Generic Name: fluocinonide
Brand Names: Lidemol, Lidex, Lyderm, Tiamol, Topactin, Topsyn, Vanos
Drug Class: Corticosteroids, Topical
What is fluocinonide, and what is it used for?
Fluocinonide is a corticosteroid medication topically applied to treat inflammatory skin conditions such as atopic dermatitis, psoriasis, and other skin conditions that respond to corticosteroid treatment. Fluocinonide relieves dryness, redness, itching, scaling, crusting, and other discomforts associated with inflammatory skin conditions.
Fluocinonide is a highly potent anti-inflammatory agent that suppresses inflammation by inducing the synthesis of lipocortins. Lipocortins are proteins that inhibit phospholipase 2 enzyme that initiates inflammatory activity. Fluocinonide binds to glucocorticoid receptors, protein molecules on cell membranes and activates multiple processes that help reduce inflammation, including:
- Inhibition of the release of proinflammatory substances such as prostaglandin, histamine, and kinins
- Stabilization of the membranes of leukocytes and lysosomes, organelles inside leukocytes, preventing the release of destructive chemicals
- Prevention of migration and aggregation of inflammatory cells to the inflamed area
- Reducing capillary permeability to prevent the leakage of inflammatory cells and proteins (cytokines) into the inflammation site
- Preventing migration of fibroblasts, cells that form extracellular matrix, the supportive structure of tissue, and preventing scar tissue formation
Warnings
- Do not use in patients with hypersensitivity to fluocinonide or any of its components.
- Systemic absorption from topical fluocinonide can cause reversible suppression of hypothalamic-pituitary-adrenal (HPA) axis with the potential for adrenal insufficiency, particularly in young children.
- Systemic absorption can also cause Cushing’s syndrome, hyperglycemia and glycosuria.
- Risk factors for increased systemic absorption include use of high potency steroids, use over large skin areas, use for prolonged periods, use with occlusive bandage, and use on compromised skin.
- Monitor patients for symptoms of HPA axis suppression with periodic tests, and if symptoms develop, use less potent steroid, reduce frequency of application or withdraw the drug.
- HPA axis function generally returns to normal with discontinuation of corticosteroid. Symptoms of adrenal insufficiency may require supplemental systemic corticosteroids.
- Prolonged topical corticosteroid therapy may interfere with growth and development in children. Growth should be regularly monitored in young children.
- Use of high potency corticosteroid should be limited for a period of less than 2 weeks and a lower potency should be used if treatment continues for a longer period.
- Avoid using medium or high potency corticosteroids on face, skin folds and groin, it can increase systemic absorption.
- Prolonged use, occlusive use or use of high potency corticosteroids can cause local adverse reactions including skin atrophy. Even short-term use can cause skin reactions when used in the face or in skin folds.
- Prolonged treatment with corticosteroid is associated with Kaposi sarcoma, a type of cancer.
- If simultaneous skin infections occur, appropriate antifungal or antibacterial drug should be used. If the infection is not immediately controlled, fluocinonide should be discontinued until infection is adequately controlled.

SLIDESHOW
Rosacea, Acne, Shingles, Covid-19 Rashes: Common Adult Skin Diseases See SlideshowWhat are the side effects of fluocinonide?
Common side effects of fluocinonide include:
- Application site reactions including:
- Pimples/zits (acne vulgaris)
- Allergic dermatitis
- Contact dermatitis
- Dermatitis around the mouth (perioral dermatitis)
- Thinning of the skin (atrophy)
- Stretch marks (striae)
- Inflammation of follicles (folliculitis)
- Excessive hair growth (hypertrichosis)
- Loss of skin color (hypopigmentation)
- Softening and breakdown of skin (maceration)
- Prickly heat/sweat rash (miliaria)
- Dry skin (xeroderma)
- Spider veins (telangiectasis)
- Rash
- Pruritus
- Skin peeling (exfoliation)
- Skin tightness
- Hypersensitivity reactions
- Headache
- Dizziness
- High blood pressure inside the skull (intracranial hypertension)
- Secondary infection
- Hypothalamus-pituitary-adrenal axis suppression
- Growth suppression in children
- Cushing’s syndrome, a disorder that causes excessive production of the stress hormone cortisol with symptoms such as moon face and abnormal fat deposits on the neck
- High blood sugar levels (hyperglycemia)
- Sugar in urine (glycosuria)
Call your doctor immediately if you experience any of the following symptoms or serious side effects while using this drug:
- Serious heart symptoms include fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness;
- Severe headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady;
- Severe nervous system reaction with very stiff muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, and feeling like you might pass out; or
- Serious eye symptoms include blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights.
