- Surprising Reasons You're in Pain Slideshow
- Take the Pain Quiz
- Joint-Friendly Exercises to Reduce RA Pain Slideshow
- What brand names are available for fentanyl transdermal system?
- Is fentanyl transdermal system available as a generic drug?
- Do I need a prescription for fentanyl transdermal system?
- What are the uses for fentanyl transdermal system?
- What are the side effects of fentanyl transdermal system?
- What is the dosage for fentanyl transdermal system?
- Which drugs or supplements interact with fentanyl transdermal system?
- What else should I know about fentanyl transdermal system?
What are the uses for fentanyl transdermal system?
What are the side effects of fentanyl transdermal system?
Physical dependence occurs commonly during therapy with opiate agonists such as fentanyl. Abruptly stopping the drug in patients can precipitate a withdrawal reaction.
Symptoms of withdrawal include:
Fentanyl can cause respiratory depression (decreased rate or depth of breathing), muscle rigidity, and slow heart rate. Nausea or vomiting, constipation, and itching can occur during treatment with fentanyl. Transdermal fentanyl can cause a variety of skin reactions. Commonly, redness occurs at the site of application and can last for 6 hours following removal of the patch.
Other side effects include:
- Dry mouth
- Abdominal pain
- Loss of appetite
Possible serious side effects include:
- Respiratory depression
- Death (overdose)
- Cardiac arrest
- Severe low blood pressure
- Slow heart rate
- Paralytic ileus
- Withdrawal symptoms
The FDA is investigating reports of deaths and other serious side effects from the use of the fentanyl transdermal system as well as overdoses.
Exposing the patch to heat can increase the amount of fentanyl released and may lead to an overdose. Some patches may cause burns of the skin if worn during an MRI (magnetic resonance imaging) scan. Patients should tell their health-care professional that they are using a medication patch prior to receiving an MRI scan.
What is the dosage for fentanyl transdermal system?
- Patches should be applied to a flat, non-irritated area on the upper torso.
- The area of application should be clean and washed with water only prior to application.
- The patch should be applied immediately after removing it from the package and pressed firmly against the skin for 10 to 20 seconds especially around the edges.
- Patches should never be cut or otherwise damaged.
- Doses required to control pain vary widely among patients.
- The recommended dose is 25 to 100 mcg/hour patch applied every 72 hours.
- The manufacturer considers a fentanyl transdermal dose of 100 µg/hour approximately equivalent to 360 mg/day of oral morphine.
Which drugs or supplements interact with fentanyl transdermal system?
The use of fentanyl with other central nervous system depressants can increase the ability of fentanyl to depress breathing, depress the brain, sedate, and lower blood pressure.
Other drugs that may result in slow heart rates in patients when used with fentanyl, and therefore, should be used cautiously include:
- Antipsychotics, for example, Thorazine and Stelazine, haloperidol (Haldol)
- Anxiolytics, for example, diazepam (Valium), lorazepam (Ativan), and zolpidem (Ambien)
- Certain antihistamines, for example, diphenhydramine (Benadryl), and hydroxyzine (Vistaril)
- Barbiturates, for example, phenobarbital (Donnatal)
- Tricyclic antidepressants, for example, amitriptyline (Elavil, Endep) and doxepin (Sinequan), ethanol
- Skeletal muscle relaxants, for example, carisoprodol (Soma), cyclobenzaprine (Flexeril), and baclofen (Lioresal). The use of fentanyl with amiodarone (Cordarone) may result in slow heart rates.
What else should I know about fentanyl transdermal system?
What preparations of fentanyl transdermal system are available?
Transdermal systems labeled as delivering 12, 25, 50, 37.5, 62.5, 75, 87.5, or 100 mcg/hour.
How should I keep fentanyl transdermal system stored?
- Patches should be stored at room temperature below 30 C (86 F). Used patches should be folded in half with the sticky sides together, and then flushed down the toilet.
- Patients must avoid exposing the patches to excessive heat as this promotes the release of fentanyl from the patch and increases the absorption of fentanyl through the skin which can result in fatal overdose.
Fentanyl transdermal patch (Duragesic) is a synthetic narcotic prescribed for severe pain in patients, for example, with cancer pain. Side effects may include:
Multimedia: Slideshows, Images & Quizzes
Understanding Cancer: Metastasis, Stages of Cancer, and More
Learn the basics about cancer including types, causes, how it spreads, symptoms and signs, stages and treatment options. Read...
Pain Quiz: Test Your IQ of Pain
Is pain all in the brain? Take the Pain Quiz to learn everything you've ever wanted to know about the unpleasant sensation we...
Top 10 Cancers Quiz
Take this quiz to learn the causes of cancer. Get the facts about the causes, symptoms, and treatments for the world's most...
Cancer-Fighting Foods in Pictures: Resveratrol, Green Tea, and More
Experts have praised certain foods for their ability to reduce cancer risks. Learn which foods and eating strategies may help...
Addicted to Pills: The Health Risks of Drug Abuse
What is drug abuse? Learn about prescription drug abuse and over-the-counter (OTC) drugs, including depressants, pain relievers,...
Chronic Pain Syndrome: Treatment and Management for CPS
What is chronic pain syndrome (CPS)? See causes, symptoms and treatment options including medications. Learn about pain...
