- What is fluvoxamine, and how does it work (mechanism of action)?
- Is fluvoxamine available as a generic drug?
- Do I need a prescription for fluvoxamine?
- What are the uses for fluvoxamine?
- What are the side effects of fluvoxamine?
- What is the dosage for fluvoxamine?
- Which drugs or supplements interact with fluvoxamine?
- Is fluvoxamine safe to take if I'm pregnant or breastfeeding?
- What else should I know about fluvoxamine?
What is fluvoxamine, and how does it work (mechanism of action)?
- Fluvoxamine is a drug that is used for treating several psychiatric disorders. It is a member of the class of drugs called selective serotonin reuptake inhibitors (SSRIs), a class that also includes fluoxetine (Prozac), sertraline (Zoloft), and paroxetine (Paxil). Selective serotonin reuptake inhibitors affect neurotransmitters, chemicals that nerves in the brain use to communicate with each other. Neurotransmitters are released by nerves, travel across the spaces between nerves and then attach to receptors on other nerves. Many experts believe that an imbalance in neurotransmitters is the cause of depression and other psychiatric disorders. Fluvoxamine works by inhibiting the uptake of serotonin, a neurotransmitter, from the spaces between nerve cells following its release. Therefore, there is more serotonin available in the spaces to attach to other nerves and stimulate them.
- Fluvoxamine was approved by the FDA for the treatment of obsessive-compulsive disorder in December 1994.
What are the uses for fluvoxamine?
What are the side effects of fluvoxamine?
Side effects of fluvoxamine include:
- Decreased appetite
- Dry mouth
- Somnolence (sleepiness)
- Weight loss
- Stomach pain
- Abnormal dreams
- Sexual dysfunction
Fluvoxamine also may cause abnormal bleeding, seizures, and manic episodes. Withdrawal of fluvoxamine may result in withdrawal symptoms. The most common symptoms of withdrawal are dizziness, tiredness, tingling of the extremities, nausea, vivid dreams, irritability, and poor mood. Other symptoms include visual disturbances and headaches.
Withdrawal reactions have been reported after an average of 12 to 36 weeks of treatment, but after as few as 5 weeks. Although most authorities recommend discontinuing treatment by gradually reducing the dose, symptoms still may occur. Symptoms generally appear within a few days of discontinuing medication and persist for an average of 12 days (up to 21 days). They are relieved within 24 hours by re-administering the medication that was discontinued. Antidepressants may increase the risk of suicide in children and adolescents. There are concerns that antidepressants also may increase the risk of suicide in adults. Patients with major depression may experience worsening of depression or suicidal thoughts regardless of whether or not they are treated. Therefore, patients started on antidepressants should be closely observed for signs of worsening suicidal thinking or changes in behavior.
Quick GuidePhysical Symptoms of Depression in Pictures
What is the dosage for fluvoxamine?
- The usual starting dose for adults is 50 mg daily given as a single dose at bedtime.
- The dose may be increased in 50 mg increments every 4-7 days to achieve the desired response.
- The maximum dose is 300 mg/day. Doses greater than 100 mg should be administered as a divided dose.
- When using extended release tablets the starting dose is 100 mg at bedtime and the maximum dose is 300 mg.
- Children (8 to 17 years old) should start with 25 mg daily given at bedtime, and the dose may be increased by 25 mg every 4-7 days up to a maximum of 200 mg/day (8-11 years old) or 300 mg/day (12-17 years old). Doses greater than 50 mg should be administered as a divided dose.
Which drugs or supplements interact with fluvoxamine?
- All SSRIs, including fluvoxamine, should not be taken with any of the monoamine oxidase inhibitor (MAOI) class of antidepressants such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane) other drugs that inhibit monoamine oxidase such as linezolid (Zyvox) and intravenous methylene blue. Such combinations may lead to confusion, high blood pressure, tremor, and increased activity. Fluvoxamine should not be administered within 14 days of discontinuing an MAO inhibitor, and MAO inhibitors should not be administered within 14 days of stopping fluvoxamine. Similar reactions occur if fluvoxamine is combined with other drugs, for example, tryptophan, St. John's wort, meperidine (Demerol), and tramadol (Ultram) that increase serotonin in the brain.
- Fluvoxamine can inhibit the elimination of clozapine (Clozaril), necessitating dosage reductions of clozapine.
- Fluvoxamine also may inhibit the elimination and increase the blood levels of theophylline (Theodur, Uniphyl), alprazolam (Xanax), and triazolam (Halcion) leading to side effects from these drugs.
- Fluvoxamine may increase the effect of warfarin (Coumadin, Jantoven), leading to excessive bleeding. Warfarin therapy should be monitored more frequently in patients who also are taking fluoxetine.
- Combining SSRIs with aspirin, nonsteroidal anti-inflammatory drugs or other drugs that affect bleeding may increase the likelihood of upper gastrointestinal bleeding. Fluvoxamine may increase blood levels of tizanidine (Zanaflex), thioridazine (Mellaril), alosetron (Lotronex), and pimozide (Orap), leading to increased side effects of these drugs.
Is fluvoxamine safe to take if I'm pregnant or breastfeeding?
- There are no adequate studies of fluvoxamine in pregnant women. Infants exposed to SSRIs in late pregnancy may have an increased risk for persistent pulmonary hypertension of the newborn (PPHN), which can be fatal.
- Fluvoxamine is excreted into breast milk. There are no adequate studies in lactating women.
What else should I know about fluvoxamine?
What preparations of fluvoxamine are available?
- Tablets: 25, 50 and 100 mg.
- Tablets (extended release): 100 and 150 mg.
How should I keep fluvoxamine stored?
Tablets should be kept at room temperature, 15 C - 30 C (59 F - 86 F).
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Bulimia NervosaPeople with bulimia nervosa, an eating disorder that involves episodes of bingeing and purging, experience symptoms and signs such as deteriorating teeth, sore throat, constipation, thinning hair, and dehydration. Treatment of bulimia may involve cognitive behavior therapy, family therapy, nutritional counseling, and medication.
DepressionDepression is an illness that involves the body, mood, and thoughts and affects the way a person eats and sleeps, the way one feels about oneself, and the way one thinks about things. The principal types of depression are major depression, dysthymia, and bipolar disease (also called manic-depressive disease).
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Obesity (Weight Loss)Obesity is the state of being well above one's normal weight. A person has traditionally been considered to be obese if they are more than 20% over their ideal weight. That ideal weight must take into account the person's height, age, sex, and build.
Obsessive Compulsive Disorder (OCD)Obsessive compulsive disorder (OCD) is an anxiety disorder that causes a person to suffer repeated obsessions and compulsions. Symptoms include irresistible impulses despite a person's realization that the thoughts are irrational, excessive hand washing, skin picking, lock checking, or repeatedly rearranging items. People with OCD are more likely to develop trichotillomania, muscle or vocal tics, or an eating disorder. Treatment for OCD includes psychotherapy, behavioral therapy, and medication.
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Separation AnxietySeparation anxiety disorder is a common childhood anxiety disorder that has many causes. Infants, children, older kids and adults can suffer from symptoms of separation anxiety disorder. Common separation anxiety treatment methods include therapy and medications. Factors that contribute to how quickly or successfully a child moves past separation anxiety by preschool age include:
- how well the parent and child reunite,
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Tourette SyndromeTourette syndrome is disorder, which symptoms include involuntary facial tics, motor tics, and vocal tics. The cause of Tourette syndrome is not known. ADHD is associated with Tourette syndrome. Treatment includes medication, psychotherapy, and in severe cases surgery.