This is not a complete list of all side effects or adverse reactions that may occur from the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may also report side effects or health problems to the FDA at 1-800-FDA-1088.
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What are the dosages of fluocinonide?
Cream, External
- Vanos: 0.1%
- Generic: 0.05%, 0.1%
Ointment/Gel/Topical Solution
- Generic: 0.05%
Adult:
Corticosteroid Responsive Dermatoses
- Apply thin layer topically once daily or every 12 hours to affected areas
- Apply thin layer topically once daily or every 12 hours to affected areas
- Apply thin layer topically once daily to affected areas
Pediatric:
Corticosteroid Responsive Dermatoses
Cream, gel, ointment, topical solution (0.05%):
Children and adolescents:
- Topical: Apply thin layer to affected area 2 to 4 times daily depending on the severity of the condition; may use occlusive dressings to manage psoriasis or recalcitrant conditions
Cream (0.1%):
Children 12 years and above and adolescents:
- Apply a thin layer once or twice daily to affected areas.
- Not recommended for use for longer than 2 consecutive weeks or more than 60 g/week total exposure.
- Therapy should be discontinued when control is achieved; if no improvement is seen within 2 weeks, reassess diagnosis.
Cream, gel, ointment, topical solution (0.05%):
Children and adolescents:
- Apply thin layer to affected area 2 to 4 times daily depending on the severity of the condition.
- Note: In children below 12 years, NICE guidelines recommend applying only once or twice daily (NICE 2007).
Cream (0.1%):
Children 12 years and above and adolescents:
- Apply a thin layer once daily to affected areas.
- Not recommended for use for longer than 2 consecutive weeks or more than 60 g/week total exposure.
- Therapy should be discontinued when control is achieved; if no improvement is seen within 2 weeks, reassess diagnosis.
Overdose
- Topical overdose of fluocinonide can cause skin eruptions, skin inflammation, burning, itching and other skin reactions.
- Topical overdose can cause sufficient absorption to produce systemic effects which can suppress the hypothalamus-pituitary-adrenal axis, leading to adrenal insufficiency. Symptoms usually resolve with withdrawal of the drug.
- Overdose treatment includes tapering and withdrawing fluocinonide and symptomatic care.
What drugs interact with fluocinonide?
Inform your doctor of all medications you are currently taking, who can advise you on any possible drug interactions. Never begin taking, suddenly discontinue, or change the dosage of any medication without your doctor’s recommendation.
- Severe interactions of fluocinonide includes:
- Fluocinonide has no known serious, moderate or mild interactions with other drugs.
The drug interactions listed above are not all of the possible interactions or adverse effects. For more information on drug interactions, visit the RxList Drug Interaction Checker.
It is important to always tell your doctor, pharmacist, or health care provider of all prescription and over-the-counter medications you use, as well as the dosage for each, and keep a list of the information. Check with your doctor or health care provider if you have any questions about the medication.
Pregnancy and breastfeeding
- There are no adequate and well-controlled studies on the safety of topical fluocinonide use in pregnant women. Animal studies indicate topical application of some corticosteroids can cause fetal harm. Use fluocinonide during pregnancy only if potential benefits outweigh potential risks to the fetus.
- Systemic corticosteroids are present in breast milk and can suppress growth, interfere with natural corticosteroid production and cause other adverse effects in the breastfed infant. It is not known if topical administration can result in sufficient systemic absorption for the drug to appear in milk. Decision should be made to discontinue the drug or nursing depending on the importance of the drug to the mother.
What else should I know about fluocinonide?
- Use fluocinonide exactly as prescribed, do not apply on larger skin areas or more frequently than recommended.
- Store safely out of reach of children.
- In case of overdose, contact your physician or Poison Control.
