Generic Name: folic acid
Brand Names: FA-8, Folacin, Folic Acid, GNC Folic Acid 400
What is oral folic acid, and what is it used for?
Folic acid and folate are water-soluble forms of vitamin B9 that is naturally found in many of the foods we eat. Folate occurs naturally in food while folic acid is the man-made form of this important vitamin. Common dietary sources of folate include
- green leafy vegetables,
- fruits and fruit juices,
- nuts,
- beans,
- peas,
- dairy products,
- poultry,
- meats,
- eggs,
- seafood,
- grains,
- yeast,
- beef kidney, and
- beef liver.
Additionally, folic acid is added to many food products (fortified) and is available as a dietary supplement.
Folic acid is an important vitamin that is needed for the proper development of the human body. Folic acid is needed to make DNA and other genetic material and for the synthesis of red blood cells. Folic acid deficiency can cause megaloblastic anemia, a red blood cell disorder that can cause symptoms of weakness, fatigue, trouble concentrating, irritability, headache, abnormal heartbeats, and shortness of breath. Folic acid is necessary for healthy skin, hair, and nails.
Therefore, folic acid deficiency may cause sores in the mouth, and changes in the color of the skin, hair, or fingernails. Additionally, maintaining healthy levels of folic acid during pregnancy is very important. Pregnant women who do not get enough folic acid are at risk of giving birth to babies with neural tube defects such as spina bifida. Folic acid deficiency during pregnancy may also increase the likelihood of having a premature delivery or a low-weight baby.
What are the side effects of folic acid?
WARNING
Folic acid supplementation is generally thought to be safe for human use. However, in rare cases, allergic or anaphylactoid reactions have occurred. Patients experiencing any signs or symptoms of a severe allergic reaction including hives, difficulty breathing or swallowing, and shortness of breath should seek emergency medical help.
What is the dosage for folic acid?
Adults
- For folic acid deficiency, the typical dose is 250 mcg (micrograms) to 1 mg (milligrams) per day.
- For preventing neural tube defects, at least 400 mcg of folic acid per day from supplements or fortified food should be taken by women capable of becoming pregnant and continued through the first month of pregnancy. Women with a history of previous pregnancy complicated by such neural tube defects usually take 4 mg per day beginning one month before and continuing for three months after conception.
- For reducing colon cancer risk, 400 mcg per day.
- For treating high levels of homocysteine in the blood, 200 mcg to 15 mg/day has been used, although 800 mcg to 1 mg/day appears to be more effective.
- In people with end-stage renal disease, high homocysteine levels may be more difficult to treat, and doses of 800 mcg to 40 mg/day have been used. Other dosage plans such as 2.5 to 5 mg 3 times weekly have also been used. Doses higher than 15 mg daily do not seem to be more effective.
- For improving the response to medications for depression, 200 to 500 mcg daily has been used.
- For vitiligo, 5 mg is typically taken twice daily.
- For reduction of toxicity associated with methotrexate therapy for rheumatoid arthritis (RA) or psoriasis, 1 mg/day is probably enough, but up to 5 mg/day may be used.
- For preventing macular degeneration, folic acid 2.5 mg, vitamin B12 (cyanocobalamin) 1000 mg, and vitamin B6 (pyridoxine) 50 mg daily.
Children
For gum problems due to a drug called phenytoin (6 to 15 years), 500 mcg of folic acid daily has been used.
The adequate intakes (AI) for infants are 65 mcg for infants 0 to 6 months and 80 mcg for infants 7 to 12 months of age.
From childhood to adulthood
The recommended dietary allowances (RDAs) for dietary folate equivalent (DFE), including both food folate and folic acid from fortified foods and supplements are:
- Children 1 to 3 years, 150 mcg;
- Children 4 to 8 years, 200 mcg;
- Children 9 to 13 years, 300 mcg;
- Adults over 13 years, 400 mcg;
- Pregnant women 600 mcg; and
- Breastfeeding women, 500 mcg.
