- High Blood Pressure Slideshow Pictures
- Take the Salt Quiz!
- Lowering Blood Pressure Exercise Tips Pictures
- What is fosinopril sodium, and how does it work (mechanism of action)?
- Is fosinopril sodium available as a generic drug?
- Do I need a prescription for fosinopril sodium?
- What are the side effects of fosinopril sodium?
- What is the dosage for fosinopril sodium?
- Which drugs or supplements interact with fosinopril sodium?
- Is fosinopril sodium safe to take if I'm pregnant or breastfeeding?
- What else should I know about fosinopril sodium?
What is fosinopril sodium, and how does it work (mechanism of action)?
Fosinopril is in a class of drugs called angiotensin converting enzyme (ACE) inhibitors. ACE inhibitors are used for treating high blood pressure, heart failure and for preventing kidney failure due to high blood pressure and diabetes. Other ACE inhibitors include enalapril (Vasotec), quinapril (Accupril), captopril (Capoten), ramipril (Altace), benazepril (Lotensin), lisinopril (Zestril, Prinivil), moexipril (Univasc) and trandolapril (Mavik). ACE is an enzyme in blood which controls the formation of angiotensin II, a chemical that circulates in blood and causes constriction of arteries and veins. Constriction of arteries and veins elevates blood pressure. ACE inhibitors inhibit ACE and block the formation of angiotensin II. By blocking the formation of angiotensin II, fosinopril relaxes the arteries and veins and lowers blood pressure. By reducing blood pressure, fosinopril also reduces the work that the heart must do to pump blood through the arteries and veins. This improves the output of blood from the heart especially when the heart is failing. The FDA approved fosinopril in May 1991.
What are the side effects of fosinopril sodium?
Fosinopril is generally well tolerated. The most common side effects are:
Other important and serious side effects, although rare, include:
What is the dosage for fosinopril sodium?
The recommended adult dose for treating hypertension or heart failure is 10-40 mg once or twice daily. The maximum dose is 80 mg daily. Fosinopril is generally prescribed once daily, although some patients may need two doses per day. Patients with reduced kidney function need lower doses since their kidneys do not eliminate fosinopril from the body as well as normal kidneys. Fosinopril may be taken with or without food.
Which drugs or supplements interact with fosinopril sodium?
Combining fosinopril with potassium supplements, potassium containing salt substitutes, or potassium-conserving diuretics such as amiloride (Moduretic), spironolactone (Aldactone), and triamterene (Dyazide, Maxzide), can lead to dangerously high blood levels of potassium (hyperkalemia) since fosinopril has a tendency to reduce the excretion of potassium. Fosinopril should not be taken at the same time as aluminum or magnesium-based antacids, such as simethicone (Mylanta, Gas-X, etc.) or Maalox since these antacids bind fosinopril and decrease the amount of fosinopril that is absorbed from the intestine. Patients should take antacids and fosinopril at least two hours apart.
Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin, Medipren, Nuprin, PediaCare Fever, etc.), indomethacin (Indocin, Indocin-SR), and naproxen (Anaprox, Naprelan, Naprosyn, Aleve) may reduce the effects of ACE inhibitors on blood pressure. Combining fosinopril or other ACE inhibitors with nonsteroidal anti-inflammatory drugs (NSAIDs) in patients who are elderly, volume-depleted (including those on diuretic therapy), or with poor kidney function may result in reduced kidney function, including kidney failure. These effects usually are reversible. Nitritoid reactions (symptoms include facial flushing, nausea, vomiting, and hypotension) may occur when injectable gold sodium aurothiomalate (Myochrysine), used in the treatment of rheumatoid arthritis, is combined with ACE inhibitors, including fosinopril.
Is fosinopril sodium safe to take if I'm pregnant or breastfeeding?
ACE inhibitors, including fosinopril, can be harmful to the fetus and should not be taken by pregnant women.
Fosinopril is secreted in breast milk and is not recommended for nursing mothers.
What else should I know about fosinopril sodium?
What preparations of fosinopril sodium are available?
Tablets: 10, 20, and 40 mg
How should I keep fosinopril sodium stored?
Tablets should be stored between 15-30 C (59-86 F).
Fosinopril sodium (Monopril) is an ACE inhibitor drug prescribed for the treatment of high blood pressure, congestive heart failure, and post-heart attack treatment. Side effects, drug interactions, warnings and precautions, and patient safety information should be reviewed prior to taking any medication.
Multimedia: Slideshows, Images & Quizzes
Related Disease Conditions
Kidney Failure (Symptoms, Signs, Stages, Causes, Treatment, and Life Expectancy)
Kidney failure can occur from an acute event or a chronic condition or disease. Prerenal kidney failure is caused by blood loss,...
12 Congestive Heart Failure Symptoms, Stages, Causes, and Life Expectancy
Congestive heart failure (CHF) refers to a condition in which the heart loses the ability to function properly. Heart disease,...
Diabetes (Type 1 and Type 2)
Diabetes is a chronic condition characterized by high levels of sugar (glucose) in the blood. The two types of diabetes are...
Diabetes Treatment (Type 1 and Type 2 Medications and Diet)
The major goal in treating diabetes is controlling elevated blood sugar without causing abnormally low levels of blood sugar....
High Blood Pressure (Hypertension) Signs, Causes, Diet, and Treatment
High blood pressure (hypertension) is a disease in which pressure within the arteries of the body is elevated. About 75 million...
A heart attack happens when a blood clot completely obstructs a coronary artery supplying blood to the heart muscle. A heart...
Heart failure (congestive) is caused by many conditions including coronary artery disease, heart attack, cardiomyopathy, and...
High Blood Pressure Treatment (Natural Home Remedies, Diet, Medications)
High blood pressure (hypertension) means high pressure (tension) in the arteries. Treatment for high blood pressure include...
Diabetes and Kidney Disease
In the United States diabetes is the most common cause of kidney failure. High blood pressure and high levels of blood glucose...
Hypertensive Kidney Disease
High blood pressure can damage the kidneys and is one of the leading causes of kidney failure (end-stage renal kidney disease)....
Pregnancy and Drugs (Prescription and OTC)
Taking prescription medications or over-the-counter drugs or supplements should be discussed with your doctor. There are some...
Febrile seizures, or convulsions caused by fever, can be frightening in small children or infants. However, in general, febrile...
Heart Attack Prevention
Heart disease and heart attacks can be prevented by leading a healthy lifestyle with diet, exercise, and stress management....
Treatment & Diagnosis
- Medication Disposal
- Dangers of Mixing Medications
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
- ACE Inhibitors (Side Effects, List of Names, Uses, and Dosage)
- Vasodilators (Drug Class Side Effects, List of Names)
- Drug Interactions
- Drugs: Questions to Ask Your Doctor or Pharmacist about Your Drugs
- lisinopril (Zestril, Prinivil, Qbrelis) ACE Inhibitor
- ramipril (Altace)
- captopril (Capoten)
- benazepril (Lotensin HTC)
- enalapril (Vasotec, Epaned)
- trandolapril, Mavik
- quinapril, Accupril
- lisinopril and hydrochlorothiazide, Zestoretic, Prinzide
- benazepril and hydrochlorothiazide, Lotensin HCT
- enalapril and hydrochlorothiazide, Vaseretic
- captopril and hydrochlorothiazide, Capozide
Prevention & Wellness
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.