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Summary
Fluocinonide is a corticosteroid medication topically applied to treat inflammatory skin conditions such as atopic dermatitis, psoriasis, and other skin conditions that respond to corticosteroid treatment. Fluocinonide relieves dryness, redness, itching, scaling, crusting, and other discomforts associated with inflammatory skin conditions. Common side effects of fluocinonide include irritation, itching (pruritus), pain, burning, swelling, redness, discoloration, aggravation of the condition treated, pimples/zits (acne vulgaris), allergic dermatitis, contact dermatitis, dermatitis around the mouth (perioral dermatitis), thinning of the skin (atrophy), stretch marks (striae), inflammation of follicles (folliculitis), excessive hair growth (hypertrichosis), and others.
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Psoriasis is a non-contagious skin disease in which the skin cells grow in numbers faster than normal, producing rashes on the body. Normally, the cells on the surface of the skin are shed as new cells grow beneath. In psoriasis, the swift build-up of skin cells collects on the surface of the skin as scales or plaques. The exact cause of psoriasis is not completely understood. It appears to involve an interplay between a person’s genes, immune system and environment.
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What Makes Guttate Psoriasis Worse?
Guttate psoriasis is often made worse by a bacterial infection, typically Streptococcus (strep throat). Learn about common triggers of guttate psoriasis.
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How Do You Get Rid of Neurodermatitis?
Treatment of neurodermatitis generally aims to control severe itching, prevent scratching, and address underlying causes. Learn about how to get rid of neurodermatitis.
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How Do You Treat Aging Dry Skin?
Dry skin is common in older adults. Treat aging dry skin my moisturizing, bathing in warm water, and using a soft washcloth.
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What Triggers Genital Psoriasis?
Triggers of genital psoriasis may include stress, smoking, excessive alcohol consumption, injury to the skin, medications, infections, and obesity.
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How Do You Manage Inverse Psoriasis?
Although there is no permanent cure for inverse psoriasis, treatment can help manage and alleviate symptoms, including itching and discoloration.
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What Does Dermatitis Herpetiformis Look Like?
Dermatitis herpetiformis (DH) or Duhring’s disease looks similar to herpes lesion (a cluster of dew drops over skin) but is not caused by herpes virus. It is characterized by a cluster of red, itchy, bumpy skin rashes that may affect the elbows, knees, buttocks, lower back, and scalp. The rash can also be confused with eczema or acne.
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Is Psoriasis Contagious?
Psoriasis is an incurable skin disease that causes reddish patches of skin topped with a thick layer of dry silvery scales. Psoriasis cannot spread and is not contagious.
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Can You Treat Eczema and Psoriasis the Same Way?
Both eczema and psoriasis are hereditary and ongoing skin conditions that cause irritated and inflamed skin. Treatment for eczema and psoriasis depends on the type and the severity.
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How Do You Stop Guttate Psoriasis From Spreading?
While there is no definitive way to stop guttate psoriasis from spreading, you can take steps to lower the risk of a flare-up and prevent symptoms from worsening.
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Atopic Dermatitis vs. Eczema
Atopic dermatitis and eczema both refer to skin conditions. Atopic dermatitis is a cause of eczema, which refers to skin conditions that cause inflammation and irritation. The terms are sometimes used interchangeably. Eczema is not a condition in itself, but a description for a group of skin diseases that cause skin inflammation and irritation.
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What Is the Difference Between Eczema and Psoriasis?
Allergies and skin reactions trigger eczema. Psoriasis isn't triggered by allergies. Signs and symptoms of eczema include skin redness, swelling, and itching while psoriasis symptoms and signs include thick, red, itchy, and scaly patches of skin.
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What Is the Best Treatment for Psoriasis?
Psoriasis is an incurable chronic autoimmune disorder of the skin that causes patches of thick, flaky, scaly skin, mostly around the scalp, knees, and elbows, though any skin surface may be involved. Some people experience only small patches while others have red, inflamed skin and think scaly patches all over the body. The exact cause of psoriasis is not clear, but it isn’t contagious.
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What Is Mild to Moderate Psoriasis?
Mild to moderate psoriasis is when the psoriatic scales or plaques (raised surfaces with a silvery cover of dead skin cells) cover less than five percent of the body surface area.
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What Are the Side Effects of Fluocinonide?
Fluocinonide, like all medications, can produce side effects; however, they are not common in most cases. Check out the center below for more medical references on skin conditions, including multimedia (slideshows, images, and quizzes), related disease conditions, treatment and diagnosis, medications, and prevention or wellness.
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What Are the Levels of Psoriasis? 5 Types
Learn the three levels of psoriasis, as well as the five different types, which each include their own symptoms, causes, triggers, treatment, duration, and prevention.
