- What is filgrastim, and how does it work (mechanism of action)?
- What brand names are available for filgrastim?
- Is filgrastim available as a generic drug?
- Do I need a prescription for filgrastim?
- What are the side effects of filgrastim?
- What is the dosage for filgrastim?
- Is filgrastim safe to take if I'm pregnant or breastfeeding?
- What else should I know about filgrastim?
What is filgrastim, and how does it work (mechanism of action)?
Filgrastim is a man-made protein that is similar to the naturally occurring protein, granulocyte-colony stimulating factor (G-CSF). G-CSF is produced in the body by the immune system and stimulates the formation of one type of white blood cell, the neutrophil. Neutrophils take part in the inflammatory reaction. They are responsible for detecting and destroying harmful bacteria and some fungi. Filgrastim is produced by bacteria through the use of genetic engineering and recombinant DNA technology. Filgrastim belongs to a class of drugs called colony-stimulating factors because of their ability to stimulate cells in the bone marrow to multiply and form colonies of new cells. Other CSFs include epoetin alfa (Epogen, Procrit) which stimulates the formation of red blood cells and sargramostim (Leukine) which also stimulates the formation of neutrophils. The FDA approved filgrastim in February 1991.
What are the side effects of filgrastim?
The most common side effects are:
Other important side effects include:
Uric acid, lactate dehydrogenase, and alkaline phosphatase levels may rise and spontaneously return to normal levels. Heart attacks and abnormal heart rhythm.
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What is the dosage for filgrastim?
The recommended dose is 5 to 10 mcg/kg per day. Filgrastim is administered intravenously or subcutaneously (under the skin) for 6 to 14 days. Filgrastim vials should not be shaken since the drug may be damaged, and bubbles may form that can prevent some of the drug from being drawn up into the syringe at the time of injection.
Is filgrastim safe to take if I'm pregnant or breastfeeding?
There are no studies to determine if filgrastim is excreted into breast milk.
What else should I know about filgrastim?
What preparations of filgrastim are available?
Filgrastim is available as a liquid for injection in vials or pre-filled syringes containing 300 or 480 micrograms of drug.
How should I keep filgrastim stored?
Filgrastim should be stored at 2 C to 8 C (36 F to 46 F) and should not be frozen.
Filgrastim (Filgrastim) is a medication prescribed to prevent infectious complications associated with neutropenia. Side effects, drug interactions, dosing, and pregnancy safety information should be reviewed prior to taking this medication.
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Biologics Biologic Drug Class
A biologic drug is a product that is produced from living organisms or contain components of living organisms. Biologics include recombinant proteins, tissues, genes, allergens, cells, blood components, blood, and vaccines. Biologics are used to treat numerous disease and conditions, for example:
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- HPV prevention
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Side effects of biologics depend upon the specific biologic drug; however, common side effects may include:
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Drug interactions, preparations, and pregnancy and breastfeeding information should be reviewed prior to administering these drugs.
CancerCancer is a disease caused by an abnormal growth of cells, also called malignancy. It is a group of 100 different diseases, and is not contagious. Cancer can be treated through chemotherapy, a treatment of drugs that destroy cancer cells.
Complete Blood CountA complete blood count (CBC) is a calculation of the cellular makeup of blood. A CBC measures:
- the concentration of white blood cells,
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Drugs: What You Should Know About Your DrugsImportant information about your drugs should be reviewed prior to taking any prescription drug. Side effects, drug interactions, warnings and precauctions, dosage, what the drug is used for, what to do if you miss a dose, how the drug is to be stored, and generic vs. brand names.
Hepatitis CHepatitis C is an inflammation of the liver due to the hepatitis C virus (HCV), which is usually spread by blood transfusion, hemodialysis, and needle sticks, especially with intravenous drug abuse. Symptoms of chronic hepatitis include fatigue, fever, muscle aches, loss of appetite, and fever. Chronic hepatitis C may be cured in most individuals with drugs that target specific genomes of hepatitis C.
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Neutropenia is a marked decrease in the number of neutrophils, neutrophils being a type of white blood cell (specifically a form of granulocyte) filled with neutrally-staining granules, tiny sacs of enzymes that help the cell to kill and digest microorganisms it has engulfed by phagocytosis.
Signs and symptoms of neutropenia include gum pain and swelling, skin abscesses, recurrent ear and sinus infections, sore mouth, low-grad fever, pneumonia-like symptoms, and pain and irritation around the rectal area.
Neutropenia has numerous causes, for example, infections (HIV, TB, mono); medications (chemotherapy); vitamin deficiencies (anemia); bone marrow diseases (leukemias), radiation therapy, autoimmune destruction of neutrophils, and hypersplenism.
Treatment of neutropenia depends upon the cause and the health of the patient.