The tolerable upper intake levels (UL) of folate are:
- 300 mcg for children 1 to 3 years of age,
- 400 mcg for children 4 to 8 years,
- 600 mcg for children 9 to 13 years,
- 800 mcg for adolescents 14 to 18 years, and
- 1 mg for everyone over 18 years of age.
Which drugs interact with folic acid?
- Coadministration of folic acid with cholestyramine (Prevalite) may decrease the absorption of folic acid. Patients taking both medications are advised to take folic acid 1 hour before or 4-6 hours after cholestyramine.
- Folic acid may interfere with methotrexate (Trexall, Rhuematrex, MTX), a medication used to treat certain cancers. Methotrexate works by decreasing the effects of folic acid and therefore, taking these medications together may decrease the effectiveness of methotrexate.
- Folic acid supplements may reduce blood levels of certain anti-seizure medications including phenytoin (Dilantin), fosphenytoin (Cerebyx), primidone (Mysoline) and phenobarbital (Luminal) thereby reducing their effectiveness. Also, these medications may also reduce the blood levels of folic acid.
- Sulfasalazine (Azulfidine) may decrease the body's ability to absorb folic acid.
- Folic acid may decrease the effectiveness of pyrimethamine (Daraprim), a medicine used to treat parasite infections.

QUESTION
The first sign of pregnancy is most often: See AnswerPregnancy and breastfeeding
- Adequate intake of folic acid during pregnancy is very important for the health of the mother and her baby. Clinical evidence shows that fetal neural defects can be prevented with folic acid supplementation in folic acid deficient mothers.
- Folic acid is safe for use during pregnancy. However, pregnant women are advised to speak to their doctor or pharmacist before starting supplementation.
- Maintaining adequate folic acid intake is important for nursing mothers. Women who are unable to get enough dietary folic acid may require supplementation to achieve adequate intake during lactation. The American Academy of Pediatrics (AAP) considers the use of folic acid supplements to be compatible with breastfeeding.
What else should I know about oral folic acid?
What preparations of folic acid-oral are available?
- Preservative free oral capsules: 5 and 20 mg
- Solution for injection: 5 mg/ml (10 ml)
- Oral tablets: 400 mcg, 800 mcg, 1 mg
- Preservative free oral tablets: 800 mcg dye free, 400 and 800 mcg
How should I keep folic acid-oral stored?
Folic acid preparations should be stored at room temperature between 15 C and 30 C (59 F and 86 F).
Summary
Folic acid, folate, vitamin B9 is used for the treatment of folate deficiency and its complications, and for the treatment of folic acid deficiency associated with liver disease, kidney dialysis, ulcerative colitis, and alcoholism. Folic acid supplements also are taken by women who are pregnant or planning to become pregnant to prevent birth defects (neural tube defects such as spina bifida) and miscarriage. Rare cases of allergic or anaphylactoid reactions have occurred with taking folic acid. Consult your doctor if pregnant or breastfeeding.
Multimedia: Slideshows, Images & Quizzes
-
16 Early Signs & Symptoms of Pregnancy: Could You Be Pregnant?
What are the early signs and symptoms of pregnancy? Can you know before your missed period? Read about nausea and vomiting...
-
What Not to Eat When Pregnant Pictures: Alcohol, Fish, Fruit Juice, Sushi
Do you know which common foods may be risky during pregnancy? Learn which foods to avoid, while pregnant, such as queso dip,...
-
Pregnancy Myths and Facts Quiz
Being pregnant is a delicate time for both mother and baby. Take this pregnancy myths and facts quiz to separate the myths and...
-
Am I Pregnant? Test Your Early Pregnancy IQ
What are early pregnancy symptoms? In some women, symptoms range from a missed period to feeling lightheaded. Others may...
-
Vitamins and Supplements: Test Your Medical IQ
Take the Vitamins & Supplements Quiz to learn just how many essential vitamins your body needs to function!
-
Premenstrual Syndrome (PMS): Track and Prevent Symptoms
Premenstrual Syndrome (PMS) can cause from mood swings, munchies, and more. Learn about the symptoms, causes and treatments of...
