Medical Definition of Fredrickson, Donald

Reviewed on 6/3/2021

Fredrickson, Donald: (1924-2002) American physiologist and biomedical research leader who made significant contributions to medicine over the course of four decades. Fredrickson's system of classification of abnormalities in fat transport was adopted by the World Health Organization (WHO) as an international standard for identifying increased risks of coronary artery disease linked to the consumption of fats and cholesterol. He also discovered two genetic diseases caused by disorders in lipid metabolism. As director of the National Institutes of Health (NIH), Fredrickson mediated between scientists and the federal government during debates over the direction of medical research policy, funding, and the dangers of genetic engineering during the second half of the 1970s.

Don Fredrickson was born in Cañon City, Colorado. He received his bachelor's in 1946 and his medical degree in 1949, both from the University of Michigan. He was certified by the American Board of Internal Medicine in 1957. While touring Europe by bicycle, Fredrickson met Henriette Priscilla Dorothea Eekhoff, a Dutch law student at the University of Leyden. They married in the Hague in 1950. During the 1950s, she supported the junior scientist and their two sons through an import company for Dutch cigars she founded.

Fredrickson conducted postgraduate research at Harvard University Medical School and Massachusetts General Hospital before arriving at the National Institutes of Health (NIH) in Bethesda, Maryland, in 1953. From an early stage in his professional career, Fredrickson sought to integrate laboratory research with clinical practice, to place science in the service of treating disease.

After a research career in laboratories devoted to cellular metabolism, physiology, and molecular diseases, he became director of the National Heart Institute in 1966, a position he held until 1968. During his term as director the first heart transplant in man was performed by South African heart surgeon Dr. Christiaan Barnard, with whom Fredrickson arranged a historic meeting on December 18, 1967, at Chicago's O'Hare airport. The meeting was attended by prominent heart surgeons in the United States who were soon to replicate Barnard's feat. Fredrickson remained at the National Heart Institute as Director of Intramural Research until 1974.

In late spring of 1974, Dr. Fredrickson left the NIH to become the second President of the Institute of Medicine, a health care and medical research policy think tank in Washington, D.C., established under the auspices of the National Academy of Sciences. He recalled that he was attracted to his new position because "there was a rich mixture of the dialects and ethics operative in the world outside the laboratory walls" that offered "an unparalleled view of the complex field of human health." During his brief tenure at IOM he proved an effective fundraiser, a new role for an administrator used to administering, not soliciting, research funds.

Almost from the moment Dr. Fredrickson joined the Institute of Medicine, he was drawn once again into the administrative politics of NIH. The directorship of NIH had become vacant for the second time in as many years. Fredrickson received phone calls from federal officials indicating dissension in the upper ranks of NIH, and asking Fredrickson to step into the void of leadership by becoming NIH director. On April 19, 1975, Fredrickson returned to Bethesda as director of NIH. In a conversation with Philip Handler, the President of the National Academy of Sciences, Fredrickson justified his decision by stating that leading NIH was "not a job; it's a cause."

Over the next six years, Fredrickson's administrative and political skills were frequently tested during the most turbulent period in the history of the NIH. Immediately he was thrown into the growing controversy over the environmental hazards and the ethics of recombinant DNA research, cutting-edge genetic experimentation that, critics warned, could produce new and untreatable pathogens and presented an unwarranted human manipulation of the natural order. During the economic and budget crises of the late 1970s, the U.S. Congress considered reducing government funding on which NIH and, through its extramural grant program, most biomedical research in the United States depended. Members of Congress who sought to curtail NIH funding said that basic research sponsored by NIH did not yield clinical applications and therapies rapidly enough to benefit patients. Not least, Fredrickson had to adjust to the changing priorities of three U.S. Presidents and five Secretaries of Health, Education, and Welfare (since 1980, Health and Human Services) under which he served.

Fredrickson's main success as NIH director lay in devising guidelines for recombinant DNA research that preserved freedom of scientific inquiry while allaying public fears of genetic manipulation; stabilizing NIH funding at a time of retrenchment; and fostering consensus among clinical and scientific researchers at NIH, groups that often found themselves at odds in their research objectives and struggle for funding. With these controversies alleviated, Fredrickson completed his tenure as director of NIH in June of 1981.

After two years as Scholar-in-Residence at the National Academy of Sciences, Fredrickson became first vice president, then president, CEO and trustee of the Howard Hughes Medical Institute (HHMI). Fredrickson oversaw the sale of the Institute's sole asset, the Hughes Aircraft Company, for six billion dollars, as well as the Institute's subsequent expansion into the largest source of philanthropic support for biomedical research in the United States, dispensing research grants and supporting laboratories in hospitals. Moreover, Fredrickson organized the relocation of the Institute from Coconut Grove, Florida, to Chevy Chase, Maryland. From 1987 until his death, Fredrickson was Scholar-in-Residence at the National Library of Medicine. Drawing on his early medical training, he became personal physician to King Hassan II of Morocco in 1975, a service for which he was elected a member of the Academy of the Kingdom of Morocco in 1991. Dr. Fredrickson died at his home in Bethesda in 2002.

Adapted from biographical information provided courtesy of the National Library of Medicine.



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