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- What is Diflucan (fluconazole)? How does it work (mechanism of action)?
- What are the uses for Diflucan (fluconazole)?
- What are the side effects of Diflucan (fluconazole)?
- What is the dosage for Diflucan (fluconazole)?
- Which drugs or supplements interact with Diflucan (fluconazole)?
- Is Diflucan (fluconazole) safe to use during pregnancy or while breastfeeding?
- What else should I know about Diflucan (fluconazole)?
What is Diflucan (fluconazole)? How does it work (mechanism of action)?
Diflucan (fluconazole) is an anti-fungal medication related to clotrimazole (Lotrimin), ketoconazole (Nizoral), itraconazole (Sporanox), and miconazole (Micatin, Monistat). Fluconazole prevents growth of fungi by preventing production of the membranes that surround fungal cells.
What are the uses for Diflucan (fluconazole)?
Ibuprofen is used for the treatment of mild to moderate pain, inflammation and fever caused by many and diverse diseases. It is used for treating menstrual cramps (dysmenorrhea), osteoarthritis, rheumatoid arthritis, and juvenile idiopathic arthritis. Intravenous ibuprofen is used for treating patent ductus arteriosus.
- Diflucan is used for treating vaginal, oral, and esophageal fungal infections caused by Candida. It is used for treating uncomplicated, complicated, or recurrent vaginal Candida infections.
- Diflucan also may be effective in treating urinary tract infections, peritonitis, pneumonia and disseminated infections caused by Candida.
- Diflucanis used for treating cryptococcal meningitis, and prevention of Candida infections in patients treated with chemotherapy or radiation after bone marrow transplantation.
What are the side effects of Diflucan (fluconazole)?
Common side effects of fluconazole include
Other important side effects include
Possible serious side effects include
- reduced number of white blood cells,
- reduced number of blood platelets, and
- toxic epidermal necrolysis.
Rarely, serious allergic reactions, including angioedema (swelling of tissues), may also occur. Liver dysfunction (jaundice, hepatitis) and abnormal heart beats have been associated with fluconazole. Stevens-Johnson syndrome has also been reported.
What is the dosage for Diflucan (fluconazole)?
- The usual adult dose is 50-400 mg daily depending on the type of infection. Although symptoms of oral Candida infections may subside in a few days, treatment is continued for 2 weeks.
- Esophageal Candida infections are treated for 3 weeks or longer.
- Treatment of cryptococcal meningitis may last for 10-12 weeks after cerebrospinal fluid cultures become negative.
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Which drugs or supplements interact with Diflucan (fluconazole)?
- Hydrochlorothiazide increases the blood concentration of fluconazole by 40%. However, dosage modification is not recommended when both drugs are combined.
- Rifampin (Rifadin, Rimactane, Rifadin, Rifater, Rifamate) reduces the blood concentration of oral fluconazole, probably by increasing the elimination of fluconazole in the liver; therefore, reducing the effectiveness of fluconazole.
- Fluconazole may increase the concentration of warfarin (Coumadin, Jantoven) in blood by reducing the elimination of warfarin. Therefore, the effect of warfarin may increase, leading to an increased tendency to bleed.
- Fluconazole also increases the concentration of the following drugs in the blood, and as a result, the risk of side effects of these drugs may increase. These drugs include:
- phenytoin (Dilantin),
- zidovudine (Retrovir),
- saquinavir (Invirase),
- theophylline (Theo-Dur, Respbid, Slo-Bid, Theo-24, Theolair, Uniphyl, Slo-Phyllin),
- glyburide (Micronase, Diabeta, Glynase),
- triazolam (Glucotrol),
- midazolam (Versed),
- celecoxib (Celebrex),
- fentanyl (Sublimaze),
- atorvastatin (Lipitor),
- simvastatin (Zocor), and
- lovastatin (Mevacor).
- As a result, the risk of side effects from the above drugs may increase.
- Combining fluconazole with amiodarone (Cordarone), pimozide (Orap), bepridil (Vascor) or other drugs that affect heart rhythm may increase the risk of abnormal heart rhythms.
Is Diflucan (fluconazole) safe to use during pregnancy or while breastfeeding?
- There are no adequate studies of Diflucan in pregnant women. There are reports of harmful effects to the fetus when high dose fluconazole was administered to pregnant women for a few months. Use of fluconazole during pregnancy is not recommended.
- Diflucan is secreted in breast milk at concentrations similar to the mother's blood level. However, fluconazole is used for treating neonates with fungal infections and for treating lactation associated Candida infections. Available evidence suggests that use of fluconazole during breastfeeding has little risk.
What else should I know about Diflucan (fluconazole)?
Preparations available for Diflucan
- Tablets: 50, 100, 150, and 200 mg.
- Oral Suspension: 10 mg/ml and 40 mg/ml.
- Injection: 2 mg/ml
How to keep Diflucan (fluconazole) stored
- Tablets and dry powder should be stored below 86 F (30 C).Injection and reconstituted suspension should be stored between 5 C and 30 C (41 F and 86 F).
- Unused portions of the reconstituted suspension should be protected from freezing and discarded after 2 weeks.
When was Diflucan (fluconazole) approved by the FDA?
- The FDA approved fluconazole in January 1990.
Generic and prescription avialability
- Diflucan is available in generic form. You need a prescription ffor Diflucan from your doctor.
