What is leaky gut syndrome?

The foods you eat and the way you feel are often connected. Eating too much at dinner can make you feel bloated, while a healthy breakfast provides you with the energy you need to power through the morning. Digestion problems like gas, diarrhea, and constipation affect millions of Americans, and more than 15% of people in Western countries have severe gut sensitivity.
One particular digestive condition affecting general health is leaky gut syndrome, referred to in the medical community as intestinal permeability. Inside your body, there's an intestinal lining that forms a tight barrier to control what substances your body absorbs. If you have a leaky gut, it means your intestinal lining has large cracks and holes that allow toxins and partially digested food to pass into your bloodstream.
Over time, leaky gut syndrome may damage your gut flora, the healthy bacteria in your stomach. Some research suggests this condition can trigger inflammation and cause problems in your digestive tract and throughout your body, leading to chronic disease.
Diseases linked to leaky gut
Leaky gut syndrome is considered an intestinal barrier defect. It is associated with many diseases, including:
- Food allergies
- Chronic fatigue syndrome
- Celiac disease
- Irritable bowel syndrome (IBS)
- Depression
- Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis
- Eczema
- Fibromyalgia
However, there aren't many studies that prove leaky gut syndrome actually causes these illnesses.
Symptoms
Symptoms of leaky gut may vary depending on the underlying disease.
For example, irritable bowel syndrome (IBS) symptoms include:
- Bloating
- Excess gas
- Stomach cramps
- Constipation
- Diarrhea
People with celiac disease, which is an autoimmune disorder, may experience:
- Fatigue
- Nausea and vomiting
- Excess gas
- Bloating or swelling of the abdomen
- Weight loss
- Constipation
- Diarrhea
Symptoms may be local to one area or spread throughout the entire body.

SLIDESHOW
Super Tips to Boost Digestive Health: Bloating, Constipation, and More See SlideshowCauses
Lifestyle choices like smoking, the foods you eat, and your general health may all contribute to your leaky gut in some way.
Diet
Certain food ingredients and nutrients can alter your gut flora. Some research suggests that diets low in fiber allow bad bacteria to flourish in your digestive system. This bacteria thins the mucus in your intestinal lining and can make you more susceptible to digestive illnesses, like colitis.
Diets high in saturated fats have also been strongly correlated with intestinal permeability.
Stress
Anxiety isn't good for your health, and over time constant stress can affect your food choices and gut flora. A stressed body creates a stressed immune system, which can make it harder for your gut to fight bad bacteria and prevent digestive disease.
Alcohol
Research suggests drinking too much or too often causes intestinal barrier dysfunction and damages gut bacteria.
Other causes include autoimmune diseases, infections, and diabetes.
Who is at risk
The intestinal lining isn't impenetrable. Otherwise, the nutrients in your food couldn't reach the bloodstream and nourish your body. Everyone has some degree of leaky gut. However, if your diet is high in fat and sugar and low in fiber, you may be more at risk for developing leaky gut syndrome.
Diet for leaky gut syndrome
Foods to Avoid
There are many foods and substances that can cause inflammation and contribute to the development of a leaky gut, including:
- Refined carbohydrates, like white bread and pasta
- Glutinous grains, like barley, rye, and oats
- White sugar found in candy, baked goods, or cereal
- Dairy products, including milk, ice cream, and some cheeses
- Vegetable oils including soybean and canola
- Artificial sweeteners like aspartame or sucralose
- Alcohol and sugary drinks
- Caffeine
Foods to Eat
There are still plenty of things you can eat while trying to heal a leaky gut. Start with removing some of the inflammatory foods listed above, like gluten, dairy, and refined sugar. Then try adding more:
- Brown rice and other whole grains
- High-fiber foods like beans and vegetables
- Leafy greens, including kale and spinach
- Low-fructose fruits like berries
- Salmon, chicken, or other lean proteins
- High-quality fats including olive oil and avocado
- Fermented foods with probiotics like plain yogurt, kombucha, and sauerkraut
Research suggests plant fibers from fruits and vegetables interact particularly well with the bacteria in your gut.
Risks and outlook
How Long Will It Last?
Intestinal permeability isn't typically considered a medical condition. It's usually regarded as a set of symptoms that often reflect an underlying issue, like IBS or celiac disease. Determining your outlook may be a challenge because digestive problems don't always have a simple, direct treatment.
Diet and lifestyle changes can reduce inflammation in your body and alleviate some of your symptoms. If you suspect you have leaky gut syndrome or a related disease, talk to your doctor.