-
Pregnancy Exercises: Safe Workouts Like Prenatal Yoga, Kegels
Pregnancy exercises and workouts for moms-to-be include Kegel exercises and prenatal yoga. A prenatal workout is an important...
-
Picture of Tubal Pregnancy
A pregnancy that is not in the usual place within the uterus but is located in the Fallopian tube. See a picture of Tubal...
-
What Vitamins and Supplements Should I Take to Increase Fertility?
What to know about fertility and increase chances of getting pregnant. Learn how the benefits of folic acid, B12, zinc, and other...
Related Disease Conditions
-
Diarrhea
Diarrhea is a change in the frequency and looseness of bowel movements. Symptoms associated with diarrhea are cramping, abdominal pain, and the sensation of rectal urgency. Causes of diarrhea include viral, bacterial, or parasite infection, gastroenteritis, food poisoning, and drugs. Absorbents and anti-motility medications are used to treat diarrhea.
-
Anemia
Anemia is the condition of having less than the normal number of red blood cells or less than the normal quantity of hemoglobin in the blood. The oxygen-carrying capacity of the blood is, therefore, decreased. There are several types of anemia such as iron deficiency anemia (the most common type), sickle cell anemia, vitamin B12 anemia, pernicious anemia, and aplastic anemia. Symptoms of anemia may include fatigue, malaise, hair loss, palpitations, menstruation, and medications. Treatment for anemia includes treating the underlying cause for the condition. Iron supplements, vitamin B12 injections, and certain medications may also be necessary.
-
Care Before and During Pregnancy--Prenatal Care
Second Source article from Government
-
What Gets Rid of Headaches Quickly?
Headaches are a common complaint for many people. There are many types of headaches such as migraine, tension, cluster, and the general run of the mill headache. These 17 natural home remedies -- for example, exercise, meditation, hydration, yoga, caffeine, essential oils such as lavender and butterbur, herbs, and supplements like magnesium -- can soothe and relieve some headaches.
-
Pernicious Anemia
Pernicious anemia is a blood disorder in which the body does not make enough red blood cells due to a lack of vitamin B12 in the blood. Pernicious anemia can develop from a lack of a protein that helps the body absorb vitamin B12, not getting enough B12 in the diet, and certain intestinal conditions that interfere with the absorption of vitamin B12 such as Crohn's disease, celiac sprue, or ulcerative colitis. There is no cure for pernicious anemia, thus treatment is life-long.
-
Pregnancy Planning (Tips)
Pregnancy planning is an important step in preparation for starting or expanding a family. Planning for a pregnancy includes taking prenatal vitamins, eating healthy for you and your baby, disease prevention (for both parents and baby) to prevent birth defects and infections, avoiding certain medications that may be harmful to your baby, how much weight gain is healthy exercise safety and pregnancy, travel during pregnancy.
-
Pregnancy Diet (Menu Plans)
When a woman is pregnant, she needs more vitamins, minerals, and other foods in her diet to stay healthy and deliver a healthy baby. A healthy pregnancy diet menu plan should consist of lots of fruits, vegetables, lean meats (unless you are vegan or vegetarian), and dairy. Examples of healthy pregnancy diet meal plans include holistic pregnancy diet, vegan or vegetarian diet, and low-carb diets. Begin your healthy eating plan around three months before you begin trying to conceive, and follow the same eating plan until after you have stopped breastfeeding. If you are overweight or obese, being pregnant is not the right time to try to lose weight. Discuss your options with your health care professional.
