- What is filgrastim (Neupogen), and how does it work (mechanism of action)?
- What are the uses for filgrastim?
- What are the side effects of filgrastim?
- What is the dosage for filgrastim?
- Which drugs or supplements interact with filgrastim?
- Is filgrastim safe to take if I'm pregnant or breastfeeding?
- What else should I know about filgrastim?
What is filgrastim (Neupogen), and how does it work (mechanism of action)?
Filgrastim (Neupogen) is a man-made protein that is similar to the naturally occurring protein, granulocyte-colony stimulating factor (G-CSF). G-CSF is produced in the body by the immune system and stimulates the formation of one type of white blood cell, the neutrophil. Neutrophils take part in the inflammatory reaction. They are responsible for detecting and destroying harmful bacteria and some fungi. Filgrastim is produced by bacteria through the use of genetic engineering and recombinant DNA technology. Filgrastim belongs to a class of drugs called colony-stimulating factors because of their ability to stimulate cells in the bone marrow to multiply and form colonies of new cells. Other CSFs include epoetin alfa (Epogen, Procrit) which stimulates the formation of red blood cells and sargramostim (Leukine) which also stimulates the formation of neutrophils. The FDA approved filgrastim in February 1991.
What brand names are available for filgrastim?
Is filgrastim available as a generic drug?
GENERIC AVAILABLE: No
Do I need a prescription for filgrastim?
What are the uses for filgrastim?
Filgrastim is used to treat neutropenia, a condition in which the body makes too few neutrophils. Neutropenia may be a long-standing condition in which the body does not make enough neutrophils or it may be caused by drugs used to treat cancer. In some cases, the body may make enough neutrophils but, as part of cancer treatment, the doctor may want to increase the number of certain blood cells (CD34 cells) and collect them. The cells are collected using a process called apheresis. These collected cells are given back to the patient after receiving very high doses of treatment for cancer to help the blood counts get back to normal more quickly.
What are the side effects of filgrastim?
The most common side effects are:
Other important side effects include:
What is the dosage for filgrastim?
The recommended dose is 5 to 10 mcg/kg per day. Filgrastim is administered intravenously or subcutaneously (under the skin) for 6 to 14 days. Filgrastim vials should not be shaken since the drug may be damaged, and bubbles may form that can prevent some of the drug from being drawn up into the syringe at the time of injection.
Which drugs or supplements interact with filgrastim?
If you or your child are receiving filgrastim because you are also receiving chemotherapy, the last dose of filgrastim should be injected at least 24 hours before your next dose of chemotherapy.
Is filgrastim safe to take if I'm pregnant or breastfeeding?
There are no studies to determine if filgrastim is excreted into breast milk.
What else should I know about filgrastim?
What preparations of filgrastim are available?
Filgrastim is available as a liquid for injection in vials or pre-filled syringes containing 300 or 480 micrograms of drug.
How should I keep filgrastim stored?
Filgrastim should be stored at 2 C to 8 C (36 F to 46 F) and should not be frozen.
Filgrastim (Neupogen) is a medication prescribed to prevent infectious complications associated with neutropenia. Review side effects, drug interactions, dosing, and pregnancy safety information prior to taking this medication.
Related Disease Conditions
Cancer is a disease caused by an abnormal growth of cells, also called malignancy. It is a group of 100 different diseases, and is not contagious. Cancer can be treated through chemotherapy, a treatment of drugs that destroy cancer cells.
Neutropenia is a marked decrease in the number of neutrophils, neutrophils being a type of white blood cell (specifically a form of granulocyte) filled with neutrally-staining granules, tiny sacs of enzymes that help the cell to kill and digest microorganisms it has engulfed by phagocytosis. Signs and symptoms of neutropenia include gum pain and swelling, skin abscesses, recurrent ear and sinus infections, sore mouth, low-grad fever, pneumonia-like symptoms, and pain and irritation around the rectal area. Neutropenia has numerous causes, for example, infections (HIV, TB, mono); medications (chemotherapy); vitamin deficiencies (anemia); bone marrow diseases (leukemias), radiation therapy, autoimmune destruction of neutrophils, and hypersplenism. Treatment of neutropenia depends upon the cause and the health of the patient.
Hepatitis C (HCV, Hep C)
Hepatitis C is an inflammation of the liver due to the hepatitis C virus (HCV), which is usually spread by blood transfusion, hemodialysis, and needle sticks, especially with intravenous drug abuse. Symptoms of chronic hepatitis include fatigue, fever, muscle aches, loss of appetite, and fever. Chronic hepatitis C may be cured in most individuals with drugs that target specific genomes of hepatitis C.
Is Hepatitis C Contagious?
Hepatitis C or hep C causes acute and chronic liver disease. Hep C is a form of liver disease with symptoms like fatigue, jaundice, nausea and vomiting, anorexia, and abdominal discomfort. Hepatitis C is a contagious viral infection caused by people sharing drug needles, surgical instruments that have not been properly sanitized, and organ transplantation.
Treatment & Diagnosis
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.