Prescription Drug Abuse: Know The Warning Signs
Learn about prescription drug abuse facts and statistics about the dangers and misconceptions of abusing common prescription...
Related Disease Conditions
Cancer is a disease caused by an abnormal growth of cells, also called malignancy. It is a group of 100 different diseases, and...
Liver cancer is cancer of the liver cells (hepatocellular carcinoma) or of the ducts in the liver (cholangiocarcinoma). Liver...
Colon cancer is a malignancy that arises from the inner lining of the colon. Most, if not all, of these cancers develop from...
Lung cancer kills more men and women than any other form of cancer. Eight out of 10 lung cancers are due to tobacco smoke. Lung...
Cervical Cancer (Cancer of the Cervix)
Cervical cancer is cancer of the entrance to the womb (uterus). Regular pelvic exams and Pap testing can detect precancerous...
Though uterine cancer's cause is unknown, there are many factors that will put a woman at risk, including being over age 50,...
Breast cancer is an invasive tumor that develops in the mammary gland. Breast cancer is detected via mammograms, breast...
Head and Neck Cancer
Head and neck cancer is cancer of the oral cavity, salivary glands, paranasal sinuses and nasal cavity, pharynx, larynx, or lymph...
Prostate cancer is the most common cancer in men after skin cancer. Risk factors include age, family history, ethnicity, and...
Gastroparesis is a medical condition in which the muscle of the stomach is paralyzed by a disease of either the stomach muscle...
Cancers that form from brain tissue are called primary brain tumors. Brain tumors may be malignant (brain cancer) or benign....
Bone cancer is a rare type of cancer that occurs in cells that make up the bones. Primary bone cancer that arises in bone cells...
There are many types of ovarian cancer, epithelial carcinoma is the most common. Women with a family history of ovarian cancer...
Pain management and treatment can be simple or complex, according to its cause. There are two basic types of pain, nociceptive...
Second Source article from Government...
Though the cause of stomach cancer is unknown, risk factors for stomach cancer include diet, H. pylori infection, smoking age,...
Pancreatic cancer is a malignant tumor of the pancreas. Pancreatic cancer has been called a "silent" disease because early...
Signs and symptoms of penile cancer include a lump on the penis and redness, irritation, or a sore on the penis. Risk of penis...
Anal cancer, cancer located at the end of the large intestine, has symptoms that include anal or rectal bleeding, anal pain or...
The shoulder is the most often dislocated joint in the body due to its mobility. Dislocation occurs when the head of the humerus...
Chronic pain is pain (an unpleasant sense of discomfort) that persists or progresses over a long period of time. In contrast to...
Treatment for bladder cancer depends on the stage of the disease, the grade of the tumor, and the type of bladder cancer. Options...
The term oral cancer includes cancer of the mouth (oral cavity) and the back of the mouth (oropharynx). Red and white patches...
Urethral cancer is a rare form of cancer that primarily affects white females, people over 60 years of age, and those who have...
Testicular cancer symptoms include a painless lump or swelling in a testicle, testicle or scrotum pain, a dull ache in the...
Larynx Cancer (Throat Cancer)
Symptoms of cancer of the larynx, the organ at the front of the neck, include hoarseness, a lump in the neck, sore throat, cough,...
There are several types of kidney cancer, including renal cell cancer (renal adenocarcinoma or hypernephroma), transitional cell...
Salivary Gland Cancer
Salivary gland cancer is cancer that affects the parotid glands, sublingual glands, or the submandibular glands. Risk factors...
Inflammatory Breast Cancer
Inflammatory breast cancer is an accelerated form of breast cancer that is not usually detected by mammogram or ultrasound....
Gallbladder cancer is a rare form of cancer with symptoms that include jaundice, abdominal pain, fever, nausea and vomiting,...
Cancer pain results from the tumor pressing on nerves or invading bones or organs. Cancer treatments like chemotherapy,...
Treatment & Diagnosis
- Pain FAQs
- Cancer FAQs
- How To Reduce Your Medication Costs
- Pharmacy Visit, How To Get The Most Out of Your Visit
- Indications for Drugs: Approved vs. Non-approved
- Drugs: Buying Prescription Drugs Online Safely
- Drugs: The Most Common Medication Errors
- Medication Disposal
- Dangers of Mixing Medications
- Generic Drugs, Are They as Good as Brand-Names?
Medications & Supplements
- Drugs: Questions to Ask Your Doctor or Pharmacist about Your Drugs
- Drug Interactions
- codeine (for Pain)
- Dilaudid vs. Fentanyl (Pain Strength Comparison and Side Effects)
- Oxycodone for Pain (OxyContin, Roxicodone, Oxecta, Oxaydo, Xtampza ER, Roxybond)
- Percocet (oxycodone and acetaminophen, Roxicet, Tylox, Oxycet)
- Benzodiazepines vs. Narcotics (Opioids)
- fentanyl injection, Sublimaze
- fentanyl tablet - buccal, Fentora
- fentanyl lozenge - buccal, Actiq
Prevention & Wellness
Quick GuideChronic Pain Syndrome: Treatment and Management for CPS
Health Solutions From Our Sponsors
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.