- What is gabapentin enacarbil, and how does it work (mechanism of action)?
- What brand names are available for gabapentin enacarbil?
- Is gabapentin enacarbil available as a generic drug?
- Do I need a prescription for gabapentin enacarbil?
- What are the side effects of gabapentin enacarbil?
- What is the dosage for gabapentin enacarbil?
- Which drugs or supplements interact with gabapentin enacarbil?
- Is gabapentin enacarbil safe to take if I'm pregnant or breastfeeding?
- What else should I know about gabapentin enacarbil?
What is gabapentin enacarbil, and how does it work (mechanism of action)?
Gabapentin enacarbil is used for treating restless leg syndrome (RLS) and postherpetic neuralgia. It is a prodrug of the anticonvulsant gabapentin, which means it is first converted to gabapentin in the body before it can have its effects. The mechanism of action of gabapentin in treating restless leg syndrome (RLS) or postherpatic neuralgia is not known. Gabapentin structurally resembles the neurotransmitter, gamma aminobutyric acid (GABA). (A neurotransmitter is a chemical that nerves use to communicate with one another.) It is possible that this similarity is related to gabapentin's mechanism of action. In animal models used for testing the anti-seizure and anti-pain (analgesic) activities of drugs, gabapentin prevents seizures and reduces pain-related responses. The FDA approved gabapentin enacarbil in April 2011.
What are the side effects of gabapentin enacarbil?
The most common side effects of gabapentin enacarbil are:
Gabapentin enacarbil is converted to gabapentin, which is an anti-seizure medication. Anti-seizure medications have been associated with an increased risk of suicidal thinking and behavior. Anyone considering the use of anti-seizure drugs must balance this risk of suicide with the clinical need. Patients who are started on therapy should be closely observed for clinical worsening, suicidal thoughts, or unusual changes in behavior.
Quick GuideRLS Remedies in Pictures: Home Care for Better Sleep
What is the dosage for gabapentin enacarbil?
Gabapentin enacarbil should be taken with food. The recommended dose for postherpetic neuralgia is 1200 mg daily. The initial dose of 600 mg daily is increased after three days to the recommended daily dose. Gabapentin enacarbil is not interchangeable with other gabapentin products. Restless leg syndrome is treated with 600 mg once daily.
Which drugs or supplements interact with gabapentin enacarbil?
Alcohol increases the amount of gabapentin enacarbil released into the body. Alcohol should not be used with gabapentin enacarbil. Combining gabapentin enacarbil with morphine significantly increases the occurrence of sedation and dizziness over either drug alone.
Is gabapentin enacarbil safe to take if I'm pregnant or breastfeeding?
Safety in pregnancy has not been established.
Gabapentin is secreted in human breast milk. Nursing mothers should only use gabapentin enacarbil if it is necessary.
What else should I know about gabapentin enacarbil?
What preparations of gabapentin enacarbil are available?
Tablets (extended release): 300, 600 mg
How should I keep gabapentin enacarbil stored?
Gabapentin enacarbil should be store between 15 C to 30 C (59 F to 86 F).
REFERENCE: FDA Prescribing Information
Gabapentin enacarbil (Horizant) is a drug prescribed for the treatment of nerve damage from herpes zoster (postherpetic neuralgia, shingles), and restless leg syndrome. Side effects, drug interactions, and pregnancy safety information should be reviewed prior to taking any medication.
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Top gabapentin enacarbil Related ArticlesComplete List
Seizures QuizDo you know the difference between seizures and epilepsy? What are the types of seizures? Take the Epilepsy & Seizures Quiz to test your knowledge and learn about this complex disorder of the brain.
Fabry disease (Fabry's disease, alpha-galactosidase-A) is a genetic disorder with symptoms such as
- burning sensations in the hands,
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Lyrica vs Gabapentin
Lyrica (pregablin) and gabapentin (Neurotin) are drugs used to prevent seizures and to treat nerve pain associated with various conditions, for example, shingles. Lyrica and gabapentin are chemically related, but researchers do not know exactly how they work. Gabapentin also has several off-label uses to treat other conditions that cause pain, and substance abuse withdrawal.
Both pain medications also treat fibromyalgia. Off-label uses (non-FDA approved) for gabapentin are hot flashes, hiccups, restless leg syndrome (RLS), hyperhidrosis (excessive sweating), headaches, and diabetic neuropathy. Lyrica also treats pain associated with spinal cord injuries.
Lyrica and gabapentin both cause similar side effects, for example, tremors, blurred or double vision, memory or concentration problems, dizziness, and drowsiness.
Side effects of Lyrica that are different from gabapentin include constipation, weight gain, dry mouth, constipation, breast enlargement, and edema (swelling). Side effects unique to gabapentin include viral infections, fever, speech problems, unusual eye movements, and jerky movements.
The generic name for Lyrica is pregabalin. Gabapentin is available in the US under the brand names Neurontin, Gralise, Horizant, Fanatrex, and FusePag.
Postherpetic NeuralgiaPostherpetic neuralgia (PHN) is a painful complication of shingles. Symptoms include:
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Take the RLS QuizRestless leg syndrome (RLS), an annoying, sometimes painful disorder that keeps millions of people awake at night. What are the symptoms of restless le syndrome? Take the quiz to find out!
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SeizureEpilepsy is a brain disorder in which the person has seizures. There are two kinds of seizures, focal and generalized. There are many causes of epilepsy. Treatment of epilepsy (seizures) depends upon the cause and type of seizures experienced.
Take the Shingles QuizShingles falls within a well-known family of viruses that cause itching, burning, blisters, and pain. Take the Shingles Quiz to get the facts, causes, symptoms, and treatments for this itchy, painful condition.
Shingles and PregnancyBecoming infected with chickenpox during pregnancy could cause birth defects in your unborn child. Likewise, shingles could also cause problems for your unborn child. If you are pregnant and haven't had chickenpox, avoid exposure to infected people. Zostavax, the shingles vaccine, can reduce the incidence of shingles by half. Women should wait at least three months after receiving the vaccine before trying to get pregnant.
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