Diflucan (fluconazole)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Do I need a prescription for Diflucan (fluconazole)?

Yes

Why is Diflucan (fluconazole) prescribed to patients?

What are the side effects of Diflucan (fluconazole)?

Common side effects of fluconazole include

Other important side effects include

Possible serious side effects include

  • seizures,
  • reduced number of white blood cells,
  • reduced number of blood platelets, and
  • toxic epidermal necrolysis.

Rarely, serious allergic reactions, including angioedema (swelling of tissues), may also occur. Liver dysfunction (jaundice, hepatitis) and abnormal heart beats have been associated with fluconazole.

What is the dosage for Diflucan (fluconazole)?

  • The usual adult dose is 50-400 mg daily depending on the type of infection. Although symptoms of oral Candida infections may subside in a few days, treatment is continued for 2 weeks.
  • Esophageal Candida infections are treated for 3 weeks or longer.
  • Treatment of cryptococcal meningitis may last for 10-12 weeks after cerebrospinal fluid cultures become negative.

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Which drugs or supplements interact with Diflucan (fluconazole)?

Is Diflucan (fluconazole) safe to use during pregnancy or while breastfeeding?

  • There are no adequate studies of Diflucan in pregnant women. There are reports of harmful effects to the fetus when high dose fluconazole was administered to pregnant women for a few months. Use of fluconazole during pregnancy is not recommended.
  • Diflucan is secreted in breast milk at concentrations similar to the mother's blood level. However, fluconazole is used for treating neonates with fungal infections and for treating lactation associated Candida infections. Available evidence suggests that use of fluconazole during breastfeeding has little risk.

What else should I know about Diflucan (fluconazole)?

What preparations of Diflucan (fluconazole) are available?
  • Tablets: 50, 100, 150 and 200 mg.
  • Oral Suspension: 10 mg/ml and 40 mg/ml.
  • Injection: 2 mg/ml
How should I keep Diflucan (fluconazole) stored?
  • Tablets and dry powder should be stored below 86 F (30 C).
  • Injection and reconstituted suspension should be stored between 5 C and 30 C (41 F and 86 F).
  • Unused portions of the reconstituted suspension should be protected from freezing and discarded after 2 weeks.
How does Diflucan (fluconazole) work?
  • Fluconazole prevents growth of fungi by preventing production of the membranes that surround fungal cells.
When was Diflucan (fluconazole) approved by the FDA?
  • The FDA approved fluconazole in January 1990.

Reference: FDA Prescribing Information

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Summary

Diflucan (fluconazole) is a drug prescribed to treat fungal infections caused by Candida, for example, vaginal, oral, esophageal, urinary tract, pneumonia, and peritonitis. Side effects include

Drug interactions, and pregnancy and breastfeeding safety information should be reviewed prior to taking this medication.

Treatment & Diagnosis

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See more info: fluconazole on RxList
Reviewed on 11/9/2016
References
Reference: FDA Prescribing Information

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