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Can You Get a Skin Rash From Stress?
Yes, the stress can make the skin break into hives. Stress induces a chemical response in the body that makes the skin more sensitive. It releases the hormone, cortisol, in the body that directs the gland in the skin to produce more oil, causing more skin problems.
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How Do You Stop Psoriasis From Stress?
Psoriasis is an autoimmune skin disease that can be passed down (hereditary) to you from your parents or grandparents. Stress is a common factor that can trigger your psoriasis. Psoriasis has a stronger association with psychiatric disorders than other skin diseases. Stress worsens psoriasis by triggering a complex network of signals between the endocrine (hormones), nervous and immune systems.
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What Are the Different Types and Causes of Scalp Psoriasis?
While there is only one type of scalp psoriasis, numerous types of psoriatic conditions can affect the scalp.
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What Does Glycolic Acid Do to Your Skin?
Glycolic acid is a skin exfoliating agent that helps remove the top layer of skin cells including dead skin cells. Glycolic acid helps smooth fine lines and surface wrinkles on the skin, unblock pores and improve skin’s texture and appearance.
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What Things Damage Skin?
The most common things that damage skin include ultraviolet radiation, smoking cigarettes, and skin irritants.
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Is Psoriasis Associated With HIV?
Psoriasis is a chronic autoimmune condition that affects the skin. HIV is linked to a higher likelihood of developing psoriasis and more severe symptoms.
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What Triggers Facial Psoriasis?
Possible triggers of facial psoriasis include smoking, obesity, medications, infections, skin injury, stress, vitamin D deficiency, and stress.
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What Causes Nail Psoriasis?
Nail psoriasis is caused by the same autoimmune mechanisms as other types of psoriasis. The immune system attacks normal tissues in the body and triggers rapid cell growth.
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Atopic Dermatitis vs Contact Dermatitis
The word dermatitis refers to inflammation (redness and swelling) of the skin. Dermatitis includes various skin conditions that cause irritation or rashes on the skin. It generally causes no serious harm to the body and does not mean that the affected person’s skin is infected or unhygienic.
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How to Get Clear Skin: 15 Proven Tips for Fighting Acne
Acne is the most common skin problem that affects more than 80% of people at some point in their life. If not treated properly, it can lead to scars and dark marks on the skin which might take longer to go away.
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How Can I Get Rid of Dry Skin Fast at Home?
Dry skin may be associated with deep cracks, redness, fine lines, itching, skin tightness, and rough-looking skin. Get rid of dry skin at home fast by avoiding long showers, moisturizing your skin, wearing lip balm, or applying coconut oil, petroleum jelly or aloe vera.
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How Is Inverse Psoriasis Diagnosed?
Diagnosis of inverse psoriasis is typically based on medical history and a clinical examination that assesses the location and appearance of the rash.
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Is Genital Psoriasis Life-Threatening?
Although genital psoriasis is neither life-threatening nor contagious, it can be uncomfortable and more difficult to treat than other types of psoriasis.
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Is Pustular Psoriasis an Autoimmune Disease?
Pustular psoriasis is an autoimmune disease that is characterized by yellowish pustules over the skin on an erythematous base.
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Where Does Psoriasis Usually Start?
The most common sites of psoriasis are the scalp, elbows, and knees, although psoriasis can involve any part of the body such as the face, palms, soles, and back.
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How Is Honey Good for Your Skin?
Honey has so many skin benefits that it often appears as an ingredient in commercial skincare products. You can also use honey straight from the jar if you want to get all the effects without other ingredients.
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How Do You Treat Mild to Moderate Psoriasis?
Mild to moderate psoriasis is typically treated with medications and therapies that aim to reduce inflammation and slow the rapid skin cell growth associated with the condition.
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Is Erythrodermic Psoriasis Rare?
Erythrodermic psoriasis is a very rare and potentially fatal form of psoriasis that affects about 1%-2.2% percent of people with the condition.
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How Can I Improve the Health of My Skin?
Healthy, glowing skin is often a result of genes and efforts you invest in your overall health. Learn the 30 tips that can help you improve the health of your skin here.
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What Is Chronic Plaque Psoriasis?
Chronic plaque psoriasis is a chronic inflammatory skin condition characterized by well-distinguished, erythematous (red and inflamed), scaly plaques on the skin of extensor surfaces.
