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- What is the fentanyl patch? What is the fentanyl patch used for?
- What are the uses for fentanyl transdermal system?
- What are the side effects of fentanyl transdermal system?
- What is the dosage for fentanyl transdermal system?
- Which drugs or supplements interact with fentanyl transdermal system?
- Is the fentanyl patch safe to use while pregnant or breastfeeding?
- What else should I know about fentanyl transdermal system?
What is the fentanyl patch? What is the fentanyl patch used for?
Patients considered opioid-tolerant are those who are taking, for one week or longer, at least 60 mg of morphine daily, or at least 30 mg of oral oxycodone daily, or at least 8 mg of oral hydromorphone daily, or an equianalgesic dose of another opioid.
Limitations Of Use
Because of the risks of addiction, abuse, and misuse with opioids, even at recommended doses, and because of the greater risks of overdose and death with extended-release opioid formulations, reserve fentanyl for use in patients for whom alternative treatment options (e.g., non-opioid analgesics or immediate-release opioids) are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain.ride
What brand names are available for fentanyl transdermal system?
Is fentanyl transdermal system available as a generic drug?
Do I need a prescription for fentanyl transdermal system?
What are the side effects of fentanyl transdermal system?
Physical dependence occurs commonly during therapy with opiate agonists such as fentanyl. Abruptly stopping the drug in patients can precipitate a withdrawal reaction.
Symptoms of withdrawal include:
Fentanyl can cause respiratory depression (decreased rate or depth of breathing), muscle rigidity, and slow heart rate. Nausea or vomiting, constipation, and itching can occur during treatment with fentanyl. Transdermal fentanyl can cause a variety of skin reactions. Commonly, redness occurs at the site of application and can last for 6 hours following removal of the patch.
Other side effects include:
- Dry mouth
- Abdominal pain
- Loss of appetite
Possible serious side effects include:
- Respiratory depression
- Death (overdose)
- Cardiac arrest
- Severe low blood pressure
- Slow heart rate
- Paralytic ileus
- Withdrawal symptoms
The FDA is investigating reports of deaths and other serious side effects from the use of the fentanyl transdermal system as well as overdoses.
Exposing the patch to heat can increase the amount of fentanyl released and may lead to an overdose. Some patches may cause burns of the skin if worn during an MRI (magnetic resonance imaging) scan. Patients should tell their health-care professional that they are using a medication patch prior to receiving an MRI scan.
What is the dosage for fentanyl transdermal system?
- Patches should be applied to a flat, non-irritated area on the upper torso.
- The area of application should be clean and washed with water only prior to application.
- The patch should be applied immediately after removing it from the package and pressed firmly against the skin for 10 to 20 seconds especially around the edges.
- Patches should never be cut or otherwise damaged.
- Doses required to control pain vary widely among patients.
- The recommended dose is 25 to 100 mcg/hour patch applied every 72 hours.
- The manufacturer considers a fentanyl transdermal dose of 100 µg/hour approximately equivalent to 360 mg/day of oral morphine.
Which drugs or supplements interact with fentanyl transdermal system?
The use of fentanyl with other central nervous system depressants can increase the ability of fentanyl to depress breathing, depress the brain, sedate, and lower blood pressure.
Other drugs that may result in slow heart rates in patients when used with fentanyl, and therefore, should be used cautiously include:
- Antipsychotics, for example, Thorazine and Stelazine, haloperidol (Haldol)
- Anxiolytics, for example, diazepam (Valium), lorazepam (Ativan), and zolpidem (Ambien)
- Certain antihistamines, for example, diphenhydramine (Benadryl), and hydroxyzine (Vistaril)
- Barbiturates, for example, phenobarbital (Donnatal)
- Tricyclic antidepressants, for example, amitriptyline (Elavil, Endep) and doxepin (Sinequan), ethanol
- Skeletal muscle relaxants, for example, carisoprodol (Soma), cyclobenzaprine (Flexeril), and baclofen (Lioresal). The use of fentanyl with amiodarone (Cordarone) may result in slow heart rates.
Is the fentanyl patch safe to use while pregnant or breastfeeding?
The fentanyl transdermal system is not recommended for use during pregnancy; it may harm a fetus.
What else should I know about fentanyl transdermal system?
What preparations of fentanyl transdermal system are available?
Transdermal systems labeled as delivering 12, 25, 50, 37.5, 62.5, 75, 87.5, or 100 mcg/hour.