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Diflucan (fluconazole) is a drug prescribed to treat fungal infections caused by Candida, for example, vaginal, oral, esophageal, urinary tract, pneumonia, and peritonitis. Side effects include nausea, diarrhea, dizziness, rash, indigestion, and abdominal pain.
Drug interactions, and pregnancy and breastfeeding safety information should be reviewed prior to taking this medication.
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Jock itch is an itchy red rash that appears in the groin area. The rash may be caused by a bacterial or fungal infection. People with diabetes and those who are obese are more susceptible to developing jock itch. Antifungal shampoos, creams, and pills may be needed to treat fungal jock itch. Bacterial jock itch may be treated with antibacterial soaps and topical and oral antibiotics.
Vaginal Yeast Infection (in Women and Men)
Vaginal yeast infections in women are caused by an organism called Candida albicans. Symptoms of a vaginal yeast infection include vaginal pain with urination, vaginal discharge, odor, and itching. Treatment is generally OTC medications. A man can contract a yeast infection from his female sexual partner. Symptoms of a yeast infection in men include penile itching. Treatment is with oral or topical medication.
The term "ringworm" or "ringworms" refers to fungal infections that are on the surface of the skin. A physical examination of the affected skin, evaluation of skin scrapings under the microscope, and culture tests can help doctors make the appropriate distinctions. A proper diagnosis is essential to successful treatment. Among the different types of ringworm are the following: tinea barbae, tinea capitis, tinea corporis, tinea cruris, tinea faciei, tinea manus, tinea pedis, and tinea unguium.
Thrush (Oral Candidiasis)
Thrush is an infection of the mouth caused by the Candida fungus. Symptoms of thrush include pain or difficulty swallowing, a feeling that food gets stuck in the throat, and fever.
There are a variety of diseases and conditions that can cause tongue problems, discoloration, and soreness. Though most tongue problems are not serious. Conditions such as leukoplakia, oral thrush, and oral lichen planus may cause a white tongue while Kawasaki syndrome, scarlet fever, and geographic tongue may cause the tongue to appear red. A black hairy tongue may be caused by overgrown papillae on the tongue. Canker sores, smoking, and trauma may cause soreness of the tongue.
Urinary Tract Infection (UTI)
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Folliculitis is a skin condition that causes small red bumps to form around the hair follicles. Skin bacteria such as Staphylococcus and Pseudomonas may infect the follicles. Treatment involves over-the-counter bacterial washes, topical antibiotics, and/or topical steroids.
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Vaginitis (Inflammation of the Vagina)
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A fungus causes ringworm. Ringworm can be transmitted from person to person. Animals may also spread ringworm. Ringworm causes an itchy, ring-shaped red rash with hair loss. Treatment incorporates the use of topical medication.
Is a Yeast Infection Contagious?
Yeast are a fungi that has many types. A type of yeast that can cause infection in humans is called Candida. Candida can infect the mouth, vagina, penis, or other areas of the body. Symptoms of yeast infections depend on the area infected, however, may include itching, bumps on the skin, a reddish rash, or patches of skin that ooze a clear or yellowy liquid. Most yeast infections are not contagious even though they are caused by a fungus.
Thrush and Other Yeast Infections in Children
Yeast infections are caused by an overgrowth of a type of fungus called Candida. Oral thrush is a yeast infection of the mouth and throat. Oral thrush and yeast infections are treated orally or topically with an antifungal antibiotic called nystatin.
Tinea versicolor is a fungus infection that mainly affects the skin of young people. Recognized by light or reddish brown spots, and areas lighter than the surrounding skin. Tinea versicolor is caused by yeast actually found in our skin. Factors like heat, humidity, and sweat help it proliferate in people, resulting in a rash that is not contagious to others.
Is Thrush Contagious?
Thrush is a fungal infection caused by Candida albicans. An infant with thrush can infect his/her mother with thrush during breastfeeding. Treatment typically involves using antifungal lozenges or mouthwash.
Histoplasmosis (Cave Disease)
Histoplasmosis (cave disease) is a disease caused by a fungus called Histoplasma capsulatum. The symptoms are similar to those of pneumonia and include chest pain, fever, and sweats. Antifungal medications are used in treatment.
Fungal arthritis is inflammation of a joint by a fungus that has invaded the body and is growing in the normally sterile joint. Symptoms and signs include pain, redness, loss of range of motion, and swelling. Fungal arthritis is treated with antibiotics.
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Fungal meningitis is a rare disease that is not contagious. Symptoms include fever, headache, stiff neck, nausea, and vomiting. Treatment involves administering high doses of antifungal medications.
Cryptococcosis is an infection caused by the Cryptococcus fungus. Cryptococcus is spread through inhalation of airborne fungi. Symptoms and signs include fever, headache, altered mental status, coughing, and shortness of breath. Treatment depends upon the severity of infection and the health status of the patient.
Is Jock Itch (Tinea Cruris) Contagious?
Jock itch is a fungal infection in the groin area that causes a raised, itchy, red rash. Jock itch can typically be treated with antifungal medications. People may need to seek medical care for jock itch if the groin area becomes swollen, tender, if red streaks appear, or if the lymph nodes become swollen.
Valley fever (coccidioidomycosis) is a disease caused by the inhalation of the Coccidioides immitis or C. posadasii fungus. Symptoms are flu-like and resolve over two to six weeks. Infection typically requires no treatment, though there are many antifungal drugs to treat valley fever.
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