Food Protein-Induced Enterocolitis Syndrome (FPIES): Symptoms & Signs

Medically Reviewed on 9/7/2022

Food protein-induced enterocolitis syndrome (FPIES) is a condition in children that can be considered to be a delayed form of food allergy. Unlike typical food allergies, symptoms of FPIES come on hours after a food is consumed. The condition often occurs in infants who are beginning to eat solid foods. Symptoms include vomiting and diarrhea. In severe cases, dehydration and shock can occur due to fluid loss. The diagnosis can be difficult because the symptoms resemble those of infections of the digestive tract.

Cause of Food Protein-Induced Enterocolitis Syndrome (FPIES)

While the exact cause is not well understood, FPIES does not involve the production of IgE antibodies seen with typical allergic reactions. Cow milk, soy, and grains are the foods that most often trigger FPIES.

Other food protein-induced enterocolitis syndrome signs

"Food Protein-Induced Enterocolitis Syndrome (FPIES)." American College of Allergy, Asthma & Immunology. Mar. 21, 2019. <>.