How should I keep fentanyl transdermal system stored?
- Patches should be stored at room temperature below 30 C (86 F). Used patches should be folded in half with the sticky sides together, and then flushed down the toilet.
- Patients must avoid exposing the patches to excessive heat as this promotes the release of fentanyl from the patch and increases the absorption of fentanyl through the skin which can result in fatal overdose.
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Daily Health News
Fentanyl transdermal patch (Duragesic) is a synthetic narcotic prescribed for severe pain in patients, for example, with cancer pain. Side effects may include yawning, nasal discharge, twitching muscles, nausea, diarrhea, and coughing. Drug interactions, dosage, and pregnancy and breastfeeding safety information should be reviewed prior to using this medication.
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Cancer is a disease caused by an abnormal growth of cells, also called malignancy. It is a group of 100 different diseases, and is not contagious. Cancer can be treated through chemotherapy, a treatment of drugs that destroy cancer cells.
Bone cancer is a rare type of cancer that occurs in cells that make up the bones. Primary bone cancer that arises in bone cells is different than metastatic bone cancer, which is cancer that arises in another part of the body and then spreads to the bones. Hereditary and environmental factors likely contribute to the risk of bone cancer. Signs and symptoms of bone cancer may include pain, the presence of a mass or lump, and bone fractures. There are different types of bone cancer (osteosarcoma, chondrosarcoma, Ewing's sarcoma, pleomorphic sarcoma, fibrosarcoma). Treatment for bone cancer may include surgical removal of the tumor, chemotherapy, radiation, and/or a stem cell transplant. The prognosis for bone cancer depends on the type of cancer and the extent of spread.
Colon Cancer (Colorectal Cancer)
Colon Cancer (Colorectal Cancer) is a malignancy that arises from the inner lining of the colon. Most, if not all, of these cancers, develop from colonic polyps. Removal of these precancerous polyps can prevent colon cancer.
Liver cancer is cancer of the liver cells (hepatocellular carcinoma) or of the ducts in the liver (cholangiocarcinoma). Liver cancer often arises due to liver damage, cirrhosis (scarring) caused by alcohol use/abuse, hepatitis B, or hepatitis C. Liver cancer may not cause any symptoms. Liver cancer is diagnosed with blood tests, imaging tests, and a liver biopsy. Treatment for liver cancer may include surgery, ablation, embolization, radiation, chemotherapy, and targeted therapy.
Larynx Cancer (Throat Cancer)
Symptoms and signs of cancer of the larynx, the organ at the front of the neck, include hoarseness, a lump in the neck, sore throat, cough, problems breathing, bad breath, earache, and weight loss. Treatment for larynx cancer depends on the stage (the extent) of the disease. Radiation therapy, surgery, and chemotherapy are all forms of treatment for laryngeal cancer.
Cancers that form from brain tissue are called primary brain tumors. Brain tumors may be malignant (brain cancer) or benign. Certain risk factors, such as working in an oil refinery, as a chemist, or embalmer, increase the likelihood of developing brain cancer. Symptoms include headaches, weakness, seizures, difficulty walking, blurry vision, nausea,vomiting, and changes in speech, memory, or personality. Treatment may involve surgery, radiation therapy, or chemotherapy.
Pancreatic cancer is a malignant tumor of the pancreas. Pancreatic cancer has been called a "silent" disease because early pancreatic cancer usually does not cause early symptoms. Typically, pancreatic cancer has metastasized (spread to adjacent organs, such as the liver) by the time most people receive a dignosis of pancreatic cancer. Symptoms and signs usually appear later in the course of the disease and include jaundice, back pain, nausea, weight loss, itching, and loss of appetite. Treatment depends upon the type of pancreatic cancer but may include surgery, chemotherapy, and/or radiation therapy.
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Cervical Cancer (Cancer of the Cervix)
Cervical cancer is cancer of the entrance to the womb (uterus) caused by the human papillomavirus (HPV). Regular pelvic exams, Pap testing, and screening can detect precancerous changes in the cervix. Cervical cancer can be prevented by a vaccine. The most common signs and symptoms are an increase in vaginal discharge, painful sex, and postmenopausal bleeding. The prognosis and survival rate depend upon the stage at which the cancer was diagnosed.