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What Is Generalized Pustular Psoriasis?
Generalized pustular psoriasis (GPP) is a rare, severe type of psoriasis that covers large areas of the body and characterized by pus-filled blisters rather than plaques.
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What Can Trigger Contact Dermatitis? Causes and Symptoms
Learn the common triggers, causes, and symptoms of contact dermatitis below.
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Is Psoriasis Linked to Anxiety?
Like other chronic conditions, psoriasis can take a toll on your emotional health. Anxiety can trigger or worsen psoriasis, and psoriasis can cause anxiety.
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Does Psoriasis Cause Cardiovascular Disease?
Long-lasting inflammation due to psoriasis can affect your heart and blood vessels, increasing your risk of developing cardiovascular disease, heart attack, or stroke.
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How Can I Get Clear and Glowing Skin at Home?
We all, regardless of our gender, wish for a fountain of youth. Men, women, and teenagers alike want a clear and glowing skin. Although genetics play a major role in skin tone and quality, you can achieve a clear and glowing skin by adhering to a decent skin-care regime.
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What Is Intertriginous Psoriasis?
Intertriginous psoriasis, also known as inverse psoriasis, is a rare type of psoriasis that occurs in skin folds, such as the armpits, under the breasts, and groin.
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Are Psoriasis and Psoriatic Arthritis the Same?
Psoriatic arthritis is a type of inflammatory arthritis that occurs due to joint inflammation in people with psoriasis; however, not every person with psoriasis gets psoriatic arthritis.
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What Is the Most Severe Form of Psoriasis?
Erythrodermic psoriasis (EP) or erythroderma is a severe type of psoriasis that causes extensive peeling, severe itching, and rashes across the entire surface of the body.
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How Can I Improve My Skin in Winter?
Winter can expose your skin to less-than-ideal conditions, from wind to dry air. Here are 15 tips for improving your skin in winter.
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Is Psoriasis a COVID-19 Risk?
Psoriasis is a chronic, autoimmune, inflammatory condition that primarily affects the skin. There is no definitive link between psoriasis and an increased risk of COVID-19.
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Can Psoriasis Lead to Psoriatic Arthritis?
It is well established that both psoriatic arthritis and psoriasis are linked. Nearly 30 percent of people with psoriasis develop psoriatic arthritis.
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How Does Psoriasis Affect the Cardiovascular System?
Psoriasis causes inflammation inside your body, which can damage your cardiovascular system over time and increase your risk of heart problems.
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What Is Considered Moderate Plaque Psoriasis?
Moderate plaque psoriasis is when patches cover 3%-10% of your body surface area. Learn about symptoms, causes, triggers, and treatment.
Treatment & Diagnosis
- Red Streaks on the Skin
- Red Spots on the Skin
- Bumps on Skin
- Peeling Skin
- Pale Skin
- Depigmentation of Skin
- Dry Skin
- Contact Dermatitis
- Sensitive Skin: Causes and Treatments
- Psoriasis
- Seborrheic Dermatitis
- Scalp Psoriasis
- Anti-Aging Techniques for Your Skin
- Skin Flaws, Correcting
- Atopic Dermatitis
- Skin: Taking Care of Aging Skin with Diane Young
- Psoriasis: The Secret to Managing Psoriasis
- Psoriasis: Routes to Relief-- Mark Lebwohl, MD
- Psoriasis: Advances in Treatment
- Skin: Winter Skin Care-- Brandith Irwin, MD
- Skin Conditions Picture FAQs
- Psoriasis FAQs
- Beauty FAQs
- Dry Skin FAQs
- Eczema FAQs
- Can You Get Gout in Your Back?
- How Does PCOS Affect Your Appearance?
- How Do You Get Psoriasis?
- Can Psoriasis Be Caused by Allergy?
- Is It Eczema or Psoriasis?
- What Are the Triggers of Psoriasis?
- Does Exercise Make Your Skin Look Younger?
- How Accurate Are Skin Biopsies?
- Do Fish Oil Supplements Cure Dry Skin?
- Seborrheic Dermatitis Treatment
- Psoriasis PUVA Therapy Can Increase Melanoma Risk
- Fats: The Skinny on Fat
Medications & Supplements
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https://reference.medscape.com/drug/vanos-fluocinonide-topical-343519
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https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021758s017lbl.pdf
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