-
Cold Agglutinin Disease
Cold agglutinin hemolytic anemia or cold agglutinin hemolytic disease, is rare disorder of the autoimmune system. There are two types of cold agglutinin disease, primary and secondary. Characteristics, symptoms, and signs of in cold agglutinin disease are premature destruction of red blood cells in the body’s natural defense antibodies. The lifespan of red blood cells is approximately 120 before the spleen destroys the antibodies. In cold agglutinin disease, the severity of the condition is determined by how long it takes for the red blood cells to survive, and at the rate that the bone marrow continues to produce more red cells. Immune hemolytic anemias are classified by the optimal temperature when the antibodies try to destroy red blood cells. Cold agglutinin anemia occurs at temperatures between 10 C (50 F) and 37 C (F 98.6) or above while the body warms antibody hemolytic anemia. Usually, cold agglutinin anemia becomes apparent between the ages of 50 to 60. Other symptoms of the disease include fatigue, jaundice (yellowing of the skin and eyes), fingers and/or toes are cold and sweat, an uneven bluish or reddish discoloration of the toes, ankles, and wrists (Raynaud's syndrome), and fingers. Usually, cold agglutinin anemia affects people that are older. The disease is diagnosed by a physical exam, and the Coomb's test. If the red blood cells destruction seem to be slowing on its own, treatment therapies, usually, isn’t needed. Other treatments for cold agglutinin anemia are corticosteroids, and splenectomy (removal of the spleen). There is no cure for cold agglutinin disease.
-
What Causes Low Blood Pressure in Pregnancy?
-
What Vitamins and Supplements Should I Avoid During Pregnancy?
You should always clear it with your obstetrician before taking any vitamins or supplements while pregnant.
-
Gestational Diabetes (Diabetes during Pregnancy))
Learning how to avoid gestational diabetes is possible and maintaining a healthy weight and diet before and during pregnancy can help. Discover risk factors, tests and treatments for, and signs and symptoms of gestational diabetes.
-
Can Lack of Folic Acid Cause Depression?
Studies identify a link between folate deficiency and depression; however, having low folate levels doesn’t always result in depression.
-
Heart Attack Treatment
A heart attack involves damage or death of part of the heart muscle due to a blood clot. The aim of heart attack treatment is to prevent or stop this damage to the heart muscle. Heart attack treatments included medications, procedures, and surgeries to protect the heart muscle against injury.
-
What Does Pregnancy Nausea Feel Like?
Nausea felt during pregnancy is known as morning sickness, which may range from mild bloating and indigestion to frank vomiting.
-
Constipation During Pregnancy: Can Not Pooping Hurt the Baby?
Although the pressure buildup from constipation during pregnancy may feel harmful, it is very unlikely to hurt your baby.
-
What Does Prenatal Care Include?
Prenatal care includes medical checkups, screening tests, and counseling. Check out the center below for more medical references on pregnancy, including multimedia (slideshows, images, and quizzes), related disease conditions, treatment and diagnosis, medications, and prevention or wellness.
-
How Does Anemia Affect Your Baby During Pregnancy?
Anemia occurs when you don't have enough red blood cells to transport adequate oxygen or iron. Anemia during pregnancy may contribute to early delivery or failure of the baby to grow to a healthy weight.
-
What Drug Causes Severe Birth Defects?
Thalidomide is a potent teratogenic drug, which is an agent known to cause abnormalities in the fetus following exposure during pregnancy.
-
What Are the 3 Prenatal Tests?
Prenatal tests are medical procedures performed during pregnancy to assess the health and development of the fetus and to help identify any potential problems or abnormalities. The three most common prenatal tests include ultrasound, amniocentesis, and chorionic villus sampling (CVS). Other prenatal tests include pregnancy test, first trimester screening, second trimester screening, noninvasive prenatal testing, fetal ultrasound, genetic counseling, biophysical profile, Group B streptococcus (GBS) test, glucose tolerance test, anomaly scan, and alpha-fetoprotein (AFP) test.
-
What Is the Best Vitamin Supplement to Take?
Dietary supplements are a general term that includes vitamins, minerals, botanicals, probiotics and other products to supplement the diet. The best vitamin supplement differs from person to person depending on their gender, age and any health conditions they have.
-
Vitamins & Exercise: Heart Attack Prevention Series
Vitamins and exercise can lower your risk for heart attack and heart disease. Folic acid, vitamins, and homocysteine levels are interconnected and affect your risk for heart disease or heart attack. For better heart health, avoid the following fried foods, hard margarine, commercial baked goods, most packaged and processed snack foods, high fat dairy, and processed meats such as bacon, sausage, and deli meats.
