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- What is gabapentin enacarbil, and how does it work (mechanism of action)?
- What brand names are available for gabapentin enacarbil?
- Is gabapentin enacarbil available as a generic drug?
- Do I need a prescription for gabapentin enacarbil?
- What are the side effects of gabapentin enacarbil?
- What is the dosage for gabapentin enacarbil?
- Which drugs or supplements interact with gabapentin enacarbil?
- Is gabapentin enacarbil safe to take if I'm pregnant or breastfeeding?
- What else should I know about gabapentin enacarbil?
What is gabapentin enacarbil, and how does it work (mechanism of action)?
Gabapentin enacarbil is used for treating restless leg syndrome (RLS) and postherpetic neuralgia. It is a prodrug of the anticonvulsant gabapentin, which means it is first converted to gabapentin in the body before it can have its effects. The mechanism of action of gabapentin in treating restless leg syndrome (RLS) or postherpatic neuralgia is not known. Gabapentin structurally resembles the neurotransmitter, gamma aminobutyric acid (GABA). (A neurotransmitter is a chemical that nerves use to communicate with one another.) It is possible that this similarity is related to gabapentin's mechanism of action. In animal models used for testing the anti-seizure and anti-pain (analgesic) activities of drugs, gabapentin prevents seizures and reduces pain-related responses. The FDA approved gabapentin enacarbil in April 2011.
What are the side effects of gabapentin enacarbil?
The most common side effects of gabapentin enacarbil are:
Gabapentin enacarbil is converted to gabapentin, which is an anti-seizure medication. Anti-seizure medications have been associated with an increased risk of suicidal thinking and behavior. Anyone considering the use of anti-seizure drugs must balance this risk of suicide with the clinical need. Patients who are started on therapy should be closely observed for clinical worsening, suicidal thoughts, or unusual changes in behavior.
Quick GuideRLS Remedies in Pictures: Home Care for Better Sleep
What is the dosage for gabapentin enacarbil?
Gabapentin enacarbil should be taken with food. The recommended dose for postherpetic neuralgia is 1200 mg daily. The initial dose of 600 mg daily is increased after three days to the recommended daily dose. Gabapentin enacarbil is not interchangeable with other gabapentin products. Restless leg syndrome is treated with 600 mg once daily.
Which drugs or supplements interact with gabapentin enacarbil?
Alcohol increases the amount of gabapentin enacarbil released into the body. Alcohol should not be used with gabapentin enacarbil. Combining gabapentin enacarbil with morphine significantly increases the occurrence of sedation and dizziness over either drug alone.
Is gabapentin enacarbil safe to take if I'm pregnant or breastfeeding?
Safety in pregnancy has not been established.
Gabapentin is secreted in human breast milk. Nursing mothers should only use gabapentin enacarbil if it is necessary.
What else should I know about gabapentin enacarbil?
What preparations of gabapentin enacarbil are available?
Tablets (extended release): 300, 600 mg
How should I keep gabapentin enacarbil stored?
Gabapentin enacarbil should be store between 15 C to 30 C (59 F to 86 F).
REFERENCE: FDA Prescribing Information
Quick GuideRLS Remedies in Pictures: Home Care for Better Sleep
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Seizures QuizDo you know the difference between seizures and epilepsy? What are the types of seizures? Take the Epilepsy & Seizures Quiz to test your knowledge and learn about this complex disorder of the brain.
Fabry disease (Fabry's disease, alpha-galactosidase-A) is a genetic disorder with symptoms such as
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- gastrointestinal (GI) difficulties.
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Take the RLS QuizRestless leg syndrome (RLS), an annoying, sometimes painful disorder that keeps millions of people awake at night. What are the symptoms of restless le syndrome? Take the quiz to find out!
Restless Legs SyndromeRestless legs syndrome treatment includes natural remedies that you can implement at home. Use exercise, sleep hygiene, and relaxation to treat RLS.
SeizureEpilepsy is a brain disorder in which the person has seizures. There are two kinds of seizures, focal and generalized. There are many causes of epilepsy. Treatment of epilepsy (seizures) depends upon the cause and type of seizures experienced.
Take the Shingles QuizShingles falls within a well-known family of viruses that cause itching, burning, blisters, and pain. Take the Shingles Quiz to get the facts, causes, symptoms, and treatments for this itchy, painful condition.
Shingles and PregnancyBecoming infected with chickenpox during pregnancy could cause birth defects in your unborn child. Likewise, shingles could also cause problems for your unborn child. If you are pregnant and haven't had chickenpox, avoid exposure to infected people. Zostavax, the shingles vaccine, can reduce the incidence of shingles by half. Women should wait at least three months after receiving the vaccine before trying to get pregnant.
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