Subscribe to MedicineNet's General Health Newsletter
By clicking Submit, I agree to the MedicineNet's Terms & Conditions & Privacy Policy and understand that I may opt out of MedicineNet's subscriptions at any time.
Food & Function: "Impact of increasing fruit and vegetables and flavonoid intake on the human gut microbiota."
Frontiers in Immunology: "Leaky Gut As a Danger Signal for Autoimmune Diseases."
Harvard Health Publishing: "Leaky gut: What is it, and what does it mean for you?"
Johns Hopkins Medicine: "5 Foods to Avoid If You Have IBS."
Johns Hopkins Medicine: "5 Foods to Improve Your Digestion."
National Institute of Diabetes and Digestive and Kidney Diseases: “Symptoms & Causes of Celiac Disease.”
National Institute of Diabetes and Digestive and Kidney Diseases: “Symptoms & Causes of Irritable Bowel Syndrome.”
Top Foods to Avoid If You Have Leaky Gut Syndrome Related Articles
Boost Digestive Health
Upset stomach? Some foods may be the culprits, and bad habits may be to blame. Treat your body right with these simple nutrition tips on how to deal with with diarrhea, gas, reflux, and more digestive ailments.Constipation Myths and Facts
Constipation results in fewer bowel movements. Laxatives, home remedies, and diet changes may bring constipation relief. Change habits that constipate you and adopt lifestyle changes to benefit your intestines and bowel. Bloating and chronic constipation are relieved with the right medical treatments.Diarrhea
Diarrhea is a change in the frequency and looseness of bowel movements. Symptoms associated with diarrhea are cramping, abdominal pain, and the sensation of rectal urgency. Causes of diarrhea include viral, bacterial, or parasite infection, gastroenteritis, food poisoning, and drugs. Absorbents and anti-motility medications are used to treat diarrhea.Digestive Disorders: Worst Foods for Digestion
Discover which foods to avoid in order to prevent diarrhea and digestive problems. Find out which foods can trigger diarrhea and other digestive problems such as gas, bloating, indigestion, heartburn and more.Digestive Disorders: How to Stop Gas Pain
When gas gets stuck in your digestive system, you may feel pain or bloating. If changes in your diet or other habits don't fix it, you might need your doctor's help.Digestive Enzymes Oral
Oral digestive enzymes are found in the digestive tract, are naturally produced by the body, and help breakdown the foods we eat. The pancreas makes and secretes digestive enzymes. Prescription and OTC digestive enzymes are available in PEPs or pancreatic enzyme products. PEPs are prescribed for people with cystic fibrosis, chronic pancreatitis, pancreatic cancer or tumors, Shwachman-Diamond syndrome, or removal of part or all of the pancreas. Side effects include life-threatening allergic reactions, difficulty breathing or talking, swelling of the mouth/face/lips/tongue/throat, chest tightness, rash or hives, itching, red, swollen, blistered, or peeling skin; wheezing.Diverticulitis (Diverticulosis)
Most people with diverticulosis have few if any symptoms at all. When people do experience signs and symptoms of diverticulosis (diverticular disease) they may include abdominal pain, abdominal cramps, diarrhea, constipation, and bloating. Diverticulitis is a condition in which diverticula in the colon rupture. The rupture results in infection in the tissues that surround the colon. Treatment methods for diverticulitis include prescription medications, and in some cases, diverticulitis surgery.Indigestion (Dyspepsia, Upset Stomach Pain)
Indigestion (dyspepsia, upset stomach) can be caused by problems related to, or not related to the gastrointestinal tract. Signs and symptoms are upper abdominal pain, belching, nausea, vomiting, abdominal bloating, and abdominal distention. Treatment depends upon the cause.Intestinal Gas and Gas Pain
Intestinal gas and painful bloating are common. Learn about what causes gas pain and how eliminating certain foods from your diet can help relieve symptoms.What Is the Main Cause of Leaky Gut, and How Do You Fix It?
A leaky gut affects your intestines. The main causes of leaky gut are HIV, inflammatory bowel disease, celiac disease, alcohol use, and abuse of NSAIDs.The Digestion Process (Parts, Organs, and Functions)
Digestion is the complex process of turning the food you eat into the energy you need to survive. The digestive process also involves creating waste to be eliminated, and is made of a series of muscles that coordinate the movement of food. Learn more about digestion and the body parts that make it possible, including the mouth, pharynx, esophagus, stomach, small intestine, colon, rectum, anus, pancreas, liver, and gallbladder.