Medical Definition of FLAP

Reviewed on 3/29/2021

FLAP: A gene that helps make a leukotriene, a signal that activates the white blood cells involved in inflammation. FLAP stands for 5-lipoxygenase-activating protein.

FLAP has been implicated in a number of inflammatory responses, including asthma, arthritis, psoriasis, heart attack and stroke. FLAP was the first gene discovered to be a major risk factor for the common form of heart attack and the second major genetic factor identified in the common form of stroke.

Also known, confusingly, as 5-lipoxygenase activating protein, five-lipoxygenase-activating protein, five-lipoxygenase activating protein, arachidonate 5-lipoxygenase-activating protein, arachidonate 5-lipoxygenase activating protein, and ALOX5AP.

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