- What is fluticasone propionate oral inhaler, and how does it work (mechanism of action)?
- What brand names are available for fluticasone propionate oral inhaler?
- Is fluticasone propionate oral inhaler available as a generic drug?
- Do I need a prescription for fluticasone propionate oral inhaler?
- What are the side effects of fluticasone propionate oral inhaler?
- What is the dosage for fluticasone propionate oral inhaler?
- Which drugs or supplements interact with fluticasone propionate oral inhaler?
- Is fluticasone propionate oral inhaler safe to take if I'm pregnant or breastfeeding?
- What else should I know about fluticasone propionate oral inhaler?
What is fluticasone propionate oral inhaler, and how does it work (mechanism of action)?
Fluticasone propionate is a man-made steroid of the glucocorticoid family which is related to the naturally-occurring steroid hormone, cortisol or hydrocortisone, produced by the adrenal glands. Glucocorticoid steroids have potent anti-inflammatory actions. When used as an inhaler, fluticasone travels to the airways in the lung. In asthmatic patients, the suppression of inflammation within the airways reduces the spasm of muscle cells that surround the airways as well as the accumulation of fluid and cells that accompanies the inflammation which lead to narrowing of the airways. The narrowing makes it difficult to get air into and out of the lungs. When used in lower doses, very little fluticasone is absorbed into the body. When higher doses are used, fluticasone is absorbed and may cause side effects elsewhere in the body. The FDA approved fluticasone in March 1996.
What are the side effects of fluticasone propionate oral inhaler?
The most common side effects of fluticasone are:
- upper respiratory infections,
- throat irritation,
- nasal congestion,
- nasal discharge, and
- hoarseness or difficulty speaking.
Fluticasone may also cause bronchospasms (wheezing). Bronchospasms should be treated with a rescue inhaler.
High doses of inhaled fluticasone may decrease formation and increase break-down of bone thereby weakening bones and promoting fractures.
Higher doses of fluticasone also may suppress the body's ability to make its own natural glucocorticoid in the adrenal gland. People with suppression of their adrenal glands (which can be diagnosed by a testing performed by doctors) need increased amounts of glucocorticoids, probably by the oral or intravenous route, during periods of high physical stress when glucocorticoids are particularly important.
Quick GuideAsthma Symptoms, Causes, and Medications
What is the dosage for fluticasone propionate oral inhaler?
Doses vary from patient to patient.
The recommended dose for the aerosol is 88 to 440 mcg twice daily.
The recommended dose for the Diskhaler is 100 to 1000 mcg twice daily. Following administration, the mouth should be rinsed thoroughly with water or mouthwash to minimize dry mouth, irritation of the throat, and hoarseness.
The aerosol inhaler must be cleaned at least once a week.
If a bronchodilator aerosol spray (a spray that causes the airways to expand), for example, albuterol (Proventil; Ventolin), is used, it should be used first, and then 5-15 minutes later fluticasone should be used.
Which drugs or supplements interact with fluticasone propionate oral inhaler?
Ritonavir (Norvir), atazanavir (Reyataz), clarithromycin (Biaxin), indinavir (Crixivan), itraconazole (Sporanox), ketoconazole, nelfinavir (Viracept), and telithromycin (Ketek) may increase levels of fluticasone in the body by reducing the breakdown of fluticasone by liver enzymes. This may increase side effects of fluticasone.
Is fluticasone propionate oral inhaler safe to take if I'm pregnant or breastfeeding?
Adequate studies of fluticasone during pregnancy have not been done. Fluticasone use during pregnancy should be avoided unless the potential benefit justifies the potential but unknown risk to the fetus.
It is not known if fluticasone is secreted in breast milk. Other medications in the same class as fluticasone are secreted into breast milk. It is not known whether the small amounts that may appear in the milk affect the infant.
What else should I know about fluticasone propionate oral inhaler?
What preparations of fluticasone propionate oral inhaler are available?
How should I keep fluticasone propionate oral inhaler stored?
Fluticasone should be kept at room temperature, 4 C - 30 C (39 F - 86 F), and the aerosol should be shaken well before each use.
Other important side effects include Allergic reactions such as:
Reference: FDA Prescribing Information
Quick GuideAsthma Symptoms, Causes, and Medications
Fluticasone propionate oral inhaler (Flovent (Discontinued), Flovent Diskus, Flovent HFA) is a medication prescribed for the treatment of asthma in patients four years of age or older. Side effects, drug interactions, dosing, and pregnancy information should be reviewed prior to taking this drug.
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AllergyAn allergy refers to a misguided reaction by our immune system in response to bodily contact with certain foreign substances. When these allergens come in contact with the body, it causes the immune system to develop an allergic reaction in people who are allergic to it. It is estimated that 50 million North Americans are affected by allergic conditions. The parts of the body that are prone to react to allergies include the eyes, nose, lungs, skin, and stomach. Common allergic disorders include hay fever, asthma, allergic eyes, allergic eczema, hives, and allergic shock.
Asthma ComplexitiesThere are many unusual symptoms of asthma, including sighing, difficulty sleeping, anxiety, chronic cough, recurrent walking pneumonia, and rapid breathing. These symptoms may vary from individual to individual. These asthma complexities make it difficult to accurately diagnose and treat asthma.
Asthma in ChildrenAsthma in children manifests with symptoms such as coughing and wheezing. Rates of asthma in children are increasing. Asthma in children is usually diagnosed based on the description of symptoms. Lung function tests may also be used. A variety of medications are used for the treatment of childhood asthma.
Asthma MedicationsThere are two types of asthma medications: long-term control with anti-inflammatory drugs and quick relief from bronchodilators. Asthma medicines may be inhaled using a metered-dose inhaler or nebulizer or they may be taken orally. People with high blood pressure, diabetes, thyroid disease, or heart disease shouldn't take OTC asthma drugs like Primatene Mist and Bronkaid.
Asthma OverviewAsthma is a condition in which hyperreactive airways constrict and result in symptoms like wheezing, coughing, and shortness of breath. Causes of asthma include genetics, environmental factors, personal history of allergies, and other factors. Asthma is diagnosed by a physician based on a patient's family history and results from lung function tests and other exams. Inhaled corticosteroids (ICS) and long-acting bronchodilators (LABAs) are used in the treatment of asthma. Generally, the prognosis for a patient with asthma is good. Exposure to allergens found on farms may protect against asthma symptoms.
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- Mild cough
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Drug InteractionsDrug interactions occur frequently. Get facts about the types of drug interactions, what substances or other things that may interact with drugs such as OTC drug and prescription drugs, vitamins, food(s) (grapefruit), and laboratory tests. Find out how to protect yourself from potential drug interactions.
Drugs: What You Should Know About Your DrugsImportant information about your drugs should be reviewed prior to taking any prescription drug. Side effects, drug interactions, warnings and precauctions, dosage, what the drug is used for, what to do if you miss a dose, how the drug is to be stored, and generic vs. brand names.
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Side effects include:
- Sinus infection
- Skin reactions
- Taste changes
- Musculoskeletal pain
Drug interactions, warnings and precautions, and pregnancy and breastfeeding safety information should be reviewed prior to taking any medication.
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