- 10 Common Allergy Triggers Slideshow Pictures
- Take the Quiz on Allergies
- Nasal Allergy Relief Products Slideshow
- What is fexofenadine, and how does it work (mechanism of action)?
- What brand names are available for fexofenadine?
- Is fexofenadine available as a generic drug?
- Do I need a prescription for fexofenadine?
- What are the uses for fexofenadine?
- What are the side effects of fexofenadine?
- What is the dosage for fexofenadine?
- Which drugs or supplements interact with fexofenadine?
- Is fexofenadine safe to take if I'm pregnant or breastfeeding?
- What else should I know about fexofenadine?
What is fexofenadine, and how does it work (mechanism of action)?
Fexofenadine is an oral, "second generation" antihistamine that is used to treat the signs and symptoms of allergy and hives. It is similar to the other second generation antihistamines loratadine (Claritin), cetirizine (Zyrtec) and azelastine (Astelin).
Histamine is a chemical that is responsible for many of the signs and symptoms of allergic reactions, for example, swelling of the lining of the nose, sneezing, and itchy eyes. Histamine is released from histamine-storing cells (mast cells) and then attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cells to be "activated," releasing other chemicals that produce the effects that we associate with allergy (for example, sneezing). Fexofenadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of H1 receptor-containing cells by histamine. Unlike the first generation antihistamines, fexofenadine and other second-generation antihistamines do not readily enter the brain from the blood. Therefore, they cause less drowsiness and are called non-sedating antihistamines. Fexofenadine was approved by the FDA in July 1995.
What brand names are available for fexofenadine?
Allegra, Allegra Allergy, Children's Allegra, Allergy 24-HR, Mucinex Allergy
What are the uses for fexofenadine?
What is the dosage for fexofenadine?
Which drugs or supplements interact with fexofenadine?
Aluminum containing antacids (for example, Maalox) reduced the absorption of fexofenadine when administered 15 minutes apart. Therefore, aluminum containing antacids and fexofenadine should not be administered together. Fruit juices (apple, orange, grapefruit) may reduce the absorption of fexofenadine. Fexofenadine should only be administered with water.
Is fexofenadine safe to take if I'm pregnant or breastfeeding?
Fexofenadine has not been adequately studied in pregnant women.
Fexofenadine has not been adequately studied in women who are breastfeeding.
What else should I know about fexofenadine?
What preparations of fexofenadine are available?
Tablets: 30, 60 and 180 mg. Suspension: 30 mg/5 ml.
Children 2-11 years of age should be given 30 mg twice daily for seasonal allergies or urticaria.
Children 6 months to 2 years old should receive 15 mg twice daily for urticaria.
The suspension is used for children less than 6 years old.
How should I keep fexofenadine stored?
Tablets and suspension should be stored at room temperature between 20 C - 25 C (68 F - 77 F).
Quick GuideBad Bugs: Identify Bug Bites From Mosquitos, Spiders and More
Multimedia: Slideshows, Images & Quizzes
Allergies Quiz: Symptoms & Home Remedies
What are the causes of allergies? This online quiz challenges your knowledge of common food and household allergens,...
Bed Bugs Quiz: How to Get Rid of Bed Bugs
That unexplained itching could be caused by bedbugs. Take the Bedbugs Quiz to learn the causes and symptoms of a bedbug...
Picture of Urticaria
This is a close-up view of wheals with white-to-light-pink color centrally and peripheral erythema. See a picture of Urticaria...
Out-of-Control Allergy Symptoms: Treatment Relief in Pictures
Learn 10 signs your allergies are out of control. See these surprising allergy symptoms and find out how to get relief for...
10 Worst Cities for Spring Allergies With Pictures
See pictures of the top 10 "spring allergy capitals", according to the Asthma and Allergy Foundation of America (AAFA). From...
Related Disease Conditions
19 Tips on How to Stop a Cough
Coughing is a reflex that helps a person clear their airways of irritants. There are many causes of an excessive or severe...
Hives (Urticaria & Angioedema)
Hives, also called urticaria, is a raised, itchy area of skin that is usually a sign of an allergic reaction. The allergy may be...
Itch (Itching or Pruritus)
Itching can be a common problem. Itches can be localized or generalized. There are many causes of itching to include: infection...
Urinary retention (inability to urinate) may be caused by nerve disease, spinal cord injury, prostate enlargement, infection,...
Cough (Chronic, Persistent Cough in Adults and Children)
Chronic cough is a cough that does not go away and is generally a symptom of another disorder such as asthma, allergic...
An allergy refers to a misguided reaction by our immune system in response to bodily contact with certain foreign substances. ...
Eye allergy (or allergic eye disease) are typically associated with hay fever and atopic dermatitis. Medications and cosmetics...
Hay Fever (Allergic Rhinitis)
Hay fever (allergic rhinitis) is an irritation of the nose caused by pollen and is associated with the following allergic...
Are Hives (Urticaria) Contagious?
Hives are not contagious are triggered by an allergic response to a substance. Symptoms and signs of hives include a raised,...
Allergy Treatment Begins At Home
Avoiding allergy triggers at home is one of the best ways to prevent allergy symptoms. Controlling temperature, humidity, and...
Treatment & Diagnosis
- Bed Bugs FAQs
- Allergies FAQs
- Drugs: The Most Common Medication Errors
- Medication Disposal
- Dangers of Mixing Medications
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Asthma Rates Increasing
- Drugs: Buying Prescription Drugs Online Safely
- OTC Cold and Cough Medications
- Grapefruit Juice and Drug Interactions
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
- Antihistamines (Oral)
- Drug Interactions
- Drugs: Questions to Ask Your Doctor or Pharmacist about Your Drugs
- Claritin (loratadine) vs. Zyrtec (cetirizine)
- Nasal Allergy Medications
- cetirizine, Zyrtec, Zyrtec Allergy, Zyrtec Hives
- loratadine, Claritin, Claritin RediTabs, Alavert, Claritin Hives Relief, Children's Claritin
- loratadine and pseudoephedrine (Alavert Allergy & Sinus, Claritin-D, Claritin-D 24 hour)
- fexofenadine and pseudoephedrine, Allegra-D
- azelastine hydrochloride and fluticasone propionate (Dymista)
Prevention & Wellness
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.