways. J Ethnopharmacol 2001;74(1):7-15. View abstract.

del Rayo Camacho M., Phillipson J. D., Croft S. L., et al. Assessment of the antiprotozoal activity of Galphimia glauca and the isolation of new nor-secofriedelanes and nor-friedelanes. J Nat Prod 2002;65(10):1457-61. View abstract.

Dorsch, W. and Wagner, H. New antiasthmatic drugs from traditional medicine? Int Arch Allergy Appl Immunol 1991;94(1-4):262-265. View abstract.

Dorsch, W., Bittinger, M., Kaas, A., Muller, A., Kreher, B., and Wagner, H. Antiasthmatic effects of Galphimia glauca, gallic acid, and related compounds prevent allergen- and platelet-activating factor-induced bronchial obstruction as well as bronchial hyperreactivity in guinea pigs. Int Arch Allergy Immunol. 1992;97(1):1-7. View abstract.

Gonzalez-Cortazar, M., Tortoriello, J., and Alvarez, L. Norsecofriedelanes as spasmolytics, advances of structure-activity relationships. Planta Med 2005;71(8):711-6. View abstract.

Herrera-Arellano, A., Jimenez-Ferrer, E., Zamilpa, A., et al. Efficacy and tolerability of a standardized herbal product from Galphimia glauca on generalized anxiety disorder. A randomized, double-blind clinical trial controlled with lorazepam. Planta Med 2007;73(8):713-7. View abstract.

Herrera-Ruiz, M., Gonzalez-Cortazar, M., Jimenez-Ferrer, E., et al. Anxiolytic effect of natural galphimines from Galphimia glauca and their chemical derivatives. J Nat Prod 2006;69(1):59-61. View abstract.

Herrera-Ruiz, M., Jimenez-Ferrer, J. E., De Lima, T. C., et al. Anxiolytic and antidepressant-like activity of a standardized extract from Galphimia glauca. Phytomedicine 2006;13(1-2):23-8. View abstract.

Ludtke, R. and Wiesenauer, M. [A meta-analysis of homeopathic treatment of pollinosis with Galphimia glauca]. Wien Med Wochenschr 1997;147(14):323-327. View abstract.

Nader, B. L., Taketa, A. T., Pereda-Miranda, R., and Villarreal, M. L. Production of triterpenoids in liquid-cultivated hairy roots of Galphimia glauca. Planta Med 2006;72(9):842-844. View abstract.

Neszmelyi, A., Kreher, B., Muller, A., Dorsch, W., and Wagner, H. Tetragalloylquinic acid, the major antiasthmatic principle of Galphimia glauca. Planta Med 1993;59(2):164-7. View abstract.

Osuna, L., Pereda-Miranda, R., Tortoriello, J., and Villarreal, M. L. Production of the sedative triterpene galphimine B in Galphimia glauca tissue culture. Planta Med 1999;65(2):149-152. View abstract.

Perusquia M, Mendoza S, Bye R, et al. Vasoactive effects of aqueous extracts from five Mexican medicinal plants on isolated rat aorta. J Ethnopharmacol 1995;46:63-9. View abstract.

Prieto-Gomez, B., Tortoriello, J., Vazquez-Alvarez, A., and Reyes-Vazquez, C. Galphimine B modulates synaptic transmission on dopaminergic ventral tegmental area neurons. Planta Med 2003;69(1):38-43. View abstract.

Sultana T, Stecher G, Abel G, Popp M, and Bonn GK. Qualitative and quantitative analysis of multiple galloyl derivatives of quinic acid from the medicinal plant Galphimia glauca Cav. using HPLC-ESI-MS (abstract). Planta Medica 2007;73(9):P306.

Tortoriello, J. and Lozoya, X. Effect of Galphimia glauca methanolic extract on neuropharmacological tests. Planta Med 1992;58(3):234-236. View abstract.

Tortoriello, J. and Ortega, A. Sedative effect of galphimine B, a nor-seco-triterpenoid from Galphimia glauca. Planta Med 1993;59(5):398-400. View abstract.

Wiesenauer M and Lüdtke R. The treatment of pollinosis with Galphimia glauca D4 - a randomized placebo-controlled double-blind clinical trial. Phytomedicine 1995;2(1):3-6. View abstract.

Wiesenauer, M and Gaus, W. Double-blind trial comparing the effectiveness of the homeopathic preparation Galphimia potentiation D6, Galphimia dilution 10(-6) and placebo on pollinosis. Arzneimittel-Forschung 1985;35:1745-7. View abstract.

Wiesenauer, M., Haussler, S., and Gaus, W. [Pollinosis therapy with Galphimia glauca]. Fortschr Med 1983;101(17):811-4. View abstract.