G6PD Deficiency: Symptoms & Signs

Medically Reviewed on 4/13/2020

G6PD deficiency stands for a deficiency in an enzyme known as glucose-6-phosphate dehydrogenase deficiency. In people with G6PD deficiency, factors like infections, certain medications, or ingesting fava beans can lead to red blood cells being destroyed faster than the body can replace them.

Signs and symptoms of hemolytic anemia include

Cause of G6PD deficiency

G6PD deficiency is a genetic (inherited) condition that causes red blood cells to break down prematurely. This causes the condition known as hemolytic anemia. The gene for glucose-6-phosphate dehydrogenase deficiency is located on the X chromosome, so the condition tends to affect men more often than women since men have only one copy of the X chromosome.

Other g6pd deficiency symptoms and signs

  • Dark Urine
  • Fatigue
  • Paleness
  • Rapid Heart Rate
  • Shortness of Breath
  • Yellowing of the Skin and Whites of the Eyes (Jaundice)

References
Jameson, J. Larry, et al. Harrison's Principles of Internal Medicine, 20th Ed. New York: McGraw-Hill Education, 2018.