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Treatment for bladder cancer depends on the stage of the disease, the grade of the tumor, and the type of bladder cancer. Options for treatment include surgery, radiation therapy, chemotherapy, and biological therapy.
Signs and symptoms of penile cancer include a lump on the penis and redness, irritation, or a sore on the penis. Risk of penis cancer is higher in uncircumcised men, due to a higher risk of HPV infection. Other risk factors include being over 60, having phimosis, having poor hygiene, using tobacco products, and having many sex partners. Prognosis and treatment depend upon the tumor's location and size, the stage of the cancer, and whether the cancer was recently diagnosed or if it recurred.
There are several types of kidney cancer, including renal cell cancer (renal adenocarcinoma or hypernephroma), transitional cell carcinoma, and Wilms tumor. Symptoms of kidney cancer include blood in the urine, an abdominal lump or mass, chronic pain in the side, and tiredness. Treatment of kidney cancer -- which may include surgery, arterial embolization, radiation therapy, biological therapy or chemotherapy -- depends upon the stage of the disease and the patient's overall health.
Chronic pain is pain (an unpleasant sense of discomfort) that persists or progresses over a long period of time. In contrast to acute pain that arises suddenly in response to a specific injury and is usually treatable, chronic pain persists over time and is often resistant to medical treatments.
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Inflammatory Breast Cancer
Inflammatory breast cancer is an accelerated form of breast cancer that is not usually detected by mammogram or ultrasound. Symptoms of inflammatory breast cancer include pain in the breast, skin change in the breast area, bruise on the breast,sudden swelling of the breast, nipple retraction or discharge, and swelling of the lymph nodes.
Testicular cancer symptoms include a painless lump or swelling in a testicle, testicle or scrotum pain, a dull ache in the abdomen, back, or groin, and a feeling of heaviness in the scrotum. Treatment for cancer of the testicles depends on the type of cancer (seminoma or nonseminoma), the stage of the cancer, and the patient's age and health.
Head and Neck Cancer
Head and neck cancer is cancer of the oral cavity, salivary glands, paranasal sinuses and nasal cavity, pharynx, larynx, or lymph nodes in the upper part of the neck. These cancers account for 3% to 5% of cancers in the U.S. Tobacco and alcohol use are important risk factors. Treatment may involve surgery, radiation therapy, and/or chemotherapy.
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There are a variety of options that may help you handle your situation. It might help you to visualize each option and decide how you feel about it. Consider reaching out to trained professionals or close friends if you get overwhelmed.
Salivary Gland Cancer
Salivary gland cancer is cancer that affects the parotid glands, sublingual glands, or the submandibular glands. Risk factors include older age, radiation therapy treatment to head or neck, and being exposed to certain substances at work. Signs include fluid draining from the ear, pain, numbness, weakness, trouble swallowing, and a lump. Treatment depends upon the stage of the cancer and usually involves surgery, radiation therapy, chemotherapy, or radiosensitizers.
Anal cancer, cancer located at the end of the large intestine, has symptoms that include anal or rectal bleeding, anal pain or pressure, anal discharge or itching, a change in bowel movements, and/or a lump in the anal region. Treatment for anal cancer may involve radiation, chemotherapy, or surgery and depends upon the stage of the cancer, its location, whether cancer is eradicated after the first treatment, and whether the patient has HIV.Anal cancer is usually curable when found localized. Early detection remains the key to long-term survival as it is in many forms of cancer.
Gallbladder cancer is a rare form of cancer with symptoms that include jaundice, abdominal pain, fever, nausea and vomiting, abdominal lumps, and bloating. Risk factors include being female and Native American. Treatment of gallbladder cancer depends upon the stage of the cancer, the type of gallbladder cancer, and whether the cancer can be removed by surgery.
Urethral cancer is a rare form of cancer that primarily affects white females, people over 60 years of age, and those who have stds or who experience frequent urinary tract infections. Symptoms and signs of urethral cancer include blood in the urine, interrupted urine flow and discharge from the urethra. Treatment involves surgery, radiation therapy, and chemotherapy.
Cancer pain results from the tumor pressing on nerves or invading bones or organs. Cancer treatments like chemotherapy, radiation, or surgery can also cause pain. Over-the-counter pain relievers, prescription medications, radiation, biofeedback, and relaxation techniques are just some treatments for cancer pain.
Treatment & Diagnosis
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Medications & Supplements
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- codeine (for Pain)
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