-
What Vitamins and Supplements Should I Take During Pregnancy?
Even if you eat a variety of nutritious foods, you may need to take pregnancy vitamins and supplements. This is especially true if you have a restricted diet, are pregnant with twins or multiples, have food allergies, or nutrient deficiencies. Talk to your doctor about your needs.
-
What Causes a Cleft Palate During Pregnancy?
A cleft palate is a facial defect in babies that occurs when they are developing inside the womb. A baby’s facial features develop in the first 3 months. Their lips form first, followed by the mouth and palate. Clefts occur if the tissues and cells don’t form in the right way.
-
4 Common Discomforts of Pregnancy
Pregnancy comes with huge hormonal changes that can cause discomfort, including morning sickness, heartburn, constipation and headaches. Learn what causes these symptoms and how you can cope with them.
-
How Does High Blood Pressure Affect Pregnancy?
High blood pressure during pregnancy can cause serious complications. Learn more about the signs of and risks associated with the condition.
Treatment & Diagnosis
- Early Pregnancy Symptoms FAQs
- Vitamins and Supplements FAQs
- Pregnancy Myths and Facts FAQs
- Medication Disposal
- Dangers of Mixing Medications
- Birth Defects Prevented by Folic Acid!
- Accutane (isotretinoin) for Acne linked to birth defects, depression and suicide
- Claritin Cleared of Birth Defect Hypospadias
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Paxil & Pregnancy, Possibilty of Birth Defect
- Does Folic Acid Prevent Leukemia?
- Can Folic Acid Prevent Leukemia?
- Is It Safe to Exercise During Pregnancy?
- Can We Eat Potatoes During Pregnancy?
- Anemia During Pregnancy
- Folic Acid: The Benefits for Women
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
- Prenatal Vitamins
- vitamin b-12/folic acid/vitamin b-6 - oral, Folgard, Folgard RX 2.2, Foltx
- iron/vitamin c/vitamin b12/folic acid - oral, Chromagen Forte, Niferex-150 F
- folic acid - injection, Folvite
- folic acid/niacinamide (nicotinamide)/copper/zinc - oral, Nicomide
- multivitamins (includes prenatal vitamins) - oral
- prenatal vitamins/iron/folic acid chewable tablet - oral
- multivitamins w/iron (includes prenatal vits) - oral liquids
- prenatal vitamins/minerals/omega-3 fatty acids - oral, CitraNatal 90 DHA, Duet DHA, M
- multivitamins w/iron (includes prenatal vitamins) - oral
- heme iron polypeptide/folic acid - oral, Proferrin-Forte
- multivitamins (includes prenatal vitamins) chewable - oral
- multivitamins/iron (includes prenatal vits) chewable tablet - oral
- multivitamins w/iron (includes prenatal vits) time release - oral
- multivitamins (includes prenatal vitamins) liquid - oral
Prevention & Wellness
- 15 Top Pregnancy Power Foods (Superfoods)
- What Painkillers Are Safe During Pregnancy?
- Which Is Better, Folic Acid or Folate?
- When Should You Start Prenatal Yoga?
- Is It Safe to Be on a Vegan Diet During Pregnancy? Benefits and Risks
- Is It Safe to Drink Kombucha Anytime During Pregnancy or While Breastfeeding?
- Which Prenatal Vitamins Do Doctors Recommend?
- 11 Foods and Beverages to Avoid During Pregnancy
- Should You Take Probiotics During Pregnancy?
- How Do You Prepare for Prenatal Care?
- Is Coffee Bad for the Baby During Pregnancy?
- Pregnancy Diet: 4 Foods to Eat and 4 Foods to Avoid When Pregnant

Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
National Institutes of Health; Office of Dietary Supplements. Folate. December 14, 2012.
<http://ods.od.nih.gov/factsheets/Folate-HealthProfessional>